{"id":"https://openalex.org/W2126507367","doi":"https://doi.org/10.1517/14656566.7.16.2243","title":"Point mutations of protein kinases and individualised cancer therapy","display_name":"Point mutations of protein kinases and individualised cancer therapy","publication_year":2006,"publication_date":"2006-10-24","ids":{"openalex":"https://openalex.org/W2126507367","doi":"https://doi.org/10.1517/14656566.7.16.2243","mag":"2126507367","pmid":"https://pubmed.ncbi.nlm.nih.gov/17059381"},"language":"en","primary_location":{"id":"doi:10.1517/14656566.7.16.2243","doi":"https://doi.org/10.1517/14656566.7.16.2243","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.7.16.2243","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Davies","raw_affiliation_strings":["University of Texas--M D Anderson Cancer Center, Department of Medical Oncology, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA. mdavies@mdanderson.org","University of Texas--M D Anderson Cancer Center, Department of Medical Oncology, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas--M D Anderson Cancer Center, Department of Medical Oncology, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA. mdavies@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas--M D Anderson Cancer Center, Department of Medical Oncology, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004102701","display_name":"Bryan T. Hennessy","orcid":"https://orcid.org/0000-0002-7871-6477","observed_orcids":["https://orcid.org/0000-0002-7871-6477"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Hennessy","raw_affiliation_strings":["Assistant Professor, Gynecologic Medical Oncology, University of Texas \u2013 M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Gynecologic Medical Oncology, University of Texas \u2013 M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 10, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B Mills","raw_affiliation_strings":["Professor, Chairman, University of Texas \u2013 M. D. Anderson Cancer Center, Department of Molecular Therapeutics, 151 Holcombe Blvd, Unit 950, Houston, TX 77030, USA","Systems Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Chairman, University of Texas \u2013 M. D. Anderson Cancer Center, Department of Molecular Therapeutics, 151 Holcombe Blvd, Unit 950, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Systems Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.7494,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.59208443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"16","first_page":"2243","last_page":"2261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.16779999434947968,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.8650000095367432},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.9240000247955322},{"id":"https://openalex.org/keywords/oncogenic-mutations","display_name":"oncogenic mutations","score":0.7059999704360962},{"id":"https://openalex.org/keywords/oncogene-addiction","display_name":"oncogene addiction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6930000185966492},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5189999938011169},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8803024291992188},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5802463293075562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49403005838394165},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.48920655250549316},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41373831033706665},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.36908453702926636},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33688879013061523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3289446532726288},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3287857174873352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27581802010536194},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26914191246032715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14656566.7.16.2243","doi":"https://doi.org/10.1517/14656566.7.16.2243","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14656566.7.16.2243","pdf_url":null,"source":{"id":"https://openalex.org/S52020611","display_name":"Expert Opinion on Pharmacotherapy","issn_l":"1465-6566","issn":["1465-6566","1744-7666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:17059381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17059381","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":193,"referenced_works":["https://openalex.org/W186739404","https://openalex.org/W1506423591","https://openalex.org/W1521633337","https://openalex.org/W1529003705","https://openalex.org/W1542395305","https://openalex.org/W1565041471","https://openalex.org/W1565532031","https://openalex.org/W1579641819","https://openalex.org/W1586476323","https://openalex.org/W1592701464","https://openalex.org/W1593108703","https://openalex.org/W1594020010","https://openalex.org/W1614313922","https://openalex.org/W1619850371","https://openalex.org/W1637493245","https://openalex.org/W1756183899","https://openalex.org/W1841041873","https://openalex.org/W1867197625","https://openalex.org/W1931438814","https://openalex.org/W1933350662","https://openalex.org/W1937853139","https://openalex.org/W1963579412","https://openalex.org/W1963981090","https://openalex.org/W1965871143","https://openalex.org/W1966271071","https://openalex.org/W1970476748","https://openalex.org/W1971369054","https://openalex.org/W1971571835","https://openalex.org/W1976508520","https://openalex.org/W1978469902","https://openalex.org/W1978577823","https://openalex.org/W1979775163","https://openalex.org/W1980568348","https://openalex.org/W1980625127","https://openalex.org/W1980642264","https://openalex.org/W1983060585","https://openalex.org/W1988442083","https://openalex.org/W1989121777","https://openalex.org/W1990030298","https://openalex.org/W1990406235","https://openalex.org/W1992734097","https://openalex.org/W1994033919","https://openalex.org/W1996537922","https://openalex.org/W1998038367","https://openalex.org/W1999614615","https://openalex.org/W2001413092","https://openalex.org/W2002937040","https://openalex.org/W2003984225","https://openalex.org/W2004477791","https://openalex.org/W2008162612","https://openalex.org/W2008409819","https://openalex.org/W2008859560","https://openalex.org/W2009096660","https://openalex.org/W2010737710","https://openalex.org/W2012952884","https://openalex.org/W2014169920","https://openalex.org/W2015015957","https://openalex.org/W2015616444","https://openalex.org/W2016086822","https://openalex.org/W2016710415","https://openalex.org/W2017289276","https://openalex.org/W2019372820","https://openalex.org/W2019558984","https://openalex.org/W2019819802","https://openalex.org/W2020830322","https://openalex.org/W2022930434","https://openalex.org/W2023726394","https://openalex.org/W2028752124","https://openalex.org/W2028959752","https://openalex.org/W2030828521","https://openalex.org/W2031819782","https://openalex.org/W2034691869","https://openalex.org/W2034820298","https://openalex.org/W2035008060","https://openalex.org/W2036180570","https://openalex.org/W2039045990","https://openalex.org/W2040950977","https://openalex.org/W2043696829","https://openalex.org/W2045156702","https://openalex.org/W2046507292","https://openalex.org/W2047070443","https://openalex.org/W2047942701","https://openalex.org/W2047964609","https://openalex.org/W2048952870","https://openalex.org/W2048993739","https://openalex.org/W2049145190","https://openalex.org/W2049274590","https://openalex.org/W2049449785","https://openalex.org/W2049507332","https://openalex.org/W2049706987","https://openalex.org/W2050973237","https://openalex.org/W2055614052","https://openalex.org/W2057360098","https://openalex.org/W2060146306","https://openalex.org/W2060317877","https://openalex.org/W2067040565","https://openalex.org/W2068427129","https://openalex.org/W2070011883","https://openalex.org/W2070841378","https://openalex.org/W2071746901","https://openalex.org/W2076426515","https://openalex.org/W2079420659","https://openalex.org/W2082219113","https://openalex.org/W2082225843","https://openalex.org/W2083158752","https://openalex.org/W2085405246","https://openalex.org/W2085983028","https://openalex.org/W2086039105","https://openalex.org/W2087861588","https://openalex.org/W2091861959","https://openalex.org/W2093672571","https://openalex.org/W2094585531","https://openalex.org/W2095156669","https://openalex.org/W2095974037","https://openalex.org/W2097946794","https://openalex.org/W2099224719","https://openalex.org/W2099938880","https://openalex.org/W2101986793","https://openalex.org/W2103894337","https://openalex.org/W2104919212","https://openalex.org/W2106726562","https://openalex.org/W2106787323","https://openalex.org/W2108914190","https://openalex.org/W2112621891","https://openalex.org/W2116117727","https://openalex.org/W2120026123","https://openalex.org/W2120365528","https://openalex.org/W2120627772","https://openalex.org/W2120718661","https://openalex.org/W2120840548","https://openalex.org/W2121695889","https://openalex.org/W2122885616","https://openalex.org/W2123571541","https://openalex.org/W2123986795","https://openalex.org/W2125676392","https://openalex.org/W2126181231","https://openalex.org/W2126665281","https://openalex.org/W2126783165","https://openalex.org/W2126920848","https://openalex.org/W2127101185","https://openalex.org/W2129172946","https://openalex.org/W2130864403","https://openalex.org/W2130883918","https://openalex.org/W2132912591","https://openalex.org/W2133867160","https://openalex.org/W2135340303","https://openalex.org/W2138297714","https://openalex.org/W2139236349","https://openalex.org/W2140626630","https://openalex.org/W2142564546","https://openalex.org/W2142850084","https://openalex.org/W2142945941","https://openalex.org/W2144424401","https://openalex.org/W2144664431","https://openalex.org/W2146384083","https://openalex.org/W2146404049","https://openalex.org/W2147703884","https://openalex.org/W2148782878","https://openalex.org/W2149026055","https://openalex.org/W2149703329","https://openalex.org/W2149908785","https://openalex.org/W2150501295","https://openalex.org/W2154692501","https://openalex.org/W2155299791","https://openalex.org/W2159082261","https://openalex.org/W2159360580","https://openalex.org/W2160275193","https://openalex.org/W2161821474","https://openalex.org/W2162724777","https://openalex.org/W2163188200","https://openalex.org/W2163243560","https://openalex.org/W2164837623","https://openalex.org/W2166103269","https://openalex.org/W2166215505","https://openalex.org/W2167010784","https://openalex.org/W2167228936","https://openalex.org/W2171620774","https://openalex.org/W2207982014","https://openalex.org/W2305352133","https://openalex.org/W2311869080","https://openalex.org/W2314511842","https://openalex.org/W2316179291","https://openalex.org/W2318605753","https://openalex.org/W2321226355","https://openalex.org/W2324850882","https://openalex.org/W2328582512","https://openalex.org/W2328999771","https://openalex.org/W2329648702","https://openalex.org/W2341333330","https://openalex.org/W2341616998","https://openalex.org/W2410122372","https://openalex.org/W2419511464","https://openalex.org/W2764507256"],"related_works":["https://openalex.org/W1980396469","https://openalex.org/W1976526593","https://openalex.org/W2104740757","https://openalex.org/W2737370888","https://openalex.org/W2107699503","https://openalex.org/W2007244965","https://openalex.org/W4211235025","https://openalex.org/W2140012510","https://openalex.org/W4407495066","https://openalex.org/W325619151"],"abstract_inverted_index":{"The":[0],"treatment":[1],"of":[2,16,20,68,86,107,119,130,138,141,146],"cancer":[3,33],"is":[4],"rapidly":[5],"changing,":[6],"with":[7],"an":[8],"increasing":[9],"focus":[10],"on":[11,44],"converting":[12],"our":[13],"improved":[14],"understanding":[15],"the":[17,45,117,128,147],"molecular":[18,132],"basis":[19],"disease":[21],"into":[22],"clinical":[23,61,66],"benefit":[24,67],"for":[25,52],"patients.":[26],"Protein":[27],"kinases":[28,87,142],"that":[29,74,110],"are":[30,92],"mutated":[31],"in":[32,41,72,116],"represent":[34],"attractive":[35],"targets,":[36],"as":[37,57,150,152],"they":[38],"may":[39],"result":[40],"cellular":[42],"dependency":[43],"mutant":[46],"kinase":[47],"or":[48],"its":[49],"associated":[50],"pathway":[51],"survival,":[53],"a":[54,105],"condition":[55],"known":[56],"'oncogene":[58],"addiction'.":[59],"Early":[60],"experiences":[62,101],"have":[63,75,102,112],"demonstrated":[64],"dramatic":[65],"targeting":[69],"oncogenic":[70],"mutations":[71],"diseases":[73],"been":[76],"largely":[77],"resistant":[78],"to":[79,94,96,113,125,143,155],"traditional":[80],"cytotoxic":[81],"chemotherapy.":[82],"Further,":[83],"mutational":[84],"activation":[85,140],"can":[88],"indicate":[89],"which":[90],"patients":[91],"likely":[93],"respond":[95],"targeted":[97],"therapeutics.":[98],"However,":[99],"these":[100],"also":[103],"illuminated":[104],"number":[106],"critical":[108],"challenges":[109],"will":[111],"be":[114,156],"addressed":[115],"development":[118],"effective":[120],"drugs":[121],"across":[122],"different":[123],"cancers,":[124],"fully":[126],"realise":[127],"potential":[129],"individualised":[131],"therapy.":[133],"This":[134],"review":[135],"utilises":[136],"examples":[137],"genetic":[139],"illustrate":[144],"many":[145],"lessons":[148],"learned,":[149],"well":[151],"those":[153],"yet":[154],"implemented.":[157]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
