{"id":"https://openalex.org/W2126325276","doi":"https://doi.org/10.7555/jbr.27.20130023","title":"A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients","display_name":"A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2126325276","doi":"https://doi.org/10.7555/jbr.27.20130023","mag":"2126325276","pmid":"https://pubmed.ncbi.nlm.nih.gov/23885270","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3721039"},"language":"en","primary_location":{"id":"doi:10.7555/jbr.27.20130023","doi":"https://doi.org/10.7555/jbr.27.20130023","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20130023","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20130023","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20130023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034257494","display_name":"Zhengshan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Zhengshan","raw_affiliation_strings":["The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108515796","display_name":"Meng Qingyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Qingyang","raw_affiliation_strings":["Department of General Surgery, Zhongshan Hospital, Fudan University General Surgery Department, Shanghai 200032, China","Liver Transplantation Center ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongshan Hospital, Fudan University General Surgery Department, Shanghai 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Liver Transplantation Center ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101427288","display_name":"Yongxiang Xia","orcid":"https://orcid.org/0000-0001-6589-797X","observed_orcids":["https://orcid.org/0000-0001-6589-797X"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Yongxiang","raw_affiliation_strings":["The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100753871","display_name":"Feng Zhang","orcid":"https://orcid.org/0000-0002-3998-8939","observed_orcids":["https://orcid.org/0000-0002-3998-8939"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Feng","raw_affiliation_strings":["The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101497703","display_name":"Wei You","orcid":"https://orcid.org/0000-0003-1852-1579","observed_orcids":["https://orcid.org/0000-0003-1852-1579"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"You Wei","raw_affiliation_strings":["The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101497703"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":null,"apc_paid":null,"fwci":0.956,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.77042941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"27","issue":"4","first_page":"305","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fk506","display_name":"FK506","score":0.9190000295639038},{"id":"https://openalex.org/keywords/low-dose-immunosuppression","display_name":"low-dose immunosuppression","score":0.949999988079071},{"id":"https://openalex.org/keywords/living-donor-liver-transplantation","display_name":"living donor liver transplantation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tacrolimus-blood-concentration","display_name":"tacrolimus blood concentration","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6610000133514404},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8989999890327454},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9490000009536743},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/acute-rejection","display_name":"acute rejection","score":0.7139999866485596},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.9672309756278992},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8889992237091064},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6165065765380859},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5674221515655518},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5620054006576538},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.558134138584137},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.5390187501907349},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.519138753414154},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.48216694593429565},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.4820745587348938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44207683205604553},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.353485107421875},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3354928493499756},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.7555/jbr.27.20130023","doi":"https://doi.org/10.7555/jbr.27.20130023","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20130023","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20130023","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2714237","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3721039","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3721039","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3721039","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Res","raw_type":"Text"},{"id":"pmid:23885270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23885270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical research","raw_type":"Journal Article"},{"id":"mag:3150855330","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85389A/201304/46853669.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306545035","display_name":"\u5357\u4eac\u533b\u79d1\u5927\u5b66\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":"1007-4376","issn":["1007-4376","1876-4819"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7269\u533b\u5b66\u7814\u7a76\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.7555/jbr.27.20130023","doi":"https://doi.org/10.7555/jbr.27.20130023","is_oa":true,"landing_page_url":"https://doi.org/10.7555/jbr.27.20130023","pdf_url":"http://www.jbr-pub.org.cn/en/article/doi/10.7555/JBR.27.20130023","source":{"id":"https://openalex.org/S165426342","display_name":"Journal of Biomedical Research","issn_l":"1674-8301","issn":["1674-8301","2352-4685"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biomedical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2126325276.pdf","grobid_xml":"https://content.openalex.org/works/W2126325276.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1571165704","https://openalex.org/W1718309258","https://openalex.org/W2018051522","https://openalex.org/W2030413250","https://openalex.org/W2032629491","https://openalex.org/W2051149062","https://openalex.org/W2058651551","https://openalex.org/W2087024234","https://openalex.org/W2102007986","https://openalex.org/W2112478701","https://openalex.org/W2127746188","https://openalex.org/W2159807891","https://openalex.org/W2332401864","https://openalex.org/W2411024667","https://openalex.org/W4236775861","https://openalex.org/W4241813475"],"related_works":["https://openalex.org/W7098085651","https://openalex.org/W2377935680","https://openalex.org/W2077277740","https://openalex.org/W2007851510","https://openalex.org/W2982358506","https://openalex.org/W4387956097","https://openalex.org/W1986355786","https://openalex.org/W2804866189","https://openalex.org/W2372843174","https://openalex.org/W2082072703"],"abstract_inverted_index":{"We":[0],"sought":[1],"to":[2,12,38,173],"evaluate":[3],"the":[4,43,51,58,88,97,101,106,153,158,162,174],"efficacy":[5],"and":[6,30,57,69,80,91,108,132,178,199,207],"effects":[7,72,185],"of":[8,22,41,67,100,127,155,176,183,202],"low-dose":[9,52,200],"tacrolimus":[10,53,60,68,189,193,203],"(FK506)":[11],"recipients":[13,44,102,163],"with":[14,188,192],"living":[15],"donor":[16],"liver":[17,130],"transplantation":[18],"(LDLT).":[19],"A":[20,137],"total":[21],"66":[23],"patients":[24],"who":[25],"underwent":[26],"LDLT":[27,211],"between":[28,157],"2001":[29],"2007":[31],"were":[32,45,82,103,138,150],"enrolled":[33],"in":[34,135,143,152,164],"this":[35],"study.":[36],"According":[37],"different":[39],"doses":[40],"tacrolimus,":[42],"randomly":[46],"divided":[47],"into":[48],"two":[49,159],"groups:":[50],"group":[54,61,136,144,166],"(group":[55,62],"A)":[56],"normal-dose":[59],"B).":[63],"The":[64,125,181],"blood":[65,78,194],"concentration":[66],"its":[70],"side":[71,184],"including":[73],"infection,":[74,128],"hyperglycemia,":[75,129],"hypertension,":[76],"high":[77],"creatinine":[79],"jaundice":[81],"monitored":[83],"once":[84,92],"a":[85,93,168,205],"week":[86],"at":[87,105],"perioperative":[89],"period,":[90],"month":[94],"thereafter.":[95],"Besides,":[96],"survival":[98,170],"rates":[99],"analyzed":[104],"1-":[107,177],"3-year":[109,179],"time":[110],"point":[111],"after":[112,123],"operation.":[113],"Among":[114],"these":[115],"patients,":[116],"no":[117,147],"significant":[118,148],"acute":[119],"rejection":[120],"was":[121],"detected":[122,151],"LDLT.":[124],"incidences":[126],"dysfunction":[131],"renal":[133],"impairment":[134],"markedly":[139],"lower":[140],"than":[141],"those":[142],"B.":[145],"However,":[146],"differences":[149],"incidence":[154,182],"hypertension":[156],"groups.":[160],"Moreover,":[161],"each":[165],"had":[167],"similar":[169],"rate":[171],"according":[172],"results":[175],"follow-up.":[180],"that":[186],"associated":[187],"positively":[190],"correlated":[191],"concentration.":[195],"In":[196],"conclusion,":[197],"long-term":[198],"administration":[201],"is":[204],"safe":[206],"effective":[208],"treatment":[209],"for":[210],"recipients.":[212]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
