{"id":"https://openalex.org/W2127091304","doi":null,"title":"Recent advances in understanding the relationship between adenosine metabolism and the function of T and B lymphocytes in diabetes.","display_name":"Recent advances in understanding the relationship between adenosine metabolism and the function of T and B lymphocytes in diabetes.","publication_year":2011,"publication_date":"2011-10-01","ids":{"openalex":"https://openalex.org/W2127091304","mag":"2127091304","pmid":"https://pubmed.ncbi.nlm.nih.gov/22204797"},"language":"en","primary_location":{"id":"pmid:22204797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22204797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005118261","display_name":"Monika Sakowicz\u2010Burkiewicz","orcid":"https://orcid.org/0000-0002-8110-7402","observed_orcids":["https://orcid.org/0000-0002-8110-7402"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Sakowicz-Burkiewicz","raw_affiliation_strings":["Department of Molecular Medicine, Medical University of Gdansk, Poland. ssak@gumed.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Medical University of Gdansk, Poland. ssak@gumed.edu.pl","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072250438","display_name":"Tadeusz Pawe\u0142czyk","orcid":"https://orcid.org/0000-0002-0375-732X","observed_orcids":["https://orcid.org/0000-0002-0375-732X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Pawelczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6416,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.78407351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"62","issue":"5","first_page":"505","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-metabolism","display_name":"adenosine metabolism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adenosine-receptors","display_name":"adenosine receptors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/adenosine-a1-receptor","display_name":"adenosine A1 receptor","score":0.6919999718666077},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/adenosine-a2b-receptor","display_name":"adenosine A2B receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/a3-adenosine-receptor","display_name":"A3 adenosine receptor","score":1.0},{"id":"https://openalex.org/keywords/nucleoside-transporters","display_name":"nucleoside transporters","score":0.9819999933242798},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":1.0},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lymphocyte-mediated-cytolysis","display_name":"lymphocyte-mediated cytolysis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6200000047683716},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.5379999876022339},{"id":"https://openalex.org/keywords/infection-susceptibility","display_name":"infection susceptibility","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.8497921228408813},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5919075608253479},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.5905470252037048},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5551106929779053},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5510245561599731},{"id":"https://openalex.org/C172590197","wikidata":"https://www.wikidata.org/wiki/Q17165723","display_name":"Purinergic signalling","level":5,"score":0.5117290019989014},{"id":"https://openalex.org/C34628245","wikidata":"https://www.wikidata.org/wiki/Q356093","display_name":"Adenosine deaminase","level":3,"score":0.47857072949409485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44866687059402466},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4006311893463135},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38868239521980286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3586333394050598},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3443892002105713},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30031096935272217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27250054478645325},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018047","descriptor_name":"Receptors, Purinergic P1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22204797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22204797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:2127091304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22204797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":101,"referenced_works":["https://openalex.org/W161060649","https://openalex.org/W292430549","https://openalex.org/W1488365423","https://openalex.org/W1501769303","https://openalex.org/W1502314841","https://openalex.org/W1512537330","https://openalex.org/W1526101793","https://openalex.org/W1536187233","https://openalex.org/W1575186397","https://openalex.org/W1600888997","https://openalex.org/W1758026723","https://openalex.org/W1808208539","https://openalex.org/W1928151495","https://openalex.org/W1946328238","https://openalex.org/W1965554200","https://openalex.org/W1971954940","https://openalex.org/W1973220831","https://openalex.org/W1973994167","https://openalex.org/W1977187462","https://openalex.org/W1977473423","https://openalex.org/W1978606234","https://openalex.org/W1978762498","https://openalex.org/W1982959390","https://openalex.org/W1983868856","https://openalex.org/W1984623240","https://openalex.org/W1986346567","https://openalex.org/W1991022265","https://openalex.org/W1991340116","https://openalex.org/W1992457570","https://openalex.org/W1993493521","https://openalex.org/W1993976335","https://openalex.org/W2000520867","https://openalex.org/W2001776200","https://openalex.org/W2001923037","https://openalex.org/W2003984228","https://openalex.org/W2004172732","https://openalex.org/W2016170157","https://openalex.org/W2017438088","https://openalex.org/W2017804283","https://openalex.org/W2019406237","https://openalex.org/W2022506311","https://openalex.org/W2025015260","https://openalex.org/W2025656644","https://openalex.org/W2031462278","https://openalex.org/W2040620327","https://openalex.org/W2043029488","https://openalex.org/W2044428726","https://openalex.org/W2044762497","https://openalex.org/W2046349103","https://openalex.org/W2049268565","https://openalex.org/W2049923726","https://openalex.org/W2050055099","https://openalex.org/W2051625512","https://openalex.org/W2052897079","https://openalex.org/W2054000735","https://openalex.org/W2055898863","https://openalex.org/W2065329851","https://openalex.org/W2065368217","https://openalex.org/W2068865855","https://openalex.org/W2069316372","https://openalex.org/W2072162711","https://openalex.org/W2077402159","https://openalex.org/W2077899782","https://openalex.org/W2079033107","https://openalex.org/W2079249099","https://openalex.org/W2081476907","https://openalex.org/W2084483597","https://openalex.org/W2088445270","https://openalex.org/W2090653190","https://openalex.org/W2090871734","https://openalex.org/W2095988220","https://openalex.org/W2101350654","https://openalex.org/W2103030499","https://openalex.org/W2111154851","https://openalex.org/W2115077792","https://openalex.org/W2116036524","https://openalex.org/W2116363269","https://openalex.org/W2117679109","https://openalex.org/W2119097189","https://openalex.org/W2119263245","https://openalex.org/W2123797012","https://openalex.org/W2128272612","https://openalex.org/W2129667982","https://openalex.org/W2132253697","https://openalex.org/W2133722275","https://openalex.org/W2134592730","https://openalex.org/W2137972602","https://openalex.org/W2148545649","https://openalex.org/W2150171929","https://openalex.org/W2153571090","https://openalex.org/W2158229692","https://openalex.org/W2160715085","https://openalex.org/W2165356900","https://openalex.org/W2168535576","https://openalex.org/W2168727631","https://openalex.org/W2170439480","https://openalex.org/W2170936621","https://openalex.org/W2339457126","https://openalex.org/W2394741065","https://openalex.org/W2416974006","https://openalex.org/W4405990760"],"related_works":["https://openalex.org/W1993976335","https://openalex.org/W2049923726","https://openalex.org/W2111154851","https://openalex.org/W2001923037","https://openalex.org/W2063888097","https://openalex.org/W1969883571","https://openalex.org/W4404918944","https://openalex.org/W345029999","https://openalex.org/W2148545649","https://openalex.org/W7100204996"],"abstract_inverted_index":{"Adenosine":[0,103],"plays":[1],"an":[2],"important":[3,128],"role":[4],"in":[5,97,101,113,124,147],"physiology":[6],"of":[7,15,28,54,83,119,132,137,143],"several":[8,21,141],"organs.":[9],"Its":[10],"turnover":[11],"inside":[12],"and":[13,23,42,68,74,105,135],"outside":[14],"the":[16,95],"cell":[17],"is":[18,31,50,79],"controlled":[19],"by":[20],"enzymes":[22],"transport":[24],"processes.":[25],"The":[26],"action":[27,118],"extracellular":[29],"adenosine":[30,49,62,99,120],"mediated":[32],"via":[33],"at":[34],"least":[35],"four":[36],"receptors":[37,104],"named":[38],"A(1),":[39],"A(2A),":[40],"A(2B),":[41],"A(3).":[43],"Recent":[44],"studies":[45],"have":[46],"reported":[47],"that":[48,61],"a":[51,80],"significant":[52],"mediator":[53],"regulatory":[55],"lymphocyte":[56,65,72,122],"function.":[57],"Numerous":[58],"data":[59,89],"indicates":[60],"affects":[63],"T":[64],"activation,":[66],"proliferation":[67],"lymphocyte-mediated":[69],"cytolysis.":[70],"Impaired":[71],"functioning":[73],"enhanced":[75],"susceptibility":[76],"to":[77,93,140],"infections":[78],"common":[81],"feature":[82],"human":[84],"diabetes.":[85,102,148],"This":[86],"review":[87],"collects":[88],"bringing":[90],"us":[91],"closer":[92],"understanding":[94,136],"disturbances":[96],"lymphocytes":[98],"homeostasis":[100],"nucleoside":[106],"transporters":[107],"are":[108],"targets":[109],"for":[110,130],"potential":[111],"drugs":[112],"many":[114],"pathophysiological":[115],"situations.":[116],"Therefore,":[117],"on":[121],"function":[123],"diabetes":[125],"may":[126],"be":[127],"target":[129],"modulation":[131],"immune":[133,144],"responses":[134],"mechanisms":[138],"leading":[139],"pathologies":[142],"cells":[145],"observed":[146]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
