{"id":"https://openalex.org/W2127168476","doi":"https://doi.org/10.1242/jcs.00231","title":"\u03b15\u03b21 integrin mediates strong tissue cohesion","display_name":"\u03b15\u03b21 integrin mediates strong tissue cohesion","publication_year":2002,"publication_date":"2002-12-13","ids":{"openalex":"https://openalex.org/W2127168476","doi":"https://doi.org/10.1242/jcs.00231","mag":"2127168476","pmid":"https://pubmed.ncbi.nlm.nih.gov/12482923"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.00231","doi":"https://doi.org/10.1242/jcs.00231","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.00231","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089278661","display_name":"Elizabeth E. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth E. Robinson","raw_affiliation_strings":["Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068757896","display_name":"Kathleen M. Zazzali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M. Zazzali","raw_affiliation_strings":["Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113622619","display_name":"Siobhan Corbett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siobhan A. Corbett","raw_affiliation_strings":["Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033930475","display_name":"Ramsey A. Foty","orcid":"https://orcid.org/0000-0002-7955-6188","observed_orcids":["https://orcid.org/0000-0002-7955-6188"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ramsey A. Foty","raw_affiliation_strings":["Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Medicine and Dentistry-Robert Wood Johnson Medical School, CAB Room 7070, New Brunswick, NJ 08648, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033930475"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":null,"apc_paid":null,"fwci":4.7737,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.95477502,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"116","issue":"2","first_page":"377","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11799","display_name":"Adhesion, Friction, and Surface Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-cell-aggregates","display_name":"3D cell aggregates","score":0.847000002861023},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cadherins","display_name":"cadherins","score":0.6930000185966492},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.968999981880188},{"id":"https://openalex.org/keywords/rgd-peptide","display_name":"RGD peptide","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.46299999952316284},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6140000224113464},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.6299999952316284},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8245818614959717},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7534935474395752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7035528421401978},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6047014594078064},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.5882838368415833},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5289706587791443},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5282993316650391},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45407235622406006},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43498462438583374},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4283078908920288},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09487447142601013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09208884835243225}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013500","descriptor_name":"Surface Tension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1242/jcs.00231","doi":"https://doi.org/10.1242/jcs.00231","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.00231","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:12482923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12482923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.117.5928","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.117.5928","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcs.biologists.org/cgi/reprint/116/2/377.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:joces:116/2/377","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/116/2/377","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W5322158","https://openalex.org/W1511595605","https://openalex.org/W1541185762","https://openalex.org/W1557783569","https://openalex.org/W1835871649","https://openalex.org/W1948747676","https://openalex.org/W1963529424","https://openalex.org/W1965576964","https://openalex.org/W1967451515","https://openalex.org/W1976925230","https://openalex.org/W1986281901","https://openalex.org/W1992043945","https://openalex.org/W1993886672","https://openalex.org/W1996650379","https://openalex.org/W1997010716","https://openalex.org/W2011497948","https://openalex.org/W2025077054","https://openalex.org/W2029231027","https://openalex.org/W2031961940","https://openalex.org/W2037550327","https://openalex.org/W2039278322","https://openalex.org/W2042765209","https://openalex.org/W2050276508","https://openalex.org/W2057138636","https://openalex.org/W2062573006","https://openalex.org/W2063035510","https://openalex.org/W2063753069","https://openalex.org/W2063897530","https://openalex.org/W2069697346","https://openalex.org/W2088574304","https://openalex.org/W2093101935","https://openalex.org/W2102877711","https://openalex.org/W2109016302","https://openalex.org/W2142634963","https://openalex.org/W2146335969","https://openalex.org/W2153128218","https://openalex.org/W2154214070","https://openalex.org/W2161410789","https://openalex.org/W2169310627","https://openalex.org/W2172026843","https://openalex.org/W2411167527","https://openalex.org/W2469203643","https://openalex.org/W3026603476","https://openalex.org/W4231259842","https://openalex.org/W4241433848"],"related_works":["https://openalex.org/W7095821502","https://openalex.org/W2116404461","https://openalex.org/W2042599488","https://openalex.org/W7095370129","https://openalex.org/W2284000964","https://openalex.org/W2057022330","https://openalex.org/W1990370414","https://openalex.org/W2081350035","https://openalex.org/W2513254033","https://openalex.org/W2586178631"],"abstract_inverted_index":{"Integrins":[0,11],"and":[1,8,43,51,157,214,294],"cadherins":[2,22],"are":[3,12,23,71,103,112],"considered":[4],"to":[5,25,64,132,153,199,208,265,276,337],"have":[6,92],"distinct":[7],"opposing":[9],"functions.":[10],"traditionally":[13],"cited":[14],"for":[15,291,303],"their":[16],"role":[17,82],"in":[18,37,100,114,254,269,278,347],"cell-substratum":[19],"interactions,":[20],"whereas":[21],"thought":[24],"mediate":[26,65],"strong":[27,66,195,344],"intercellular":[28,67,345],"cohesion.":[29],"Together,":[30],"these":[31,160,266,326],"adhesion":[32],"systems":[33],"play":[34],"crucial":[35],"roles":[36],"a":[38,115,174,231,270],"wide":[39],"variety":[40],"of":[41,77,83,87,118,135,181,193,201,211,258,261,281,299,309],"cellular":[42,349],"developmental":[44],"processes":[45],"including":[46],"cell":[47,97],"migration,":[48],"morphology,":[49],"differentiation":[50],"proliferation.":[52],"In":[53,109],"this":[54,125,144,304],"manuscript":[55],"we":[56,146],"present":[57],"evidence":[58],"that":[59,159,177,188,240,287,295,331],"integrins":[60,84],"possess":[61],"the":[62,78,81,219,279,296,310],"ability":[63],"cohesion":[68,205,235,346],"when":[69],"cells":[70,102,111,136,140,152,161,224,239,267,340],"grown":[72],"as":[73,85],"3D":[74,116,348],"aggregates.":[75,165,350],"Much":[76],"data":[79,285,327],"elucidating":[80],"mediators":[86],"cell-extracellular":[88],"matrix":[89],"(ECM)":[90],"interactions":[91,128],"been":[93],"generated":[94],"using":[95,170],"conventional":[96],"culture":[98],"techniques":[99],"which":[101],"plated":[104],"onto":[105,222],"ECM-coated":[106],"2D":[107],"surfaces.":[108],"vivo,":[110],"embedded":[113],"meshwork":[117],"ECM":[119],"proteins.":[120],"We":[121,166,186],"hypothesized":[122],"that,":[123],"within":[124],"meshwork,":[126],"integrin-ECM":[127],"may":[129],"impart":[130],"cohesivity":[131,169,180,196,220],"an":[133,317],"aggregate":[134,168,307],"by":[137,316],"linking":[138],"adjacent":[139,339],"together.":[141],"To":[142],"test":[143],"hypothesis,":[145],"transfected":[147,225],"Chinese":[148],"hamster":[149],"ovary":[150],"(CHO-B2)":[151],"express":[154,241],"alpha5beta1":[155,189,242,322,332],"integrin":[156,190,243,312,323,333],"found":[158,207],"formed":[162],"compact,":[163],"spherical":[164],"measured":[167],"tissue":[171],"surface":[172],"tensiometry,":[173],"novel":[175],"technique":[176],"quantifies":[178],"cell-cell":[179,234],"spheroids":[182],"under":[183],"physiological":[184],"conditions.":[185],"determined":[187],"is":[191,289,301],"capable":[192],"conferring":[194],"(sigma=8.22+/-0.68":[197],"dynes/cm)":[198],"aggregates":[200,253],"alpha5-integrin-transfected":[202],"cells.":[203],"This":[204],"was":[206,215,314],"be":[209],"independent":[210],"cadherin":[212],"expression":[213],"significantly":[216],"greater":[217],"than":[218],"conferred":[221],"CHO-B2":[223],"with":[226],"N-cadherin":[227],"(sigma=3.14+/-0.20":[228],"dynes/cm,":[229],"P