{"id":"https://openalex.org/W2127128559","doi":"https://doi.org/10.1007/s00210-003-0778-4","title":"Characterisation of a novel class of polyamine-based neuroprotective compounds","display_name":"Characterisation of a novel class of polyamine-based neuroprotective compounds","publication_year":2003,"publication_date":"2003-08-06","ids":{"openalex":"https://openalex.org/W2127128559","doi":"https://doi.org/10.1007/s00210-003-0778-4","mag":"2127128559","pmid":"https://pubmed.ncbi.nlm.nih.gov/12904829"},"language":"en","primary_location":{"id":"doi:10.1007/s00210-003-0778-4","doi":"https://doi.org/10.1007/s00210-003-0778-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-003-0778-4","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049415219","display_name":"Ashley K. Pringle","orcid":"https://orcid.org/0000-0003-2421-4380","observed_orcids":["https://orcid.org/0000-0003-2421-4380"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ashley K. Pringle","raw_affiliation_strings":["Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, SO16 7PX, Southampton, UK. akp1@soton.ac.uk","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, SO16 7PX, Southampton, UK. akp1@soton.ac.uk","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019039663","display_name":"Barclay Morrison","orcid":"https://orcid.org/0000-0001-7676-0864","observed_orcids":["https://orcid.org/0000-0001-7676-0864"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barclay Morrison","raw_affiliation_strings":["Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017198334","display_name":"Mark Bradley","orcid":"https://orcid.org/0000-0001-7893-1575","observed_orcids":["https://orcid.org/0000-0001-7893-1575"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Bradley","raw_affiliation_strings":["Combinatorial Centre of Excellence, University of Southampton, Highfield, Southampton, SO17 1BJ, UK","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Combinatorial Centre of Excellence, University of Southampton, Highfield, Southampton, SO17 1BJ, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113647117","display_name":"Fausto Iannotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fausto Iannotti","raw_affiliation_strings":["Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086778438","display_name":"Lars Sundstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lars E. Sundstrom","raw_affiliation_strings":["Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","University of Southampton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurosciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton, SO16 7PX, UK","institution_ids":["https://openalex.org/I43439940"]},{"raw_affiliation_string":"University of Southampton","institution_ids":["https://openalex.org/I43439940"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049415219"],"corresponding_institution_ids":["https://openalex.org/I43439940"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.3825,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61584906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"368","issue":"3","first_page":"216","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.9150000214576721},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8529999852180481},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"combinatorial chemistry","score":0.6840000152587891},{"id":"https://openalex.org/keywords/organotypic-hippocampal-slice-cultures","display_name":"organotypic hippocampal slice cultures","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8889999985694885},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.9449999928474426},{"id":"https://openalex.org/keywords/arginine-analogues","display_name":"arginine analogues","score":0.5320000052452087},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.972647488117218},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.669593334197998},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5700363516807556},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5466979742050171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5248063802719116},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.504365086555481},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4868609309196472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42765673995018005},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.42612382769584656},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.42349761724472046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30771932005882263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1831587553024292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08316364884376526},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.052971333265304565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.049579232931137085},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011073","descriptor_name":"Polyamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00210-003-0778-4","doi":"https://doi.org/10.1007/s00210-003-0778-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00210-003-0778-4","pdf_url":null,"source":{"id":"https://openalex.org/S159534381","display_name":"Naunyn-Schmiedeberg s Archives of Pharmacology","issn_l":"0028-1298","issn":["0028-1298","0340-5249","1432-1912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's Archives of Pharmacology","raw_type":"journal-article"},{"id":"pmid:12904829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12904829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naunyn-Schmiedeberg's archives of pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:eprints.soton.ac.uk:27690","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/27690/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320277","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1553653089","https://openalex.org/W1585639756","https://openalex.org/W1841262243","https://openalex.org/W1867012516","https://openalex.org/W1971671517","https://openalex.org/W1973981614","https://openalex.org/W1982984728","https://openalex.org/W1984949427","https://openalex.org/W1987099808","https://openalex.org/W1987176581","https://openalex.org/W1988937009","https://openalex.org/W1991722935","https://openalex.org/W1992372295","https://openalex.org/W1996886208","https://openalex.org/W2002737452","https://openalex.org/W2003505203","https://openalex.org/W2013083961","https://openalex.org/W2014482741","https://openalex.org/W2018500240","https://openalex.org/W2020827630","https://openalex.org/W2030123358","https://openalex.org/W2036451115","https://openalex.org/W2038297374","https://openalex.org/W2043295013","https://openalex.org/W2048580896","https://openalex.org/W2052269200","https://openalex.org/W2059640915","https://openalex.org/W2069440400","https://openalex.org/W2071452513","https://openalex.org/W2072359294","https://openalex.org/W2074664180","https://openalex.org/W2076943188","https://openalex.org/W2079054696","https://openalex.org/W2082761047","https://openalex.org/W2089245964","https://openalex.org/W2117545703","https://openalex.org/W2144540216","https://openalex.org/W2156188621","https://openalex.org/W2169079203","https://openalex.org/W2412083584","https://openalex.org/W2470200677","https://openalex.org/W2949390926"],"related_works":["https://openalex.org/W2117545703","https://openalex.org/W2068844122","https://openalex.org/W1998232218","https://openalex.org/W2018270266","https://openalex.org/W1976418203","https://openalex.org/W2114044744","https://openalex.org/W1976123061","https://openalex.org/W2012402662","https://openalex.org/W1841262243","https://openalex.org/W1985547466"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}