{"id":"https://openalex.org/W2125975264","doi":null,"title":"Functional contributions of carbohydrate on AIDS virus glycoprotein.","display_name":"Functional contributions of carbohydrate on AIDS virus glycoprotein.","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2125975264","mag":"2125975264","pmid":"https://pubmed.ncbi.nlm.nih.gov/21165339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3002149"},"language":"en","primary_location":{"id":"pmid:21165339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21165339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Yale journal of biology and medicine","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3002149/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032168191","display_name":"Elizabeth Stansell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Stansell","raw_affiliation_strings":["New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069303302","display_name":"Ronald C. Desrosiers","orcid":"https://orcid.org/0000-0001-6851-3003","observed_orcids":["https://orcid.org/0000-0001-6851-3003"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald C Desrosiers","raw_affiliation_strings":["Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.1979,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.11372549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"83","issue":"4","first_page":"201","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.7505000233650208,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.2371000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6840000152587891},{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.949999988079071},{"id":"https://openalex.org/keywords/viral-envelope-glycoprotein","display_name":"viral envelope glycoprotein","score":0.7910000085830688},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/antibody-neutralization","display_name":"antibody neutralization","score":0.9269999861717224},{"id":"https://openalex.org/keywords/reticuloendothelial-system","display_name":"reticuloendothelial system","score":0.6890000104904175},{"id":"https://openalex.org/keywords/virus-dissemination","display_name":"virus dissemination","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sooty-mangabey","display_name":"sooty mangabey","score":0.9049999713897705},{"id":"https://openalex.org/keywords/natural-hosts","display_name":"natural hosts","score":0.48399999737739563},{"id":"https://openalex.org/keywords/host-virus-coevolution","display_name":"host-virus coevolution","score":0.7820000052452087},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.727840006351471},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7268103361129761},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6583962440490723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6172305941581726},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.6031787991523743},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5601090788841248},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5016994476318359},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.49586591124534607},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.4708784520626068},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.4696703851222992},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3810079097747803},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.2544102072715759},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16677570343017578}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:21165339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21165339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Yale journal of biology and medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3002149","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3002149/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/4773992","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:4773992","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"mag:2181579537","doi":null,"is_oa":false,"landing_page_url":"http://dash.harvard.edu/bitstream/handle/1/4773992/3002149.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2125975264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21165339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3002149","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3002149/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yale J Biol Med","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W96640158","https://openalex.org/W116794318","https://openalex.org/W1517203114","https://openalex.org/W1532310879","https://openalex.org/W1547260693","https://openalex.org/W1559504720","https://openalex.org/W1584590512","https://openalex.org/W1604267887","https://openalex.org/W1762774688","https://openalex.org/W1971650271","https://openalex.org/W1972932827","https://openalex.org/W1982749682","https://openalex.org/W1982977832","https://openalex.org/W1985025703","https://openalex.org/W1988398636","https://openalex.org/W1990693013","https://openalex.org/W1992551845","https://openalex.org/W1994654252","https://openalex.org/W1997677784","https://openalex.org/W2001675486","https://openalex.org/W2001773708","https://openalex.org/W2004548429","https://openalex.org/W2006907788","https://openalex.org/W2012097474","https://openalex.org/W2019293593","https://openalex.org/W2020465880","https://openalex.org/W2022322687","https://openalex.org/W2023323209","https://openalex.org/W2033966179","https://openalex.org/W2039899944","https://openalex.org/W2042476299","https://openalex.org/W2044141862","https://openalex.org/W2047919622","https://openalex.org/W2048034139","https://openalex.org/W2050293562","https://openalex.org/W2051005349","https://openalex.org/W2054915946","https://openalex.org/W2061145598","https://openalex.org/W2062561488","https://openalex.org/W2063918211","https://openalex.org/W2079683200","https://openalex.org/W2086325331","https://openalex.org/W2091107017","https://openalex.org/W2095747840","https://openalex.org/W2095749962","https://openalex.org/W2097125112","https://openalex.org/W2100057660","https://openalex.org/W2102733228","https://openalex.org/W2108934160","https://openalex.org/W2112604471","https://openalex.org/W2113045961","https://openalex.org/W2117786107","https://openalex.org/W2123220889","https://openalex.org/W2124660271","https://openalex.org/W2125091383","https://openalex.org/W2132138777","https://openalex.org/W2133160469","https://openalex.org/W2133629725","https://openalex.org/W2134123088","https://openalex.org/W2138802639","https://openalex.org/W2140893264","https://openalex.org/W2143794378","https://openalex.org/W2151489679","https://openalex.org/W2152281378","https://openalex.org/W2156643487","https://openalex.org/W2156764168","https://openalex.org/W2157104740","https://openalex.org/W2165415478","https://openalex.org/W2168398800","https://openalex.org/W2171992047","https://openalex.org/W2172027452","https://openalex.org/W2181039790","https://openalex.org/W2185414611"],"related_works":["https://openalex.org/W157431217","https://openalex.org/W2117230039","https://openalex.org/W2108043643","https://openalex.org/W7098310648","https://openalex.org/W2326890156","https://openalex.org/W4298283509","https://openalex.org/W2005283961","https://openalex.org/W2172027452","https://openalex.org/W2027082037","https://openalex.org/W7100017469"],"abstract_inverted_index":{"Envelope":[0],"glycoprotein":[1,54,131],"spikes":[2,32],"on":[3,127,177,219,227],"the":[4,7,15,30,34,48,51,74,93,107,125,128,139,150,155,160,172,175,181,184,188,191,228,237,244,250],"surface":[5,53],"of":[6,36,47,50,55,58,73,92,95,110,138,152,162,174,183,236],"human":[8],"immunodeficiency":[9,64,252],"virus":[10,16,65,153,221,229],"(HIV)":[11],"are":[12,33],"used":[13],"by":[14,134],"to":[17,19,22,99],"bind":[18],"cellular":[20,136],"receptors":[21],"gain":[23],"entry":[24],"into":[25],"target":[26,109],"cells.":[27],"As":[28],"such,":[29],"envelope":[31,130],"targets":[35],"antibodies":[37,111],"that":[38,79,90,103,112,124,198,209,248],"can":[39,80],"neutralize":[40,114],"viral":[41,101,115,129],"infectivity.":[42],"Fifty":[43],"percent":[44],"or":[45],"more":[46],"mass":[49],"viral-encoded":[52],"HIV,":[56],"and":[57,143,222,230],"its":[59,204],"close":[60],"monkey":[61],"relative":[62],"simian":[63],"(SIV),":[66],"is":[67,71,98,120,132],"actually":[68],"carbohydrate;":[69],"it":[70,119],"one":[72,91],"most":[75],"heavily":[76],"glycosylated":[77],"proteins":[78,235],"be":[81,106,240],"found":[82],"in":[83,149,171,190,213,233],"mammals.":[84],"It":[85],"has":[86],"been":[87],"clearly":[88],"demonstrated":[89,168],"functions":[94],"this":[96,210],"carbohydrate":[97,126,176,214,225],"shield":[100],"epitopes":[102],"would":[104],"otherwise":[105],"direct":[108],"could":[113,239],"infection.":[116,205],"In":[117],"addition,":[118],"now":[121,207],"generally":[122],"accepted":[123],"recognized":[133],"multiple":[135],"lectins":[137],"host":[140,156,197,238],"lymphoreticular":[141],"system,":[142],"these":[144],"interactions":[145],"play":[146],"a":[147,195],"role":[148],"dissemination":[151],"within":[154],"as":[157,159],"well":[158],"release":[161],"modulatory":[163],"cytokines.":[164],"Our":[165],"work":[166],"recently":[167],"fundamental":[169,211],"differences":[170,232],"composition":[173,215,226],"HIV":[178],"type":[179],"1,":[180],"cause":[182],"AIDS":[185],"pandemic,":[186],"versus":[187],"SIV":[189],"sooty":[192],"mangabey":[193],"monkey,":[194],"natural":[196],"does":[199],"not":[200],"develop":[201],"disease":[202],"from":[203],"We":[206],"speculate":[208],"difference":[212],"reflects":[216],"evolutionary":[217],"pressures":[218],"both":[220],"host.":[223],"Furthermore,":[224],"genetic":[231],"carbohydrate-sensing":[234],"critically":[241],"important":[242],"for":[243],"generalized":[245],"lymphoid":[246],"activation":[247],"characterizes":[249],"acquired":[251],"syndrome":[253],"(AIDS).":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}