{"id":"https://openalex.org/W2127277635","doi":"https://doi.org/10.1097/fjc.0b013e31819715c4","title":"Antigrowth Properties of BAY 41-2272 in Vascular Smooth Muscle Cells","display_name":"Antigrowth Properties of BAY 41-2272 in Vascular Smooth Muscle Cells","publication_year":2009,"publication_date":"2009-02-01","ids":{"openalex":"https://openalex.org/W2127277635","doi":"https://doi.org/10.1097/fjc.0b013e31819715c4","mag":"2127277635","pmid":"https://pubmed.ncbi.nlm.nih.gov/19188837","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682708"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0b013e31819715c4","doi":"https://doi.org/10.1097/fjc.0b013e31819715c4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0b013e31819715c4","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065199930","display_name":"Natalia Mendelev","orcid":"https://orcid.org/0000-0001-8596-2986","observed_orcids":["https://orcid.org/0000-0001-8596-2986"]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Natalia N Mendelev","raw_affiliation_strings":["Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA","Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA","institution_ids":["https://openalex.org/I123127086"]},{"raw_affiliation_string":"Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC","institution_ids":["https://openalex.org/I123127086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058112054","display_name":"Verietta S Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Verietta S Williams","raw_affiliation_strings":["Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC","institution_ids":["https://openalex.org/I123127086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005382945","display_name":"David A. Tulis","orcid":"https://orcid.org/0000-0003-3490-2283","observed_orcids":["https://orcid.org/0000-0003-3490-2283"]},"institutions":[{"id":"https://openalex.org/I123127086","display_name":"North Carolina Central University","ror":"https://ror.org/051r3tx83","country_code":"US","type":"education","lineage":["https://openalex.org/I123127086"]},{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A Tulis","raw_affiliation_strings":["Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC","Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Research Program, J.L. Chambers Biomedical/Biotechnology Research Institute and \u2020Department of Biology, North Carolina Central University, Durham, NC","institution_ids":["https://openalex.org/I123127086"]},{"raw_affiliation_string":"Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC","institution_ids":["https://openalex.org/I186335123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005382945","https://openalex.org/A5058112054","https://openalex.org/A5065199930"],"corresponding_institution_ids":["https://openalex.org/I123127086","https://openalex.org/I186335123"],"apc_list":null,"apc_paid":null,"fwci":0.9384,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.72921402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"53","issue":"2","first_page":"121","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bay-41-2272","display_name":"BAY 41-2272","score":1.0},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase-stimulator","display_name":"soluble guanylate cyclase stimulator","score":0.9100000262260437},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/cyclin-e","display_name":"cyclin E","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9110000133514404},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9570000171661377},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9990000128746033},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/a7r5-cells","display_name":"A7r5 cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/vasp","display_name":"VASP","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6706453561782837},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6022502779960632},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5959287285804749},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.5136362910270691},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.5032374262809753},{"id":"https://openalex.org/C115880899","wikidata":"https://www.wikidata.org/wiki/Q1124247","display_name":"Bay","level":2,"score":0.4641462564468384},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.45718878507614136},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4530271887779236},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4213925302028656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4173718988895416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3410889208316803},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30652686953544617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2687240242958069},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.13234007358551025},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.10331207513809204},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09640321135520935},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071756","descriptor_name":"Soluble Guanylyl Cyclase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006131","descriptor_name":"Growth Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051361","descriptor_name":"Cyclin-Dependent Kinase 6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1097/fjc.0b013e31819715c4","doi":"https://doi.org/10.1097/fjc.0b013e31819715c4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0b013e31819715c4","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:19188837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19188837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2682708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682708","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cardiovasc Pharmacol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.941.3987","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.941.3987","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thescholarship.ecu.edu/bitstream/handle/10342/3354/Anti%20growth%20properties%20of%20BAY.pdf%3Bjsessionid%3D5369C8865E240F4D9D362AC831785431?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:TheScholarship.intra.ecu.edu:10342/3354","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10342/3354","pdf_url":null,"source":{"id":"https://openalex.org/S4306402312","display_name":"The Scholarship East Carolina University's Institutional Repository (East Carolina University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186335123","host_organization_name":"East Carolina University","host_organization_lineage":["https://openalex.org/I186335123"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2682708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2682708","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Cardiovasc Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3499744517","display_name":null,"funder_award_id":"HL 59868","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3758213330","display_name":"NO-independent cGMP regulation of vascular remodeling","funder_award_id":"R01HL081720","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4173963871","display_name":null,"funder_award_id":"HL-81720","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G873734879","display_name":"CARDIOVASCULAR HEALTH AMONG AFRICAN AMERICANS","funder_award_id":"UH1HL059868","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G968137028","display_name":"Cardiovascular Health Among African Americans","funder_award_id":"R25HL059868","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W119510731","https://openalex.org/W1562892413","https://openalex.org/W1566160921","https://openalex.org/W1568637595","https://openalex.org/W1969091160","https://openalex.org/W1974046965","https://openalex.org/W1974766153","https://openalex.org/W1978314464","https://openalex.org/W1995066852","https://openalex.org/W2001644495","https://openalex.org/W2003630942","https://openalex.org/W2003913161","https://openalex.org/W2015501967","https://openalex.org/W2016361419","https://openalex.org/W2021785566","https://openalex.org/W2023191701","https://openalex.org/W2024098866","https://openalex.org/W2024711033","https://openalex.org/W2025802593","https://openalex.org/W2032339573","https://openalex.org/W2033436239","https://openalex.org/W2054935021","https://openalex.org/W2064063264","https://openalex.org/W2065303013","https://openalex.org/W2067107703","https://openalex.org/W2083303225","https://openalex.org/W2086263835","https://openalex.org/W2091117890","https://openalex.org/W2091138507","https://openalex.org/W2098388756","https://openalex.org/W2099658480","https://openalex.org/W2101093001","https://openalex.org/W2107950990","https://openalex.org/W2118837782","https://openalex.org/W2119537606","https://openalex.org/W2119836020","https://openalex.org/W2121060403","https://openalex.org/W2124821916","https://openalex.org/W2128304597","https://openalex.org/W2131280359","https://openalex.org/W2132469312","https://openalex.org/W2133970318","https://openalex.org/W2143058092","https://openalex.org/W2149407335","https://openalex.org/W2151679290","https://openalex.org/W2162802291","https://openalex.org/W2165822524","https://openalex.org/W2181861265","https://openalex.org/W2267941286","https://openalex.org/W2409601113"],"related_works":["https://openalex.org/W3170378844","https://openalex.org/W7098483321","https://openalex.org/W2046685063","https://openalex.org/W3173891870","https://openalex.org/W3171201186","https://openalex.org/W2608374663","https://openalex.org/W3176395421","https://openalex.org/W2061141093","https://openalex.org/W2056951304","https://openalex.org/W2031555618"],"abstract_inverted_index":{"Vascular":[0],"smooth":[1],"muscle":[2],"(VSM)":[3],"growth":[4,23,79],"is":[5,24],"integral":[6],"in":[7,35,91,178,187],"the":[8,43,55,134,167,173,188],"pathophysiology":[9],"of":[10,45,57,70,115,133,143,155,172],"blood":[11],"vessel":[12],"diseases,":[13],"and":[14,37,40,49,68,94,100,110,120,139,149,152,180,190],"identifying":[15],"approaches":[16],"that":[17],"have":[18],"capacity":[19],"to":[20],"regulate":[21],"VSM":[22,77,85,179],"critically":[25],"essential.":[26],"Cyclic":[27],"nucleotide":[28],"signaling":[29,105],"has":[30,41],"been":[31,42],"generally":[32],"considered":[33],"protective":[34],"cardiac":[36],"vascular":[38],"tissues":[39],"target":[44],"numerous":[46],"basic":[47,191],"science":[48],"clinical":[50,189],"studies.":[51],"In":[52,82],"this":[53],"project,":[54],"influence":[56],"BAY":[58,87,97,125,176],"41-2272":[59],"(BAY),":[60],"a":[61,92],"recently":[62],"described":[63],"soluble":[64],"guanylate":[65],"cyclase":[66],"stimulator":[67],"inducer":[69],"cyclic":[71,101,116],"guanosine":[72],"monophosphate":[73,103],"(cGMP)":[74],"synthesis,":[75],"on":[76],"cell":[78,144,169],"was":[80],"analyzed.":[81],"rat":[83],"A7R5":[84],"cells,":[86],"significantly":[88,126],"reduced":[89,153],"proliferation":[90],"dose-":[93],"time-dependent":[95],"fashion.":[96],"activated":[98],"cGMP":[99,109],"adenosine":[102],"(cAMP)":[104],"evidenced":[106],"through":[107],"elevated":[108,127],"cAMP":[111],"content,":[112],"increased":[113,141],"expression":[114,132,142,154],"nucleotide-dependent":[117],"protein":[118],"kinases,":[119],"differential":[121],"vasodilator-stimulated":[122],"phosphoprotein":[123],"phosphorylation.":[124],"cyclin":[128],"E":[129],"expression,":[130],"decreased":[131],"regulatory":[135],"cyclin-dependent":[136],"kinases":[137],"-2":[138],"-6,":[140],"cycle":[145],"inhibitory":[146],"p21":[147],"WAF1/Cip1":[148],"p27":[150],"Kip1,":[151],"phosphorylated":[156],"focal":[157],"adhesion":[158],"kinase.":[159],"These":[160],"comprehensive":[161],"findings":[162],"provide":[163],"first":[164],"evidence":[165],"for":[166,183],"antigrowth":[168],"cycle-regulatory":[170],"properties":[171],"neoteric":[174],"agent,":[175],"41-2272,":[177],"lend":[181],"support":[182],"its":[184],"continued":[185],"study":[186],"cardiovascular":[192],"sciences.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}