{"id":"https://openalex.org/W2125884064","doi":"https://doi.org/10.1091/mbc.2.11.897","title":"Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.","display_name":"Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2125884064","doi":"https://doi.org/10.1091/mbc.2.11.897","mag":"2125884064","pmid":"https://pubmed.ncbi.nlm.nih.gov/1809396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/361888"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.2.11.897","doi":"https://doi.org/10.1091/mbc.2.11.897","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.2.11.897","pdf_url":null,"source":{"id":"https://openalex.org/S4210196122","display_name":"Cell Regulation","issn_l":"1044-2030","issn":["1044-2030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Regulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/361888","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110029154","display_name":"Jin-Keon Pai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Pai","raw_affiliation_strings":["Schering-Plough Research, Bloomfield, New Jersey 07003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research, Bloomfield, New Jersey 07003","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018977621","display_name":"Emily Dobek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Dobek","raw_affiliation_strings":["Schering-Plough Research, Bloomfield, New Jersey 07003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research, Bloomfield, New Jersey 07003","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035909919","display_name":"Walter Robert Bishop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W R Bishop","raw_affiliation_strings":["Schering-Plough Research, Bloomfield, New Jersey 07003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schering-Plough Research, Bloomfield, New Jersey 07003","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5667,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.94128884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"11","first_page":"897","last_page":"903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.39010000228881836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":1.0},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.9020000100135803},{"id":"https://openalex.org/keywords/phosphatidic-acid-phosphohydrolase","display_name":"phosphatidic acid phosphohydrolase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.8790000081062317},{"id":"https://openalex.org/keywords/phosphatidylcholine-metabolism","display_name":"phosphatidylcholine metabolism","score":0.9509999752044678},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mitogenic-response","display_name":"mitogen response","score":0.6209999918937683},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9039999842643738},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.7979999780654907},{"id":"https://openalex.org/keywords/phorbol-ester","display_name":"phorbol ester","score":0.8889999985694885},{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2780202252","wikidata":"https://www.wikidata.org/wiki/Q7187448","display_name":"Phosphatidylethanol","level":5,"score":0.8166204690933228},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8118073344230652},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.7680573463439941},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.6920496225357056},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.5645999908447266},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5408814549446106},{"id":"https://openalex.org/C2909649922","wikidata":"https://www.wikidata.org/wiki/Q106318493","display_name":"Endothelins","level":4,"score":0.5185697674751282},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.48828721046447754},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4782601594924927},{"id":"https://openalex.org/C2776387844","wikidata":"https://www.wikidata.org/wiki/Q161466","display_name":"Diglyceride","level":3,"score":0.4572638273239136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43078845739364624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36898374557495117},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3473697900772095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3408028483390808},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.33662211894989014},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.3299696445465088},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21044030785560608},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18184548616409302},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.14106076955795288},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10949444770812988},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08391943573951721},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010711","descriptor_name":"Phosphatidate Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020404","descriptor_name":"Glycerophospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1091/mbc.2.11.897","doi":"https://doi.org/10.1091/mbc.2.11.897","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.2.11.897","pdf_url":null,"source":{"id":"https://openalex.org/S4210196122","display_name":"Cell Regulation","issn_l":"1044-2030","issn":["1044-2030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Regulation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/361888","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:1809396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1809396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell regulation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:361888","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC361888/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Regul","raw_type":"Text"},{"id":"mag:2185136895","doi":null,"is_oa":false,"landing_page_url":"http://www.molbiolcell.org/content/2/11/897.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/361888","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W230487446","https://openalex.org/W1245295209","https://openalex.org/W1493283928","https://openalex.org/W1499552262","https://openalex.org/W1502565639","https://openalex.org/W1516809639","https://openalex.org/W1534013912","https://openalex.org/W1536585049","https://openalex.org/W1588320719","https://openalex.org/W1589100504","https://openalex.org/W1598425752","https://openalex.org/W1883395900","https://openalex.org/W1969178507","https://openalex.org/W1974391793","https://openalex.org/W1980762198","https://openalex.org/W1982713420","https://openalex.org/W1994378208","https://openalex.org/W2007319015","https://openalex.org/W2017349436","https://openalex.org/W2019282948","https://openalex.org/W2025624617","https://openalex.org/W2053332583","https://openalex.org/W2056857208","https://openalex.org/W2059369537","https://openalex.org/W2073969885","https://openalex.org/W2103802455","https://openalex.org/W2133404596","https://openalex.org/W2142339245","https://openalex.org/W2151869895","https://openalex.org/W2152311269","https://openalex.org/W2162804111","https://openalex.org/W2235684658"],"related_works":["https://openalex.org/W2185136895","https://openalex.org/W2148874057","https://openalex.org/W2125356128","https://openalex.org/W2025288234","https://openalex.org/W7095331263","https://openalex.org/W2417993370","https://openalex.org/W1898841977","https://openalex.org/W2039021970","https://openalex.org/W2073969885","https://openalex.org/W230487446"],"abstract_inverted_index":{"Endothelins":[0],"(ETs)":[1],"are":[2,132,152],"a":[3,15,94,162,179,204,232],"family":[4],"of":[5,32,65,71,112,119,137,145,189,231,235,242],"extremely":[6],"potent":[7,16],"vasoconstrictor":[8],"peptides.":[9],"In":[10],"addition,":[11],"ET-1":[12,33,78,89,173,190,217],"acts":[13],"as":[14],"mitogen":[17],"and":[18,26,38,45,63,125,147,158],"activates":[19],"phospholipase":[20,72],"C":[21,52],"in":[22,41,46,84,165,170,182,196,218,229,240],"smooth":[23],"muscle":[24],"cells":[25,47,168,199,221],"fibroblasts.":[27],"We":[28],"examined":[29],"the":[30,85,110,135,142,183,197,219,225,236],"effects":[31],"on":[34,191],"phosphatidylcholine":[35],"(PC)":[36],"metabolism":[37],"thymidine":[39,156,176,192],"incorporation":[40,157,177,193],"control":[42,171],"Rat-6":[43],"fibroblasts":[44],"that":[48],"overexpress":[49],"protein":[50],"kinase":[51],"beta":[53],"1":[54],"(PKC).":[55],"PC":[56,140],"pools":[57],"were":[58],"labeled":[59],"with":[60,93,134,203],"[3H]myristic":[61],"acid,":[62],"formation":[64,83,107,136],"phosphatidylethanol":[66],"(PEt),":[67],"an":[68,117],"unambiguous":[69],"marker":[70],"D":[73],"(PLD)":[74],"activation,":[75],"was":[76,91,200],"monitored.":[77],"stimulated":[79],"much":[80],"greater":[81,163,180],"PEt":[82],"PKC":[86,166,184],"overexpressing":[87,167,185,198,220],"cells.":[88,172,186],"action":[90,144],"dose-dependent":[92,202],"half-maximal":[95,205],"effect":[96,188,206],"at":[97,109,207],"1.0":[98],"x":[99,209],"10(-9)":[100,210],"M.":[101,211],"With":[102],"increasing":[103],"ethanol":[104],"concentrations,":[105],"[3H]PEt":[106],"increased":[108,122],"expense":[111],"[3H]phosphatidic":[113],"acid":[114],"(PA).":[115],"Propranolol,":[116],"inhibitor":[118],"PA":[120,148],"phosphohydrolase,":[121],"[3H]PA":[123],"accumulation":[124],"decreased":[126],"[3H]diacylglycerol":[127],"(DAG)":[128],"formation.":[129],"These":[130],"data":[131],"consistent":[133],"[3H]DAG":[138],"from":[139],"by":[141,216],"sequential":[143],"PLD":[146,159,213,237],"phosphohydrolase.":[149],"Phorbol":[150],"esters":[151],"known":[153],"to":[154,161,178,224],"stimulate":[155],"activity":[160,214],"extent":[164,181],"than":[169],"also":[174,201],"stimulates":[175],"The":[187],"into":[194],"DNA":[195],"0.3":[208],"Enhanced":[212],"induced":[215],"may":[222],"contribute":[223],"mitogenic":[226],"response,":[227],"especially":[228],"light":[230],"possible":[233],"role":[234],"product,":[238],"PA,":[239],"regulation":[241],"cell":[243],"growth.":[244]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
