{"id":"https://openalex.org/W2126459232","doi":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","title":"Dominant-Negative Synthesis Suppression of Voltage-Gated Calcium Channel Cav2.2 Induced by Truncated Constructs","display_name":"Dominant-Negative Synthesis Suppression of Voltage-Gated Calcium Channel Cav2.2 Induced by Truncated Constructs","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2126459232","doi":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","mag":"2126459232","pmid":"https://pubmed.ncbi.nlm.nih.gov/11606638","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762802"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.21-21-08495.2001","doi":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/21/8495.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2126459232"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jneurosci.org/content/jneuro/21/21/8495.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066402168","display_name":"Ayesha Raghib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ayesha Raghib","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071045285","display_name":"Federica Bertaso","orcid":"https://orcid.org/0000-0003-3140-019X","observed_orcids":["https://orcid.org/0000-0003-3140-019X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Federica Bertaso","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109955538","display_name":"Anthony Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony Davies","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013121079","display_name":"Karen M. Page","orcid":"https://orcid.org/0000-0003-4189-4664","observed_orcids":["https://orcid.org/0000-0003-4189-4664"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen M. Page","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534375","display_name":"Alon Meir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alon Meir","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070263300","display_name":"Yury D. Bogdanov","orcid":"https://orcid.org/0000-0003-4667-5890","observed_orcids":["https://orcid.org/0000-0003-4667-5890"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yuri Bogdanov","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057481214","display_name":"ANNETTE C. DOLPHIN","orcid":"https://orcid.org/0000-0003-4626-4856","observed_orcids":["https://orcid.org/0000-0003-4626-4856"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Annette C. Dolphin","raw_affiliation_strings":["Department of Pharmacology, University College London, London WC1E6BT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University College London, London WC1E6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":2.0196,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.86643731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"21","first_page":"8495","last_page":"8504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cav2-2","display_name":"CaV2.2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8389999866485596},{"id":"https://openalex.org/keywords/alpha1b-subunit","display_name":"alpha1B subunit","score":0.8989999890327454},{"id":"https://openalex.org/keywords/truncated-isoform","display_name":"truncated protein isoform","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dominant-negative-suppression","display_name":"dominant-negative suppression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/co-expression","display_name":"co-expression","score":0.4350000023841858},{"id":"https://openalex.org/keywords/alpha2delta-1-subunit","display_name":"\u03b12\u03b4-1 subunit","score":0.8769999742507935},{"id":"https://openalex.org/keywords/transmembrane-helices","display_name":"transmembrane helices","score":0.7229999899864197},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7059999704360962},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5960777401924133},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5934049487113953},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.5674640536308289},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5254125595092773},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5242745876312256},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.51743084192276},{"id":"https://openalex.org/C92645518","wikidata":"https://www.wikidata.org/wiki/Q26916851","display_name":"N-type calcium channel","level":5,"score":0.4997396469116211},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4924343526363373},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.48209407925605774},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46518462896347046},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.46422287821769714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4446139931678772},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41280868649482727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38726550340652466},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.33264482021331787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2920709252357483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2303755283355713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21674519777297974},{"id":"https://openalex.org/C30979828","wikidata":"https://www.wikidata.org/wiki/Q2487620","display_name":"T-type calcium channel","level":4,"score":0.13123777508735657},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11021089553833008},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020864","descriptor_name":"Calcium Channels, N-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020864","descriptor_name":"Calcium Channels, N-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1523/jneurosci.21-21-08495.2001","doi":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/21/8495.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:11606638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11606638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6762802","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6762802/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.4694","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.4694","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ucl.ac.uk/~ucklado/raghibetal2001.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.soton.ac.uk:467713","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/467713/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:131345","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/131345/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroscience , 21 (21) 8495 - 8504. (2001)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:131387","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/131387/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J NEUROSCI , 21 (21) 8495 - 8504. (2001)","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:9551","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/9551/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Neuroscience , 21 (21) pp. 8495-8504. (2001)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.21-21-08495.2001","doi":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-21-08495.2001","pdf_url":"http://www.jneurosci.org/content/jneuro/21/21/8495.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126459232.pdf","grobid_xml":"https://content.openalex.org/works/W2126459232.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1965543460","https://openalex.org/W1968587471","https://openalex.org/W1975987859","https://openalex.org/W1986644498","https://openalex.org/W1994918408","https://openalex.org/W1997393290","https://openalex.org/W2007441670","https://openalex.org/W2010831941","https://openalex.org/W2015285707","https://openalex.org/W2025197615","https://openalex.org/W2037009497","https://openalex.org/W2038756774","https://openalex.org/W2063807479","https://openalex.org/W2065857917","https://openalex.org/W2068543323","https://openalex.org/W2083093113","https://openalex.org/W2087753869","https://openalex.org/W2091222105","https://openalex.org/W2104928299","https://openalex.org/W2106138867","https://openalex.org/W2107514224","https://openalex.org/W2110310164","https://openalex.org/W2112520390","https://openalex.org/W2112749067","https://openalex.org/W2114021208","https://openalex.org/W2164478940","https://openalex.org/W2169929759","https://openalex.org/W2171396245","https://openalex.org/W2219179202","https://openalex.org/W2253202008","https://openalex.org/W2263103019","https://openalex.org/W2912991414","https://openalex.org/W4233808990","https://openalex.org/W4296759753"],"related_works":["https://openalex.org/W2013933380","https://openalex.org/W2142573125","https://openalex.org/W2063966787","https://openalex.org/W2101950146","https://openalex.org/W1993855785","https://openalex.org/W2227164114","https://openalex.org/W3129374513","https://openalex.org/W2414727562"],"abstract_inverted_index":{"Voltage-gated":[0],"calcium":[1],"channel":[2,117,234],"alpha1":[3],"subunits":[4,65],"consist":[5],"of":[6,17,28,41,45,51,145,152,163,169,177,183,198,221,223,233,241],"four":[7],"domains":[8,56],"(I-IV),":[9],"each":[10],"with":[11,48,62,84,104,136],"six":[12],"transmembrane":[13,202],"segments.":[14],"A":[15],"number":[16],"truncated":[18,49,226,244],"isoforms":[19],"have":[20,34,212],"been":[21],"identified":[22],"to":[23,87],"occur":[24],"as":[25],"a":[26,239],"result":[27],"alternative":[29],"splicing":[30],"or":[31,55,98,140,186],"mutation.":[32],"We":[33],"examined":[35],"the":[36,63,115,143,164,175,181,194,205,219],"functional":[37,72,82,111],"consequences":[38],"for":[39],"expression":[40,151,171],"full-length":[42,105],"Ca(v)2.2":[43,153,207,224],"(alpha1B)":[44],"its":[46,110],"coexpression":[47],"constructs":[50,227],"Ca(v)2.2.":[52,199],"Domains":[53],"I-II":[54,139,185,196],"III-IV,":[57,97],"when":[58,93,119,132],"expressed":[59,243],"individually,":[60],"together":[61],"accessory":[64],"beta1b":[66],"and":[67,81,150,180],"alpha2delta-1,":[68],"did":[69,210],"not":[70,160,190,211],"form":[71],"channels.":[73],"When":[74],"they":[75,107],"were":[76,90,102,121,124],"coexpressed,":[77],"low-density":[78],"whole-cell":[79],"currents":[80],"channels":[83,89,120],"properties":[85],"similar":[86],"wild-type":[88],"observed.":[91],"However,":[92],"domain":[94,96,99,138,141,184,187,229],"I-II,":[95],"I":[100,188,230],"alone":[101],"coexpressed":[103,135],"Ca(v)2.2,":[106],"markedly":[108],"suppressed":[109],"expression,":[112],"although":[113],"at":[114],"single":[116],"level,":[118],"recorded,":[122],"there":[123],"no":[125],"differences":[126],"in":[127,174],"their":[128],"biophysical":[129],"properties.":[130],"Furthermore,":[131],"it":[133],"was":[134,155],"either":[137],"I,":[142],"fluorescence":[144],"green":[146],"fluorescent":[147],"protein":[148,154],"(GFP)-Ca(v)2.2":[149],"almost":[156],"abolished.":[157],"Suppression":[158],"does":[159],"involve":[161],"sequestration":[162],"Ca(v)beta":[165],"subunit,":[166,179],"because":[167,204],"loss":[168],"GFP-Ca(v)2.2":[170],"also":[172],"occurred":[173],"absence":[176],"beta":[178],"effect":[182],"could":[189],"be":[191],"mimicked":[192],"by":[193,225],"cytoplasmic":[195],"loop":[197],"It":[200],"requires":[201],"segments,":[203],"isolated":[206],"N":[208],"terminus":[209],"any":[213],"effect.":[214],"Our":[215],"results":[216],"indicate":[217],"that":[218],"mechanism":[220],"suppression":[222],"containing":[228],"involves":[231],"inhibition":[232],"synthesis,":[235],"which":[236],"may":[237],"represent":[238],"role":[240],"endogenously":[242],"Ca(v)":[245],"isoforms.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
