{"id":"https://openalex.org/W2126615487","doi":"https://doi.org/10.1073/pnas.1010383107","title":"Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict","display_name":"Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict","publication_year":2010,"publication_date":"2010-08-23","ids":{"openalex":"https://openalex.org/W2126615487","doi":"https://doi.org/10.1073/pnas.1010383107","mag":"2126615487","pmid":"https://pubmed.ncbi.nlm.nih.gov/20798037","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2936610"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1010383107","doi":"https://doi.org/10.1073/pnas.1010383107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1010383107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2936610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020961284","display_name":"Bernardo Lemos","orcid":"https://orcid.org/0000-0001-6996-9483","observed_orcids":["https://orcid.org/0000-0001-6996-9483"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bernardo Lemos","raw_affiliation_strings":["Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045861406","display_name":"Alan Trindade Branco","orcid":"https://orcid.org/0000-0002-1641-4254","observed_orcids":["https://orcid.org/0000-0002-1641-4254"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan T. Branco","raw_affiliation_strings":["Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061240448","display_name":"Daniel L. Hartl","orcid":"https://orcid.org/0000-0002-0302-306X","observed_orcids":["https://orcid.org/0000-0002-0302-306X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Hartl","raw_affiliation_strings":["Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge, MA 02138"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Organismic and Evolutionary Biology Harvard University 16 Divinity Avenue Cambridge, MA 02138","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":7.0072,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.97758765,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"107","issue":"36","first_page":"15826","last_page":"15831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.11249999701976776,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/y-chromosome-polymorphism","display_name":"Y chromosome polymorphism","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/epigenetic-variation","display_name":"epigenetic variation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/position-effect-variegation","display_name":"position effect variegation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/sex-chromosomes","display_name":"sex chromosomes","score":0.5180000066757202},{"id":"https://openalex.org/keywords/sexual-conflict","display_name":"sexual conflict","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/chromatin-assembly","display_name":"chromatin assembly","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hp1","display_name":"HP1","score":0.6389999985694885},{"id":"https://openalex.org/keywords/su-var-3-9","display_name":"Su(var)3-9","score":0.968999981880188},{"id":"https://openalex.org/keywords/brahma","display_name":"Brahma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/mcm2","display_name":"MCM2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/orc2","display_name":"ORC2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/immune-response-genes","display_name":"immune response genes","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.8960000276565552},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8695758581161499},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.8014835715293884},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7510920763015747},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.739425003528595},{"id":"https://openalex.org/C72391661","wikidata":"https://www.wikidata.org/wiki/Q5164350","display_name":"Constitutive heterochromatin","level":5,"score":0.5487353801727295},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5469914674758911},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.542500913143158},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.4967547059059143},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49009931087493896},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.45717576146125793},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.4151766896247864},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.34170371294021606}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012726","descriptor_name":"Sexual Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1010383107","doi":"https://doi.org/10.1073/pnas.1010383107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1010383107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2936610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2936610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:20798037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20798037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/9938754","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:9938754","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2936610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2936610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3736985062","display_name":null,"funder_award_id":"GM084236","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5339373616","display_name":"Novel genomic effects of Y-linked polymorphisms","funder_award_id":"R01GM084236","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W297633788","https://openalex.org/W406387941","https://openalex.org/W1520399163","https://openalex.org/W1599969036","https://openalex.org/W1654410153","https://openalex.org/W1945013952","https://openalex.org/W1970353161","https://openalex.org/W1982453928","https://openalex.org/W1991072105","https://openalex.org/W1994366041","https://openalex.org/W2001785571","https://openalex.org/W2002875167","https://openalex.org/W2004000260","https://openalex.org/W2029939022","https://openalex.org/W2035169037","https://openalex.org/W2037810819","https://openalex.org/W2045978910","https://openalex.org/W2052860141","https://openalex.org/W2058036468","https://openalex.org/W2059533718","https://openalex.org/W2060347801","https://openalex.org/W2062923229","https://openalex.org/W2064512698","https://openalex.org/W2075136677","https://openalex.org/W2096891351","https://openalex.org/W2097822523","https://openalex.org/W2099249565","https://openalex.org/W2103229988","https://openalex.org/W2107268689","https://openalex.org/W2112008510","https://openalex.org/W2117734505","https://openalex.org/W2122555950","https://openalex.org/W2140461124","https://openalex.org/W2157376474","https://openalex.org/W2162584510","https://openalex.org/W2163623853","https://openalex.org/W2167164290","https://openalex.org/W2170340195","https://openalex.org/W2170700353","https://openalex.org/W2172076792"],"related_works":["https://openalex.org/W2140198582","https://openalex.org/W2084301274","https://openalex.org/W2144561973","https://openalex.org/W2124755338","https://openalex.org/W7099647434","https://openalex.org/W3013447887","https://openalex.org/W2004000260","https://openalex.org/W2006314079","https://openalex.org/W3095771934","https://openalex.org/W7006829394"],"abstract_inverted_index":{"Genetic":[0],"conflicts":[1,206],"between":[2,207],"sexes":[3],"and":[4,17,32,75,140,147,164,174,202,209],"generations":[5],"provide":[6],"a":[7,33,118,191,222],"foundation":[8],"for":[9],"understanding":[10],"the":[11,78,97,124,134,194,200,238],"functional":[12,186],"evolution":[13],"of":[14,23,28,35,50,81,99,101,121,127,193,196,204,225,240],"sex":[15],"chromosomes":[16,22,49,94],"sexually":[18],"dimorphic":[19],"phenotypes.":[20],"Y":[21,48,93,182,217],"Drosophila":[24,51],"contain":[25],"multi-megabase":[26],"stretches":[27],"satellite":[29],"DNA":[30],"repeats":[31],"handful":[34],"protein-coding":[36,110],"genes":[37,102,111,128],"that":[38,61,216,231],"are":[39,112,141,177],"monomorphic":[40],"within":[41],"species.":[42],"Nevertheless,":[43],"polymorphic":[44,92],"variation":[45,67,227],"in":[46,53,72,103,107,143,199,228],"heterochromatic":[47],"result":[52],"genome-wide":[54],"gene":[55],"expression":[56,98,126,239],"variation.":[57,244],"Here":[58],"we":[59],"show":[60,117],"such":[62,154],"naturally":[63],"occurring":[64],"Y-linked":[65,109,197],"regulatory":[66],"(YRV)":[68],"can":[69],"be":[70],"detected":[71],"somatic":[73],"tissues":[74],"contributes":[76],"to":[77,133,236],"epigenetic":[79,226],"balance":[80],"heterochromatin/euchromatin":[82],"at":[83],"three":[84],"distinct":[85],"loci":[86],"showing":[87],"position-effect":[88],"variegation":[89],"(PEV).":[90],"Moreover,":[91],"differentially":[95],"affect":[96],"thousands":[100],"XXY":[104],"female":[105],"genotypes":[106],"which":[108],"not":[113],"transcribed.":[114],"The":[115],"data":[116],"disproportionate":[119],"influence":[120],"YRV":[122],"on":[123],"variable":[125],"whose":[129],"protein":[130],"products":[131],"localize":[132],"nucleus,":[135],"have":[136],"nucleic-acid":[137],"binding":[138],"activity,":[139],"involved":[142],"transcription,":[144],"chromosome":[145,183,218],"organization,":[146],"chromatin":[148,234],"assembly.":[149],"These":[150,185],"include":[151],"key":[152],"components":[153,235],"as":[155,190,221],"HP1,":[156],"Trithorax-like":[157],"(GAGA":[158],"factor),":[159],"Su(var)3-9,":[160],"Brahma,":[161],"MCM2,":[162],"ORC2,":[163],"inner":[165],"centromere":[166],"protein.":[167],"Furthermore,":[168],"mitochondria-related":[169],"genes,":[170,173],"immune":[171],"response":[172],"transposable":[175],"elements":[176],"also":[178],"disproportionally":[179],"affected":[180],"by":[181],"polymorphism.":[184],"clusterings":[187],"may":[188],"arise":[189],"consequence":[192],"involvement":[195],"heterochromatin":[198,219],"origin":[201],"resolution":[203],"genetic":[205],"males":[208],"females.":[210],"Taken":[211],"together,":[212],"our":[213],"results":[214],"indicate":[215],"serves":[220],"major":[223],"source":[224],"natural":[229],"populations":[230],"interacts":[232],"with":[233],"modulate":[237],"biologically":[241],"relevant":[242],"phenotypic":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
