{"id":"https://openalex.org/W2126412697","doi":"https://doi.org/10.1161/01.hyp.31.1.409","title":"Chronic Leptin Infusion Increases Arterial Pressure","display_name":"Chronic Leptin Infusion Increases Arterial Pressure","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2126412697","doi":"https://doi.org/10.1161/01.hyp.31.1.409","mag":"2126412697","pmid":"https://pubmed.ncbi.nlm.nih.gov/9453337"},"language":"en","primary_location":{"id":"doi:10.1161/01.hyp.31.1.409","doi":"https://doi.org/10.1161/01.hyp.31.1.409","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.31.1.409","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021388254","display_name":"Eugene W. Shek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene W. Shek","raw_affiliation_strings":["From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064950429","display_name":"Michael W. Brands","orcid":"https://orcid.org/0000-0002-5005-1733","observed_orcids":["https://orcid.org/0000-0002-5005-1733"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W. Brands","raw_affiliation_strings":["From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss","institution_ids":["https://openalex.org/I29606459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015203519","display_name":"John Edward Hall","orcid":"https://orcid.org/0000-0001-9867-5855","observed_orcids":["https://orcid.org/0000-0001-9867-5855"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Hall","raw_affiliation_strings":["From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, Miss","institution_ids":["https://openalex.org/I29606459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":13.6594,"has_fulltext":false,"cited_by_count":688,"citation_normalized_percentile":{"value":0.9909991,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"31","issue":"1","first_page":"409","last_page":"414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.996999979019165},{"id":"https://openalex.org/keywords/arterial-pressure","display_name":"arterial pressure","score":0.8740000128746033},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.7699999809265137},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.722000002861023},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.5350000262260437},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.8489999771118164},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8529999852180481},{"id":"https://openalex.org/keywords/plasma-leptin","display_name":"plasma leptin","score":0.5109999775886536},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.46299999952316284},{"id":"https://openalex.org/keywords/neuroendocrine-regulation-of-blood-pressure","display_name":"neuroendocrine regulation of blood pressure","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.39500001072883606},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.843999981880188},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8427753448486328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.805600643157959},{"id":"https://openalex.org/C2780520971","wikidata":"https://www.wikidata.org/wiki/Q2264329","display_name":"Abdominal aorta","level":3,"score":0.6779739260673523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6087605357170105},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5923638343811035},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.591098964214325},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5800795555114746},{"id":"https://openalex.org/C2779723990","wikidata":"https://www.wikidata.org/wiki/Q707174","display_name":"Femoral artery","level":2,"score":0.5666558146476746},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.5306291580200195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5282071232795715},{"id":"https://openalex.org/C2910590557","wikidata":"https://www.wikidata.org/wiki/Q707794","display_name":"Arterial catheter","level":3,"score":0.4427553415298462},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3757500946521759},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2426401972770691},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.18136003613471985}],"mesh":[{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005268","descriptor_name":"Femoral Vein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.hyp.31.1.409","doi":"https://doi.org/10.1161/01.hyp.31.1.409","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.hyp.31.1.409","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:9453337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9453337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6129585621","display_name":"Cardiovascular Dynamics & Their Control","funder_award_id":"P01HL051971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W384121584","https://openalex.org/W1490814708","https://openalex.org/W1977226572","https://openalex.org/W1978666616","https://openalex.org/W1996713062","https://openalex.org/W2001300907","https://openalex.org/W2013583119","https://openalex.org/W2014093920","https://openalex.org/W2025846514","https://openalex.org/W2051559850","https://openalex.org/W2060682066","https://openalex.org/W2067932098","https://openalex.org/W2075019242","https://openalex.org/W2089641994","https://openalex.org/W2090032724","https://openalex.org/W2334337188","https://openalex.org/W2401554380"],"related_works":["https://openalex.org/W2025226891","https://openalex.org/W1999892971","https://openalex.org/W2332505512","https://openalex.org/W2103893515","https://openalex.org/W7097541166","https://openalex.org/W2112569582","https://openalex.org/W4250805974","https://openalex.org/W2055473886","https://openalex.org/W1975292276","https://openalex.org/W2093469755"],"abstract_inverted_index":{"Plasma":[0],"leptin":[1,11,105,140,147,274,312,324,342],"concentration":[2],"is":[3,20],"increased":[4,15,145,213,236,266],"in":[5,18,31,38,45,70,169,191,197,220,246,259,268,287,322,328,343],"hypertensive":[6],"obese":[7],"humans,":[8],"but":[9,163,186,224],"whether":[10,28],"contributes":[12],"to":[13,33,36,152,159,242,255,308],"the":[14,50,71,109,173,183,192,198,205,216,221,231,247,260,289,298],"arterial":[16,46,210,329],"pressure":[17,47,211,330],"obesity":[19,344],"not":[21,180,227],"known.":[22],"In":[23],"this":[24,225],"study,":[25],"we":[26],"tested":[27],"chronic":[29,67,320],"increases":[30,321,327],"leptin,":[32],"levels":[34,281,310],"comparable":[35],"those":[37],"obesity,":[39],"could":[40],"cause":[41,325],"a":[42,129,338],"sustained":[43,326],"increase":[44,168],"and":[48,74,81,92,121,136,155,195,250,279,294,297,302,331,334],"also":[49,178,265],"importance":[51],"of":[52,103,139,204],"central":[53],"nervous":[54],"system":[55],"(CNS)":[56],"versus":[57],"systemic":[58],"mechanisms.":[59],"Five":[60],"male":[61],"Sprague-Dawley":[62],"rats":[63,84],"were":[64,85],"implanted":[65,86],"with":[66,87,337],"nonoccluding":[68],"catheters":[69],"abdominal":[72,89],"aorta":[73,90],"both":[75,269,288],"carotid":[76,110,134,193,222,248,290],"arteries":[77,111],"for":[78,96,118,124,341],"CNS":[79],"infusion,":[80],"five":[82],"other":[83],"an":[88],"catheter":[91,95],"femoral":[93,113],"vein":[94,114],"intravenous":[97],"(I.V.)":[98],"infusion.":[99,208,275],"After":[100],"7":[101,125,202],"days":[102,120,203],"control,":[104],"was":[106,165,226,314],"infused":[107],"into":[108],"or":[112],"at":[115,141,172,182,215,271,284],"0.1":[116],"microg/kg/min":[117,123,143,207,273,286],"5":[119],"1.0":[122],"days,":[126],"followed":[127],"by":[128,188],"7-day":[130],"recovery":[131],"period.":[132],"The":[133],"artery":[135,291],"i.v.":[137,199,261,299],"infusions":[138],"1":[142,206,272,285],"significantly":[144,237,267,283],"plasma":[146],"levels,":[148],"from":[149,156,238,251],"1.2+/-0.4":[150],"ng/mL":[151,154,158],"91+/-5":[153],"0.9+/-0.1":[157],"94+/-9":[160],"ng/mL,":[161],"respectively,":[162],"there":[164],"no":[166],"significant":[167],"either":[170],"group":[171,194,200,249,292,300],"low":[174,184,217],"dose.":[175],"Food":[176],"intake":[177],"did":[179],"change":[181],"dose":[185,218],"decreased":[187,282],"approximately":[189],"65%":[190],"69%":[196],"after":[201,311],"Mean":[209],"(MAP)":[212],"slightly":[214],"only":[219],"group,":[223],"statistically":[228],"significant.":[229],"At":[230],"higher":[232],"dose,":[233],"however,":[234],"MAP":[235],"86+/-1":[239],"mm":[240,244,253,257],"Hg":[241,245,254,258],"94+/-1":[243],"87+/-1":[252],"93+/-1":[256],"group.":[262],"Heart":[263],"rate":[264,333],"groups":[270],"Fasting":[276],"blood":[277],"glucose":[278],"insulin":[280],"(-10.5%":[293],"-82.5%,":[295],"respectively)":[296],"(-13.6%":[301],"-80.4%,":[303],"respectively).":[304],"All":[305],"variables":[306],"returned":[307],"control":[309],"infusion":[313],"stopped.":[315],"These":[316],"results":[317],"indicate":[318],"that":[319],"circulating":[323],"heart":[332],"are":[335],"consistent":[336],"possible":[339],"role":[340],"hypertension.":[345]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":27},{"year":2012,"cited_by_count":31}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
