{"id":"https://openalex.org/W2125754454","doi":"https://doi.org/10.3109/08977199609034571","title":"Expression of Trefoil Peptides in The Gastric Mucosa of Transgenic Mice Overexpressing Transforming Growth Factor-\u03b1","display_name":"Expression of Trefoil Peptides in The Gastric Mucosa of Transgenic Mice Overexpressing Transforming Growth Factor-\u03b1","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2125754454","doi":"https://doi.org/10.3109/08977199609034571","mag":"2125754454","pmid":"https://pubmed.ncbi.nlm.nih.gov/8962716"},"language":"en","primary_location":{"id":"doi:10.3109/08977199609034571","doi":"https://doi.org/10.3109/08977199609034571","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08977199609034571","pdf_url":null,"source":{"id":"https://openalex.org/S152803389","display_name":"Growth Factors","issn_l":"0897-7194","issn":["0897-7194","1026-7964","1029-2292"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth Factors","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010236925","display_name":"James R. Goldenring","orcid":"https://orcid.org/0000-0002-7833-2940","observed_orcids":["https://orcid.org/0000-0002-7833-2940"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James R. Goldenring","raw_affiliation_strings":["Department of Medicine, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912, USA","Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta 30912, USA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043932592","display_name":"Richard Poulsom","orcid":"https://orcid.org/0000-0001-8567-3543","observed_orcids":["https://orcid.org/0000-0001-8567-3543"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Poulsom","raw_affiliation_strings":["Histopathology Unit, Imperial Cancer Research Fund, London, UK; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Histopathology Unit, Imperial Cancer Research Fund, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histopathology Unit, Imperial Cancer Research Fund, London, UK; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Histopathology Unit, Imperial Cancer Research Fund, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030962569","display_name":"Gregory S. Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S. Ray","raw_affiliation_strings":["Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicholas Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Wright","raw_affiliation_strings":["Histopathology Unit, Imperial Cancer Research Fund, London, UK; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Histopathology Unit, Imperial Cancer Research Fund, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histopathology Unit, Imperial Cancer Research Fund, London, UK; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]},{"raw_affiliation_string":"Histopathology Unit, Imperial Cancer Research Fund, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061586311","display_name":"Katherine S. Meise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine S. Meise","raw_affiliation_strings":["Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA","Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I2799702486","https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I2799702486","display_name":"Charlie Norwood VA Medical Center","ror":"https://ror.org/01ng1yh19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799702486","https://openalex.org/I2799886695","https://openalex.org/I4210131075"]},{"id":"https://openalex.org/I4210103776","display_name":"Nashville VA Medical Center","ror":"https://ror.org/024xyyq03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210103776","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Coffey","raw_affiliation_strings":["Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA","Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA; Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I2799702486","https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Vanderbilt University and the Nashville VA Medical Center, Nashville, Tennessee, 37232, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210103776","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Departments of Medicine, Cellular Biology and Anatomy, and Surgery, Institute for Molecular Medicine and Genetics, Medical College of Georgia and the Augusta VA Medical Center, Augusta, Georgia, 30912, USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010236925"],"corresponding_institution_ids":["https://openalex.org/I25041050","https://openalex.org/I2799702486"],"apc_list":null,"apc_paid":null,"fwci":2.4384,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89057386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"13","issue":"1-2","first_page":"111","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trefoil-peptides","display_name":"trefoil peptides","score":0.9739999771118164},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.9850000143051147},{"id":"https://openalex.org/keywords/goblet-cell-hyperplasia","display_name":"goblet cell hyperplasia","score":0.8450000286102295},{"id":"https://openalex.org/keywords/ps2","display_name":"pS2","score":0.7730000019073486},{"id":"https://openalex.org/keywords/trefoil-factor-3","display_name":"TFF3","score":0.9610000252723694},{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chief-cells","display_name":"chief cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cadmium-sulfate","display_name":"cadmium sulfate","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C90378955","wikidata":"https://www.wikidata.org/wiki/Q5476344","display_name":"Foveolar cell","level":4,"score":0.8942172527313232},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.7585663199424744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7129554152488708},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.6024259328842163},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.520165205001831},{"id":"https://openalex.org/C66595182","wikidata":"https://www.wikidata.org/wiki/Q2595765","display_name":"Gastric chief cell","level":4,"score":0.4735621213912964},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.45197439193725586},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44863080978393555},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.44453132152557373},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2633504867553711},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2565821707248688},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.18163982033729553},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059232354164123535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.047328829765319824}],"mesh":[{"descriptor_ui":"D000071164","descriptor_name":"Trefoil Factor-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071165","descriptor_name":"Trefoil Factor-3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016211","descriptor_name":"Transforming Growth Factor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/08977199609034571","doi":"https://doi.org/10.3109/08977199609034571","is_oa":false,"landing_page_url":"https://doi.org/10.3109/08977199609034571","pdf_url":null,"source":{"id":"https://openalex.org/S152803389","display_name":"Growth Factors","issn_l":"0897-7194","issn":["0897-7194","1026-7964","1029-2292"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth Factors","raw_type":"journal-article"},{"id":"pmid:8962716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8962716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Growth factors (Chur, Switzerland)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2085485765","display_name":null,"funder_award_id":"DK-43405","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8868505193","display_name":"Role of EGFR Ligands in Neoplasia","funder_award_id":"R01CA046413","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000900904","display_name":"Small GTP Binding Proteins in Gastrointestinal Mucosa","funder_award_id":"R01DK048370","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1503167124","https://openalex.org/W1616273863","https://openalex.org/W1704710159","https://openalex.org/W1981107040","https://openalex.org/W1999556404","https://openalex.org/W2024721720","https://openalex.org/W2033613795","https://openalex.org/W2046515864","https://openalex.org/W2050608860","https://openalex.org/W2061139841","https://openalex.org/W2067419365","https://openalex.org/W2071607446","https://openalex.org/W2076243351","https://openalex.org/W2091145180","https://openalex.org/W2107336884","https://openalex.org/W2111493908","https://openalex.org/W2134812217","https://openalex.org/W2144512179","https://openalex.org/W2147782099","https://openalex.org/W2153517923","https://openalex.org/W2156315689","https://openalex.org/W2337828249","https://openalex.org/W4298437252"],"related_works":["https://openalex.org/W2076243351","https://openalex.org/W2107336884","https://openalex.org/W124916940","https://openalex.org/W2153517923","https://openalex.org/W2067849918","https://openalex.org/W4247053566","https://openalex.org/W1981107040","https://openalex.org/W2128891019","https://openalex.org/W1704710159","https://openalex.org/W2408395510"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,10,25,31,38,48,80,103,123,166,184,252,259,271,283,293,301,316],"transforming":[2],"growth":[3],"factor-alpha":[4],"(TGF-alpha)":[5],"in":[6,22,45,67,72,83,132,144,147,154,169,181,194,202,210,217,222,240,249,256,267,290,307],"the":[7,23,26,32,36,46,62,68,78,112,164,175,182,218,235,250,253,277,299,302,314],"gastric":[8,117,224,281],"mucosa":[9,118,183],"metallothionein-TGF":[11],"alpha":[12,74,85,88,128,137,152,159,190,204,228,309],"(MT-TGF":[13],"alpha)":[14],"transgenic":[15],"mice":[16,75,89,205,310],"leads":[17,34],"to":[18,35,58,276,313],"a":[19,42,268],"marked":[20],"alteration":[21],"ontogeny":[24],"fundic":[27,167],"cellular":[28],"lineages.":[29,54],"Induction":[30],"transgene":[33],"over-production":[37],"mucous":[39,63,69,196,220,272,304],"cells":[40,197,201,221,274,319],"with":[41,96],"concomitant":[43],"diminution":[44],"development":[47],"parietal":[49,200],"cell":[50,53,64,70,305],"and":[51,90,116,126,131,198],"chief":[52],"We":[55],"have":[56],"sought":[57],"define":[59],"more":[60,179],"precisely":[61],"lineages":[65],"involved":[66],"hyperplasia":[71,315],"MT-TGF":[73,84,87,151,203,227,308],"by":[76,129,143],"investigating":[77],"expression":[79,122,139,176,246,264,282],"trefoil":[81,124,285,324],"peptides":[82,125],"mice.":[86,149,260,294],"their":[91,321],"non-transgenic":[92,148],"littermates":[93],"were":[94,106,161],"treated":[95],"cadmium":[97],"sulfate":[98],"beginning":[99],"at":[100,109,163,206],"13":[101,170],"days":[102],"age.":[104],"Animals":[105],"then":[107],"sacrificed":[108],"intervals":[110],"over":[111],"following":[113],"2":[114],"weeks":[115],"was":[119,177,192,215,232,247,265,288],"examined":[120],"for":[121,157],"TGF":[127,136,158,189],"immunohistochemistry":[130],"situ":[133,145,155,211,241],"hybridization.":[134],"No":[135,280],"mRNA":[138,160,214,231],"could":[140],"be":[141],"demonstrated":[142],"hybridization":[146],"In":[150,226],"mice,":[153,229],"grains":[156],"detected":[162,216],"base":[165],"glands":[168],"day":[171],"old":[172],"animals,":[173],"whereas":[174],"observed":[178,193,248],"widely":[180],"older":[185],"animals":[186],"(28":[187],"days).":[188],"immunoreactivity":[191],"foveolar":[195,237,303],"residual":[199],"all":[207],"ages.":[208],"By":[209,239,261],"hybridization,":[212,242],"pS2":[213,230],"surface":[219,318],"normal":[223,317],"mucosa.":[225],"found":[233],"throughout":[234],"expanded":[236],"region.":[238],"spasmolytic":[243],"peptide":[244],"(SP)":[245],"region":[251],"progenitor":[254,278],"zone":[255],"both":[257],"groups":[258],"immunohistochemistry,":[262],"SP":[263],"noted":[266,289],"broad":[269],"band":[270],"neck":[273],"deep":[275],"zone.":[279],"intestinal":[284],"factor":[286],"(ITF)":[287],"either":[291],"group":[292],"The":[295],"results":[296],"demonstrate":[297],"that":[298],"expansion":[300],"compartment":[306],"is":[311],"due":[312],"expressing":[320],"particular":[322],"mucin-associated":[323],"peptide,":[325],"pS2.":[326]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
