{"id":"https://openalex.org/W2126338307","doi":"https://doi.org/10.1152/ajplung.00026.2004","title":"Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis","display_name":"Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis","publication_year":2004,"publication_date":"2004-06-15","ids":{"openalex":"https://openalex.org/W2126338307","doi":"https://doi.org/10.1152/ajplung.00026.2004","mag":"2126338307","pmid":"https://pubmed.ncbi.nlm.nih.gov/15194563"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00026.2004","doi":"https://doi.org/10.1152/ajplung.00026.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00026.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061394861","display_name":"Ryan R. Driskell","orcid":"https://orcid.org/0000-0001-7673-2564","observed_orcids":["https://orcid.org/0000-0001-7673-2564"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan R. Driskell","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011424433","display_name":"Xiaoming Liu","orcid":"https://orcid.org/0000-0002-3902-9105","observed_orcids":["https://orcid.org/0000-0002-3902-9105"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming Liu","raw_affiliation_strings":["","Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103563088","display_name":"Meihui Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meihui Luo","raw_affiliation_strings":["","Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050840752","display_name":"Mohammed S. Filali","orcid":"https://orcid.org/0000-0002-7471-3455","observed_orcids":["https://orcid.org/0000-0002-7471-3455"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammed Filali","raw_affiliation_strings":["","Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103537586","display_name":"Weihong Zhou","orcid":"https://orcid.org/0009-0003-2287-6441","observed_orcids":["https://orcid.org/0009-0003-2287-6441"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weihong Zhou","raw_affiliation_strings":["","Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015216138","display_name":"Duane Abbott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duane Abbott","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038925363","display_name":"Ningli Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ningli Cheng","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002678686","display_name":"Chris Moothart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Moothart","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022804707","display_name":"Curt D. Sigmund","orcid":"https://orcid.org/0000-0002-1453-0921","observed_orcids":["https://orcid.org/0000-0002-1453-0921"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt D. Sigmund","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022115776","display_name":"John F. Engelhardt","orcid":"https://orcid.org/0000-0003-2389-9277","observed_orcids":["https://orcid.org/0000-0003-2389-9277"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John F. Engelhardt","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and Internal Medicine, and Center for Gene Therapy of Cystic Fibrosis and Other Genetic Diseases, University of Iowa College of Medicine, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8777,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.69010742,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"287","issue":"4","first_page":"L752","last_page":"L763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lef1","display_name":"LEF1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/wnt1","display_name":"Wnt1","score":0.8180000185966492},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.675000011920929},{"id":"https://openalex.org/keywords/submucosal-glands","display_name":"submucosal glands","score":0.8700000047683716},{"id":"https://openalex.org/keywords/airway-development","display_name":"airway development","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.996999979019165},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8381273746490479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7258805632591248},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.6037960648536682},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5873311758041382},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5153493285179138},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4657341539859772},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.45163944363594055},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4414486587047577},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4144340455532074},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.28449445962905884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24921485781669617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17141792178153992},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15744620561599731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07484802603721619},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06415298581123352},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001940","descriptor_name":"Breast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020545","descriptor_name":"Respiratory Mucosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051155","descriptor_name":"Wnt1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051821","descriptor_name":"Lymphoid Enhancer-Binding Factor 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajplung.00026.2004","doi":"https://doi.org/10.1152/ajplung.00026.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00026.2004","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:15194563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15194563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.381.6560","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.381.6560","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://elab.genetics.uiowa.edu/Engelhardt Manuscripts/2004/Am J Phys - Driskell.pdf","raw_type":"text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/3bab7539-417c-4e66-a5d8-fdc1fe23982d","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/3bab7539-417c-4e66-a5d8-fdc1fe23982d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Driskell, R, Liu, X, Luo, M, Filali, M, Zhou, W, Abbott, D, Cheng, N, Moothart, C, Sigmund, C D & Engelhardt, J F 2004, 'Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis', AMERICAN JOURNAL OF PHYSIOLOGY: LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, vol. 287, no. 4, pp. L752-L763. https://doi.org/10.1152/ajplung.00026.2004","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1482897854","display_name":null,"funder_award_id":"DK47967","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2326343604","display_name":"Biology of Submucosal Gland Stem Cells in the Airway","funder_award_id":"R01DK047967","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W275936519","https://openalex.org/W1484163259","https://openalex.org/W1518735225","https://openalex.org/W1974821414","https://openalex.org/W1982342854","https://openalex.org/W1987483436","https://openalex.org/W1988365075","https://openalex.org/W1990768206","https://openalex.org/W1995795849","https://openalex.org/W2007717461","https://openalex.org/W2016241489","https://openalex.org/W2016913151","https://openalex.org/W2017372544","https://openalex.org/W2027648808","https://openalex.org/W2033113800","https://openalex.org/W2038062523","https://openalex.org/W2054439316","https://openalex.org/W2055824128","https://openalex.org/W2062860706","https://openalex.org/W2066078074","https://openalex.org/W2070144997","https://openalex.org/W2077269764","https://openalex.org/W2077658669","https://openalex.org/W2079289749","https://openalex.org/W2083961968","https://openalex.org/W2089068494","https://openalex.org/W2096242114","https://openalex.org/W2105516543","https://openalex.org/W2108616533","https://openalex.org/W2124537431","https://openalex.org/W2130237654","https://openalex.org/W2137075665","https://openalex.org/W2141175150","https://openalex.org/W2147864074","https://openalex.org/W2161725170","https://openalex.org/W2165061154","https://openalex.org/W2170408009","https://openalex.org/W2188453072"],"related_works":["https://openalex.org/W1972098154","https://openalex.org/W2153278284","https://openalex.org/W2188453072","https://openalex.org/W2016913151","https://openalex.org/W2317122636","https://openalex.org/W7099846255","https://openalex.org/W7100748919","https://openalex.org/W2152357375","https://openalex.org/W197070073","https://openalex.org/W7097153070"],"abstract_inverted_index":{"Regulated":[0],"expression":[1,77,157,186,201],"of":[2,16,30,110,123,137,162,177,212],"lymphoid":[3],"enhancer":[4],"factor":[5],"1":[6],"(Lef-1)":[7],"plays":[8],"an":[9,221],"obligatory":[10],"role":[11,73,223],"in":[12,58,74,97,113,119,125,140,159,166,187,202],"the":[13,31,59,88,108,111,135,141,178,182,213,217],"transcriptional":[14],"control":[15],"epithelial":[17,102],"bud":[18,146,173,228],"formation":[19],"during":[20,40,78,144,224],"airway":[21,79,99,225],"submucosal":[22,171,191,226],"gland":[23,26,82,169],"and":[24,37,80,100,170,189],"mammary":[25,81,101,168,203],"development.":[27,83,174],"However,":[28],"regions":[29],"Lef-1":[32,60,76,89,116,142,150,156,183,214],"promoter":[33,90,117,143,151,184,215],"required":[34],"for":[35],"spatial":[36],"temporal":[38],"regulation":[39,211],"glandular":[41,145,172,192,204,227],"development":[42],"have":[43],"yet":[44],"to":[45,94,133],"be":[46,64],"defined.":[47],"We":[48],"hypothesized":[49],"that":[50,87,209],"a":[51,72,160],"previously":[52],"reported":[53],"110-bp":[54,179],"Wnt-responsive":[55,138],"element":[56],"(WRE)":[57],"promoter,":[61],"which":[62],"can":[63],"induced":[65],"by":[66],"Wnt-3a/beta-catenin":[67],"signals,":[68],"may":[69,219],"also":[70,92],"play":[71,220],"regulating":[75,115],"Here":[84],"we":[85,127],"show":[86],"is":[91],"responsive":[93],"Wnt-1":[95],"signals":[96],"both":[98,167],"cell":[103,163],"lines.":[104],"To":[105],"better":[106],"understand":[107],"importance":[109],"WRE":[112,180,218],"dynamically":[114],"activation":[118],"these":[120],"two":[121],"types":[122,164],"epithelia":[124],"vivo,":[126],"utilized":[128],"LacZ":[129],"reporter":[130],"transgenic":[131],"mice":[132],"evaluate":[134],"significance":[136],"sequences":[139],"formation.":[147,229],"A":[148],"2.5-kb":[149],"fragment":[152],"partially":[153],"reproduced":[154],"endogenous":[155],"patterns":[158],"subset":[161],"involved":[165],"Interestingly,":[175],"removal":[176],"from":[181],"ablated":[185],"nasal":[188],"tracheal":[190],"buds":[193],"while":[194],"having":[195],"no":[196],"significant":[197],"effect":[198],"on":[199],"developmental":[200],"buds.":[205],"These":[206],"findings":[207],"suggest":[208],"Wnt":[210],"at":[216],"important":[222]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}