{"id":"https://openalex.org/W2126822372","doi":null,"title":"NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells.","display_name":"NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells.","publication_year":2010,"publication_date":"2010-07-29","ids":{"openalex":"https://openalex.org/W2126822372","mag":"2126822372","pmid":"https://pubmed.ncbi.nlm.nih.gov/20680101","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2913141"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2913141","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091558604","display_name":"Federica Sornelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Sornelli","raw_affiliation_strings":["Institute of Neurobiology and Molecular Medicine, Department of Neurobiology, National Research Council (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine, Department of Neurobiology, National Research Council (CNR), Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081222861","display_name":"Alessandro Lamb\u00ecase","orcid":"https://orcid.org/0000-0002-8974-991X","observed_orcids":["https://orcid.org/0000-0002-8974-991X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Lambiase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013431023","display_name":"Flavio Mantelli","orcid":"https://orcid.org/0000-0003-3459-4866","observed_orcids":["https://orcid.org/0000-0003-3459-4866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flavio Mantelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018870384","display_name":"Luigi Aloe","orcid":"https://orcid.org/0000-0002-9796-1283","observed_orcids":["https://orcid.org/0000-0002-9796-1283"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Aloe","raw_affiliation_strings":["National Res. Council, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Res. Council, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6839,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81873352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1439","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.5669000148773193,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.31619998812675476,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":1.0},{"id":"https://openalex.org/keywords/ngf-receptor","display_name":"NGF receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/corneal-endothelial-cells","display_name":"corneal endothelial cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.921999990940094},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cell-viability","display_name":"endothelial cell viability","score":0.7860000133514404},{"id":"https://openalex.org/keywords/ocular-surface-homeostasis","display_name":"ocular surface homeostasis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/anti-ngf-antibody","display_name":"anti-NGF antibody","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7053639888763428},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.6999572515487671},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6535338163375854},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5530110001564026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.532594621181488},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.5118321776390076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48410093784332275},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47429636120796204},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.46530041098594666},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43176621198654175},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4003795385360718},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3825964331626892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37354883551597595},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.36931777000427246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2713804841041565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2215670645236969},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18244343996047974},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004728","descriptor_name":"Endothelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020800","descriptor_name":"Receptor, Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020917","descriptor_name":"Receptor, trkA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2913141","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:20680101","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20680101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.353.7235","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.353.7235","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0c/99/Mol_Vis_2010_Jul_29_16_1439-1447.tar.gz","raw_type":"text"},{"id":"pmh:oai:iris.uniroma1.it:11573/807451","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/807451","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2126822372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20680101","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2913141","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2913141/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126822372.pdf","grobid_xml":"https://content.openalex.org/works/W2126822372.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W408021019","https://openalex.org/W1480067530","https://openalex.org/W1488489148","https://openalex.org/W1529699134","https://openalex.org/W1590974871","https://openalex.org/W1596048577","https://openalex.org/W1677079502","https://openalex.org/W1962154683","https://openalex.org/W1963898471","https://openalex.org/W1979499962","https://openalex.org/W1985712533","https://openalex.org/W1997405480","https://openalex.org/W2020002728","https://openalex.org/W2024725915","https://openalex.org/W2027243420","https://openalex.org/W2030208949","https://openalex.org/W2058199689","https://openalex.org/W2058296840","https://openalex.org/W2063695629","https://openalex.org/W2067275215","https://openalex.org/W2067626374","https://openalex.org/W2071114718","https://openalex.org/W2074301535","https://openalex.org/W2078006048","https://openalex.org/W2079077850","https://openalex.org/W2079102586","https://openalex.org/W2107083699","https://openalex.org/W2120533615","https://openalex.org/W2151482092","https://openalex.org/W2168428039","https://openalex.org/W2337729957"],"related_works":["https://openalex.org/W7097699997","https://openalex.org/W7096011403","https://openalex.org/W1596048577","https://openalex.org/W1529699134","https://openalex.org/W1982646583","https://openalex.org/W2357351463","https://openalex.org/W2095017136","https://openalex.org/W2046510744","https://openalex.org/W7213544550","https://openalex.org/W1994064612"],"abstract_inverted_index":{"PURPOSE:":[0],"Several":[1],"growth":[2,6,12,31],"factors,":[3],"including":[4],"nerve":[5],"factor":[7,13],"(NGF)":[8],"and":[9,89,95,119,134,142,151,153,160,167,186],"vascular":[10],"endothelial":[11,60,74,106,158,177],"(VEGF),":[14],"play":[15],"an":[16],"important":[17],"role":[18,55],"in":[19,33,97,101],"the":[20,23,34,44,54,59,76,84,87,90,182],"homeostasis":[21],"of":[22,28,36,46,56,71,78,86,93,122,125,149,155,184],"ocular":[24],"surface.":[25],"The":[26],"involvement":[27],"both":[29],"these":[30,135,161,188],"factors":[32],"pathophysiology":[35],"intraocular":[37],"tissues":[38],"has":[39],"been":[40],"extensively":[41],"investigated.":[42],"Despite":[43],"expression":[45,85],"NGF":[47,57,94,146,185,192],"receptors":[48],"by":[49,157],"corneal":[50,73,176],"endothelium,":[51],"to":[52,63,82,165,181],"date":[53],"on":[58],"cell":[61,69,99,107],"remains":[62],"be":[64],"determined.":[65],"Using":[66],"a":[67],"clonal":[68],"line":[70,108],"human":[72,105,175],"cells,":[75],"aim":[77],"this":[79],"study":[80],"was":[81,110],"investigate":[83],"NGF-receptor":[88],"potential":[91],"partnership":[92],"VEGF":[96,130,156],"maintaining":[98],"viability":[100],"vitro.":[102],"METHODS:":[103],"A":[104],"(B4G12),":[109],"cultured":[111],"under":[112],"serum-free":[113],"conditions":[114],"as":[115],"previously":[116],"described":[117],"with":[118],"without":[120],"addition":[121],"different":[123],"concentrations":[124],"NGF,":[126],"anti-NGF-antibody":[127],"(ANA),":[128],"or":[129],"for":[131,139],"4":[132],"days":[133],"cells":[136,159,162,178,189],"were":[137],"used":[138],"immuno-istochemical,":[140],"biochemical,":[141],"molecular":[143],"analyses.":[144],"RESULTS:":[145],"induces":[147],"overexpression":[148],"NGF-receptors":[150],"synthesis":[152],"release":[154],"are":[163,179],"able":[164],"produce":[166],"secrete":[168],"NGF.":[169],"CONCLUSIONS:":[170],"These":[171],"observations":[172],"indicate":[173],"that":[174,187],"receptive":[180],"action":[183],"may":[190],"regulate":[191],"activity":[193],"through":[194],"autocrine/paracrine":[195],"mechanisms.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}