{"id":"https://openalex.org/W2126399705","doi":"https://doi.org/10.1039/b508966m","title":"Acetylcholinesterase inhibitors from plants and fungi","display_name":"Acetylcholinesterase inhibitors from plants and fungi","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2126399705","doi":"https://doi.org/10.1039/b508966m","mag":"2126399705","pmid":"https://pubmed.ncbi.nlm.nih.gov/16572227"},"language":"en","primary_location":{"id":"doi:10.1039/b508966m","doi":"https://doi.org/10.1039/b508966m","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b508966m","pdf_url":null,"source":{"id":"https://openalex.org/S18855311","display_name":"Natural Product Reports","issn_l":"0265-0568","issn":["0265-0568","1460-4752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Reports","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073277560","display_name":"Peter John Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter J. Houghton","raw_affiliation_strings":["Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074353332","display_name":"Yuhao Ren","orcid":"https://orcid.org/0000-0002-0983-8681","observed_orcids":["https://orcid.org/0000-0002-0983-8681"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yuhao Ren","raw_affiliation_strings":["Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacognosy Research Laboratories, Pharmaceutical Sciences Research Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085863167","display_name":"Melanie\u2010Jayne R. Howes","orcid":"https://orcid.org/0000-0003-1065-6209","observed_orcids":["https://orcid.org/0000-0003-1065-6209"]},"institutions":[{"id":"https://openalex.org/I2799614521","display_name":"Royal Botanic Gardens, Kew","ror":"https://ror.org/00ynnr806","country_code":"GB","type":"archive","lineage":["https://openalex.org/I2799614521"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melanie-Jayne Howes","raw_affiliation_strings":["Jodrell Research Laboratories, Royal Botanic Gardens Kew, Richmond, Surrey, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jodrell Research Laboratories, Royal Botanic Gardens Kew, Richmond, Surrey, UK","institution_ids":["https://openalex.org/I2799614521"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073277560"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":null,"apc_paid":null,"fwci":2.3647,"has_fulltext":false,"cited_by_count":583,"citation_normalized_percentile":{"value":0.91924399,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"2","first_page":"181","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plant-natural-products","display_name":"plant natural products","score":0.7639999985694885},{"id":"https://openalex.org/keywords/fungal-natural-products","display_name":"fungal natural products","score":0.9070000052452087},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.9210000038146973},{"id":"https://openalex.org/keywords/meroterpenoids","display_name":"meroterpenoids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.871999979019165},{"id":"https://openalex.org/keywords/enzyme-selectivity","display_name":"enzyme selectivity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.9205081462860107},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.808953046798706},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5847709774971008},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5505257248878479},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.5456287860870361},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5112793445587158},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5089609622955322},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46463918685913086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4085140824317932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31303900480270386},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2307336926460266},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10156413912773132},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1039/b508966m","doi":"https://doi.org/10.1039/b508966m","is_oa":false,"landing_page_url":"https://doi.org/10.1039/b508966m","pdf_url":null,"source":{"id":"https://openalex.org/S18855311","display_name":"Natural Product Reports","issn_l":"0265-0568","issn":["0265-0568","1460-4752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Reports","raw_type":"journal-article"},{"id":"pmid:16572227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16572227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product reports","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/9f977e7a-cb9e-4070-83e4-f5ec6b188729","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/9f977e7a-cb9e-4070-83e4-f5ec6b188729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Houghton, P J, Ren, Y H & Howes, M J 2006, 'Acetylcholinesterase inhibitors from plants and fungi', Natural Product Reports, vol. 23, no. 2, pp. 181 - 199. https://doi.org/10.1039/b508966m","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W43637279","https://openalex.org/W93632731","https://openalex.org/W393262163","https://openalex.org/W1964095432","https://openalex.org/W1964103211","https://openalex.org/W1968312733","https://openalex.org/W1971048984","https://openalex.org/W1971521629","https://openalex.org/W1973440311","https://openalex.org/W1973786803","https://openalex.org/W1974392545","https://openalex.org/W1974773436","https://openalex.org/W1975463072","https://openalex.org/W1976517254","https://openalex.org/W1977508016","https://openalex.org/W1977675317","https://openalex.org/W1977751440","https://openalex.org/W1978685846","https://openalex.org/W1979059207","https://openalex.org/W1981152626","https://openalex.org/W1983312692","https://openalex.org/W1987170637","https://openalex.org/W1989691313","https://openalex.org/W1992123323","https://openalex.org/W1993893313","https://openalex.org/W1995961618","https://openalex.org/W1996259742","https://openalex.org/W1997522432","https://openalex.org/W1998490335","https://openalex.org/W2000167518","https://openalex.org/W2000212196","https://openalex.org/W2003061656","https://openalex.org/W2004713321","https://openalex.org/W2008222160","https://openalex.org/W2008448768","https://openalex.org/W2009546047","https://openalex.org/W2011490130","https://openalex.org/W2011559245","https://openalex.org/W2012367952","https://openalex.org/W2012691421","https://openalex.org/W2014155633","https://openalex.org/W2014289512","https://openalex.org/W2015331537","https://openalex.org/W2016139786","https://openalex.org/W2019252070","https://openalex.org/W2021354710","https://openalex.org/W2028433131","https://openalex.org/W2032718793","https://openalex.org/W2034161911","https://openalex.org/W2034863319","https://openalex.org/W2037174696","https://openalex.org/W2041999499","https://openalex.org/W2045694972","https://openalex.org/W2047982390","https://openalex.org/W2048322642","https://openalex.org/W2050414322","https://openalex.org/W2052727827","https://openalex.org/W2052743475","https://openalex.org/W2053552819","https://openalex.org/W2056615752","https://openalex.org/W2059358513","https://openalex.org/W2061089370","https://openalex.org/W2063764057","https://openalex.org/W2065569515","https://openalex.org/W2066442963","https://openalex.org/W2069294211","https://openalex.org/W2069883813","https://openalex.org/W2071026308","https://openalex.org/W2071364419","https://openalex.org/W2071710906","https://openalex.org/W2072355219","https://openalex.org/W2078072646","https://openalex.org/W2078914970","https://openalex.org/W2084337571","https://openalex.org/W2084622474","https://openalex.org/W2085083700","https://openalex.org/W2085958374","https://openalex.org/W2088639430","https://openalex.org/W2089015588","https://openalex.org/W2094062632","https://openalex.org/W2098437204","https://openalex.org/W2099854437","https://openalex.org/W2101400633","https://openalex.org/W2102399993","https://openalex.org/W2106403947","https://openalex.org/W2106409095","https://openalex.org/W2115885329","https://openalex.org/W2116497718","https://openalex.org/W2118346486","https://openalex.org/W2125377984","https://openalex.org/W2126545309","https://openalex.org/W2136798512","https://openalex.org/W2137809729","https://openalex.org/W2140642212","https://openalex.org/W2145249203","https://openalex.org/W2148292160","https://openalex.org/W2159373139","https://openalex.org/W2161672891","https://openalex.org/W2164176196","https://openalex.org/W2177177498","https://openalex.org/W2238113976","https://openalex.org/W2243716407","https://openalex.org/W2246767587","https://openalex.org/W2274811202","https://openalex.org/W2313900509","https://openalex.org/W2317919691","https://openalex.org/W2326147218","https://openalex.org/W2413026170","https://openalex.org/W2420411199","https://openalex.org/W2950518031","https://openalex.org/W2951816806","https://openalex.org/W2952945723"],"related_works":["https://openalex.org/W2361502179","https://openalex.org/W2570188447","https://openalex.org/W1998449920","https://openalex.org/W2385926869","https://openalex.org/W2910120110","https://openalex.org/W2060288971","https://openalex.org/W2412757402","https://openalex.org/W6912851036","https://openalex.org/W1192459059","https://openalex.org/W1978252405"],"abstract_inverted_index":{"This":[0],"review":[1],"describes":[2],"183":[3],"compounds":[4,47],"obtained":[5],"from":[6,59],"plants":[7],"and":[8,68],"fungi":[9,60],"which":[10],"have":[11,61],"been":[12,63],"shown":[13],"to":[14,65],"inhibit":[15],"acetylcholinesterase.":[16],"The":[17,41,50],"mechanism":[18],"of":[19,21,35,37,44],"action":[20,36],"cholinesterase,":[22],"together":[23],"with":[24],"the":[25,33,45],"binding":[26],"sites,":[27],"and,":[28],"where":[29],"this":[30],"is":[31,39],"known,":[32],"mode":[34],"inhibitors":[38,52],"described.":[40],"relative":[42],"activities":[43],"different":[46],"are":[48,53],"recorded.":[49],"strongest":[51],"generally":[54],"alkaloids":[55],"although":[56],"some":[57],"meroterpenoids":[58],"also":[62],"found":[64],"be":[66],"active":[67],"display":[69],"better":[70],"selectivity.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":38},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":30},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":35},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
