{"id":"https://openalex.org/W2126861972","doi":"https://doi.org/10.1091/mbc.e08-10-1084","title":"Down-Regulation of a Manganese Transporter in the Face of Metal Toxicity","display_name":"Down-Regulation of a Manganese Transporter in the Face of Metal Toxicity","publication_year":2009,"publication_date":"2009-04-16","ids":{"openalex":"https://openalex.org/W2126861972","doi":"https://doi.org/10.1091/mbc.e08-10-1084","mag":"2126861972","pmid":"https://pubmed.ncbi.nlm.nih.gov/19369420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2695789"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e08-10-1084","doi":"https://doi.org/10.1091/mbc.e08-10-1084","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e08-10-1084","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2695789","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014507574","display_name":"Laran T. Jensen","orcid":"https://orcid.org/0000-0003-3199-1743","observed_orcids":["https://orcid.org/0000-0003-3199-1743"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laran T. Jensen","raw_affiliation_strings":["*Department of Environmental Health Sciences and","Department of Environmental Health Sciences and Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Environmental Health Sciences and","institution_ids":[]},{"raw_affiliation_string":"Department of Environmental Health Sciences and Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark C. Carroll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark C. Carroll","raw_affiliation_strings":["*Department of Environmental Health Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Environmental Health Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101554309","display_name":"Matthew D. Hall","orcid":"https://orcid.org/0000-0002-5073-442X","observed_orcids":["https://orcid.org/0000-0002-5073-442X","https://orcid.org/0000-0002-8307-8633"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Hall","raw_affiliation_strings":["*Department of Environmental Health Sciences and","Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Environmental Health Sciences and","institution_ids":[]},{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher J. Harvey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. Harvey","raw_affiliation_strings":["*Department of Environmental Health Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Environmental Health Sciences and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080077211","display_name":"Sara E. Beese\u2010Sims","orcid":"https://orcid.org/0000-0002-4080-4615","observed_orcids":["https://orcid.org/0000-0002-4080-4615"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara E. Beese","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089873570","display_name":"Valeria Culotta","orcid":"https://orcid.org/0000-0002-3213-1326","observed_orcids":["https://orcid.org/0000-0002-3213-1326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeria C. Culotta","raw_affiliation_strings":["*Department of Environmental Health Sciences and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Environmental Health Sciences and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4903,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.79002287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"12","first_page":"2810","last_page":"2819"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.15469999611377716,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.9679999947547913},{"id":"https://openalex.org/keywords/vacuolar-degradation","display_name":"vacuolar degradation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.7419999837875366},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8220000267028809},{"id":"https://openalex.org/keywords/exocytic-pathway","display_name":"exocytic pathway","score":0.9160000085830688},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.75},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.6970000267028809},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.9121309518814087},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.6474269032478333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6157117486000061},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5793896913528442},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5775774717330933},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.57747882604599},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5609806776046753},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.44245675206184387},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4416932463645935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42548519372940063},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.41575801372528076},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37301716208457947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26155558228492737},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21789345145225525},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16802316904067993},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.07469207048416138},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043743","descriptor_name":"Ubiquitin-Protein Ligase Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.e08-10-1084","doi":"https://doi.org/10.1091/mbc.e08-10-1084","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e08-10-1084","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1502596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2695789","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2695789","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2695789","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:19369420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19369420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.925.1030","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.925.1030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.spectracell.com/media/uploaded/4/0e2041603_423fullpaper2009mbcdownregulationofmanganesetransporterinmetaltoxicity.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1502596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2695789","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2928677264","display_name":"Intracellular Pathways of manganese Trafficking","funder_award_id":"R01ES008996","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6486518977","display_name":"Johns Hopkins Center in Urban Environmental Health","funder_award_id":"P30ES003819","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000881543","display_name":"Training in Areas Fundamental to Cancer Research","funder_award_id":"T32CA009110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308406","display_name":"American Australian Association","ror":"https://ror.org/04fxadq33"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W168124872","https://openalex.org/W1526043578","https://openalex.org/W1533165142","https://openalex.org/W1534809362","https://openalex.org/W1548999503","https://openalex.org/W1555714096","https://openalex.org/W1568628619","https://openalex.org/W1591303932","https://openalex.org/W1792262679","https://openalex.org/W1839658873","https://openalex.org/W1935962442","https://openalex.org/W1967101536","https://openalex.org/W1971589776","https://openalex.org/W1975302004","https://openalex.org/W1983448385","https://openalex.org/W1984303321","https://openalex.org/W1984632019","https://openalex.org/W1984701284","https://openalex.org/W1990081368","https://openalex.org/W1990741894","https://openalex.org/W1999672276","https://openalex.org/W2003110129","https://openalex.org/W2022456060","https://openalex.org/W2024513455","https://openalex.org/W2025144653","https://openalex.org/W2025234158","https://openalex.org/W2037728003","https://openalex.org/W2038142268","https://openalex.org/W2041543608","https://openalex.org/W2042013644","https://openalex.org/W2044569209","https://openalex.org/W2049172756","https://openalex.org/W2059620285","https://openalex.org/W2065593669","https://openalex.org/W2072318122","https://openalex.org/W2073909199","https://openalex.org/W2091423057","https://openalex.org/W2098476798","https://openalex.org/W2100582146","https://openalex.org/W2106360060","https://openalex.org/W2107356219","https://openalex.org/W2107376675","https://openalex.org/W2110522042","https://openalex.org/W2110949951","https://openalex.org/W2112748678","https://openalex.org/W2116522492","https://openalex.org/W2123319557","https://openalex.org/W2123550712","https://openalex.org/W2123738381","https://openalex.org/W2124025161","https://openalex.org/W2124438628","https://openalex.org/W2130905895","https://openalex.org/W2146375872","https://openalex.org/W2150104537","https://openalex.org/W2154534551","https://openalex.org/W2155135457","https://openalex.org/W2159394127","https://openalex.org/W2163350914","https://openalex.org/W2164186781","https://openalex.org/W2164272263","https://openalex.org/W2168102576","https://openalex.org/W2168684404","https://openalex.org/W2169333620","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098076467","https://openalex.org/W7098487805","https://openalex.org/W2155135457","https://openalex.org/W2038142268","https://openalex.org/W2022456060","https://openalex.org/W2112748678","https://openalex.org/W2165246198","https://openalex.org/W59825912","https://openalex.org/W7034159735","https://openalex.org/W2124025161"],"abstract_inverted_index":{"The":[0],"yeast":[1],"Smf1p":[2,12,48,76,100,106,118,134,152],"Nramp":[3],"manganese":[4,20,31,71,87,93,124,137,155,161,164,174,186],"transporter":[5],"is":[6,13,23,63,149,176,188],"posttranslationally":[7],"regulated":[8],"by":[9,77,85,135,154],"environmental":[10],"manganese.":[11],"stabilized":[14],"at":[15],"the":[16,27,36,80,108,112,130,158,179,182,195],"cell":[17,98],"surface":[18,99],"with":[19,29,52,67,122],"starvation,":[21],"but":[22,56],"largely":[24,64],"degraded":[25],"in":[26],"vacuole":[28],"physiological":[30,68],"through":[32,79,107],"a":[33],"mechanism":[34],"involving":[35],"Rsp5p":[37],"adaptor":[38],"complex":[39],"Bsd2p/Tre1p/Tre2p.":[40,91],"We":[41,170],"now":[42],"describe":[43],"an":[44,191],"additional":[45],"level":[46],"of":[47,75,97,104,114,133,143,181,194],"regulation":[49,62,84,153],"that":[50,173],"occurs":[51],"toxicity":[53,165,187],"from":[54],"manganese,":[55,69],"not":[57,89,139],"other":[58],"essential":[59],"metals.":[60],"This":[61],"Smf1p-specific.":[65],"As":[66],"toxic":[70,86,123,136],"triggers":[72,94],"vacuolar":[73,102,115],"degradation":[74],"trafficking":[78],"multivesicular":[81],"body.":[82],"However,":[83],"does":[88,138],"involve":[90,166],"Toxic":[92],"both":[95],"endocytosis":[96],"and":[101,125,163],"targeting":[103,116],"intracellular":[105],"exocytic":[109],"pathway.":[110],"Notably,":[111],"kinetics":[113],"for":[117,151],"are":[119],"relatively":[120],"slow":[121],"require":[126,140],"prolonged":[127],"exposures":[128],"to":[129,160],"metal.":[131],"Down-regulation":[132],"transport":[141,147],"activity":[142,148],"Smf1p,":[144],"whereas":[145,185],"such":[146],"needed":[150],"starvation.":[156],"Furthermore,":[157],"responses":[159],"starvation":[162,175],"separate":[167],"cellular":[168],"compartments.":[169],"provide":[171],"evidence":[172],"sensed":[177,189],"within":[178,190],"lumen":[180],"secretory":[183],"pathway,":[184],"extra-Golgi/cytosolic":[192],"compartment":[193],"cell.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
