{"id":"https://openalex.org/W2125846063","doi":"https://doi.org/10.1067/mhj.2001.109947","title":"The smooth muscle cell membrane during atherogenesis: A potential target for amlodipine in atheroprotection","display_name":"The smooth muscle cell membrane during atherogenesis: A potential target for amlodipine in atheroprotection","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2125846063","doi":"https://doi.org/10.1067/mhj.2001.109947","mag":"2125846063","pmid":"https://pubmed.ncbi.nlm.nih.gov/11174352"},"language":"en","primary_location":{"id":"doi:10.1067/mhj.2001.109947","doi":"https://doi.org/10.1067/mhj.2001.109947","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mhj.2001.109947","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056933276","display_name":"Thomas N. Tulenko","orcid":"https://orcid.org/0000-0002-7802-418X","observed_orcids":["https://orcid.org/0000-0002-7802-418X"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I2802476176","display_name":"Lankenau Medical Center","ror":"https://ror.org/00f2gwr16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313504624","https://openalex.org/I2802476176"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.N. Tulenko","raw_affiliation_strings":["Division of Vascular Biology, Lankenau Medical Research Center, Wynnewood, and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University School of Medicine, Philadelphia, USA. tulenko@MLHS.org","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vascular Biology, Lankenau Medical Research Center, Wynnewood, and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University School of Medicine, Philadelphia, USA. tulenko@MLHS.org","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I2802476176"]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021181045","display_name":"Anne E. Sumner","orcid":"https://orcid.org/0000-0001-9640-8999","observed_orcids":["https://orcid.org/0000-0001-9640-8999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.E. Sumner","raw_affiliation_strings":["Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Chen","raw_affiliation_strings":["Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066444153","display_name":"Yingfei Huang","orcid":"https://orcid.org/0000-0003-2225-6341","observed_orcids":["https://orcid.org/0000-0003-2225-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Huang","raw_affiliation_strings":["Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059216200","display_name":"Lisa D. Laury\u2010Kleintop","orcid":"https://orcid.org/0000-0002-4297-9128","observed_orcids":["https://orcid.org/0000-0002-4297-9128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Laury-Kleintop","raw_affiliation_strings":["Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006955282","display_name":"Francis D. Ferdinand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F.D. Ferdinand","raw_affiliation_strings":["Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","Bethesda, Md","Charlottesville, Va","Wynnewood and Philadelphia, Pa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa; Bethesda, Md; and Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Bethesda, Md","institution_ids":[]},{"raw_affiliation_string":"Charlottesville, Va","institution_ids":[]},{"raw_affiliation_string":"Wynnewood and Philadelphia, Pa","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":0.4185,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.46568627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"141","issue":"2","first_page":"S1","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.984000027179718},{"id":"https://openalex.org/keywords/atheroprotection","display_name":"atheroprotection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/free-cholesterol","display_name":"free cholesterol","score":0.847000002861023},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/calcium-permeability","display_name":"calcium permeability","score":0.7390000224113464},{"id":"https://openalex.org/keywords/plaque-formation","display_name":"plaque formation","score":0.4909999966621399},{"id":"https://openalex.org/keywords/membrane-remodeling","display_name":"membrane remodeling","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8636236190795898},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6056796908378601},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.534599244594574},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.44486480951309204},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4431675970554352},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4388121962547302},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.43209052085876465},{"id":"https://openalex.org/C3020090656","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Arterial wall","level":2,"score":0.426568865776062},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34850743412971497},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34440165758132935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2921484112739563},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.23530462384223938},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1067/mhj.2001.109947","doi":"https://doi.org/10.1067/mhj.2001.109947","is_oa":false,"landing_page_url":"https://doi.org/10.1067/mhj.2001.109947","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},{"id":"pmid:11174352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11174352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American heart journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2875615668","display_name":null,"funder_award_id":"HL-51538","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3838684156","display_name":"PLATELET AND LIPOPROTEIN FUNCTION IN AFRICAN-AMERICANS","funder_award_id":"7r01hl051538-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G750158792","display_name":null,"funder_award_id":"HL-66273","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G757396721","display_name":"SMOOTH MUSCLE CELL MEMBRANE DURING ATHEROGENESIS","funder_award_id":"R01HL066273","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W15264890","https://openalex.org/W90395005","https://openalex.org/W113714250","https://openalex.org/W180946569","https://openalex.org/W200100059","https://openalex.org/W566776808","https://openalex.org/W1243991366","https://openalex.org/W1499736085","https://openalex.org/W1500080863","https://openalex.org/W1514900157","https://openalex.org/W1525444530","https://openalex.org/W1595210603","https://openalex.org/W1857052429","https://openalex.org/W1957207912","https://openalex.org/W1968171440","https://openalex.org/W1974520442","https://openalex.org/W1977909041","https://openalex.org/W1979788647","https://openalex.org/W1982675479","https://openalex.org/W1987292860","https://openalex.org/W1987904634","https://openalex.org/W1991419403","https://openalex.org/W1996672595","https://openalex.org/W1997526709","https://openalex.org/W2000239031","https://openalex.org/W2001392137","https://openalex.org/W2003185073","https://openalex.org/W2004532334","https://openalex.org/W2005910570","https://openalex.org/W2009789367","https://openalex.org/W2016746678","https://openalex.org/W2019127252","https://openalex.org/W2020454682","https://openalex.org/W2024016453","https://openalex.org/W2032319088","https://openalex.org/W2035381251","https://openalex.org/W2042617777","https://openalex.org/W2045862477","https://openalex.org/W2054728789","https://openalex.org/W2056034929","https://openalex.org/W2057624406","https://openalex.org/W2061755142","https://openalex.org/W2063673474","https://openalex.org/W2065858058","https://openalex.org/W2067091655","https://openalex.org/W2069157264","https://openalex.org/W2071733813","https://openalex.org/W2083647583","https://openalex.org/W2084240983","https://openalex.org/W2084744450","https://openalex.org/W2084870400","https://openalex.org/W2095530088","https://openalex.org/W2103342908","https://openalex.org/W2117140855","https://openalex.org/W2120491756","https://openalex.org/W2121972309","https://openalex.org/W2130497556","https://openalex.org/W2131900346","https://openalex.org/W2132248886","https://openalex.org/W2132337803","https://openalex.org/W2135902934","https://openalex.org/W2137570167","https://openalex.org/W2151426663","https://openalex.org/W2151892297","https://openalex.org/W2154641472","https://openalex.org/W2158865088","https://openalex.org/W2162458714","https://openalex.org/W2165773709","https://openalex.org/W2165852896","https://openalex.org/W2246457688","https://openalex.org/W2254967054","https://openalex.org/W2265277925","https://openalex.org/W2315403385","https://openalex.org/W2316167515","https://openalex.org/W2317242858","https://openalex.org/W2324841714","https://openalex.org/W2329306090","https://openalex.org/W2416595332","https://openalex.org/W2472201763","https://openalex.org/W3023642540","https://openalex.org/W3153495156","https://openalex.org/W6608074492","https://openalex.org/W6716115897"],"related_works":["https://openalex.org/W1996672595","https://openalex.org/W1679789629","https://openalex.org/W2083722269","https://openalex.org/W1989099597","https://openalex.org/W2157089989","https://openalex.org/W1975371898","https://openalex.org/W2133084112","https://openalex.org/W2419457469","https://openalex.org/W2947052764","https://openalex.org/W1975618767"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}