{"id":"https://openalex.org/W2127320439","doi":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","title":"Pluripotential liver stem cells: facultative stem cells located in the biliary tree","display_name":"Pluripotential liver stem cells: facultative stem cells located in the biliary tree","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2127320439","doi":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","mag":"2127320439","pmid":"https://pubmed.ncbi.nlm.nih.gov/8883463"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2184.1996.tb00982.x","doi":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043821826","display_name":"Malcolm Ronald Alison","orcid":"https://orcid.org/0000-0002-7348-3387","observed_orcids":["https://orcid.org/0000-0002-7348-3387"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. R. Alison","raw_affiliation_strings":["Department of Histopathology, Royal Postgraduate Medical School, London, UK","Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Royal Postgraduate Medical School, London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023003857","display_name":"M H Golding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. H. C. Golding","raw_affiliation_strings":["Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109170501","display_name":"Catherine Sarraf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. E. Sarraf","raw_affiliation_strings":["Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histopathology, Royal Postgraduate Medical School, Du Cane Road, London W12 ONN, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043821826"],"corresponding_institution_ids":[],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":1.1432,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.7706422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"7","first_page":"373","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-stem-cells","display_name":"liver stem cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/biliary-tract","display_name":"biliary tract","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oval-cells","display_name":"oval cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ductular-reaction","display_name":"ductular reaction","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hepatocyte-regeneration","display_name":"hepatocyte regeneration","score":0.7850000262260437},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.6970000267028809},{"id":"https://openalex.org/keywords/biliary-epithelium","display_name":"biliary epithelium","score":0.7620000243186951},{"id":"https://openalex.org/keywords/stem-cell-hierarchy","display_name":"stem cell hierarchy","score":0.5720000267028809},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ex-vivo-gene-therapy","display_name":"ex vivo gene therapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hepatocyte-differentiation","display_name":"hepatocyte differentiation","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7389405369758606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7372298240661621},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6664034724235535},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5946801900863647},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5690010786056519},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5152797698974609},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4467499852180481},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3603479266166687},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12764805555343628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0992979109287262},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06499984860420227},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2184.1996.tb00982.x","doi":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2184.1996.tb00982.x","pdf_url":null,"source":{"id":"https://openalex.org/S86484535","display_name":"Cell Proliferation","issn_l":"0960-7722","issn":["0960-7722","1365-2184"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Proliferation","raw_type":"journal-article"},{"id":"pmid:8883463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8883463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell proliferation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":174,"referenced_works":["https://openalex.org/W3326930","https://openalex.org/W13263631","https://openalex.org/W13615411","https://openalex.org/W63500506","https://openalex.org/W65170271","https://openalex.org/W67016167","https://openalex.org/W85922660","https://openalex.org/W92234937","https://openalex.org/W110259188","https://openalex.org/W121307156","https://openalex.org/W132493370","https://openalex.org/W143089095","https://openalex.org/W143918118","https://openalex.org/W150568786","https://openalex.org/W153985129","https://openalex.org/W155790071","https://openalex.org/W181931712","https://openalex.org/W194075009","https://openalex.org/W214049826","https://openalex.org/W235516904","https://openalex.org/W269467774","https://openalex.org/W307100496","https://openalex.org/W1224253673","https://openalex.org/W1276127231","https://openalex.org/W1514235737","https://openalex.org/W1525130584","https://openalex.org/W1548038310","https://openalex.org/W1558031393","https://openalex.org/W1561339124","https://openalex.org/W1567101341","https://openalex.org/W1583618104","https://openalex.org/W1593105968","https://openalex.org/W1604066767","https://openalex.org/W1606465625","https://openalex.org/W1647145872","https://openalex.org/W1702287731","https://openalex.org/W1786861597","https://openalex.org/W1823130351","https://openalex.org/W1862882655","https://openalex.org/W1872985496","https://openalex.org/W1942046763","https://openalex.org/W1968391842","https://openalex.org/W1972487225","https://openalex.org/W1973657908","https://openalex.org/W1973997143","https://openalex.org/W1974586745","https://openalex.org/W1976332957","https://openalex.org/W1978349753","https://openalex.org/W1978507181","https://openalex.org/W1980938275","https://openalex.org/W1981112337","https://openalex.org/W1983755961","https://openalex.org/W1984393404","https://openalex.org/W1985400766","https://openalex.org/W1989815162","https://openalex.org/W1991506429","https://openalex.org/W1997100869","https://openalex.org/W2000830487","https://openalex.org/W2007094387","https://openalex.org/W2009848160","https://openalex.org/W2010081432","https://openalex.org/W2010248689","https://openalex.org/W2015017222","https://openalex.org/W2016693266","https://openalex.org/W2018508514","https://openalex.org/W2018906660","https://openalex.org/W2020747990","https://openalex.org/W2022217882","https://openalex.org/W2022766129","https://openalex.org/W2024721720","https://openalex.org/W2034483815","https://openalex.org/W2037377193","https://openalex.org/W2039618230","https://openalex.org/W2042213831","https://openalex.org/W2043344911","https://openalex.org/W2044423704","https://openalex.org/W2046083532","https://openalex.org/W2051172626","https://openalex.org/W2051980794","https://openalex.org/W2052764651","https://openalex.org/W2055690685","https://openalex.org/W2060655489","https://openalex.org/W2062372588","https://openalex.org/W2062521096","https://openalex.org/W2063529172","https://openalex.org/W2064268635","https://openalex.org/W2066644227","https://openalex.org/W2070776588","https://openalex.org/W2071545773","https://openalex.org/W2073808856","https://openalex.org/W2074461807","https://openalex.org/W2074966846","https://openalex.org/W2076965242","https://openalex.org/W2081631539","https://openalex.org/W2084767118","https://openalex.org/W2086781527","https://openalex.org/W2088119816","https://openalex.org/W2088394579","https://openalex.org/W2089140170","https://openalex.org/W2089899888","https://openalex.org/W2090016127","https://openalex.org/W2090497358","https://openalex.org/W2091353697","https://openalex.org/W2094133811","https://openalex.org/W2095166272","https://openalex.org/W2097772140","https://openalex.org/W2104428993","https://openalex.org/W2104856326","https://openalex.org/W2105438437","https://openalex.org/W2106232482","https://openalex.org/W2106448791","https://openalex.org/W2109971285","https://openalex.org/W2110229128","https://openalex.org/W2110278880","https://openalex.org/W2111219257","https://openalex.org/W2111367456","https://openalex.org/W2114023159","https://openalex.org/W2117113805","https://openalex.org/W2121562333","https://openalex.org/W2123601573","https://openalex.org/W2129849944","https://openalex.org/W2130157555","https://openalex.org/W2136145106","https://openalex.org/W2136218955","https://openalex.org/W2136873073","https://openalex.org/W2141617559","https://openalex.org/W2144967340","https://openalex.org/W2145980749","https://openalex.org/W2147727142","https://openalex.org/W2148459495","https://openalex.org/W2162939439","https://openalex.org/W2163432983","https://openalex.org/W2164204589","https://openalex.org/W2164498029","https://openalex.org/W2168362482","https://openalex.org/W2169994464","https://openalex.org/W2170478111","https://openalex.org/W2253293478","https://openalex.org/W2261330103","https://openalex.org/W2277261569","https://openalex.org/W2287106463","https://openalex.org/W2313537195","https://openalex.org/W2315457571","https://openalex.org/W2316532201","https://openalex.org/W2316743387","https://openalex.org/W2316962700","https://openalex.org/W2322839894","https://openalex.org/W2331630900","https://openalex.org/W2332056710","https://openalex.org/W2332521194","https://openalex.org/W2398380335","https://openalex.org/W2399534402","https://openalex.org/W2411642255","https://openalex.org/W2412599474","https://openalex.org/W2413471168","https://openalex.org/W2414135564","https://openalex.org/W2416085730","https://openalex.org/W2419367292","https://openalex.org/W2425060694","https://openalex.org/W2436518012","https://openalex.org/W2439613061","https://openalex.org/W2442877185","https://openalex.org/W2460166033","https://openalex.org/W2460296630","https://openalex.org/W2460555444","https://openalex.org/W2470172399","https://openalex.org/W4240521352","https://openalex.org/W4299682351","https://openalex.org/W4299975681","https://openalex.org/W4322701961","https://openalex.org/W4407851515","https://openalex.org/W6610065985","https://openalex.org/W6715547717","https://openalex.org/W7118136980"],"related_works":["https://openalex.org/W2124548234","https://openalex.org/W1983411076","https://openalex.org/W2020417048","https://openalex.org/W1971664569","https://openalex.org/W2380419197","https://openalex.org/W2127736557","https://openalex.org/W3013942657","https://openalex.org/W1606465625","https://openalex.org/W2033181526","https://openalex.org/W2083377818"],"abstract_inverted_index":{"The":[0,134],"ability":[1],"of":[2,17,72,117,130,156,209,222,237],"the":[3,14,24,39,46,98,115,128,154,189,199,207,220,234,244,247,263,280],"liver":[4,74,135,190,248],"to":[5,58,97,112,282,290],"regenerate":[6],"after":[7,120],"parenchymal":[8],"damage":[9],"is":[10,31,136,148,226,239,249],"usually":[11,85],"accomplished":[12],"by":[13,150],"ephemeral":[15],"entry":[16],"normally":[18],"proliferatively":[19],"quiescent":[20],"(G0)":[21],"hepatocytes":[22,238,293],"into":[23,45],"cell":[25,106,277,296],"cycle.":[26],"However,":[27],"when":[28,233],"hepatocyte":[29,122],"regeneration":[30,94],"defective,":[32],"arborizing":[33],"ductules":[34],"which":[35,195,230],"are":[36,84,110,127,196],"continuous":[37],"with":[38,92,279],"biliary":[40,52,200,264],"tree,":[41],"proliferate":[42,283],"and":[43,63,65,89,174,202,213,241,287,294],"migrate":[44],"surrounding":[47],"parenchyma.":[48],"In":[49,78],"man":[50],"these":[51,101,164,210],"cells":[53,83,102,109,158,165,194,205,212],"have":[54,66],"variously":[55],"been":[56,67],"referred":[57],"as":[59,141,163,215,252,268,275],"ductular":[60],"structures,":[61],"neoductules":[62],"neocholangioles,":[64],"observed":[68],"in":[69],"many":[70],"forms":[71],"chronic":[73],"disease,":[75],"including":[76],"cancer.":[77],"experimental":[79],"animals":[80],"similar":[81],"ductal":[82],"called":[86],"oval":[87,157,204],"cells,":[88],"their":[90],"association":[91],"defective":[93],"has":[95,159],"led":[96],"belief":[99],"that":[100,125,188,203],"represent":[103,167,206],"a":[104,142,168,227,253,269,276],"progenitor":[105],"population.":[107],"Oval":[108],"thought":[111],"take":[113],"over":[114],"burden":[116],"regenerative":[118,235],"growth":[119],"substantial":[121],"loss,":[123],"suggesting":[124],"they":[126,175],"progeny":[129,208],"facultative":[131],"stem":[132,143,193,211,257],"cells.":[133],"not,":[137],"however,":[138],"generally":[139],"considered":[140],"cell-fed":[144,258],"hierarchy,":[145],"although":[146],"this":[147],"disputed":[149],"others.":[151],"Despite":[152],"this,":[153],"subject":[155],"aroused":[160],"intense":[161],"interest":[162],"may":[166,176],"target":[169],"population":[170],"for":[171,180,219,271],"hepatic":[172],"carcinogens,":[173],"be":[177],"useful":[178],"vehicles":[179],"ex":[181],"vivo":[182],"gene":[183],"therapy.":[184],"This":[185,225],"review":[186],"proposes":[187],"does":[191],"harbour":[192],"located":[197],"throughout":[198],"epithelium,":[201,246],"function":[214],"an":[216],"amplification":[217],"compartment":[218,278],"generation":[221],"'new'":[223],"hepatocytes.":[224],"conditional":[228],"process":[229],"only":[231],"occurs":[232],"capacity":[236],"overwhelmed":[240],"thus,":[242],"unlike":[243],"intestinal":[245],"not":[250,266],"behaving":[251],"classical":[254],"continually":[255],"renewing":[256],"lineage.":[259],"We":[260],"focus":[261],"on":[262],"network,":[265],"merely":[267],"conduit":[270],"bile,":[272],"but":[273],"also":[274],"potential":[281],"under":[284],"appropriate":[285],"conditions":[286],"give":[288],"rise":[289],"fully":[291],"differentiated":[292],"other":[295],"types.":[297]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}