{"id":"https://openalex.org/W2126505582","doi":null,"title":"The Role Of IL-8-Mediated Src Family Kinase Activation In Tumor-Tumor And Tumor-Stromal Interactions In Metastasis Of Prostate Cancer","display_name":"The Role Of IL-8-Mediated Src Family Kinase Activation In Tumor-Tumor And Tumor-Stromal Interactions In Metastasis Of Prostate Cancer","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2126505582","mag":"2126505582"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1378","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091493189","display_name":"Lynnelle Thorpe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lynnelle Thorpe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091493189"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.39160001277923584,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-metastasis","display_name":"prostate cancer metastasis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8709999918937683},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9890000224113464},{"id":"https://openalex.org/keywords/feedforward-loop","display_name":"feed-forward loop","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-stroma-interactions","display_name":"tumor-stroma interactions","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6100000143051147},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tyrosine-kinase-signaling","display_name":"tyrosine kinase signaling","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.661149263381958},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6488023400306702},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5744409561157227},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.545671820640564},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5178301930427551},{"id":"https://openalex.org/C2779976819","wikidata":"https://www.wikidata.org/wiki/Q7582406","display_name":"Src family kinase","level":4,"score":0.5035478472709656},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.48652949929237366},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4665270447731018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45828643441200256},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4464327394962311},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34380781650543213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.337044358253479},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11733004450798035}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1378","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:2126505582","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1378&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1378","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","pdf_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/342","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126505582.pdf","grobid_xml":"https://content.openalex.org/works/W2126505582.grobid-xml"},"referenced_works_count":244,"referenced_works":["https://openalex.org/W46364339","https://openalex.org/W52512388","https://openalex.org/W74620963","https://openalex.org/W103613556","https://openalex.org/W128841889","https://openalex.org/W169444311","https://openalex.org/W1486569222","https://openalex.org/W1491071974","https://openalex.org/W1534395710","https://openalex.org/W1547303097","https://openalex.org/W1553274044","https://openalex.org/W1568076150","https://openalex.org/W1581533309","https://openalex.org/W1585888204","https://openalex.org/W1589166971","https://openalex.org/W1624649331","https://openalex.org/W1639450499","https://openalex.org/W1750158760","https://openalex.org/W1776891179","https://openalex.org/W1836956425","https://openalex.org/W1893347245","https://openalex.org/W1909358044","https://openalex.org/W1956569991","https://openalex.org/W1965008373","https://openalex.org/W1968508823","https://openalex.org/W1969146836","https://openalex.org/W1970213932","https://openalex.org/W1972035895","https://openalex.org/W1972287875","https://openalex.org/W1975120553","https://openalex.org/W1975448482","https://openalex.org/W1975577875","https://openalex.org/W1976677295","https://openalex.org/W1977790106","https://openalex.org/W1978118647","https://openalex.org/W1980006154","https://openalex.org/W1980685929","https://openalex.org/W1981570197","https://openalex.org/W1982895658","https://openalex.org/W1983225862","https://openalex.org/W1984539870","https://openalex.org/W1986767807","https://openalex.org/W1990915902","https://openalex.org/W1991062723","https://openalex.org/W1993060456","https://openalex.org/W1993330697","https://openalex.org/W1995827621","https://openalex.org/W1996952546","https://openalex.org/W1998076166","https://openalex.org/W1998149576","https://openalex.org/W2000170431","https://openalex.org/W2000792691","https://openalex.org/W2002384741","https://openalex.org/W2004344128","https://openalex.org/W2004771750","https://openalex.org/W2009948823","https://openalex.org/W2010246016","https://openalex.org/W2011681270","https://openalex.org/W2012315119","https://openalex.org/W2013107571","https://openalex.org/W2013229653","https://openalex.org/W2013300935","https://openalex.org/W2014096612","https://openalex.org/W2014098577","https://openalex.org/W2014132187","https://openalex.org/W2014351671","https://openalex.org/W2015370039","https://openalex.org/W2015423024","https://openalex.org/W2015616869","https://openalex.org/W2017148342","https://openalex.org/W2017757468","https://openalex.org/W2017896209","https://openalex.org/W2018307268","https://openalex.org/W2020320512","https://openalex.org/W2021466588","https://openalex.org/W2022976618","https://openalex.org/W2025541527","https://openalex.org/W2026991540","https://openalex.org/W2028638661","https://openalex.org/W2028718288","https://openalex.org/W2030161097","https://openalex.org/W2030536448","https://openalex.org/W2030971688","https://openalex.org/W2032545841","https://openalex.org/W2034558617","https://openalex.org/W2038809664","https://openalex.org/W2039436096","https://openalex.org/W2040964625","https://openalex.org/W2042576072","https://openalex.org/W2044409803","https://openalex.org/W2046234516","https://openalex.org/W2046701189","https://openalex.org/W2047070443","https://openalex.org/W2049205984","https://openalex.org/W2049700579","https://openalex.org/W2050973237","https://openalex.org/W2051056497","https://openalex.org/W2053773278","https://openalex.org/W2053970131","https://openalex.org/W2054177711","https://openalex.org/W2055489437","https://openalex.org/W2055936726","https://openalex.org/W2056010202","https://openalex.org/W2056963048","https://openalex.org/W2059445646","https://openalex.org/W2059860426","https://openalex.org/W2062265555","https://openalex.org/W2062393202","https://openalex.org/W2065016129","https://openalex.org/W2065874620","https://openalex.org/W2066728549","https://openalex.org/W2067438553","https://openalex.org/W2069115610","https://openalex.org/W2069580608","https://openalex.org/W2073077695","https://openalex.org/W2074061641","https://openalex.org/W2075675512","https://openalex.org/W2076243964","https://openalex.org/W2076695266","https://openalex.org/W2078365768","https://openalex.org/W2078377719","https://openalex.org/W2080439368","https://openalex.org/W2080709087","https://openalex.org/W2080994268","https://openalex.org/W2081346425","https://openalex.org/W2082107721","https://openalex.org/W2082462837","https://openalex.org/W2084684602","https://openalex.org/W2085425586","https://openalex.org/W2086416171","https://openalex.org/W2087207490","https://openalex.org/W2087233597","https://openalex.org/W2087998073","https://openalex.org/W2088146533","https://openalex.org/W2088357471","https://openalex.org/W2089780525","https://openalex.org/W2090531876","https://openalex.org/W2091443952","https://openalex.org/W2092816381","https://openalex.org/W2092892928","https://openalex.org/W2093312816","https://openalex.org/W2093395043","https://openalex.org/W2095253850","https://openalex.org/W2096764577","https://openalex.org/W2096909126","https://openalex.org/W2100408216","https://openalex.org/W2101257013","https://openalex.org/W2101606728","https://openalex.org/W2102497054","https://openalex.org/W2104062445","https://openalex.org/W2104762821","https://openalex.org/W2106601257","https://openalex.org/W2106943429","https://openalex.org/W2107633226","https://openalex.org/W2108179736","https://openalex.org/W2108706718","https://openalex.org/W2108955823","https://openalex.org/W2110567472","https://openalex.org/W2111631361","https://openalex.org/W2113615565","https://openalex.org/W2114059045","https://openalex.org/W2115382934","https://openalex.org/W2115620743","https://openalex.org/W2117412547","https://openalex.org/W2118263555","https://openalex.org/W2119504728","https://openalex.org/W2121158863","https://openalex.org/W2122680090","https://openalex.org/W2123884323","https://openalex.org/W2123910382","https://openalex.org/W2123970190","https://openalex.org/W2124673524","https://openalex.org/W2125495763","https://openalex.org/W2125752165","https://openalex.org/W2126826059","https://openalex.org/W2127757047","https://openalex.org/W2130860611","https://openalex.org/W2131083314","https://openalex.org/W2132051411","https://openalex.org/W2132541027","https://openalex.org/W2132663758","https://openalex.org/W2133785821","https://openalex.org/W2133801707","https://openalex.org/W2134391588","https://openalex.org/W2135798683","https://openalex.org/W2136280424","https://openalex.org/W2136929338","https://openalex.org/W2136988344","https://openalex.org/W2137909325","https://openalex.org/W2139181055","https://openalex.org/W2139695668","https://openalex.org/W2140975775","https://openalex.org/W2141569270","https://openalex.org/W2143211793","https://openalex.org/W2143807312","https://openalex.org/W2143841173","https://openalex.org/W2144136905","https://openalex.org/W2144831154","https://openalex.org/W2145718840","https://openalex.org/W2145941456","https://openalex.org/W2146578030","https://openalex.org/W2147200519","https://openalex.org/W2148468786","https://openalex.org/W2151701983","https://openalex.org/W2152786784","https://openalex.org/W2154430204","https://openalex.org/W2156047942","https://openalex.org/W2156383385","https://openalex.org/W2157310617","https://openalex.org/W2157674746","https://openalex.org/W2157677540","https://openalex.org/W2157820793","https://openalex.org/W2158684700","https://openalex.org/W2158798646","https://openalex.org/W2160527918","https://openalex.org/W2162511447","https://openalex.org/W2163070470","https://openalex.org/W2164942212","https://openalex.org/W2164979145","https://openalex.org/W2165500494","https://openalex.org/W2165542862","https://openalex.org/W2165726895","https://openalex.org/W2165823301","https://openalex.org/W2165948908","https://openalex.org/W2166159531","https://openalex.org/W2167442936","https://openalex.org/W2167609397","https://openalex.org/W2167749314","https://openalex.org/W2168377000","https://openalex.org/W2169811862","https://openalex.org/W2169900020","https://openalex.org/W2170129858","https://openalex.org/W2170641343","https://openalex.org/W2170726369","https://openalex.org/W2313363788","https://openalex.org/W2313472862","https://openalex.org/W2323868208","https://openalex.org/W2330669764","https://openalex.org/W2340426088","https://openalex.org/W2409889182","https://openalex.org/W2411129094","https://openalex.org/W2417547879","https://openalex.org/W2419153609","https://openalex.org/W2460779682"],"related_works":["https://openalex.org/W2025614479","https://openalex.org/W1975120553","https://openalex.org/W2093312816","https://openalex.org/W2605809536","https://openalex.org/W1505821987","https://openalex.org/W7095247981","https://openalex.org/W6903549571","https://openalex.org/W2763252083","https://openalex.org/W7097173053","https://openalex.org/W1966763146"],"abstract_inverted_index":{"Men":[0],"with":[1,20,229,252,338],"localized":[2],"prostate":[3],"cancer":[4],"(PCa)":[5],"have":[6],"a":[7,97,128,181,262],"100%":[8],"five-year":[9],"survival":[10],"rate,":[11],"but":[12,247],"this":[13],"rate":[14],"drops":[15],"to":[16,32,50,59,102,158,175,241,250,292],"33%":[17],"for":[18,36,311,346],"men":[19],"metastatic":[21,28,176,195,318,330],"disease.":[22],"A":[23],"better":[24,34],"understanding":[25],"of":[26,40,56,62,107,178,188,197,243,297,332,350],"the":[27,68,103,186,293,329,339],"process":[29],"is":[30,76,112,307],"needed":[31],"develop":[33],"therapies":[35],"PCa.":[37],"Aberrant":[38],"activation":[39],"protein":[41],"tyrosine":[42],"kinases,":[43],"including":[44],"Src":[45,71,89,93,143,154,289,326],"Family":[46],"Kinases":[47],"(SFKs)":[48],"contribute":[49,174],"metastasis":[51],"through":[52],"numerous":[53],"functions,":[54],"one":[55],"which":[57],"leads":[58],"increased":[60,142,239],"expression":[61,278],"cytokines,":[63],"such":[64],"as":[65,133,164],"IL-8.":[66],"However,":[67,110],"relationship":[69],"between":[70],"activity":[72,144,155,327],"and":[73,90,105,167,194,204,207,216,226,235,255,269,290,295,302,317,334,348],"IL-8":[74,87,95,111,150,173,222,273,277,287,306],"regulation":[75],"not":[77],"completely":[78],"understood.":[79],"In":[80,119],"cell":[81],"line":[82],"models,":[83],"I":[84,126,201,211],"determined":[85,212],"that":[86,213,324],"activates":[88,94,274,288],"in":[91,136,145,151,161,199,223,266,279,282,300,309,313],"turn":[92],"demonstrating":[96],"feed":[98,129,263],"forward":[99,130,264],"loop":[100,131,265],"contributing":[101],"migration":[104,166,294],"invasion":[106,296],"PCa":[108,146,162,179,198,205,230,244,253,280,298,314,333],"cells.":[109,118,138,147,257],"also":[113],"produced":[114,286,305],"by":[115,180],"tumor-associated":[116],"stromal":[117,123,170,189,270,285,304],"bone":[120],"marrow":[121],"derived":[122],"cells":[124,163,171,190,206,225,231,245,254,281,299],"(HS5),":[125],"demonstrated":[127,323],"occurs":[132],"was":[134,156,165],"observed":[135],"tumor":[137,192,214,233,268,315],"HS5":[139,152,203,224,256],"conditioned":[140],"media":[141],"By":[148,220],"silencing":[149,221],"cells,":[153,271],"decreased":[157,248],"control":[159],"levels":[160],"invasion.":[168],"Thus,":[169],"producing":[172],"properties":[177],"paracrine":[182],"mechanism.":[183],"To":[184],"examine":[185],"effect":[187],"on":[191],"growth":[193,215,234,316],"potential":[196,331],"vivo,":[200],"mixed":[202],"co-injected":[208],"them":[209,228],"intraprostatically.":[210],"metastases":[217,236],"were":[218,237],"increased.":[219],"co-injecting":[227],"intraprostatically,":[232],"still":[238],"relative":[240,249],"injection":[242],"alone,":[246],"co-injections":[251],"These":[258],"studies":[259,322],"demonstrated:":[260],"(1)":[261],"both":[267],"whereby":[272],"Src,":[275],"derepressing":[276],"vitro;":[283,301],"(2)":[284],"contributes":[291],"(3)":[303],"responsible,":[308],"part,":[310],"increases":[312,328],"potential.":[319],"Together,":[320],"these":[321],"IL-8-mediated":[325],"therapeutic":[335],"agents":[336],"interfering":[337],"IL-8/SFK":[340],"signaling":[341],"axis":[342],"may":[343],"be":[344],"useful":[345],"prevention":[347],"treatment":[349],"metastases.":[351]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
