{"id":"https://openalex.org/W2127290948","doi":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","title":"Role of Na+/H+exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3","display_name":"Role of Na+/H+exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2127290948","doi":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","mag":"2127290948","pmid":"https://pubmed.ncbi.nlm.nih.gov/10710541"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.2000.278.3.f375","doi":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085734264","display_name":"Volker Vallon","orcid":"https://orcid.org/0000-0002-9211-2063","observed_orcids":["https://orcid.org/0000-0002-9211-2063"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Vallon","raw_affiliation_strings":["Department of Pharmacology, University of T\u00fcbingen, D-72074 T\u00fcbingen; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of T\u00fcbingen, D-72074 T\u00fcbingen; and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019748496","display_name":"Jan-Robert Schwark","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan-Robert Schwark","raw_affiliation_strings":["Hoechst Marion Roussel, D-65926 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoechst Marion Roussel, D-65926 Frankfurt am Main, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112063775","display_name":"Kerstin Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Richter","raw_affiliation_strings":["Department of Pharmacology, University of T\u00fcbingen, D-72074 T\u00fcbingen; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of T\u00fcbingen, D-72074 T\u00fcbingen; and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028904025","display_name":"M. Hropot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Hropot","raw_affiliation_strings":["Hoechst Marion Roussel, D-65926 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hoechst Marion Roussel, D-65926 Frankfurt am Main, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1331,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.76312938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"278","issue":"3","first_page":"F375","last_page":"F379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.9580000042915344},{"id":"https://openalex.org/keywords/na-h-exchanger","display_name":"Na+/H+ exchanger","score":0.949999988079071},{"id":"https://openalex.org/keywords/proximal-convoluted-tubule","display_name":"proximal convoluted tubule","score":0.9679999947547913},{"id":"https://openalex.org/keywords/loop-of-henle","display_name":"loop of Henle","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sodium-reabsorption","display_name":"sodium reabsorption","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fluid-reabsorption","display_name":"fluid reabsorption","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tubuloglomerular-feedback","display_name":"tubuloglomerular feedback","score":0.972000002861023},{"id":"https://openalex.org/keywords/macula-densa","display_name":"macula densa","score":0.968999981880188},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.5239999890327454},{"id":"https://openalex.org/keywords/nephron-function","display_name":"nephron function","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2776844834","wikidata":"https://www.wikidata.org/wiki/Q1813955","display_name":"Loop of Henle","level":4,"score":0.9193905591964722},{"id":"https://openalex.org/C2781236342","wikidata":"https://www.wikidata.org/wiki/Q1883079","display_name":"Macula densa","level":4,"score":0.8602389097213745},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.8322744369506836},{"id":"https://openalex.org/C7643261","wikidata":"https://www.wikidata.org/wiki/Q3742013","display_name":"Tubuloglomerular feedback","level":3,"score":0.8302531242370605},{"id":"https://openalex.org/C2778437025","wikidata":"https://www.wikidata.org/wiki/Q7850936","display_name":"Tubular fluid","level":4,"score":0.8019508123397827},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7865124940872192},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.7854363918304443},{"id":"https://openalex.org/C2779010597","wikidata":"https://www.wikidata.org/wiki/Q5166601","display_name":"Convoluted tubule","level":3,"score":0.7237299084663391},{"id":"https://openalex.org/C2776777027","wikidata":"https://www.wikidata.org/wiki/Q2914731","display_name":"Distal convoluted tubule","level":4,"score":0.5584250688552856},{"id":"https://openalex.org/C2780222010","wikidata":"https://www.wikidata.org/wiki/Q2916078","display_name":"Proximal tubule","level":3,"score":0.5283154845237732},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.4938693642616272},{"id":"https://openalex.org/C57476199","wikidata":"https://www.wikidata.org/wiki/Q7312501","display_name":"Renal sodium reabsorption","level":4,"score":0.44740110635757446},{"id":"https://openalex.org/C2909587778","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Kidney tubules","level":3,"score":0.44718092679977417},{"id":"https://openalex.org/C161457703","wikidata":"https://www.wikidata.org/wiki/Q3317402","display_name":"Renal physiology","level":3,"score":0.44414022564888},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4337167739868164},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4136020541191101},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39852553606033325},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3779255747795105},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.2735670208930969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11561468243598938},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.08917450904846191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0849437415599823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07658159732818604},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.07242095470428467},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000042","descriptor_name":"Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000074083","descriptor_name":"Sodium-Hydrogen Exchanger 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007687","descriptor_name":"Kidney Tubules, Proximal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008138","descriptor_name":"Loop of Henle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008689","descriptor_name":"Methacrylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009399","descriptor_name":"Nephrons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011677","descriptor_name":"Punctures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajprenal.2000.278.3.f375","doi":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.2000.278.3.f375","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmid:10710541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10710541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.875.7272","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.875.7272","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajprenal.physiology.org/content/ajprenal/278/3/F375.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1482741711","https://openalex.org/W1502733965","https://openalex.org/W1554578780","https://openalex.org/W1589657989","https://openalex.org/W1593418419","https://openalex.org/W2004347894","https://openalex.org/W2017279447","https://openalex.org/W2022394342","https://openalex.org/W2025100148","https://openalex.org/W2039855931","https://openalex.org/W2040732119","https://openalex.org/W2042294891","https://openalex.org/W2046847372","https://openalex.org/W2057169294","https://openalex.org/W2164080605","https://openalex.org/W2184950970","https://openalex.org/W2256417214","https://openalex.org/W2289765832","https://openalex.org/W2404392180","https://openalex.org/W2404562794","https://openalex.org/W2411531555","https://openalex.org/W2426210392","https://openalex.org/W2460384389"],"related_works":["https://openalex.org/W7099908975","https://openalex.org/W2275275432","https://openalex.org/W2245041715","https://openalex.org/W2078649992","https://openalex.org/W2162475964","https://openalex.org/W149093433","https://openalex.org/W2055790786","https://openalex.org/W2531037478","https://openalex.org/W3176004698","https://openalex.org/W2905059253"],"abstract_inverted_index":{"Na(+)/H(+)":[0],"exchanger":[1],"NHE3":[2,28,135,147],"is":[3],"expressed":[4],"in":[5,33,36,117,122,143,158],"the":[6,26,94,107,115,159,164],"luminal":[7],"membrane":[8],"of":[9,18,41,45,55,58,65,73,87,96,127,161,167,174],"proximal":[10,46,78,118,144,168],"tubule":[11,48],"and":[12,14,69,140],"thin":[13],"thick":[15],"ascending":[16],"limb":[17],"Henle's":[19,74],"loop.":[20],"To":[21],"further":[22],"define":[23],"its":[24],"role,":[25],"novel":[27],"inhibitor":[29],"S3226":[30,50,88,103],"was":[31,100],"employed":[32],"micropuncture":[34],"experiments":[35],"nephrons":[37],"with":[38,49,61],"superficial":[39,77,81],"glomeruli":[40],"anesthetized":[42],"rats.":[43],"Microperfusion":[44],"convoluted":[47,145],"revealed":[51],"a":[52,62],"dose-dependent":[53],"inhibition":[54,64],"reabsorption":[56,95,142,157],"(IC(50)":[57],"4-5":[59],"microM)":[60,92,105],"maximum":[63],"30%":[66],"for":[67],"fluid":[68,97,139,154],"Na(+).":[70],"During":[71],"microperfusion":[72],"loop":[75,126,160],"(last":[76],"to":[79,124,138,150,153],"first":[80],"distal":[82],"tubular":[83,119],"loop),":[84],"no":[85],"effect":[86],"(10":[89],"or":[90,98,155,170],"30":[91],"on":[93],"Na(+)":[99,141,156],"observed.":[101],"Finally,":[102],"(30":[104],"left":[106],"tubuloglomerular":[108],"feedback":[109],"response":[110,123],"unaltered":[111],"as":[112],"determined":[113],"by":[114],"fall":[116],"stop-flow":[120],"pressure":[121],"increasing":[125],"Henle":[128,162],"perfusion":[129],"rate.":[130],"These":[131],"studies":[132],"indicate":[133],"that":[134],"significantly":[136,151],"contributes":[137],"tubule.":[146],"appears":[148],"not":[149],"contribute":[152],"(including":[163],"S3":[165],"segment":[166],"tubule)":[169],"macula":[171],"densa":[172],"control":[173],"nephron":[175],"filtration.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}