{"id":"https://openalex.org/W2127245407","doi":"https://doi.org/10.1152/ajpgi.00409.2013","title":"Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease","display_name":"Granulocyte macrophage colony-stimulating factor and the intestinal innate immune cell homeostasis in Crohn's disease","publication_year":2014,"publication_date":"2014-02-07","ids":{"openalex":"https://openalex.org/W2127245407","doi":"https://doi.org/10.1152/ajpgi.00409.2013","mag":"2127245407","pmid":"https://pubmed.ncbi.nlm.nih.gov/24503766"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00409.2013","doi":"https://doi.org/10.1152/ajpgi.00409.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00409.2013","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083009182","display_name":"Jan D\u00e4britz","orcid":"https://orcid.org/0000-0003-4219-5283","observed_orcids":["https://orcid.org/0000-0003-4219-5283"]},"institutions":[{"id":"https://openalex.org/I1321649718","display_name":"Royal Children's Hospital","ror":"https://ror.org/02rktxt32","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1321649718"]},{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]},{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU","DE"],"is_corresponding":true,"raw_author_name":"Jan D\u00e4britz","raw_affiliation_strings":["The Royal Children's Hospital Melbourne, Murdoch Children's Research Institute, Gastrointestinal Research in Inflammation & Pathology, Parkville, Victoria, Australia; University of Melbourne, Melbourne Medical School, Department of Paediatrics, Parkville, Victoria, Australia; University Children's Hospital M\u00fcnster, Department of Pediatric Rheumatology and Immunology, M\u00fcnster, Germany; and University of M\u00fcnster, Interdisciplinary Center for Clinical Research, M\u00fcnster, Germany","University of Melbourne, Melbourne Medical School, Department of Paediatrics, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Royal Children's Hospital Melbourne, Murdoch Children's Research Institute, Gastrointestinal Research in Inflammation & Pathology, Parkville, Victoria, Australia; University of Melbourne, Melbourne Medical School, Department of Paediatrics, Parkville, Victoria, Australia; University Children's Hospital M\u00fcnster, Department of Pediatric Rheumatology and Immunology, M\u00fcnster, Germany; and University of M\u00fcnster, Interdisciplinary Center for Clinical Research, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I22465464","https://openalex.org/I4210103666","https://openalex.org/I4210150290"]},{"raw_affiliation_string":"University of Melbourne, Melbourne Medical School, Department of Paediatrics, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083009182"],"corresponding_institution_ids":["https://openalex.org/I1321649718","https://openalex.org/I165779595","https://openalex.org/I22465464","https://openalex.org/I4210103666","https://openalex.org/I4210150290"],"apc_list":null,"apc_paid":null,"fwci":1.3026,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.76299376,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"306","issue":"6","first_page":"G455","last_page":"G465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9480000138282776},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/intestinal-innate-immunity","display_name":"intestinal innate immunity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intestinal-macrophages","display_name":"intestinal macrophages","score":0.8539999723434448},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immune-cell-homeostasis","display_name":"immune cell homeostasis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mucosal-barrier-function","display_name":"mucosal barrier function","score":0.7960000038146973},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.7710000276565552},{"id":"https://openalex.org/keywords/myeloid-cell-activation","display_name":"myeloid cell activation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7070404291152954},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6954064965248108},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5696188807487488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5532749891281128},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5284673571586609},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5197753310203552},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.45908868312835693},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.44505512714385986},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4153948426246643},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23647525906562805},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.189980149269104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016187","descriptor_name":"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpgi.00409.2013","doi":"https://doi.org/10.1152/ajpgi.00409.2013","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00409.2013","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:24503766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24503766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"},{"id":"mag:2536196113","doi":null,"is_oa":false,"landing_page_url":"https://ajpgi.physiology.org/content/ajpgi/early/2014/01/31/ajpgi.00409.2013.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W199378999","https://openalex.org/W1505884591","https://openalex.org/W1517947402","https://openalex.org/W1575247562","https://openalex.org/W1587901643","https://openalex.org/W1813646352","https://openalex.org/W1855390974","https://openalex.org/W1855512575","https://openalex.org/W1872587559","https://openalex.org/W1950482131","https://openalex.org/W1963826116","https://openalex.org/W1965974880","https://openalex.org/W1966770137","https://openalex.org/W1970575075","https://openalex.org/W1971058409","https://openalex.org/W1971391491","https://openalex.org/W1974283419","https://openalex.org/W1976161742","https://openalex.org/W1976310228","https://openalex.org/W1978972720","https://openalex.org/W1979292513","https://openalex.org/W1979603997","https://openalex.org/W1980130314","https://openalex.org/W1982072697","https://openalex.org/W1984172500","https://openalex.org/W1985859986","https://openalex.org/W1986392539","https://openalex.org/W1986933031","https://openalex.org/W1989673842","https://openalex.org/W1989997677","https://openalex.org/W1991792802","https://openalex.org/W1993150527","https://openalex.org/W1994487913","https://openalex.org/W1999283406","https://openalex.org/W2002070350","https://openalex.org/W2004150448","https://openalex.org/W2004608617","https://openalex.org/W2006474456","https://openalex.org/W2006883921","https://openalex.org/W2010180994","https://openalex.org/W2010506461","https://openalex.org/W2011858056","https://openalex.org/W2012405690","https://openalex.org/W2014266007","https://openalex.org/W2014501256","https://openalex.org/W2015278859","https://openalex.org/W2015640498","https://openalex.org/W2017027775","https://openalex.org/W2017410942","https://openalex.org/W2018449740","https://openalex.org/W2020069357","https://openalex.org/W2024258010","https://openalex.org/W2024263435","https://openalex.org/W2025065287","https://openalex.org/W2025875287","https://openalex.org/W2025946577","https://openalex.org/W2028142068","https://openalex.org/W2033976955","https://openalex.org/W2035213168","https://openalex.org/W2036054943","https://openalex.org/W2039952319","https://openalex.org/W2044286043","https://openalex.org/W2047208232","https://openalex.org/W2049538981","https://openalex.org/W2049981804","https://openalex.org/W2056558971","https://openalex.org/W2058964725","https://openalex.org/W2060672294","https://openalex.org/W2061512720","https://openalex.org/W2062363040","https://openalex.org/W2062843719","https://openalex.org/W2063680739","https://openalex.org/W2065771591","https://openalex.org/W2069182180","https://openalex.org/W2069571875","https://openalex.org/W2069850690","https://openalex.org/W2070142403","https://openalex.org/W2070363994","https://openalex.org/W2072723200","https://openalex.org/W2073195681","https://openalex.org/W2074024369","https://openalex.org/W2074471464","https://openalex.org/W2075867500","https://openalex.org/W2077771862","https://openalex.org/W2079425534","https://openalex.org/W2079745078","https://openalex.org/W2081116126","https://openalex.org/W2085099489","https://openalex.org/W2087115854","https://openalex.org/W2088428906","https://openalex.org/W2090348764","https://openalex.org/W2092743770","https://openalex.org/W2093291384","https://openalex.org/W2093440835","https://openalex.org/W2095342336","https://openalex.org/W2100820895","https://openalex.org/W2101005104","https://openalex.org/W2103747137","https://openalex.org/W2105665962","https://openalex.org/W2105854609","https://openalex.org/W2105984192","https://openalex.org/W2110957620","https://openalex.org/W2112635226","https://openalex.org/W2117519175","https://openalex.org/W2120505341","https://openalex.org/W2121938085","https://openalex.org/W2123306235","https://openalex.org/W2125647281","https://openalex.org/W2126479453","https://openalex.org/W2128175802","https://openalex.org/W2128986200","https://openalex.org/W2130855582","https://openalex.org/W2132784721","https://openalex.org/W2134422149","https://openalex.org/W2134442010","https://openalex.org/W2138276685","https://openalex.org/W2140233906","https://openalex.org/W2149912273","https://openalex.org/W2150781849","https://openalex.org/W2154697999","https://openalex.org/W2157202822","https://openalex.org/W2163229571","https://openalex.org/W2171974929","https://openalex.org/W2221352580","https://openalex.org/W2336749545","https://openalex.org/W2344230491","https://openalex.org/W2502123448","https://openalex.org/W4211241312"],"related_works":["https://openalex.org/W2208445863","https://openalex.org/W2117519175","https://openalex.org/W2190804159","https://openalex.org/W3041183942","https://openalex.org/W7127938769","https://openalex.org/W1980130314","https://openalex.org/W1556169907","https://openalex.org/W2003492168","https://openalex.org/W7097707919","https://openalex.org/W2053185103"],"abstract_inverted_index":{"Current":[0],"literature":[1],"consolidates":[2],"the":[3,21,37,42,46,56,93,103,122,127,166,171],"view":[4],"of":[5,12,16,23,58,90,95,121,140,149,165,173],"Crohn's":[6],"disease":[7],"(CD)":[8],"as":[9],"a":[10,32,66,81],"form":[11],"immunodeficiency":[13,174],"highlighting":[14],"dysregulation":[15],"intestinal":[17,115,152,167],"innate":[18,38,153],"immunity":[19],"in":[20,35,41,84,97,102,126,151,163,170,175],"pathogenesis":[22],"CD.":[24,59,176],"Intestinal":[25],"macrophages":[26],"derived":[27],"from":[28],"blood":[29],"monocytes":[30],"play":[31],"key":[33],"role":[34,94,162],"sustaining":[36],"immune":[39,98,154,168],"homeostasis":[40,156],"intestine,":[43,128],"suggesting":[44],"that":[45,70],"monocyte/macrophage":[47],"compartment":[48],"might":[49],"be":[50],"an":[51],"attractive":[52],"therapeutic":[53],"target":[54],"for":[55],"management":[57],"Granulocyte":[60],"macrophage":[61],"colony-stimulating":[62],"factor":[63,69],"(GM-CSF)":[64],"is":[65,105,143],"hematopoietic":[67],"growth":[68],"also":[71],"promotes":[72],"myeloid":[73],"cell":[74,131,155],"activation,":[75],"proliferation,":[76,132],"and":[77,87,99,135,157],"differentiation.":[78],"GM-CSF":[79,96,113,150],"has":[80],"protective":[82],"effect":[83],"human":[85],"CD":[86],"mouse":[88],"models":[89],"colitis.":[91],"However,":[92],"inflammatory":[100],"reactions":[101],"intestine":[104],"not":[106],"well":[107],"defined.":[108],"Beneficial":[109],"effects":[110],"exerted":[111],"by":[112],"during":[114],"inflammation":[116],"could":[117],"relate":[118],"to":[119,144,158],"modulation":[120],"mucosal":[123],"barrier":[124,169],"function":[125],"including":[129],"epithelial":[130],"survival,":[133],"restitution,":[134],"immunomodulatory":[136],"actions.":[137],"The":[138],"aim":[139],"this":[141],"review":[142],"summarize":[145],"potential":[146],"mechanistic":[147],"roles":[148],"highlight":[159],"its":[160],"central":[161],"maintenance":[164],"context":[172]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
