{"id":"https://openalex.org/W2126089889","doi":"https://doi.org/10.1152/japplphysiol.00870.2012","title":"Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strain","display_name":"Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strain","publication_year":2012,"publication_date":"2012-11-30","ids":{"openalex":"https://openalex.org/W2126089889","doi":"https://doi.org/10.1152/japplphysiol.00870.2012","mag":"2126089889","pmid":"https://pubmed.ncbi.nlm.nih.gov/23195632"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.00870.2012","doi":"https://doi.org/10.1152/japplphysiol.00870.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00870.2012","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052715735","display_name":"Christopher D. Pascoe","orcid":"https://orcid.org/0000-0002-5229-9927","observed_orcids":["https://orcid.org/0000-0002-5229-9927"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chris D. Pascoe","raw_affiliation_strings":["University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091593411","display_name":"Chun Yong Seow","orcid":"https://orcid.org/0000-0002-9653-8520","observed_orcids":["https://orcid.org/0000-0002-9653-8520"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chun Y. Seow","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada;","University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada;","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107827687","display_name":"Peter D. Par\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter D. Par\u00e9","raw_affiliation_strings":["Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, British Columbia, Canada","University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010189586","display_name":"Ynuk Boss\u00e9","orcid":"https://orcid.org/0000-0002-2023-3130","observed_orcids":["https://orcid.org/0000-0002-2023-3130"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ynuk Boss\u00e9","raw_affiliation_strings":["University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of British Columbia, James Hogg Research Center, St. Paul's Hospital Vancouver, British Columbia, Canada;","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010189586"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"],"apc_list":null,"apc_paid":null,"fwci":2.2488,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.87037037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"114","issue":"3","first_page":"335","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.2583000063896179,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.1680999994277954,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.10769999772310257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/airway-smooth-muscle-contractility","display_name":"airway smooth muscle contractility","score":0.9179999828338623},{"id":"https://openalex.org/keywords/breathing-maneuvers","display_name":"breathing maneuvers","score":0.7440000176429749},{"id":"https://openalex.org/keywords/smooth-muscle-tone","display_name":"smooth muscle tone","score":0.7929999828338623},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tracheal-smooth-muscle","display_name":"tracheal smooth muscle","score":0.7149999737739563},{"id":"https://openalex.org/keywords/transpulmonary-pressure","display_name":"transpulmonary pressure","score":0.7170000076293945},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.8411251306533813},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6318022012710571},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5660274028778076},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5416392087936401},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.5090200901031494},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4742923080921173},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.463886559009552},{"id":"https://openalex.org/C2781375409","wikidata":"https://www.wikidata.org/wiki/Q1147377","display_name":"Muscle tone","level":2,"score":0.4125981032848358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35045069456100464},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31984585523605347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31487107276916504},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/japplphysiol.00870.2012","doi":"https://doi.org/10.1152/japplphysiol.00870.2012","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.00870.2012","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:23195632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23195632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"mag:2181324112","doi":null,"is_oa":false,"landing_page_url":"https://jap.physiology.org/content/jap/early/2012/11/21/japplphysiol.00870.2012.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5301215330","display_name":null,"funder_award_id":"MOP13271","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G9000221039","display_name":null,"funder_award_id":"MOP-37924","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1509047519","https://openalex.org/W1698593587","https://openalex.org/W1708366040","https://openalex.org/W1937043149","https://openalex.org/W1965162921","https://openalex.org/W1968199450","https://openalex.org/W1991524561","https://openalex.org/W2013426829","https://openalex.org/W2013613525","https://openalex.org/W2021400722","https://openalex.org/W2031113923","https://openalex.org/W2039721686","https://openalex.org/W2042027156","https://openalex.org/W2042760500","https://openalex.org/W2053299045","https://openalex.org/W2054992221","https://openalex.org/W2056926754","https://openalex.org/W2062128449","https://openalex.org/W2074096822","https://openalex.org/W2076512203","https://openalex.org/W2093464302","https://openalex.org/W2100144388","https://openalex.org/W2109911119","https://openalex.org/W2110501046","https://openalex.org/W2126790740","https://openalex.org/W2134312563","https://openalex.org/W2135514741","https://openalex.org/W2143932517","https://openalex.org/W2163496762","https://openalex.org/W2170621629","https://openalex.org/W2180290358","https://openalex.org/W2227709721","https://openalex.org/W2259347332","https://openalex.org/W2314907436"],"related_works":["https://openalex.org/W2013426829","https://openalex.org/W2181324112","https://openalex.org/W3000219837","https://openalex.org/W2129390478","https://openalex.org/W2269644498","https://openalex.org/W2263884411","https://openalex.org/W2035796389","https://openalex.org/W1791425165","https://openalex.org/W2178190895","https://openalex.org/W2084802407"],"abstract_inverted_index":{"The":[0],"lung":[1],"is":[2,27,31,39],"a":[3],"dynamic":[4],"organ":[5],"and":[6,51,80,84,119,181],"the":[7,12,32,35,42,56,62,81,91,148,182,192,213,219,230,244],"oscillating":[8,74],"stress":[9,33,75,107,125,157],"applied":[10],"to":[11,73,240],"airway":[13,20],"wall":[14],"during":[15,129,224],"breathing":[16,49,78,225,251],"maneuvers":[17],"can":[18,54],"decrease":[19],"smooth":[21],"muscle":[22],"(ASM)":[23],"contractility.":[24],"However,":[25,189],"it":[26,30],"unclear":[28],"whether":[29,52],"or":[34,93],"attendant":[36],"strain":[37,83,138,169,209,220,233],"that":[38,76,216],"responsible":[40],"for":[41],"decline":[43,57,85,149,183,199,245],"of":[44,58,86,95,98,131,143,150,177,184,200,232,246],"ASM":[45,115,223],"force":[46,59,87,121,151,185,201,247],"associated":[47],"with":[48],"maneuvers,":[50,79],"tone":[53,99,135,217,236],"prevent":[55],"by":[60,101,117,122,222,235,249],"attenuating":[61],"strain.":[63],"To":[64],"investigate":[65],"these":[66],"questions,":[67],"ovine":[68],"tracheal":[69],"strips":[70,116],"were":[71,88,127,159],"subjected":[72],"simulates":[77],"resulting":[82],"measured":[89],"in":[90],"absence":[92],"presence":[94],"different":[96],"levels":[97],"elicited":[100],"acetylcholine.":[102],"In":[103],"relaxed":[104],"ASM,":[105],"high":[106],"simulating":[108],"20":[109],"cm":[110],"H(2)O-transpulmonary":[111],"pressure":[112],"excursions":[113],"strained":[114],"20.7%":[118],"decreased":[120],"17.1%.":[123],"When":[124,156],"oscillations":[126,158],"initiated":[128,160],"measurement":[130],"ACh":[132,141,175,194],"concentration-response":[133],"curves,":[134],"almost":[136,171],"abrogated":[137,172],"at":[139,173,191],"an":[140,174],"concentration":[142,176,195],"10(-6)":[144,178],"M":[145,179],"(1.1%)":[146],"but":[147],"was":[152,170,186,203,237],"not":[153,238],"affected":[154],"(18.9%).":[155],"after":[161],"ACh-induced":[162],"contraction":[163],"had":[164],"reached":[165],"its":[166,241],"maximal":[167],"force,":[168],"(0.9%)":[180],"attenuated":[187,218],"(10.1%).":[188],"even":[190],"highest":[193],"(10(-4)":[196],"M),":[197],"substantial":[198],"(6.1%)":[202],"still":[204],"observed":[205],"despite":[206],"very":[207],"small":[208],"(0.7%).":[210],"As":[211],"expected,":[212],"results":[214],"indicate":[215],"experienced":[221],"maneuver":[226],"simulations.":[227],"More":[228],"surprisingly,":[229],"reduction":[231],"induced":[234,248],"proportional":[239],"effect":[242],"on":[243],"simulated":[250],"maneuvers.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}