{"id":"https://openalex.org/W2126830227","doi":"https://doi.org/10.1073/pnas.131067798","title":"Endothelial cell surface F 1 -F O ATP synthase is active in ATP synthesis and is inhibited by angiostatin","display_name":"Endothelial cell surface F 1 -F O ATP synthase is active in ATP synthesis and is inhibited by angiostatin","publication_year":2001,"publication_date":"2001-05-29","ids":{"openalex":"https://openalex.org/W2126830227","doi":"https://doi.org/10.1073/pnas.131067798","mag":"2126830227","pmid":"https://pubmed.ncbi.nlm.nih.gov/11381144","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/34409"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.131067798","doi":"https://doi.org/10.1073/pnas.131067798","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.131067798","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC34409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tammy L. Moser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy L. Moser","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","Department of Pathology and Duke University School of Nursing, Duke University Medical Center, Durham, NC 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pathology and Duke University School of Nursing, Duke University Medical Center, Durham, NC 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012553646","display_name":"Daniel J. Kenan","orcid":"https://orcid.org/0000-0002-5284-7284","observed_orcids":["https://orcid.org/0000-0002-5284-7284"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Kenan","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010600485","display_name":"Timothy A. Ashley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Ashley","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027441560","display_name":"Julie A. Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Roy","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081028909","display_name":"Michael D. Goodman","orcid":"https://orcid.org/0000-0001-7218-4855","observed_orcids":["https://orcid.org/0000-0001-7218-4855"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Goodman","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106763949","display_name":"Uma Kant Misra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uma K. Misra","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012720582","display_name":"Dennis J. Cheek","orcid":"https://orcid.org/0000-0002-3545-8228","observed_orcids":["https://orcid.org/0000-0002-3545-8228"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Cheek","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090928660","display_name":"Salvatore Vincent Pizzo","orcid":"https://orcid.org/0000-0001-6202-3118","observed_orcids":["https://orcid.org/0000-0001-6202-3118"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salvatore V. Pizzo","raw_affiliation_strings":["Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Duke University School\r of Nursing, Duke University Medical Center, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0589,"has_fulltext":false,"cited_by_count":315,"citation_normalized_percentile":{"value":0.9784094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"98","issue":"12","first_page":"6656","last_page":"6661"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiostatin","display_name":"angiostatin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8920000195503235},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/atp-metabolism","display_name":"ATP metabolism","score":0.5540000200271606},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.4950000047683716},{"id":"https://openalex.org/keywords/endothelial-cell-surface","display_name":"endothelial cell surface","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C106812560","wikidata":"https://www.wikidata.org/wiki/Q2063189","display_name":"Angiostatin","level":3,"score":0.9382621049880981},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.7884502410888672},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5820547342300415},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5611424446105957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5174625515937805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4998135566711426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47718608379364014},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47306621074676514},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41866278648376465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37551528215408325},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11485728621482849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.09324198961257935}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010958","descriptor_name":"Plasminogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043168","descriptor_name":"Angiostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.131067798","doi":"https://doi.org/10.1073/pnas.131067798","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.131067798","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:180914","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC34409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:11381144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11381144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:34409","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC34409/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"mag:2793555645","doi":null,"is_oa":false,"landing_page_url":"http://jglobal.jst.go.jp/public/20090422/200902127129084431","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:180914","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC34409","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W584225389","https://openalex.org/W613425975","https://openalex.org/W625127032","https://openalex.org/W1569297824","https://openalex.org/W1590084917","https://openalex.org/W1607187127","https://openalex.org/W1722659238","https://openalex.org/W1920446910","https://openalex.org/W1963776052","https://openalex.org/W1964976203","https://openalex.org/W1968673560","https://openalex.org/W1978139448","https://openalex.org/W1985528986","https://openalex.org/W1985804036","https://openalex.org/W1994190235","https://openalex.org/W1995034367","https://openalex.org/W1999908691","https://openalex.org/W2012230565","https://openalex.org/W2028227922","https://openalex.org/W2029974037","https://openalex.org/W2034269086","https://openalex.org/W2043297474","https://openalex.org/W2054572692","https://openalex.org/W2054728198","https://openalex.org/W2061129088","https://openalex.org/W2068734705","https://openalex.org/W2069303418","https://openalex.org/W2072928113","https://openalex.org/W2099757747","https://openalex.org/W2111395353","https://openalex.org/W2144373920","https://openalex.org/W2150048971","https://openalex.org/W2151089147","https://openalex.org/W2291903346","https://openalex.org/W2324235425","https://openalex.org/W2418752850","https://openalex.org/W2468957571","https://openalex.org/W2490891784","https://openalex.org/W4248769391","https://openalex.org/W4302491434"],"related_works":["https://openalex.org/W1974607158","https://openalex.org/W2070893935","https://openalex.org/W2054572692","https://openalex.org/W2097199032","https://openalex.org/W2099955070","https://openalex.org/W1993077665","https://openalex.org/W2041218674","https://openalex.org/W140433562","https://openalex.org/W1587757013","https://openalex.org/W1975745957"],"abstract_inverted_index":{"Angiostatin":[0],"blocks":[1],"tumor":[2],"angiogenesis":[3],"in":[4,50,79,114,152,171],"vivo,":[5],"almost":[6],"certainly":[7],"through":[8],"its":[9],"demonstrated":[10],"ability":[11],"to":[12,197],"block":[13],"endothelial":[14,39,65,99,193],"cell":[15,40,100],"migration":[16],"and":[17,67,122,128,147,154],"proliferation.":[18],"Although":[19],"the":[20,33,38,51,57,89,98,132,145],"mechanism":[21],"of":[22,28,59,88,131,149,166,189,199],"angiostatin":[23,52,137,161,207],"action":[24],"remains":[25],"unknown,":[26],"identification":[27],"F(1)-F(O)":[29],"ATP":[30,44,61,80,91,115,126,150,168,190],"synthase":[31,62,92,127,151,191],"as":[32,117,138,140,206],"major":[34],"angiostatin-binding":[35],"site":[36],"on":[37,64,97],"surface":[41],"suggests":[42],"that":[43,85,160,184,198,202],"metabolism":[45],"may":[46,173],"play":[47],"a":[48],"role":[49],"response.":[53],"Previous":[54],"studies":[55],"noting":[56],"presence":[58],"F(1)":[60,90],"subunits":[63,188],"cells":[66,70],"certain":[68],"cancer":[69],"did":[71],"not":[72],"determine":[73],"whether":[74],"this":[75],"enzyme":[76,111,133],"was":[77],"functional":[78],"synthesis.":[81],"We":[82,180],"now":[83,181],"demonstrate":[84],"all":[86],"components":[87],"catalytic":[93],"core":[94],"are":[95,134],"present":[96],"surface,":[101],"where":[102],"they":[103],"colocalize":[104],"into":[105],"discrete":[106],"punctate":[107],"structures.":[108],"The":[109],"surface-associated":[110],"is":[112],"active":[113],"synthesis":[116],"shown":[118,183],"by":[119,136,141,164,177],"dual-label":[120],"TLC":[121],"bioluminescence":[123],"assays.":[124,156],"Both":[125],"ATPase":[129],"activities":[130,195],"inhibited":[135],"well":[139],"antibodies":[142,185,204],"directed":[143,186],"against":[144,187],"alpha-":[146],"beta-subunits":[148],"cell-based":[153],"biochemical":[155],"Our":[157],"data":[158],"suggest":[159],"inhibits":[162],"vascularization":[163],"suppression":[165],"endothelial-surface":[167],"metabolism,":[169],"which,":[170],"turn,":[172],"regulate":[174],"vascular":[175],"physiology":[176],"established":[178],"mechanisms.":[179],"have":[182],"exhibit":[192],"cell-inhibitory":[194],"comparable":[196],"angiostatin,":[200],"indicating":[201],"these":[203],"function":[205],"mimetics.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}