{"id":"https://openalex.org/W2126507337","doi":"https://doi.org/10.1073/pnas.94.24.12736","title":"Advances in apoptosis research","display_name":"Advances in apoptosis research","publication_year":1997,"publication_date":"1997-11-25","ids":{"openalex":"https://openalex.org/W2126507337","doi":"https://doi.org/10.1073/pnas.94.24.12736","mag":"2126507337","pmid":"https://pubmed.ncbi.nlm.nih.gov/9398063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/34166"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.94.24.12736","doi":"https://doi.org/10.1073/pnas.94.24.12736","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.24.12736","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC34166","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056606410","display_name":"Marcus E. Peter","orcid":"https://orcid.org/0000-0003-3216-036X","observed_orcids":["https://orcid.org/0000-0003-3216-036X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Marcus E. Peter","raw_affiliation_strings":["Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2750212522","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108468053","display_name":"Armin E. Heufelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Armin E. Heufelder","raw_affiliation_strings":["Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2750212522","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108038480","display_name":"Michael Otmar Hengartner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Michael O. Hengartner","raw_affiliation_strings":["Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Immunology Program, German Cancer Research Center, Im\r Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Division of\r Molecular Endocrinology, Department of Internal Medicine, Ludwig\r Maximilians University, Ziemssenstrasse 1, D-80336 Munich, Germany; and\r Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring\r Harbor, NY 11724","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2750212522","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.9259,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.97266103,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"94","issue":"24","first_page":"12736","last_page":"12737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14208","display_name":"Death, Funerary Practices, and Mourning","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":1.0},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoptosis-regulating-genes","display_name":"apoptosis-regulating genes","score":0.6740000247955322},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cysteine-protease","display_name":"cysteine protease","score":0.9309999942779541},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.765999972820282},{"id":"https://openalex.org/keywords/death-receptors","display_name":"death receptors","score":0.828000009059906},{"id":"https://openalex.org/keywords/death-ligands","display_name":"death ligands","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7679101824760437},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6727057695388794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6569862961769104},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6496860384941101},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6036352515220642},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5693067312240601},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5660318732261658},{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.4866979420185089},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.47679877281188965},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.4576221704483032},{"id":"https://openalex.org/C149150037","wikidata":"https://www.wikidata.org/wiki/Q554446","display_name":"Bcl-2 family","level":4,"score":0.42955464124679565},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.4285168945789337},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3099178075790405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25511491298675537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07591578364372253},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.94.24.12736","doi":"https://doi.org/10.1073/pnas.94.24.12736","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.94.24.12736","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:192403","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC34166","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:34166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/34166","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9398063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9398063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:959","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/959/9/Peter1997V.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/959/9/Peter1997V.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Peter, M E; Heufelder, A E; Hengartner, M O (1997). Advances in apoptosis research. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 94(24):12736-12737.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/31144","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/31144","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Peter, M. E., Heufelder, A. E., & Hengartner, M. O. (1997). Advances in apoptosis research. Proceedings of the National Academy of Sciences of the United States of America, 94, 12736\u201312737. https://doi.org/10.1073/pnas.94.24.12736","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-959","doi":"https://doi.org/10.5167/uzh-959","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-959","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:192403","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC34166","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1514099677","https://openalex.org/W2016198585","https://openalex.org/W2016774048","https://openalex.org/W2030892254","https://openalex.org/W2065482981","https://openalex.org/W2114654929","https://openalex.org/W2144701362"],"related_works":["https://openalex.org/W2030221255","https://openalex.org/W4211081956","https://openalex.org/W1966493552","https://openalex.org/W1820524566","https://openalex.org/W2020165452","https://openalex.org/W196876568","https://openalex.org/W121451660","https://openalex.org/W1975878225","https://openalex.org/W7204685695","https://openalex.org/W2061369072"],"abstract_inverted_index":{"Apoptosis,":[0],"also":[1],"called":[2],"programmed":[3],"cell":[4,117],"death,":[5],"has":[6,69,152,175],"attracted":[7],"great":[8],"attention":[9],"in":[10,19,32,46,57,214],"recent":[11],"years.":[12],"After":[13],"its":[14],"discovery":[15],"by":[16,48,184],"Carl":[17],"Vogt":[18],"1842,":[20],"apoptosis":[21,45,68,111,151,212],"research":[22],"was":[23],"dormant":[24],"for":[25],"more":[26],"than":[27],"a":[28,108,165,194],"century.":[29],"Its":[30],"rediscovery":[31],"the":[33,40,43,101,146,156,171,201],"second":[34],"half":[35],"of":[36,42,60,64,86,110,127,145,150,158,168,186,190,196],"this":[37,58],"century,":[38],"and":[39,51,92,198,217],"coining":[41],"term":[44],"1972":[47],"Kerr,":[49],"Wyllie,":[50],"Currie,":[52],"ignited":[53],"an":[54,120],"unparalleled":[55],"interest":[56],"field":[59],"science.":[61],"The":[62,205],"number":[63,109],"publications":[65],"related":[66],"to":[67,81,139,155,209,218],"been":[70,89],"growing":[71],"exponentially":[72],"every":[73],"year":[74],"ever":[75],"since.":[76],"This":[77],"is":[78,95,119,208],"mainly":[79],"due":[80],"three":[82],"major":[83],"advances,":[84],"two":[85],"which":[87],"have":[88,106,130],"made":[90],"recently":[91],"one":[93],"that":[94,116,179],"currently":[96],"seen.":[97],"First,":[98],"studies":[99],"with":[100,211],"small":[102],"nematode":[103],"Caenorhabditis":[104],"elegans":[105],"identified":[107],"regulating":[112],"genes--the":[113],"first":[114],"evidence":[115],"death":[118,160,202],"active":[121],"process":[122],"under":[123],"genetic":[124],"control.":[125],"Many":[126,189],"these":[128,191,215],"genes":[129],"mammalian":[131,141],"homologs":[132],"that,":[133],"like":[134],"their":[135,199],"worm":[136],"counterparts,":[137],"seem":[138],"regulate":[140],"apoptosis.":[142],"Second,":[143],"elucidation":[144],"signal":[147],"transduction":[148],"pathways":[149],"lead":[153],"especially":[154],"identification":[157],"specific":[159],"signaling":[161],"molecules":[162],"such":[163],"as":[164],"new":[166,220],"family":[167,195],"cysteine":[169],"proteases,":[170],"caspases.":[172],"Third,":[173],"it":[174],"now":[176,207],"become":[177],"clear":[178],"many":[180],"diseases":[181],"are":[182],"characterized":[183],"dysregulation":[185],"apoptotic":[187],"programs.":[188],"programs":[192],"involve":[193],"receptors":[197],"ligands,":[200],"receptor/ligand":[203],"family.":[204],"hope":[206],"interfere":[210],"regulation":[213],"systems":[216],"develop":[219],"therapeutic":[221],"concepts.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
