{"id":"https://openalex.org/W2126996873","doi":"https://doi.org/10.1210/me.2014-1100","title":"Inhibitor of Differentiation 4 (ID4) Inactivation Promotes De Novo Steroidogenesis and Castration-Resistant Prostate Cancer","display_name":"Inhibitor of Differentiation 4 (ID4) Inactivation Promotes De Novo Steroidogenesis and Castration-Resistant Prostate Cancer","publication_year":2014,"publication_date":"2014-06-12","ids":{"openalex":"https://openalex.org/W2126996873","doi":"https://doi.org/10.1210/me.2014-1100","mag":"2126996873","pmid":"https://pubmed.ncbi.nlm.nih.gov/24921661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116589"},"language":"en","primary_location":{"id":"doi:10.1210/me.2014-1100","doi":"https://doi.org/10.1210/me.2014-1100","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2014-1100","pdf_url":"https://academic.oup.com/mend/article-pdf/28/8/1239/8906166/mend1239.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/28/8/1239/8906166/mend1239.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101623032","display_name":"Divya Patel","orcid":"https://orcid.org/0000-0003-2659-3695","observed_orcids":["https://orcid.org/0000-0003-2659-3695","https://orcid.org/0000-0001-9627-2745"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Patel","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051052123","display_name":"Ashley Evans Knowell","orcid":"https://orcid.org/0009-0001-4532-3036","observed_orcids":["https://orcid.org/0009-0001-4532-3036"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley E. Knowell","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015607835","display_name":"Maxwell Korang\u2010Yeboah","orcid":"https://orcid.org/0000-0001-7646-9436","observed_orcids":["https://orcid.org/0000-0001-7646-9436"]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]},{"id":"https://openalex.org/I2801518522","display_name":"Mercer University Health Sciences Center","ror":"https://ror.org/01g67by91","country_code":"US","type":"education","lineage":["https://openalex.org/I2801518522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell Korang-Yeboah","raw_affiliation_strings":["College of Pharmacy (M.K.-Y., R.P.), Mercer University, Atlanta, Georgia 30341"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy (M.K.-Y., R.P.), Mercer University, Atlanta, Georgia 30341","institution_ids":["https://openalex.org/I150149174","https://openalex.org/I2801518522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036360503","display_name":"Pankaj Sharma","orcid":"https://orcid.org/0000-0002-2439-6690","observed_orcids":["https://orcid.org/0000-0002-2439-6690"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Sharma","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058716819","display_name":"Jugal Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jugal Joshi","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020314406","display_name":"Shanora Glymph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanora Glymph","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014984712","display_name":"Swathi Chinaranagari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swathi Chinaranagari","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010949788","display_name":"Peri Nagappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peri Nagappan","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103789663","display_name":"Ravi Palaniappan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]},{"id":"https://openalex.org/I2801518522","display_name":"Mercer University Health Sciences Center","ror":"https://ror.org/01g67by91","country_code":"US","type":"education","lineage":["https://openalex.org/I2801518522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Palaniappan","raw_affiliation_strings":["College of Pharmacy (M.K.-Y., R.P.), Mercer University, Atlanta, Georgia 30341"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy (M.K.-Y., R.P.), Mercer University, Atlanta, Georgia 30341","institution_ids":["https://openalex.org/I150149174","https://openalex.org/I2801518522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035913839","display_name":"Nathan J. Bowen","orcid":"https://orcid.org/0000-0002-1609-6698","observed_orcids":["https://orcid.org/0000-0002-1609-6698"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan J. Bowen","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072992833","display_name":"Jaideep Chaudhary","orcid":"https://orcid.org/0000-0002-8793-4329","observed_orcids":["https://orcid.org/0000-0002-8793-4329"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaideep Chaudhary","raw_affiliation_strings":["Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Research and Therapeutic Development (D.P., A.E.K., P.S., J.J., S.G., S.C., P.N., N.J.B., J.C.), Clark Atlanta University, Atlanta, Georgia 30314;","institution_ids":["https://openalex.org/I52064589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072992833"],"corresponding_institution_ids":["https://openalex.org/I52064589"],"apc_list":null,"apc_paid":null,"fwci":3.7109,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93238011,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"8","first_page":"1239","last_page":"1253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/id4","display_name":"Id4","score":0.718999981880188},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/androgen-receptor-activation","display_name":"androgen receptor activation","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nkx3-1","display_name":"NKX3.1","score":0.968999981880188},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7699999809265137},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8573856353759766},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7824799418449402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7297340631484985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6940631866455078},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.651615560054779},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5818187594413757},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.514055609703064},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5065642595291138},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.4818497896194458},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.442320317029953},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4281888008117676},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4218323230743408},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37246620655059814},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3290722370147705},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26101255416870117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17960849404335022},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09015130996704102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08612090349197388}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051796","descriptor_name":"Inhibitor of Differentiation Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/me.2014-1100","doi":"https://doi.org/10.1210/me.2014-1100","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2014-1100","pdf_url":"https://academic.oup.com/mend/article-pdf/28/8/1239/8906166/mend1239.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4116589","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4116589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Endocrinol","raw_type":"Text"},{"id":"pmid:24921661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24921661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/me.2014-1100","doi":"https://doi.org/10.1210/me.2014-1100","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2014-1100","pdf_url":"https://academic.oup.com/mend/article-pdf/28/8/1239/8906166/mend1239.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G46838166","display_name":"Inhibitor of Differentiation Gene Expression and Function in Prostate Cells","funder_award_id":"R01CA128914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7255487679","display_name":null,"funder_award_id":"CA128914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7546212254","display_name":"CNTR OF EXCELLENCE FOR PROSTATE CANCER RESEARCH EDUCATION AND COMM SERVICE","funder_award_id":"P20MD002285","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G7737758266","display_name":"CANCER RESEARCH INFRASTRUCTURE DEVELOPMENT","funder_award_id":"G12MD007590","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8029105834","display_name":"Clark Atlanta University Biomedical Science Development","funder_award_id":"G12RR003062","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126996873.pdf","grobid_xml":"https://content.openalex.org/works/W2126996873.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1491170524","https://openalex.org/W1979210605","https://openalex.org/W1990002146","https://openalex.org/W1999383800","https://openalex.org/W2003541059","https://openalex.org/W2007192053","https://openalex.org/W2017896209","https://openalex.org/W2018179657","https://openalex.org/W2019020763","https://openalex.org/W2019818723","https://openalex.org/W2020023326","https://openalex.org/W2029012584","https://openalex.org/W2032297742","https://openalex.org/W2050871127","https://openalex.org/W2057216898","https://openalex.org/W2062440930","https://openalex.org/W2067722046","https://openalex.org/W2071642351","https://openalex.org/W2075319732","https://openalex.org/W2075379080","https://openalex.org/W2084903524","https://openalex.org/W2086449036","https://openalex.org/W2086602305","https://openalex.org/W2093522178","https://openalex.org/W2099540110","https://openalex.org/W2099731916","https://openalex.org/W2107633226","https://openalex.org/W2108426942","https://openalex.org/W2109193598","https://openalex.org/W2109639557","https://openalex.org/W2109837506","https://openalex.org/W2112104987","https://openalex.org/W2114843025","https://openalex.org/W2118238803","https://openalex.org/W2118321738","https://openalex.org/W2119504728","https://openalex.org/W2121451529","https://openalex.org/W2123964155","https://openalex.org/W2124883945","https://openalex.org/W2125164793","https://openalex.org/W2125989214","https://openalex.org/W2128197399","https://openalex.org/W2129509993","https://openalex.org/W2140729960","https://openalex.org/W2149441684","https://openalex.org/W2157189284","https://openalex.org/W2160427174","https://openalex.org/W2161813168","https://openalex.org/W2164508669","https://openalex.org/W2166820820","https://openalex.org/W2169385429","https://openalex.org/W2916022153","https://openalex.org/W3147148312","https://openalex.org/W6655460415"],"related_works":["https://openalex.org/W2953849367","https://openalex.org/W2591739428","https://openalex.org/W1967537767","https://openalex.org/W2803102053","https://openalex.org/W2118321738","https://openalex.org/W2576244515","https://openalex.org/W2003541059","https://openalex.org/W2071641998","https://openalex.org/W2504051591","https://openalex.org/W3155929859"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,8],"(PCa)":[2],"is":[3,23,76],"the":[4,12,68,81,86,104,118,141,158],"most":[5],"commonly":[6],"diagnosed":[7],"in":[9,11,55,58,80,96,110,125,130,140,151,157,168,176,199,222,227,240,247],"men":[10],"Western":[13],"world.":[14],"The":[15,230],"transition":[16],"of":[17,43,45,70,83,106,108,123,143,182,195,206,216],"androgen-dependent":[18],"PCa":[19,97,111],"to":[20],"castration-resistant":[21],"(CRPC)":[22],"a":[24,33,49,190,214,237],"major":[25],"clinical":[26,87],"manifestation":[27],"during":[28],"disease":[29],"progression":[30],"and":[31,63,89,116,135,147,242],"presents":[32],"therapeutic":[34],"challenge.":[35],"Our":[36],"studies":[37],"have":[38],"shown":[39],"that":[40,156,180,194,233],"genetic":[41],"ablation":[42],"inhibitor":[44],"differentiation":[46],"4":[47],"(Id4),":[48],"dominant-negative":[50],"helix":[51,53],"loop":[52],"protein,":[54],"mice":[56],"results":[57,231],"prostatic":[59],"intraepithelial":[60],"neoplasia":[61],"lesions":[62],"decreased":[64],"Nkx3.1":[65],"expression":[66,212],"without":[67],"loss":[69,107,181],"androgen":[71],"receptor":[72],"(Ar)":[73],"expression.":[74],"ID4":[75,94,109,124,183,234],"also":[77,174],"epigenetically":[78],"silenced":[79],"majority":[82],"PCa.":[84],"However,":[85],"relevance":[88],"molecular":[90],"pathways":[91],"altered":[92],"by":[93],"inactivation":[95],"are":[98],"not":[99,226],"known.":[100],"This":[101],"study":[102],"investigates":[103],"effect":[105],"cell":[112],"lines":[113],"on":[114],"tumorigenicity":[115],"addresses":[117],"underlying":[119],"mechanism.":[120],"Stable":[121],"silencing":[122],"LNCaP":[126,159],"cells":[127,160,224],"(L-ID4)":[128],"resulted":[129],"increased":[131],"proliferation,":[132],"migration,":[133],"invasion,":[134],"anchorage-independent":[136],"growth.":[137],"An":[138],"increase":[139],"rate":[142],"tumor":[144,238],"growth,":[145],"weight,":[146],"volume":[148],"was":[149,202,220],"observed":[150,175,221,246],"L-ID4":[152,223],"xenografts":[153],"compared":[154],"with":[155,162,204],"transfected":[161],"nonspecific":[163],"short":[164],"hairpin":[165],"RNA":[166,186],"(L+ns)":[167],"noncastrated":[169],"mice.":[170],"Interestingly,":[171],"tumors":[172],"were":[173],"castrated":[177],"mice,":[178],"suggesting":[179],"promotes":[184,249],"CRPC.":[185],"sequence":[187],"analysis":[188],"revealed":[189],"gene":[191],"signature":[192],"mimicking":[193],"constitutively":[196],"active":[197],"AR":[198,218,253],"L-ID4,":[200],"which":[201],"consistent":[203],"gain":[205],"de":[207],"novo":[208],"steroidogenesis.":[209],"Prostate-specific":[210],"antigen":[211],"as":[213,236],"result":[215],"persistent":[217],"activation":[219],"but":[225],"L+ns":[228],"cells.":[229],"demonstrate":[232],"acts":[235],"suppressor":[239],"PCa,":[241,248],"its":[243],"loss,":[244],"frequently":[245],"CRPC":[250],"through":[251],"constitutive":[252],"activation.":[254]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
