{"id":"https://openalex.org/W2125849751","doi":"https://doi.org/10.1016/j.jchromb.2011.05.048","title":"Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry","display_name":"Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry","publication_year":2011,"publication_date":"2011-06-25","ids":{"openalex":"https://openalex.org/W2125849751","doi":"https://doi.org/10.1016/j.jchromb.2011.05.048","mag":"2125849751","pmid":"https://pubmed.ncbi.nlm.nih.gov/21704573"},"language":"en","primary_location":{"id":"doi:10.1016/j.jchromb.2011.05.048","doi":"https://doi.org/10.1016/j.jchromb.2011.05.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2011.05.048","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019155943","display_name":"Yuzhong Deng","orcid":"https://orcid.org/0009-0003-2066-5878","observed_orcids":["https://orcid.org/0009-0003-2066-5878"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuzhong Deng","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA. yuzhongd@gene.com","Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA. yuzhongd@gene.com","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006218365","display_name":"Harvey H. Wong","orcid":"https://orcid.org/0000-0003-1550-5071","observed_orcids":["https://orcid.org/0000-0003-1550-5071"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey Wong","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111983289","display_name":"Richard Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Graham","raw_affiliation_strings":["Clinical Pharmacology, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373258","display_name":"Wenbin Liu","orcid":"https://orcid.org/0000-0002-7111-2638","observed_orcids":["https://orcid.org/0000-0002-7111-2638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenbin Liu","raw_affiliation_strings":["QPS, Newark, DE 19711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QPS, Newark, DE 19711, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080073544","display_name":"Heuy-shin Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heuy-shin Shen","raw_affiliation_strings":["QPS, Newark, DE 19711, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"QPS, Newark, DE 19711, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yao Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao Shi","raw_affiliation_strings":["Tandem Labs, Salt Lake City, UT 84124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tandem Labs, Salt Lake City, UT 84124, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076731050","display_name":"Laixin Wang","orcid":"https://orcid.org/0000-0002-8850-3782","observed_orcids":["https://orcid.org/0000-0002-8850-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laixin Wang","raw_affiliation_strings":["Tandem Labs, Salt Lake City, UT 84124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tandem Labs, Salt Lake City, UT 84124, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103354149","display_name":"Min Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Meng","raw_affiliation_strings":["Tandem Labs, Salt Lake City, UT 84124, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tandem Labs, Salt Lake City, UT 84124, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076085121","display_name":"Vikram Malhi","orcid":"https://orcid.org/0000-0003-0185-3091","observed_orcids":["https://orcid.org/0000-0003-0185-3091"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Malhi","raw_affiliation_strings":["Clinical Pharmacology, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101398995","display_name":"Xiao Ding","orcid":"https://orcid.org/0000-0002-3851-1792","observed_orcids":["https://orcid.org/0000-0002-3851-1792","https://orcid.org/0000-0002-3287-7611"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Ding","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090073956","display_name":"Brian Dean","orcid":"https://orcid.org/0000-0001-7773-4473","observed_orcids":["https://orcid.org/0000-0001-7773-4473"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Dean","raw_affiliation_strings":["Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019155943"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":1.3146,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.75123505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"879","issue":"22","first_page":"2119","last_page":"2126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vismodegib","display_name":"vismodegib","score":1.0},{"id":"https://openalex.org/keywords/unbound-drug-concentration","display_name":"unbound drug concentration","score":0.9380000233650208},{"id":"https://openalex.org/keywords/plasma-drug-quantitation","display_name":"plasma drug quantification","score":0.7269999980926514},{"id":"https://openalex.org/keywords/equilibrium-dialysis","display_name":"equilibrium dialysis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lc-ms-ms-method-development","display_name":"LC-MS/MS method development","score":0.8629999756813049},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"plasma protein binding","score":0.5170000195503235},{"id":"https://openalex.org/keywords/clinical-pharmacokinetics","display_name":"clinical pharmacokinetics","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9087144136428833},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.8900039792060852},{"id":"https://openalex.org/C2779545874","wikidata":"https://www.wikidata.org/wiki/Q2070286","display_name":"Vismodegib","level":4,"score":0.8261024355888367},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.6323710680007935},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.6195604801177979},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.581948459148407},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.5581153035163879},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5427120327949524},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.5069723129272461},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.4551749527454376},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052616","descriptor_name":"Solid Phase Extraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jchromb.2011.05.048","doi":"https://doi.org/10.1016/j.jchromb.2011.05.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jchromb.2011.05.048","pdf_url":null,"source":{"id":"https://openalex.org/S103248676","display_name":"Journal of Chromatography B","issn_l":"1570-0232","issn":["1570-0232","1873-376X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography B","raw_type":"journal-article"},{"id":"pmid:21704573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21704573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1963493384","https://openalex.org/W1965431780","https://openalex.org/W1987380529","https://openalex.org/W2003055758","https://openalex.org/W2010237337","https://openalex.org/W2014523565","https://openalex.org/W2016151415","https://openalex.org/W2050569781","https://openalex.org/W2117774671","https://openalex.org/W2121017846","https://openalex.org/W2139433233","https://openalex.org/W2139499843","https://openalex.org/W2163122422"],"related_works":["https://openalex.org/W2181758709","https://openalex.org/W1986765936","https://openalex.org/W2082326552","https://openalex.org/W2799479772","https://openalex.org/W2327313300","https://openalex.org/W4403612254","https://openalex.org/W2133190858","https://openalex.org/W4405808075","https://openalex.org/W2793592117","https://openalex.org/W2771515957"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}