{"id":"https://openalex.org/W2127166176","doi":"https://doi.org/10.1016/s0008-6363(02)00600-4","title":"MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells","display_name":"MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells","publication_year":2002,"publication_date":"2002-10-21","ids":{"openalex":"https://openalex.org/W2127166176","doi":"https://doi.org/10.1016/s0008-6363(02)00600-4","mag":"2127166176","pmid":"https://pubmed.ncbi.nlm.nih.gov/12393099"},"language":"en","primary_location":{"id":"doi:10.1016/s0008-6363(02)00600-4","doi":"https://doi.org/10.1016/s0008-6363(02)00600-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0008-6363(02)00600-4","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076612263","display_name":"Martina Werle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M WERLE","raw_affiliation_strings":["Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097176664","display_name":"U SCHMAL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"U SCHMAL","raw_affiliation_strings":["Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047471049","display_name":"Katherina Hanna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K HANNA","raw_affiliation_strings":["Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111493214","display_name":"J. Kreuzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J KREUZER","raw_affiliation_strings":["Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innere Medizin III, Universit\u00e4t Heidelberg, Bergheimer Strasse, 58 69115 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111493214"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":1.7919,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.84522312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56","issue":"2","first_page":"284","last_page":"292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.9670000076293945},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.925000011920929},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9390000104904175},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/proatherogenic-effects","display_name":"proatherogenic effects","score":0.7369999885559082},{"id":"https://openalex.org/keywords/monocyte-recruitment","display_name":"monocyte recruitment","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.8157176971435547},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7879087328910828},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7860249876976013},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.6822412014007568},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6599547266960144},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6160573959350586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5127697587013245},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.4744350016117096},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4490814208984375},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.43414872884750366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25991371273994446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21098974347114563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1276628077030182},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06414636969566345}],"mesh":[{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0008-6363(02)00600-4","doi":"https://doi.org/10.1016/s0008-6363(02)00600-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0008-6363(02)00600-4","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:12393099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12393099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1509507060","https://openalex.org/W1516434930","https://openalex.org/W1742363076","https://openalex.org/W1824182589","https://openalex.org/W1944400542","https://openalex.org/W1969191130","https://openalex.org/W1974301074","https://openalex.org/W1975375148","https://openalex.org/W1976858755","https://openalex.org/W1977799997","https://openalex.org/W1981111760","https://openalex.org/W1986610158","https://openalex.org/W1989478136","https://openalex.org/W1999465006","https://openalex.org/W2004403689","https://openalex.org/W2017662347","https://openalex.org/W2019978702","https://openalex.org/W2031272027","https://openalex.org/W2040125444","https://openalex.org/W2067403399","https://openalex.org/W2074087689","https://openalex.org/W2076995420","https://openalex.org/W2091229977","https://openalex.org/W2101198954","https://openalex.org/W2111194166","https://openalex.org/W2114559914","https://openalex.org/W2120188047","https://openalex.org/W2129301938","https://openalex.org/W2140372161","https://openalex.org/W2149364554","https://openalex.org/W2150913549","https://openalex.org/W2155634388","https://openalex.org/W2157603347","https://openalex.org/W2167058667","https://openalex.org/W2415614417","https://openalex.org/W2474861722","https://openalex.org/W2498155094"],"related_works":["https://openalex.org/W2056587454","https://openalex.org/W2052637836","https://openalex.org/W2009713593","https://openalex.org/W2310080439","https://openalex.org/W2202150720","https://openalex.org/W2034952875","https://openalex.org/W2374048249","https://openalex.org/W2132354411","https://openalex.org/W1545005818","https://openalex.org/W2033879223"],"abstract_inverted_index":{"Activation":[0],"of":[1,14,24,28,43,70,80,99,122,128,143],"vascular":[2],"endothelial":[3],"cells":[4],"(ECs)":[5],"plays":[6],"an":[7],"important":[8],"pathogenic":[9],"role":[10],"in":[11,130],"the":[12,40,50,140],"development":[13],"atherosclerosis.":[15],"Monocyte":[16],"chemoattractant":[17,23],"protein-1":[18],"(MCP-1)":[19],"is":[20],"a":[21,75,136],"potent":[22],"monocytes.":[25],"Besides":[26],"induction":[27,127],"monocyte":[29],"recruitment,":[30],"it":[31],"has":[32],"been":[33],"suggested":[34],"that":[35,115],"MCP-1":[36,48,73,95,116],"can":[37,117],"also":[38,96],"affect":[39],"cellular":[41],"responses":[42],"ECs.":[44,131],"We":[45],"investigated":[46],"whether":[47],"activated":[49,54],"three":[51,82],"major":[52],"mitogen":[53],"protein":[55],"(MAP)-kinases":[56],"extracellular":[57],"signal-regulated":[58],"kinase":[59,64],"(ERK),":[60],"c-Jun":[61],"amino":[62],"terminal":[63],"(JNK)":[65],"and":[66,77],"p38":[67],"MAPK.":[68],"Stimulation":[69],"ECs":[71],"with":[72,105,126],"induced":[74,97],"time-":[76],"concentration-dependent":[78],"activation":[79,107,121],"all":[81],"MAP-kinases,":[83],"concentrations":[84],"as":[85,87],"low":[86],"0.1":[88],"ng/ml":[89],"were":[90],"sufficient":[91],"for":[92,139],"this":[93],"mechanism.":[94],"secretion":[98],"matrix":[100],"metalloproteinase":[101],"(MMP)-2":[102],"which":[103],"along":[104],"ERK":[106],"was":[108],"inhibited":[109],"by":[110],"PD098059.":[111],"The":[112],"results":[113],"demonstrate":[114],"lead":[118],"to":[119],"direct":[120],"MAP":[123],"kinases":[124],"together":[125],"MMP2":[129],"Our":[132],"data":[133],"thus":[134],"propose":[135],"new":[137],"mechanism":[138],"proatherogenic":[141],"effect":[142],"MCP-1.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
