{"id":"https://openalex.org/W2126647650","doi":"https://doi.org/10.1309/q0fluxfj4fttw1xr","title":"Immunohistochemical Detection of the von Hippel-Lindau Gene Product (pVHL) in Human Tissues and Tumors","display_name":"Immunohistochemical Detection of the von Hippel-Lindau Gene Product (pVHL) in Human Tissues and Tumors","publication_year":2008,"publication_date":"2008-03-15","ids":{"openalex":"https://openalex.org/W2126647650","doi":"https://doi.org/10.1309/q0fluxfj4fttw1xr","mag":"2126647650","pmid":"https://pubmed.ncbi.nlm.nih.gov/18343787"},"language":"en","primary_location":{"id":"doi:10.1309/q0fluxfj4fttw1xr","doi":"https://doi.org/10.1309/q0fluxfj4fttw1xr","is_oa":false,"landing_page_url":"https://doi.org/10.1309/q0fluxfj4fttw1xr","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057196082","display_name":"Fan Lin","orcid":"https://orcid.org/0000-0001-9169-9416","observed_orcids":["https://orcid.org/0000-0001-9169-9416"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fan Lin","raw_affiliation_strings":["Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA","Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA 17822, USA","institution_ids":["https://openalex.org/I1293487830"]},{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007568115","display_name":"Jianhui Shi","orcid":"https://orcid.org/0000-0002-1692-8474","observed_orcids":["https://orcid.org/0000-0002-1692-8474"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhui Shi","raw_affiliation_strings":["Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378949","display_name":"Haiyan Liu","orcid":"https://orcid.org/0000-0001-9327-7583","observed_orcids":["https://orcid.org/0000-0001-9327-7583"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiyan Liu","raw_affiliation_strings":["Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007433995","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-7973-8416","observed_orcids":["https://orcid.org/0000-0002-7973-8416"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Pathology, Mayo clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Mayo clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026346515","display_name":"Ping L. Zhang","orcid":"https://orcid.org/0000-0002-6177-9244","observed_orcids":["https://orcid.org/0000-0002-6177-9244"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping L. Zhang","raw_affiliation_strings":["Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019364542","display_name":"Hanlin L. Wang","orcid":"https://orcid.org/0000-0003-1409-5234","observed_orcids":["https://orcid.org/0000-0003-1409-5234"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanlin L. Wang","raw_affiliation_strings":["Cedars-Sinai Medical Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080276829","display_name":"Ximing J. Yang","orcid":"https://orcid.org/0000-0002-3370-6208","observed_orcids":["https://orcid.org/0000-0002-3370-6208"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ximing J. Yang","raw_affiliation_strings":["Weill Medical College Cornell University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Medical College Cornell University, New York, NY","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":null,"display_name":"Conrad Schuerch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conrad Schuerch","raw_affiliation_strings":["Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Laboratory Medicine, Geisinger Medical Center, Danville, PA","institution_ids":["https://openalex.org/I1293487830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":2.9562,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.91458206,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"129","issue":"4","first_page":"592","last_page":"605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-hippel-lindau-protein","display_name":"von Hippel-Lindau protein","score":0.9449999928474426},{"id":"https://openalex.org/keywords/vhl-tumor-suppressor-gene","display_name":"VHL tumor suppressor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.796999990940094},{"id":"https://openalex.org/keywords/normal-tissue-expression","display_name":"normal tissue expression","score":0.6269999742507935},{"id":"https://openalex.org/keywords/renal-tubules","display_name":"renal tubules","score":0.8830000162124634},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.75},{"id":"https://openalex.org/keywords/islets","display_name":"islets","score":0.7609999775886536},{"id":"https://openalex.org/keywords/bile-ducts","display_name":"bile ducts","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.735867440700531},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6883673667907715},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.6634867191314697},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.663037896156311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5820633172988892},{"id":"https://openalex.org/C195286587","wikidata":"https://www.wikidata.org/wiki/Q424689","display_name":"Gene product","level":4,"score":0.5803439021110535},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5267093777656555},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5128172039985657},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.4695611298084259},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4691155254840851},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41874194145202637},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3124738931655884},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2869623899459839},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22991371154785156},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20164260268211365},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18069440126419067},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12389540672302246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014594","descriptor_name":"Uterine Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018262","descriptor_name":"Adenocarcinoma, Clear Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018262","descriptor_name":"Adenocarcinoma, Clear Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051794","descriptor_name":"Von Hippel-Lindau Tumor Suppressor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1309/q0fluxfj4fttw1xr","doi":"https://doi.org/10.1309/q0fluxfj4fttw1xr","is_oa":false,"landing_page_url":"https://doi.org/10.1309/q0fluxfj4fttw1xr","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:18343787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18343787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7136053984","https://openalex.org/W2163169730","https://openalex.org/W2054959151","https://openalex.org/W4248132665","https://openalex.org/W4388498734","https://openalex.org/W2382030540","https://openalex.org/W1974969357","https://openalex.org/W2112113822","https://openalex.org/W2610355462","https://openalex.org/W2023760663"],"abstract_inverted_index":{"Genetic":[0],"alteration":[1],"of":[2,27,46,56,71,76,81,85,132,146],"the":[3,28,44,86,115,147],"von":[4],"Hippel-Lindau":[5],"(VHL)":[6],"tumor":[7],"suppressor":[8],"gene":[9,30],"has":[10],"been":[11,39],"linked":[12],"to":[13],"hereditary":[14],"and":[15,36,58,61,79,88,104,109,135,149],"sporadic":[16],"clear":[17,82,143],"cell":[18,20,83,144],"renal":[19,57,73,99],"carcinomas":[21,84,145],"(RCCs).":[22],"Inconsistent":[23],"data":[24,119],"on":[25],"immunodetection":[26],"VHL":[29],"product":[31],"(pVHL)":[32],"in":[33,53,68,98,129],"normal":[34,62,91],"tissues":[35],"tumors":[37],"have":[38],"reported.":[40],"We":[41],"immunohistochemically":[42],"reevaluated":[43],"usefulness":[45],"a":[47,126,139],"specific":[48],"rabbit":[49],"polyclonal":[50],"anti-pVHL":[51,123],"antibody":[52,124],"531":[54],"cases":[55],"nonrenal":[59],"neoplasms":[60],"tissues.":[63],"Positive":[64],"immunostaining":[65,116],"was":[66,95],"observed":[67,96],"nearly":[69],"100%":[70],"primary":[72],"neoplasms,":[74],"95%":[75],"metastatic":[77,133],"RCCs,":[78],"90%":[80],"ovary":[87,148],"uterus.":[89,150],"In":[90],"tissues,":[92],"positive":[93],"immunoreactivity":[94],"only":[97],"tubules,":[100],"exocrine":[101],"pancreas,":[102],"islets,":[103],"bile":[105],"ducts.":[106],"Western":[107],"blot":[108],"reverse":[110],"transcription-polymerase":[111],"chain":[112],"reaction":[113],"confirmed":[114],"results.":[117],"These":[118],"indicate":[120],"that":[121],"this":[122],"is":[125],"useful":[127],"marker":[128,141],"assisting":[130],"diagnosis":[131],"RCC":[134],"may":[136],"serve":[137],"as":[138],"diagnostic":[140],"for":[142]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}