{"id":"https://openalex.org/W2126904693","doi":"https://doi.org/10.1083/jcb.106.3.629","title":"Posttranslational oligomerization and cooperative acid activation of mixed influenza hemagglutinin trimers.","display_name":"Posttranslational oligomerization and cooperative acid activation of mixed influenza hemagglutinin trimers.","publication_year":1988,"publication_date":"1988-03-01","ids":{"openalex":"https://openalex.org/W2126904693","doi":"https://doi.org/10.1083/jcb.106.3.629","mag":"2126904693","pmid":"https://pubmed.ncbi.nlm.nih.gov/3279048","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115101"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.106.3.629","doi":"https://doi.org/10.1083/jcb.106.3.629","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.106.3.629","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108481824","display_name":"Fran\u00e7ois Boulay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Boulay","raw_affiliation_strings":["Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110411605","display_name":"Robert W. Doms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R W Doms","raw_affiliation_strings":["Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454011","display_name":"Robert G. Webster","orcid":"https://orcid.org/0000-0002-1899-1856","observed_orcids":["https://orcid.org/0000-0002-1899-1856"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R G Webster","raw_affiliation_strings":["Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111379110","display_name":"Ari Helenius","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Helenius","raw_affiliation_strings":["Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":11.7326,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.9878921,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"106","issue":"3","first_page":"629","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-hemagglutinin","display_name":"influenza hemagglutinin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.6420000195503235},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8009999990463257},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.847000002861023},{"id":"https://openalex.org/keywords/sequence-specificity","display_name":"sequence specificity","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.7698202133178711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7523952722549438},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6551660299301147},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.5581272840499878},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5507673621177673},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.5459401607513428},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5100827813148499},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.5066893696784973},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.502291202545166},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4479385316371918},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.43436217308044434},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.41269612312316895},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4007296562194824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39926666021347046},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3489609956741333},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.25965237617492676},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21805164217948914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11422455310821533},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.08016988635063171},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006389","descriptor_name":"Hemagglutinins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.106.3.629","doi":"https://doi.org/10.1083/jcb.106.3.629","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.106.3.629","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2115101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115101","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:3279048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3279048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2115101","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115101","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1386501374","display_name":null,"funder_award_id":"AI-08831","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4020157209","display_name":null,"funder_award_id":"AI 18599","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W6092899","https://openalex.org/W100269210","https://openalex.org/W113442559","https://openalex.org/W163847268","https://openalex.org/W195136444","https://openalex.org/W317171138","https://openalex.org/W959496044","https://openalex.org/W1497148118","https://openalex.org/W1541186016","https://openalex.org/W1554825533","https://openalex.org/W1580917700","https://openalex.org/W1591950279","https://openalex.org/W1606498438","https://openalex.org/W1965381942","https://openalex.org/W1970081885","https://openalex.org/W1976232165","https://openalex.org/W1977567513","https://openalex.org/W1981821615","https://openalex.org/W1984412128","https://openalex.org/W1984416131","https://openalex.org/W1986981622","https://openalex.org/W1989526931","https://openalex.org/W1990747840","https://openalex.org/W1997662437","https://openalex.org/W2004477764","https://openalex.org/W2012059692","https://openalex.org/W2013453931","https://openalex.org/W2018289835","https://openalex.org/W2021209936","https://openalex.org/W2028983108","https://openalex.org/W2029230587","https://openalex.org/W2045018678","https://openalex.org/W2048349216","https://openalex.org/W2060834058","https://openalex.org/W2062207296","https://openalex.org/W2064805716","https://openalex.org/W2067746491","https://openalex.org/W2067826649","https://openalex.org/W2070599926","https://openalex.org/W2075390465","https://openalex.org/W2081123727","https://openalex.org/W2083999896","https://openalex.org/W2090541956","https://openalex.org/W2091403158","https://openalex.org/W2094971347","https://openalex.org/W2100837269","https://openalex.org/W2114138957","https://openalex.org/W2138270253","https://openalex.org/W2142040409","https://openalex.org/W2143561568","https://openalex.org/W2148944790","https://openalex.org/W2150405813","https://openalex.org/W2154116964","https://openalex.org/W2159031835","https://openalex.org/W2159770207","https://openalex.org/W2242144825","https://openalex.org/W2495033447"],"related_works":["https://openalex.org/W7096824210","https://openalex.org/W7131437204","https://openalex.org/W2159770207","https://openalex.org/W1982785263","https://openalex.org/W2810745432","https://openalex.org/W1968226989","https://openalex.org/W2145975995","https://openalex.org/W2043285409","https://openalex.org/W2148742615","https://openalex.org/W2143467723"],"abstract_inverted_index":{"The":[0,32],"influenza":[1],"virus":[2],"hemagglutinin":[3],"(HA)":[4],"is":[5,55,91,117],"a":[6,57,66,118],"well-characterized":[7],"integral":[8],"membrane":[9,112],"glycoprotein":[10],"composed":[11],"of":[12,21,40,69,115],"three":[13],"identical":[14],"subunits.":[15],"We":[16],"have":[17],"analyzed":[18],"the":[19,46,50,72,88,105,111],"formation":[20],"mixed":[22],"trimers":[23,43,76,95],"in":[24,71,110],"cells":[25],"expressing":[26],"two":[27],"different":[28,84],"HA":[29,52,116],"gene":[30],"products.":[31],"results":[33],"show":[34],"efficient":[35],"and":[36,60],"essentially":[37],"random":[38],"assembly":[39],"functional":[41],"hybrid":[42],"provided":[44],"that":[45,87,104],"HAs":[47,81],"are":[48,62],"from":[49,65,83],"same":[51],"subtype.":[53],"Trimerization":[54],"thus":[56],"posttranslational":[58],"event,":[59],"subunits":[61,98],"recruited":[63],"randomly":[64],"common":[67],"pool":[68],"monomers":[70],"endoplasmic":[73],"reticulum.":[74],"Mixed":[75,94],"were":[77],"not":[78],"observed":[79],"between":[80],"derived":[82],"subtypes,":[85],"indicating":[86],"trimerization":[89],"event":[90],"sequence":[92],"specific.":[93],"containing":[96],"mutant":[97],"were,":[99],"moreover,":[100],"used":[101],"to":[102],"establish":[103],"acid-induced":[106],"conformational":[107],"change":[108],"involved":[109],"fusion":[113],"activity":[114],"highly":[119],"cooperative":[120],"event.":[121]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}