{"id":"https://openalex.org/W2127322399","doi":"https://doi.org/10.1152/ajprenal.00581.2009","title":"Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells","display_name":"Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells","publication_year":2010,"publication_date":"2010-04-29","ids":{"openalex":"https://openalex.org/W2127322399","doi":"https://doi.org/10.1152/ajprenal.00581.2009","mag":"2127322399","pmid":"https://pubmed.ncbi.nlm.nih.gov/20427472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904182"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00581.2009","doi":"https://doi.org/10.1152/ajprenal.00581.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00581.2009","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904182","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041145611","display_name":"Kristine Holthouser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristine A. Holthouser","raw_affiliation_strings":["Departments of 1Medicine/Kidney Disease Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Medicine/Kidney Disease Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112320295","display_name":"Amritlal Mandal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amritlal Mandal","raw_affiliation_strings":["Department of Physiology, University of Arizona, Tucson, Arizona; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Arizona, Tucson, Arizona; and","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085061817","display_name":"Michael L. Merchant","orcid":"https://orcid.org/0000-0003-4128-4057","observed_orcids":["https://orcid.org/0000-0003-4128-4057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Merchant","raw_affiliation_strings":["Departments of 1Medicine/Kidney Disease Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Medicine/Kidney Disease Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079294410","display_name":"Jeffrey R. Schelling","orcid":"https://orcid.org/0000-0003-3503-2208","observed_orcids":["https://orcid.org/0000-0003-3503-2208"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey R. Schelling","raw_affiliation_strings":["Department of Medicine, Case Western Reserve University, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Case Western Reserve University, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013597405","display_name":"Nicholas A. Delamere","orcid":"https://orcid.org/0000-0002-3018-1645","observed_orcids":["https://orcid.org/0000-0002-3018-1645"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Delamere","raw_affiliation_strings":["Department of Physiology, University of Arizona, Tucson, Arizona; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Arizona, Tucson, Arizona; and","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081905509","display_name":"Ronald R. Valdes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald R. Valdes","raw_affiliation_strings":["Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003454740","display_name":"Suresh Chand Tyagi","orcid":"https://orcid.org/0000-0002-2457-5576","observed_orcids":["https://orcid.org/0000-0002-2457-5576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh C. Tyagi","raw_affiliation_strings":["Physiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011298885","display_name":"Eleanor DeLand Lederer","orcid":"https://orcid.org/0000-0002-5935-3746","observed_orcids":["https://orcid.org/0000-0002-5935-3746"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210111273","display_name":"Louisville VA Medical Center","ror":"https://ror.org/01zd7yk57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111273","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor D. Lederer","raw_affiliation_strings":["Departments of 1Medicine/Kidney Disease Program,","Physiology, and","Veterans Administration Medical Center, University of Louisville, Louisville, Kentucky;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Medicine/Kidney Disease Program,","institution_ids":[]},{"raw_affiliation_string":"Physiology, and","institution_ids":[]},{"raw_affiliation_string":"Veterans Administration Medical Center, University of Louisville, Louisville, Kentucky;","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210111273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021395049","display_name":"Syed Jalal Khundmiri","orcid":"https://orcid.org/0000-0002-0364-0412","observed_orcids":["https://orcid.org/0000-0002-0364-0412"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Syed J. Khundmiri","raw_affiliation_strings":["Departments of 1Medicine/Kidney Disease Program,","Physiology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Medicine/Kidney Disease Program,","institution_ids":[]},{"raw_affiliation_string":"Physiology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021395049"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0635,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.86845883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"299","issue":"1","first_page":"F77","last_page":"F90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":1.0},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/nhe1","display_name":"NHE1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.8550000190734863},{"id":"https://openalex.org/keywords/kidney-proximal-tubule","display_name":"kidney proximal tubule","score":0.8190000057220459},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.4180000126361847},{"id":"https://openalex.org/keywords/eipa","display_name":"EIPA","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/na-k-atpase-alpha1-subunit","display_name":"Na+/K+-ATPase alpha1 subunit","score":0.8040000200271606},{"id":"https://openalex.org/keywords/basolateral-membrane","display_name":"basolateral membrane","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.6769999861717224},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.8413217663764954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6334846615791321},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5422649383544922},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.523395836353302},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.5113739371299744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5040663480758667},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4643092155456543},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4494098722934723},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.43363291025161743},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4128114581108093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3214215338230133},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2428865134716034},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16931423544883728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08781403303146362},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074082","descriptor_name":"Sodium-Hydrogen Exchanger 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009893","descriptor_name":"Opossums","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajprenal.00581.2009","doi":"https://doi.org/10.1152/ajprenal.00581.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00581.2009","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2120343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2904182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904182","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},{"id":"pmid:20427472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20427472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2120343","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904182","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2295993604","display_name":"Mechanisms of glomerular disesase progression","funder_award_id":"R01DK072348","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5888826072","display_name":"Renal Disease Progression in African Americans","funder_award_id":"R01DK059997","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5948761502","display_name":null,"funder_award_id":"R01-DK-067528","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6311744384","display_name":null,"funder_award_id":"EY-040414","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000866389","display_name":"Mechanisms of Tubular Atrophy","funder_award_id":"5r01dk067528-16","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W177255110","https://openalex.org/W1570452788","https://openalex.org/W1576990557","https://openalex.org/W1841061580","https://openalex.org/W1965009930","https://openalex.org/W1968320638","https://openalex.org/W1969955179","https://openalex.org/W1970128059","https://openalex.org/W1974615597","https://openalex.org/W1976505198","https://openalex.org/W1979301883","https://openalex.org/W1980673430","https://openalex.org/W1983344502","https://openalex.org/W1985922024","https://openalex.org/W1992267503","https://openalex.org/W2009678908","https://openalex.org/W2009755318","https://openalex.org/W2016081191","https://openalex.org/W2017241167","https://openalex.org/W2030058279","https://openalex.org/W2032292804","https://openalex.org/W2032553975","https://openalex.org/W2042006767","https://openalex.org/W2046836400","https://openalex.org/W2050728158","https://openalex.org/W2052141890","https://openalex.org/W2052932372","https://openalex.org/W2052938761","https://openalex.org/W2059249920","https://openalex.org/W2072856314","https://openalex.org/W2079899892","https://openalex.org/W2081787890","https://openalex.org/W2082305701","https://openalex.org/W2083467450","https://openalex.org/W2086680916","https://openalex.org/W2087784543","https://openalex.org/W2088924345","https://openalex.org/W2093085618","https://openalex.org/W2094709807","https://openalex.org/W2097262291","https://openalex.org/W2101313549","https://openalex.org/W2108973226","https://openalex.org/W2113239058","https://openalex.org/W2113564075","https://openalex.org/W2114170740","https://openalex.org/W2122252852","https://openalex.org/W2127234348","https://openalex.org/W2127514154","https://openalex.org/W2127688994","https://openalex.org/W2128679135","https://openalex.org/W2140644734","https://openalex.org/W2141940718","https://openalex.org/W2144470409","https://openalex.org/W2151465237","https://openalex.org/W2154377445","https://openalex.org/W2155123009","https://openalex.org/W2160268500","https://openalex.org/W2162746728","https://openalex.org/W2163948875","https://openalex.org/W2168658716","https://openalex.org/W2187378057","https://openalex.org/W2287209278","https://openalex.org/W2346310888","https://openalex.org/W2442519853","https://openalex.org/W2992823852","https://openalex.org/W4248418271"],"related_works":["https://openalex.org/W7825723","https://openalex.org/W28091386","https://openalex.org/W2033062888","https://openalex.org/W3174310911","https://openalex.org/W3175532779","https://openalex.org/W2482805319","https://openalex.org/W2101737761","https://openalex.org/W1973392260","https://openalex.org/W2019329765","https://openalex.org/W3174535072"],"abstract_inverted_index":{"Recent":[0],"investigations":[1],"demonstrate":[2],"increased":[3,157,178,187,209],"Na/H":[4],"exchanger-1":[5],"(NHE-1)":[6],"activity":[7,37,89],"and":[8,28,40,79,81,90,100,130,136,162,183,232],"plasma":[9],"levels":[10,111],"of":[11,38,61,66,112,115,127,140,148,160,221,230],"ouabain-like":[12],"factor":[13],"in":[14,63,68,93,104,133,143,188,208,212,240],"spontaneously":[15],"hypertensive":[16],"rats.":[17,214],"At":[18],"nanomolar":[19],"concentrations,":[20],"ouabain":[21,50,156,169,198],"increases":[22],"Na-K-ATPase":[23,41,52,67,88,131,149,161,179,224,231],"activity,":[24,180],"induces":[25],"cell":[26,72],"proliferation,":[27],"activates":[29],"complex":[30],"signaling":[31],"cascades.":[32],"We":[33],"hypothesize":[34],"that":[35,95,107,218,233],"the":[36,59,219],"NHE-1":[39,62,97,116,142,186,222],"are":[42],"interdependent.":[43],"To":[44],"test":[45],"whether":[46],"treatment":[47,196],"with":[48,117,154,168,185,197,223],"picomolar":[49,151,155],"regulates":[51],"through":[53],"an":[54],"NHE-1-dependent":[55],"mechanism,":[56],"we":[57],"examined":[58],"role":[60,239],"ouabain-mediated":[64,125,228],"stimulation":[65,126],"kidney":[69,75,83,190],"proximal":[70],"tubule":[71],"lines":[73],"[opossum":[74],"(OK),":[76],"HK-2,":[77],"HKC-5,":[78,99,135],"HKC-11]":[80],"rat":[82,189],"basolateral":[84,192],"membranes.":[85,193],"Ouabain":[86],"stimulated":[87],"tyrosine":[91],"phosphorylation":[92,132],"cells":[94,106,145],"express":[96,108],"(OK,":[98],"HKC-11)":[101],"but":[102],"not":[103],"HK-2":[105],"very":[109],"low":[110],"NHE-1.":[113],"Inhibition":[114],"5":[118],"microM":[119],"EIPA,":[120],"a":[121,238],"NHE-1-specific":[122],"inhibitor,":[123],"prevented":[124],"(86)Rb":[128],"uptake":[129],"OK,":[134],"HKC-11":[137],"cells.":[138],"Expression":[139],"wild-type":[141],"HK2":[144],"restored":[146],"regulation":[147,229],"by":[150],"ouabain.":[152],"Treatment":[153,167],"membrane":[158],"expression":[159],"enhanced":[163],"NHE-1-Na-K-ATPase":[164],"alpha1-subunit":[165],"association.":[166],"(1":[170,199],"microg":[171,200],"x":[172,176,201,205],"kg":[173,202],"body":[174,203],"wt(-1)":[175,204],"day(-1))":[177,206],"expression,":[181],"phosphorylation,":[182],"association":[184,220],"cortical":[191],"Eight":[194],"days'":[195],"resulted":[207],"blood":[210],"pressure":[211],"these":[213,234],"These":[215],"results":[216],"suggest":[217],"is":[225],"critical":[226],"for":[227],"effects":[235],"may":[236],"play":[237],"cardioglycoside-stimulated":[241],"hypertension.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
