{"id":"https://openalex.org/W2127367694","doi":"https://doi.org/10.1007/s13631-014-0072-0","title":"K Index in cerebrospinal fluid: a valid tool in multiple sclerosis diagnosis","display_name":"K Index in cerebrospinal fluid: a valid tool in multiple sclerosis diagnosis","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2127367694","doi":"https://doi.org/10.1007/s13631-014-0072-0","mag":"2127367694"},"language":"it","primary_location":{"id":"doi:10.1007/s13631-014-0072-0","doi":"https://doi.org/10.1007/s13631-014-0072-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13631-014-0072-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210223908","display_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","issn_l":"1825-859X","issn":["1825-859X","2039-6821"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2108/92507","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067528375","display_name":"Massimo Pieri","orcid":"https://orcid.org/0000-0002-3463-0268","observed_orcids":["https://orcid.org/0000-0002-3463-0268"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Pieri","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","\u201cTor Vergata\u201d University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","institution_ids":["https://openalex.org/I4210138843"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089704259","display_name":"Fabio Duranti","orcid":"https://orcid.org/0000-0002-8677-5493","observed_orcids":["https://orcid.org/0000-0002-8677-5493"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Duranti","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","\u201cTor Vergata\u201d University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","institution_ids":["https://openalex.org/I4210138843"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001899447","display_name":"Diego Centonze","orcid":"https://orcid.org/0000-0002-8390-8545","observed_orcids":["https://orcid.org/0000-0002-8390-8545"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diego Centonze","raw_affiliation_strings":["Department of Systems Medicine, \u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia, Roma, Italy","\u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, \u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia, Roma, Italy","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088864859","display_name":"Fabio Buttari","orcid":"https://orcid.org/0000-0002-6089-4670","observed_orcids":["https://orcid.org/0000-0002-6089-4670"]},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Buttari","raw_affiliation_strings":["Department of Systems Medicine, \u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia, Roma, Italy","\u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Medicine, \u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia, Roma, Italy","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital & IRCCS Fondazione Santa Lucia","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006082027","display_name":"Sergio Bernardini","orcid":"https://orcid.org/0000-0003-1984-6834","observed_orcids":["https://orcid.org/0000-0003-1984-6834"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sergio Bernardini","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","\u201cTor Vergata\u201d University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","institution_ids":["https://openalex.org/I4210138843"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042738567","display_name":"Mariarita Dess\u00ec","orcid":"https://orcid.org/0000-0002-9624-6456","observed_orcids":["https://orcid.org/0000-0002-9624-6456"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mariarita Dess\u00ec","raw_affiliation_strings":["Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","\u201cTor Vergata\u201d University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine and Surgery, \u201cTor Vergata\u201d University Hospital, Viale Oxford 81, 00133, Roma, Italy","institution_ids":["https://openalex.org/I4210138843"]},{"raw_affiliation_string":"\u201cTor Vergata\u201d University Hospital","institution_ids":["https://openalex.org/I4210138843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042738567"],"corresponding_institution_ids":["https://openalex.org/I4210138843"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":0.2111,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53925142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"10","issue":"3","first_page":"167","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/kappa-free-light-chains","display_name":"kappa free light chains","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/oligoclonal-bands","display_name":"oligoclonal bands","score":0.9290000200271606},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.8510000109672546},{"id":"https://openalex.org/keywords/leukoencephalopathy","display_name":"leukoencephalopathy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/free-light-chains","display_name":"free light chains","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.8428407907485962},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.7653641104698181},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.6981315016746521},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.5711878538131714},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5545284152030945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5542464256286621},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5160664916038513},{"id":"https://openalex.org/C164585084","wikidata":"https://www.wikidata.org/wiki/Q12133588","display_name":"Nephelometry","level":3,"score":0.5035437941551208},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43455269932746887},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3215232491493225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3000473082065582},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27656516432762146}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s13631-014-0072-0","doi":"https://doi.org/10.1007/s13631-014-0072-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13631-014-0072-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210223908","display_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","issn_l":"1825-859X","issn":["1825-859X","2039-6821"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"pmh:oai:art.torvergata.it:2108/92507","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2108/92507","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:art.torvergata.it:2108/92507","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2108/92507","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1244620587","https://openalex.org/W1758510320","https://openalex.org/W1965100435","https://openalex.org/W1967126548","https://openalex.org/W1997236586","https://openalex.org/W2032190399","https://openalex.org/W2049991417","https://openalex.org/W2059898133","https://openalex.org/W2065496524","https://openalex.org/W2074856102","https://openalex.org/W2080477550","https://openalex.org/W2082706341","https://openalex.org/W2111708109","https://openalex.org/W2120297836","https://openalex.org/W2122545833","https://openalex.org/W2123646700","https://openalex.org/W2127679344","https://openalex.org/W2153225124","https://openalex.org/W2396815809"],"related_works":["https://openalex.org/W7216242650","https://openalex.org/W2614063182","https://openalex.org/W2031694038","https://openalex.org/W2766799416","https://openalex.org/W3194101085","https://openalex.org/W3094042003","https://openalex.org/W2091261566","https://openalex.org/W2883187593","https://openalex.org/W7118122528","https://openalex.org/W3198017924"],"abstract_inverted_index":{"Background.":[0],"Detection":[1],"of":[2,35,66,106,117,142,165,198,209],"oligoclonal":[3,166],"IgG":[4],"bands":[5,168],"in":[6,23,40,48,81,97,150,216],"cerebrospinal":[7],"fluid":[8],"by":[9,103],"isoelectrocfocusing":[10],"and":[11,50,89,176,221],"immunodetection":[12],"is":[13,61],"the":[14,24,33,63,104,130,140,143,163,172,179,196,207,210,223,226],"current":[15],"gold":[16],"standard":[17],"to":[18,86,129,157,191,213,218,222],"detect":[19],"an":[20,84],"inflammatory":[21],"process":[22],"central":[25],"nervous":[26],"system.":[27],"It":[28],"has":[29],"been":[30],"proposed":[31],"that":[32],"presence":[34],"free":[36,76],"light":[37,77],"chains":[38],"(FLCs)":[39],"CSF":[41],"was":[42],"associated":[43],"with":[44,187],"recent":[45],"demyelination":[46],"activity":[47],"MS":[49,215],"might":[51],"be":[52,158],"used":[53],"as":[54,83,146,194],"a":[55,67,107,147],"prognosis":[56],"marker.":[57],"Our":[58],"study\u2019s":[59],"objective":[60],"assessing":[62],"diagnostic":[64,148],"accuracy":[65],"new":[68,108,202],"highly":[69,109],"sensitive":[70,110],"latex-enhanced":[71,111],"nephelometric":[72,112],"assay":[73],"for":[74,115],"k":[75,144,211],"chain":[78],"(kFLC)":[79],"determination":[80,164],"CSF/serum":[82,98],"alternative":[85],"traditional":[87],"tests":[88],"its":[90],"clinical":[91],"application.":[92],"Methods.":[93],"kFLCs":[94],"were":[95,123],"measured":[96],"pairs":[99],"from":[100],"80":[101],"patients":[102,122,184],"use":[105,141,208],"automated":[113],"immunoassay":[114],"detection":[116],"immunoglobulin":[118,167],"FLC.":[119],"The":[120],"eighty":[121],"split":[124],"into":[125],"three":[126],"groups":[127],"according":[128],"neurological":[131],"diagnosis.":[132],"In":[133],"this":[134],"study":[135],"we":[136],"confirm":[137],"even":[138,205],"more":[139,159,206],"Index":[145,155,174,212],"aid":[149],"multiple":[151],"sclerosis.":[152],"Results.":[153],"kFLC":[154],"seems":[156],"accurate":[160],"parameter":[161],"respect":[162,178],"(OCBs).":[169],"We":[170],"recalculate":[171],"K":[173],"sensitivity":[175],"specificity":[177],"precedent":[180],"published":[181],"result.":[182],"Two":[183],"previously":[185],"diagnosed":[186],"leukoencephalopathy":[188],"have":[189],"gone":[190],"group":[192],"3":[193],"confirmed":[195],"diagnosis":[197],"MS.":[199],"Conclusions.":[200],"These":[201],"data":[203],"reinforce":[204],"diagnose":[214],"comparison":[217],"classical":[219],"methods":[220],"reference":[224],"method,":[225],"OCBs.":[227]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
