{"id":"https://openalex.org/W2125963799","doi":"https://doi.org/10.1056/nejmoa1012912","title":"Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection","display_name":"Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection","publication_year":2011,"publication_date":"2011-06-22","ids":{"openalex":"https://openalex.org/W2125963799","doi":"https://doi.org/10.1056/nejmoa1012912","mag":"2125963799","pmid":"https://pubmed.ncbi.nlm.nih.gov/21696307"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa1012912","doi":"https://doi.org/10.1056/nejmoa1012912","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1012912","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012912?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012912?articleTools=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073144925","display_name":"Ira M. Jacobson","orcid":"https://orcid.org/0000-0003-1803-2214","observed_orcids":["https://orcid.org/0000-0003-1803-2214"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira M. Jacobson","raw_affiliation_strings":["Weill Cornell Medical College and Center for the Study of Hepatitis C, New York, NY 10021, USA. imj2001@med.cornell.edu","Weill Cornell Medical College and Center for the Study of Hepatitis C, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medical College and Center for the Study of Hepatitis C, New York, NY 10021, USA. imj2001@med.cornell.edu","institution_ids":[]},{"raw_affiliation_string":"Weill Cornell Medical College and Center for the Study of Hepatitis C, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064179616","display_name":"John G. McHutchison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. McHutchison","raw_affiliation_strings":["Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052742729","display_name":"Geoffrey M Dusheiko","orcid":"https://orcid.org/0000-0002-9579-4469","observed_orcids":["https://orcid.org/0000-0002-9579-4469"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geoffrey Dusheiko","raw_affiliation_strings":["Royal Free Hospital, Centre for Hepatology, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free Hospital, Centre for Hepatology, London","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022731052","display_name":"Adrian M. Di Bisceglie","orcid":"https://orcid.org/0000-0002-6075-9305","observed_orcids":["https://orcid.org/0000-0002-6075-9305"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian M. Di Bisceglie","raw_affiliation_strings":["Saint Louis University School of Medicine, St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University School of Medicine, St. Louis","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039066540","display_name":"K. Rajender Reddy","orcid":"https://orcid.org/0000-0002-4898-7778","observed_orcids":["https://orcid.org/0000-0002-4898-7778"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Rajender Reddy","raw_affiliation_strings":["Division of Gastroenterology, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108118027","display_name":"Natalie H. Bzowej","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801780550","display_name":"California Pacific Medical Center","ror":"https://ror.org/02bjh0167","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114073160","https://openalex.org/I2801780550"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie H. Bzowej","raw_affiliation_strings":["California Pacific Medical Center, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Pacific Medical Center, San Francisco","institution_ids":["https://openalex.org/I2801780550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013246678","display_name":"Patrick Marcellin","orcid":"https://orcid.org/0000-0001-8950-0287","observed_orcids":["https://orcid.org/0000-0001-8950-0287"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Marcellin","raw_affiliation_strings":["H\u00f4pital Beaujon, Service d'H\u00e9patologie and INSERM CRB3, Clichy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Beaujon, Service d'H\u00e9patologie and INSERM CRB3, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2799502834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112868903","display_name":"Andrew J. Muir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Muir","raw_affiliation_strings":["Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute and Division of Gastroenterology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073197069","display_name":"P\u00e9ter Ferenci","orcid":"https://orcid.org/0000-0003-2306-1992","observed_orcids":["https://orcid.org/0000-0003-2306-1992"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Peter Ferenci","raw_affiliation_strings":["University of Vienna, Vienna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Vienna","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058746547","display_name":"Robert Flisiak","orcid":"https://orcid.org/0000-0003-3394-1635","observed_orcids":["https://orcid.org/0000-0003-3394-1635"]},"institutions":[{"id":"https://openalex.org/I146122375","display_name":"Medical University of Bia\u0142ystok","ror":"https://ror.org/00y4ya841","country_code":"PL","type":"education","lineage":["https://openalex.org/I146122375"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Robert Flisiak","raw_affiliation_strings":["Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland","institution_ids":["https://openalex.org/I146122375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101478389","display_name":"Jacob George","orcid":"https://orcid.org/0000-0002-6592-3215","observed_orcids":["https://orcid.org/0000-0002-6592-3215","https://orcid.org/0000-0002-1811-1118"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]},{"id":"https://openalex.org/I4210145422","display_name":"Westmead Institute for Medical Research","ror":"https://ror.org/04zj3ra44","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210145422"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacob George","raw_affiliation_strings":["Storr Liver Unit, Westmead Millennium Institute for Medical Research and Westmead Hospital, University of Sydney, Westmead, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Storr Liver Unit, Westmead Millennium Institute for Medical Research and Westmead Hospital, University of Sydney, Westmead, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705","https://openalex.org/I4210145422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108104775","display_name":"Mario Rizzetto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Rizzetto","raw_affiliation_strings":["Department of Gastroenterology, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085278805","display_name":"Daniel Shouval","orcid":"https://orcid.org/0000-0002-0512-6513","observed_orcids":["https://orcid.org/0000-0002-0512-6513"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Shouval","raw_affiliation_strings":["Liver Unit, Hadassah\u2013Hebrew University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Unit, Hadassah\u2013Hebrew University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104043390","display_name":"Ricard L. Sola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ricard Sola","raw_affiliation_strings":["Hospital del Mar, Institut Municipal d'Investigaci\u00f3 M\u00e9dica, Universitat Aut\u00f3noma de Barcelona, Barcelona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar, Institut Municipal d'Investigaci\u00f3 M\u00e9dica, Universitat Aut\u00f3noma de Barcelona, Barcelona","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042248916","display_name":"Rub\u00e9n Terg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruben A. Terg","raw_affiliation_strings":["Hospital de Gastroenterolog\u00eda Dr. Bonorino Udaondo, Buenos Aires"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Gastroenterolog\u00eda Dr. Bonorino Udaondo, Buenos Aires","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067141465","display_name":"Eric M. Yoshida","orcid":"https://orcid.org/0000-0003-2910-7461","observed_orcids":["https://orcid.org/0000-0003-2910-7461"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2802832906","display_name":"Vancouver General Hospital","ror":"https://ror.org/02zg69r60","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I141074466","https://openalex.org/I2799475292","https://openalex.org/I2802832906"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric M. Yoshida","raw_affiliation_strings":["University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2802832906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040817770","display_name":"Nathalie Adda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathalie Adda","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010156977","display_name":"Leif Bengtsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif Bengtsson","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073452309","display_name":"Abdul J. Sankoh","orcid":"https://orcid.org/0009-0001-2618-0447","observed_orcids":["https://orcid.org/0009-0001-2618-0447"]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul J. Sankoh","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057269368","display_name":"Tara L. Kieffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara L. Kieffer","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041578015","display_name":"Shelley George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley George","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011659892","display_name":"Robert S. Kauffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Kauffman","raw_affiliation_strings":["Vertex Pharmaceuticals, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Cambridge, MA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108469430","display_name":"Stefan Zeuzem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Zeuzem","raw_affiliation_strings":["Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]}],"institutions":[],"countries_distinct_count":11,"institutions_distinct_count":22,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":272.7971,"has_fulltext":true,"cited_by_count":2398,"citation_normalized_percentile":{"value":0.99987676,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"364","issue":"25","first_page":"2405","last_page":"2416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telaprevir","display_name":"telaprevir","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/peginterferon-alfa-2a","display_name":"peginterferon alfa-2a","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peginterferon-ribavirin","display_name":"peginterferon/ribavirin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9319999814033508},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.5720000267028809},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.6769999861717224},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.7129999995231628},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.7210000157356262},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.6460000276565552},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.7400000095367432},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hcv-rna","display_name":"HCV RNA","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9571608304977417},{"id":"https://openalex.org/C2778159067","wikidata":"https://www.wikidata.org/wiki/Q408557","display_name":"Telaprevir","level":5,"score":0.8689744472503662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8599853515625},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6833974123001099},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6446505784988403},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6121631860733032},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5786467790603638},{"id":"https://openalex.org/C2776235749","wikidata":"https://www.wikidata.org/wiki/Q420056","display_name":"Peginterferon alfa-2a","level":5,"score":0.5750113129615784},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4214402139186859},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.41821444034576416},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.285892128944397},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.096520334482193},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1056/nejmoa1012912","doi":"https://doi.org/10.1056/nejmoa1012912","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1012912","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012912?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:21696307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21696307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial, Phase III"},{"id":"pmh:oai:cris.unibo.it:11585/129215","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/129215","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1356662","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1356662/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NEW ENGLAND JOURNAL OF MEDICINE , 364 (25) pp. 2405-2416. (2011)","raw_type":"Article"},{"id":"pmh:oai:iris.unimore.it:11380/1237244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1237244","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/97842","doi":null,"is_oa":true,"landing_page_url":"http://www.nejm.org/doi/full/10.1056/NEJMoa1012912","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1056/nejmoa1012912","doi":"https://doi.org/10.1056/nejmoa1012912","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejmoa1012912","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJMoa1012912?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312517","display_name":"Vertex Pharmaceuticals","ror":"https://ror.org/00anb1726"},{"id":"https://openalex.org/F4320337533","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/00py81415"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125963799.pdf","grobid_xml":"https://content.openalex.org/works/W2125963799.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1970734373","https://openalex.org/W1979174109","https://openalex.org/W1982433898","https://openalex.org/W1983585538","https://openalex.org/W1984175031","https://openalex.org/W1995724407","https://openalex.org/W2024043429","https://openalex.org/W2027545702","https://openalex.org/W2058538904","https://openalex.org/W2063285149","https://openalex.org/W2063859957","https://openalex.org/W2075282196","https://openalex.org/W2077719713","https://openalex.org/W2099703904","https://openalex.org/W2100797437","https://openalex.org/W2103362199","https://openalex.org/W2119764771","https://openalex.org/W2127685726","https://openalex.org/W2168911689","https://openalex.org/W2321119966","https://openalex.org/W2792087431"],"related_works":["https://openalex.org/W2331799591","https://openalex.org/W1574395574","https://openalex.org/W1968396938","https://openalex.org/W2087556592","https://openalex.org/W1977139658","https://openalex.org/W2022967203","https://openalex.org/W2161030888","https://openalex.org/W1970047932","https://openalex.org/W2031877686","https://openalex.org/W1488272728"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,42],"phase":[2,45],"2":[3],"trials,":[4],"telaprevir,":[5],"a":[6,37,74,119,155,216,268],"hepatitis":[7],"C":[8],"virus":[9],"(HCV)":[10],"genotype":[11,57,331],"1":[12,58,332],"protease":[13],"inhibitor,":[14],"in":[15,36,204,211,296,304,327,347],"combination":[16],"with":[17,21,28,55,79,123,130,159,236,248,310,314,319,329,340],"peginterferon-ribavirin,":[18,311],"as":[19,312],"compared":[20,313],"peginterferon-ribavirin":[22,91,124,131,144,160,169,279,315],"alone,":[23,316],"has":[24],"shown":[25],"improved":[26,321],"efficacy,":[27],"potential":[29],"for":[30,66,84,93,107,125,132,161,227],"shortening":[31],"the":[32,67,146,149,177,190,205,212,228,231,237,245,287,297,305,348],"duration":[33],"of":[34,39,71,143,148,168,179,194,230,242,244,256,284,286,323,344,350],"treatment":[35,65,196,288],"majority":[38,349],"patients.":[40,351],"METHODS:":[41],"this":[43],"international,":[44],"3,":[46],"randomized,":[47],"double-blind,":[48],"placebo-controlled":[49],"trial,":[50],"we":[51],"assigned":[52],"1088":[53],"patients":[54,180,203,246,272,328],"HCV":[56,97,111,151,185,330],"infection":[59,68,333],"who":[60,181,334],"had":[61,182,215,335],"not":[62,336],"received":[63,337],"previous":[64,338],"to":[69,252,291],"one":[70],"three":[72],"groups:":[73],"group":[75,120,156,209,214,235],"receiving":[76,121,157,273,278],"telaprevir":[77,122,249,274],"combined":[78],"peginterferon":[80],"alfa-2a":[81],"and":[82,104,128,221,263,299,302,356],"ribavirin":[83],"12":[85,94,105,139,162],"weeks":[86,95,102,109,127,134,142,167,188,255,343],"(T12PR":[87],"group),":[88,136],"followed":[89,137,164],"by":[90,138,165,353],"alone":[92],"if":[96,110],"RNA":[98,112,152,186],"was":[99,113,176,294,317],"undetectable":[100,183],"at":[101,115,267],"4":[103,133],"or":[106,140,154,207,233],"36":[108,141,166],"detectable":[114],"either":[116],"time":[117],"point;":[118],"8":[126],"placebo":[129,158],"(T8PR":[135],"on":[145],"basis":[147],"same":[150],"criteria;":[153],"weeks,":[163],"(PR":[170],"group).":[171,239],"The":[172,281],"primary":[173],"end":[174],"point":[175],"proportion":[178],"plasma":[184],"24":[187,254,342],"after":[189],"last":[191],"planned":[192],"dose":[193],"study":[195],"(sustained":[197],"virologic":[198,218,325],"response).":[199],"RESULTS:":[200],"Significantly":[201],"more":[202],"T12PR":[206,232,298],"T8PR":[208,234,300],"than":[210,275],"PR":[213,238,306],"sustained":[217,324],"response":[219,326],"(75%":[220],"69%,":[222],"respectively,":[223],"vs.":[224],"44%;":[225],"P<0.001":[226],"comparison":[229],"A":[240],"total":[241,257],"58%":[243],"treated":[247],"were":[250],"eligible":[251],"receive":[253],"treatment.":[258],"Anemia,":[259],"gastrointestinal":[260],"side":[261],"effects,":[262],"skin":[264],"rashes":[265],"occurred":[266],"higher":[269],"incidence":[270],"among":[271,276],"those":[277],"alone.":[280],"overall":[282],"rate":[283],"discontinuation":[285],"regimen":[289],"owing":[290],"adverse":[292],"events":[293],"10%":[295],"groups":[301],"7%":[303],"group.":[307],"CONCLUSIONS:":[308],"Telaprevir":[309],"associated":[318],"significantly":[320],"rates":[322],"treatment,":[339],"only":[341],"therapy":[345],"administered":[346],"(Funded":[352],"Vertex":[354],"Pharmaceuticals":[355],"Tibotec;":[357],"ADVANCE":[358],"ClinicalTrials.gov":[359],"number,":[360],"NCT00627926.).":[361]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":56},{"year":2018,"cited_by_count":58},{"year":2017,"cited_by_count":103},{"year":2016,"cited_by_count":200},{"year":2015,"cited_by_count":333},{"year":2014,"cited_by_count":488},{"year":2013,"cited_by_count":491},{"year":2012,"cited_by_count":394}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}