{"id":"https://openalex.org/W2125883556","doi":"https://doi.org/10.1093/humrep/17.7.1820","title":"Sperm DNA damage in potentially fertile homozygous -thalassaemia patients with iron overload","display_name":"Sperm DNA damage in potentially fertile homozygous -thalassaemia patients with iron overload","publication_year":2002,"publication_date":"2002-07-01","ids":{"openalex":"https://openalex.org/W2125883556","doi":"https://doi.org/10.1093/humrep/17.7.1820","mag":"2125883556","pmid":"https://pubmed.ncbi.nlm.nih.gov/12093845"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/17.7.1820","doi":"https://doi.org/10.1093/humrep/17.7.1820","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/17.7.1820","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113597391","display_name":"Doreen M.D. Perera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Perera","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University College Hospital, UCL London, Huntley Street, London WC1E 6AU, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University College Hospital, UCL London, Huntley Street, London WC1E 6AU, UK","institution_ids":["https://openalex.org/I1289784979","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036112795","display_name":"Arnold R. Pizzey","orcid":"https://orcid.org/0000-0003-1850-1121","observed_orcids":["https://orcid.org/0000-0003-1850-1121"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Pizzey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060117858","display_name":"Alexis J. Campbell","orcid":"https://orcid.org/0009-0006-0524-5543","observed_orcids":["https://orcid.org/0009-0006-0524-5543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108501838","display_name":"M. Katz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Katz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049244658","display_name":"John B. Porter","orcid":"https://orcid.org/0000-0003-3000-9359","observed_orcids":["https://orcid.org/0000-0003-3000-9359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Porter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016883742","display_name":"Mary Petrou","orcid":"https://orcid.org/0000-0003-3756-7230","observed_orcids":["https://orcid.org/0000-0003-3756-7230"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Petrou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113878672","display_name":"D. Stewart Irvine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D.S. Irvine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035245655","display_name":"R Chatterjee","orcid":"https://orcid.org/0000-0002-2895-7678","observed_orcids":["https://orcid.org/0000-0002-2895-7678","https://orcid.org/0000-0001-8344-1394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Chatterjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":0.6512,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.75335147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"17","issue":"7","first_page":"1820","last_page":"1825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sperm-dna-damage","display_name":"sperm DNA damage","score":0.9860000014305115},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8500000238418579},{"id":"https://openalex.org/keywords/sperm-chromatin-structure","display_name":"sperm chromatin structure","score":0.5929999947547913},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.722000002861023},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.6209999918937683},{"id":"https://openalex.org/keywords/chelation-therapy","display_name":"chelation therapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.656000018119812},{"id":"https://openalex.org/keywords/fertilizing-capacity","display_name":"sperm fertility","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.8551839590072632},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7326979041099548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6995673775672913},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.674516499042511},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6711322069168091},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.582872748374939},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.5492435097694397},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.4991161823272705},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23841407895088196},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.20021232962608337},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17186039686203003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11733171343803406}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019190","descriptor_name":"Iron Overload","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/humrep/17.7.1820","doi":"https://doi.org/10.1093/humrep/17.7.1820","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/17.7.1820","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:12093845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12093845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:91674","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/91674/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HUM REPROD , 17 (7) 1820 - 1825. (2002)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W145128157","https://openalex.org/W1506187431","https://openalex.org/W1830759764","https://openalex.org/W1983884639","https://openalex.org/W1986902208","https://openalex.org/W1991270389","https://openalex.org/W1995569721","https://openalex.org/W2000581213","https://openalex.org/W2001758547","https://openalex.org/W2004062071","https://openalex.org/W2006250045","https://openalex.org/W2010446305","https://openalex.org/W2016788433","https://openalex.org/W2017350478","https://openalex.org/W2032704919","https://openalex.org/W2044665824","https://openalex.org/W2049773799","https://openalex.org/W2066243076","https://openalex.org/W2076741728","https://openalex.org/W2077949060","https://openalex.org/W2092206306","https://openalex.org/W2105161027","https://openalex.org/W2109269254","https://openalex.org/W2138657902","https://openalex.org/W2145352726","https://openalex.org/W2152118525","https://openalex.org/W2155235097","https://openalex.org/W2164156793","https://openalex.org/W2347602582","https://openalex.org/W2414320303","https://openalex.org/W2417341788","https://openalex.org/W2441756603","https://openalex.org/W2539048729","https://openalex.org/W2615205751","https://openalex.org/W2726382541","https://openalex.org/W4387926694","https://openalex.org/W4387926919"],"related_works":["https://openalex.org/W2404804961","https://openalex.org/W2800354024","https://openalex.org/W2298557760","https://openalex.org/W2770968902","https://openalex.org/W2461857165","https://openalex.org/W7096871449","https://openalex.org/W2904282509","https://openalex.org/W21001382","https://openalex.org/W4412955779","https://openalex.org/W4396826635"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"test":[2],"the":[3,46,71,105,136,187,229],"hypothesis":[4],"that":[5,197],"human":[6],"sperm":[7,47,101,111,143,176,183,191,203],"DNA":[8,102,112,144,177,184,194,227],"could":[9],"sustain":[10],"iron-induced":[11],"oxidative":[12,205],"damage":[13,103,113,145,185,195],"and":[14,39,52,70,91,116,126,142,158,186,193],"reduce":[15],"its":[16],"fertilizing":[17],"ability,":[18],"we":[19],"studied":[20],"patients":[21,38,81,98],"with":[22,82,149,175],"homozygous":[23],"beta-thalassaemia":[24],"major":[25],"(HbTh)":[26],"as":[27,217],"a":[28],"model":[29],"of":[30,65,73,94,138,140,224],"iron":[31,68,85,198],"overload.":[32],"METHODS:":[33],"Sperm":[34,124],"from":[35],"six":[36],"thalassaemic":[37],"five":[40],"age-matched":[41],"controls":[42,106],"were":[43,76,84,118,129,146,173],"assessed":[44],"by":[45,114],"chromatin":[48],"structure":[49],"assay":[50],"(SCSA)":[51],"terminal":[53],"deoxynucleotidyl":[54],"transferase-mediated":[55],"dUTP":[56],"nick-end":[57],"labelling":[58],"(TUNEL)":[59],"assay.":[60],"Semen":[61],"parameters,":[62],"endocrine":[63],"markers":[64],"testicular":[66],"function,":[67],"profiles":[69],"presence":[72],"organ":[74],"dysfunction":[75],"also":[77],"determined.":[78],"RESULTS:":[79],"All":[80],"HbTh":[83,201],"overloaded":[86],"(median":[87],"ferritin:":[88],"2251":[89],"microg/l)":[90],"had":[92,99],"evidence":[93],"spontaneous":[95],"spermatogenesis.":[96],"Thalassaemic":[97],"more":[100],"than":[104],"(P":[107,121,132],"<":[108,122,133,165],"0.01).":[109],"The":[110,180],"SCSA":[115,151],"TUNEL":[117,127,159],"positively":[119,147],"correlated":[120,131],"0.05).":[123],"motility":[125,192],"results":[128],"negatively":[130],"0.05),":[134],"while":[135],"age":[137],"onset":[139],"chelation":[141],"associated":[148,174],"both":[150],"(R(2)":[152,161],"=":[153,156,162],"0.80,":[154],"P":[155,164],"0.016)":[157],"data":[160,172],"0.67,":[163],"0.044).":[166],"No":[167],"other":[168],"biochemical":[169],"or":[170],"clinical":[171],"damage.":[178],"CONCLUSIONS:":[179],"increase":[181],"in":[182,200,212],"negative":[188],"correlation":[189],"between":[190],"suggest":[196],"overload":[199],"predisposes":[202],"to":[204,228],"injury.":[206],"This":[207],"finding":[208],"has":[209],"important":[210],"implications":[211],"assisted":[213],"reproductive":[214],"procedures":[215],"such":[216],"ICSI":[218],"where":[219],"there":[220],"is":[221],"increased":[222],"risk":[223],"transmitting":[225],"defective":[226],"offspring.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
