{"id":"https://openalex.org/W2126403835","doi":"https://doi.org/10.1073/pnas.93.22.12559","title":"Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.","display_name":"Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons.","publication_year":1996,"publication_date":"1996-10-29","ids":{"openalex":"https://openalex.org/W2126403835","doi":"https://doi.org/10.1073/pnas.93.22.12559","mag":"2126403835","pmid":"https://pubmed.ncbi.nlm.nih.gov/8901621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/38031"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.93.22.12559","doi":"https://doi.org/10.1073/pnas.93.22.12559","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.22.12559","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008561366","display_name":"Martin Vreugdenhil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M Vreugdenhil","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110225552","display_name":"C. Bruehl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C Bruehl","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086146022","display_name":"Robert A. Voskuyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R A Voskuyl","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108699342","display_name":"Jing Xuan Kang","orcid":"https://orcid.org/0000-0001-9055-3044","observed_orcids":["https://orcid.org/0000-0001-9055-3044"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J X Kang","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079152086","display_name":"Alexander Leaf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Leaf","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006345103","display_name":"Wytse Jan Wadman","orcid":"https://orcid.org/0000-0002-1658-4894","observed_orcids":["https://orcid.org/0000-0002-1658-4894"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W J Wadman","raw_affiliation_strings":["Institute of Neurobiology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I887064364"],"apc_list":null,"apc_paid":null,"fwci":8.6622,"has_fulltext":true,"cited_by_count":304,"citation_normalized_percentile":{"value":0.98381087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"93","issue":"22","first_page":"12559","last_page":"12563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9210000038146973},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/sodium-current","display_name":"sodium current","score":0.8180000185966492},{"id":"https://openalex.org/keywords/calcium-current","display_name":"calcium current","score":0.9980000257492065},{"id":"https://openalex.org/keywords/voltage-dependent-inactivation","display_name":"voltage-dependent inactivation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.843999981880188},{"id":"https://openalex.org/keywords/ca1-neurons","display_name":"CA1 neurons","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.7379999756813049},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7593134641647339},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.7567555904388428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6447204947471619},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.5750262141227722},{"id":"https://openalex.org/C2779936771","wikidata":"https://www.wikidata.org/wiki/Q209727","display_name":"Palmitic acid","level":3,"score":0.5702556371688843},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.5376405119895935},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.48752352595329285},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4863158166408539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47541362047195435},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.45206722617149353},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.4127758741378784},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.37678390741348267},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3198246955871582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25958123803138733},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015118","descriptor_name":"Eicosapentaenoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.93.22.12559","doi":"https://doi.org/10.1073/pnas.93.22.12559","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.93.22.12559","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:38031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38031","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:8901621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8901621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:dare.uva.nl:openaire_cris_publications/8a49f6d3-4add-44b5-9e17-6a255407477d","doi":null,"is_oa":false,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/polyunsatured-fatty-acids-modulate-sodium-and-calcium-currents-in-ca1-neurons(8a49f6d3-4add-44b5-9e17-6a255407477d).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vreugdenhil, M, Bruehl, C, Voskuyl, R A, Kang, J X, Leaf, A & Wadman, W J 1996, 'Polyunsatured fatty acids modulate sodium and calcium currents in CA1 neurons', Proceedings of the National Academy of Sciences of the United States of America, vol. 93, pp. 12559-12563. https://doi.org/10.1073/pnas.93.22.12559","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.uva.nl:publications/8a49f6d3-4add-44b5-9e17-6a255407477d","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/polyunsatured-fatty-acids-modulate-sodium-and-calcium-currents-in-ca1-neurons(8a49f6d3-4add-44b5-9e17-6a255407477d).html","pdf_url":"https://pure.uva.nl/ws/files/2941338/1510_15883y.pdf","source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vreugdenhil, M, Bruehl, C, Voskuyl, R A, Kang, J X, Leaf, A & Wadman, W J 1996, 'Polyunsatured fatty acids modulate sodium and calcium currents in CA1 neurons', Proceedings of the National Academy of Sciences of the United States of America, vol. 93, pp. 12559-12563. https://doi.org/10.1073/pnas.93.22.12559","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/8a49f6d3-4add-44b5-9e17-6a255407477d","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/polyunsatured-fatty-acids-modulate-sodium-and-calcium-currents-in-ca1-neurons(8a49f6d3-4add-44b5-9e17-6a255407477d).html","pdf_url":"https://dare.uva.nl/personal/pure/en/publications/polyunsatured-fatty-acids-modulate-sodium-and-calcium-currents-in-ca1-neurons(8a49f6d3-4add-44b5-9e17-6a255407477d).html","source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 93, 12559 - 12563. National Academy of Sciences","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:38031","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/38031","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2485126375","display_name":null,"funder_award_id":"DK-38165","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G755109007","display_name":"MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS","funder_award_id":"R01DK038165","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126403835.pdf","grobid_xml":"https://content.openalex.org/works/W2126403835.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1967182629","https://openalex.org/W1974300998","https://openalex.org/W1983531379","https://openalex.org/W1991825108","https://openalex.org/W1994452561","https://openalex.org/W2002865741","https://openalex.org/W2010224190","https://openalex.org/W2024169307","https://openalex.org/W2028622837","https://openalex.org/W2030042443","https://openalex.org/W2043353612","https://openalex.org/W2044260691","https://openalex.org/W2044575298","https://openalex.org/W2046877734","https://openalex.org/W2049447364","https://openalex.org/W2050451659","https://openalex.org/W2070497389","https://openalex.org/W2070863450","https://openalex.org/W2074616189","https://openalex.org/W2088269052","https://openalex.org/W2089640144","https://openalex.org/W2092288244","https://openalex.org/W2098083786","https://openalex.org/W2115052737","https://openalex.org/W2121413985","https://openalex.org/W2160411766","https://openalex.org/W2166154572","https://openalex.org/W2166326216","https://openalex.org/W2296260021","https://openalex.org/W2329057544","https://openalex.org/W2337488597"],"related_works":["https://openalex.org/W1964721333","https://openalex.org/W2010224190","https://openalex.org/W1973611043","https://openalex.org/W2490485559","https://openalex.org/W4240393177","https://openalex.org/W1994452561","https://openalex.org/W2005566908","https://openalex.org/W2169828142","https://openalex.org/W2128995864","https://openalex.org/W2152702694"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"indicates":[2],"that":[3],"long-chain":[4],"polyunsaturated":[5],"fatty":[6],"acids":[7],"(PUFAs)":[8],"can":[9],"prevent":[10],"cardiac":[11],"arrhythmias":[12],"by":[13],"a":[14,26,72],"reduction":[15],"of":[16,28,32,50,69,75,79,81,106,174,191],"cardiomyocyte":[17],"excitability.":[18],"This":[19],"was":[20,112,140],"shown":[21],"to":[22,25,86],"be":[23],"due":[24],"modulation":[27],"the":[29,48,64,76,93,97,104,107,133,136,171,181,192],"voltage-dependent":[30],"inactivation":[31,80,94,110,138],"both":[33,82,157],"sodium":[34],"(INa)":[35],"and":[36,54,84,95,121,146,154,159,180,196,202],"calcium":[37],"(ICa)":[38],"currents.":[39],"To":[40],"establish":[41],"whether":[42],"PUFAs":[43,51,70,167,193],"also":[44],"regulate":[45],"neuronal":[46,200],"excitability,":[47],"effects":[49,190,206],"on":[52,135,194],"INa":[53,83,108,158,195],"ICa":[55,85,137,160,197],"were":[56,185],"assessed":[57],"in":[58,207],"CA1":[59],"neurons":[60],"freshly":[61],"isolated":[62],"from":[63,99],"rat":[65],"hippocampus.":[66],"Extracellular":[67],"application":[68],"produced":[71],"concentration-dependent":[73],"shift":[74,105,134],"voltage":[77,172],"dependence":[78,173],"more":[87],"hyperpolarized":[88],"potentials.":[89],"Consequently,":[90],"they":[91],"accelerated":[92],"retarded":[96],"recovery":[98],"inactivation.":[100],"The":[101,130,176,188],"EC50":[102,131],"for":[103,117,126,132,144,150],"steady-state":[109],"curve":[111,139],"2.1":[113,141],"+/-":[114,123,142],"0.4":[115,124,143],"microM":[116,125,149],"docosahexaenoic":[118],"acid":[119,128,179,184],"(DHA)":[120],"4":[122],"eicosapentaenoic":[127],"(EPA).":[129],"DHA":[145,153],">":[147,164],"15":[148],"EPA.":[151],"Additionally,":[152],"EPA":[155],"suppressed":[156],"amplitude":[161],"at":[162],"concentrations":[163],"10":[165],"microM.":[166],"did":[168],"not":[169],"affect":[170],"activation.":[175],"monounsaturated":[177],"oleic":[178],"saturated":[182],"palmitic":[183],"virtually":[186],"ineffective.":[187],"combined":[189],"may":[198,203],"reduce":[199],"excitability":[201],"exert":[204],"anticonvulsive":[205],"vivo.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}