{"id":"https://openalex.org/W2126237672","doi":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","title":"Thalidomide in the treatment of sixty cases of chronic discoid lupus erythematosus","display_name":"Thalidomide in the treatment of sixty cases of chronic discoid lupus erythematosus","publication_year":1983,"publication_date":"1983-04-01","ids":{"openalex":"https://openalex.org/W2126237672","doi":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","mag":"2126237672","pmid":"https://pubmed.ncbi.nlm.nih.gov/6838771"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.1983.tb04600.x","doi":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049103293","display_name":"J. Knop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J. KNOP","raw_affiliation_strings":["Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043481471","display_name":"Gisela Bonsmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. BONSMANN","raw_affiliation_strings":["Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076611539","display_name":"Rudolf Happle","orcid":"https://orcid.org/0000-0002-6338-1766","observed_orcids":["https://orcid.org/0000-0002-6338-1766"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. HAPPLE","raw_affiliation_strings":["Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111577299","display_name":"AC Ludolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. LUDOLPH","raw_affiliation_strings":["Department of Neurology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089536853","display_name":"Dieter Matz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D.R. MATZ","raw_affiliation_strings":["Department of Neurology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109227508","display_name":"Erika Mifsud","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E.J. MIFSUD","raw_affiliation_strings":["British Military Hospital, M\u00fcnster, F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Military Hospital, M\u00fcnster, F.R.G","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052066562","display_name":"E. Macher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. MACHER","raw_affiliation_strings":["Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of M\u00fcnster, D\u20104400 Munster","institution_ids":["https://openalex.org/I22465464"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049103293"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":8.2321,"has_fulltext":false,"cited_by_count":216,"citation_normalized_percentile":{"value":0.97895229,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"108","issue":"4","first_page":"461","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-discoid-lupus-erythematosus","display_name":"chronic discoid lupus erythematosus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cutaneous-lupus-erythematosus","display_name":"cutaneous lupus erythematosus","score":0.8650000095367432},{"id":"https://openalex.org/keywords/treatment-relapse","display_name":"treatment relapse","score":0.5139999985694885},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.6589999794960022},{"id":"https://openalex.org/keywords/neurological-adverse-events","display_name":"neurological adverse events","score":0.734000027179718},{"id":"https://openalex.org/keywords/polyneuropathy","display_name":"polyneuropathy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/long-term-treatment-response","display_name":"long-term treatment response","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.8492879867553711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7801113128662109},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7021933197975159},{"id":"https://openalex.org/C2775915377","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Lupus erythematosus","level":3,"score":0.5622957348823547},{"id":"https://openalex.org/C2776748653","wikidata":"https://www.wikidata.org/wiki/Q1228801","display_name":"Discoid lupus erythematosus","level":4,"score":0.5146464109420776},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4681442379951477},{"id":"https://openalex.org/C2911091503","wikidata":"https://www.wikidata.org/wiki/Q188297","display_name":"Cutaneous Lupus Erythematosus","level":4,"score":0.4635201394557953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19636273384094238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16199269890785217},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10417461395263672},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008179","descriptor_name":"Lupus Erythematosus, Discoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013792","descriptor_name":"Thalidomide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013792","descriptor_name":"Thalidomide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2133.1983.tb04600.x","doi":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1983.tb04600.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:6838771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6838771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2090043776","https://openalex.org/W2146126581","https://openalex.org/W2395650621","https://openalex.org/W2415574184","https://openalex.org/W2418446688","https://openalex.org/W4230878363"],"related_works":["https://openalex.org/W2090043776","https://openalex.org/W2418098300","https://openalex.org/W3137908875","https://openalex.org/W2139609692","https://openalex.org/W2402129932","https://openalex.org/W2359793010","https://openalex.org/W4220866529","https://openalex.org/W1874557549","https://openalex.org/W2060662745","https://openalex.org/W3042446096"],"abstract_inverted_index":{"The":[0],"therapeutic":[1],"effect":[2,158],"of":[3,32,45,55,62,103,106,125],"thalidomide":[4,40,56,74,121,141],"in":[5,13,65,149,152],"chronic":[6],"discoid":[7],"lupus":[8],"erythematosus":[9],"(CDLE)":[10],"was":[11,35,41],"studied":[12],"sixty":[14],"patients":[15,25,48,64,104,170],"who":[16,76],"were":[17,99],"followed":[18],"up":[19],"for":[20],"2":[21],"years.":[22],"In":[23],"fifty-four":[24],"(90%)":[26],"a":[27,52,86,90,145],"complete":[28],"or":[29,92],"marked":[30],"regression":[31],"the":[33,39,63,67,120,123],"disease":[34,68],"observed,":[36],"but":[37,132,151],"when":[38],"stopped,":[42],"thirty":[43],"out":[44],"forty-one":[46],"(71%)":[47],"relapsed.":[49],"Patients":[50],"undergoing":[51],"second":[53,91],"course":[54,94],"treatment":[57,72,82,161],"again":[58],"responded":[59],"well.":[60],"Nine":[61],"whom":[66],"recurred":[69],"after":[70],"successful":[71],"with":[73,83,95],"and":[75,101,138,175],"had":[77,115],"been":[78,117],"unresponsive":[79],"to":[80,89,108,169,172],"intermittent":[81],"antimalarials,":[84],"showed":[85],"good":[87],"response":[88],"third":[93],"thalidomide.":[96],"Mild":[97],"side-effects":[98,127],"common":[100],"25%":[102],"complained":[105],"slight":[107],"moderate":[109],"polyneuritic":[110],"symptoms.":[111],"Since":[112],"electroneurological":[113],"examinations":[114,136],"not":[116],"performed":[118],"before":[119,137],"therapy,":[122],"frequency":[124],"neurological":[126,135],"cannot":[128],"be":[129,167],"accurately":[130],"calculated":[131],"we":[133],"recommend":[134],"periodically":[139],"during":[140],"treatment.":[142],"Thalidomide":[143],"is":[144,162],"very":[146],"effective":[147],"drug":[148],"CDLE,":[150],"most":[153],"cases":[154],"it":[155],"exerts":[156],"its":[157],"only":[159],"whilst":[160],"continued.":[163],"Its":[164],"use":[165],"should":[166],"restricted":[168],"resistant":[171],"topical":[173],"steroids":[174],"systemic":[176],"antimalarials.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}