{"id":"https://openalex.org/W2125697196","doi":"https://doi.org/10.2174/1381612811319310002","title":"Commercial Aspects of Pharmaceutical Protein Production in Plants","display_name":"Commercial Aspects of Pharmaceutical Protein Production in Plants","publication_year":2013,"publication_date":"2013-08-01","ids":{"openalex":"https://openalex.org/W2125697196","doi":"https://doi.org/10.2174/1381612811319310002","mag":"2125697196","pmid":"https://pubmed.ncbi.nlm.nih.gov/23394566"},"language":"en","primary_location":{"id":"doi:10.2174/1381612811319310002","doi":"https://doi.org/10.2174/1381612811319310002","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612811319310002","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049288387","display_name":"Rainer Fischer","orcid":"https://orcid.org/0000-0002-6704-2569","observed_orcids":["https://orcid.org/0000-0002-6704-2569"]},"institutions":[{"id":"https://openalex.org/I4210134473","display_name":"Fraunhofer Institute for Molecular Biology and Applied Ecology","ror":"https://ror.org/03j85fc72","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210134473","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Fischer","raw_affiliation_strings":["Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, 52074 Aachen, Germany. rainer.fischer@molbiotech.rwth-aachen.de","Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Forckenbeckstrasse 6, 52074, Aachen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, 52074 Aachen, Germany. rainer.fischer@molbiotech.rwth-aachen.de","institution_ids":["https://openalex.org/I4210134473"]},{"raw_affiliation_string":"Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Forckenbeckstrasse 6, 52074, Aachen, Germany","institution_ids":["https://openalex.org/I4210134473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047164999","display_name":"Stefan Schillberg","orcid":"https://orcid.org/0000-0002-1896-4575","observed_orcids":["https://orcid.org/0000-0002-1896-4575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Schillberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080120118","display_name":"Johannes F. Buyel","orcid":"https://orcid.org/0000-0003-2361-143X","observed_orcids":["https://orcid.org/0000-0003-2361-143X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johannes Buyel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018974531","display_name":"Richard M. Twyman","orcid":"https://orcid.org/0000-0002-8764-3003","observed_orcids":["https://orcid.org/0000-0002-8764-3003"]},"institutions":[{"id":"https://openalex.org/I4210134473","display_name":"Fraunhofer Institute for Molecular Biology and Applied Ecology","ror":"https://ror.org/03j85fc72","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210134473","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Richard Twyman","raw_affiliation_strings":["Fraunhofer IME, Forckenbeckstrasse 6, 52074 Aachen, Germany.,Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fraunhofer IME, Forckenbeckstrasse 6, 52074 Aachen, Germany.,Germany","institution_ids":["https://openalex.org/I4210134473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018974531"],"corresponding_institution_ids":["https://openalex.org/I4210134473"],"apc_list":null,"apc_paid":null,"fwci":15.7228,"has_fulltext":false,"cited_by_count":127,"citation_normalized_percentile":{"value":0.99955746,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"19","issue":"31","first_page":"5471","last_page":"5477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-farming","display_name":"molecular farming","score":0.9700000286102295},{"id":"https://openalex.org/keywords/commercialization","display_name":"commercialization","score":0.7089999914169312},{"id":"https://openalex.org/keywords/manufacturing-economics","display_name":"manufacturing economics","score":0.6819999814033508},{"id":"https://openalex.org/keywords/regulatory-approval","display_name":"regulatory approval","score":0.7459999918937683},{"id":"https://openalex.org/keywords/plant-based-drugs","display_name":"plant-derived drugs","score":0.5450000166893005},{"id":"https://openalex.org/keywords/biopharmaceutical-manufacturing","display_name":"biopharmaceutical manufacturing","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.7524251341819763},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.6171546578407288},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.5719431042671204},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.5448753833770752},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5164085030555725},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.5109009146690369},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5066186189651489},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4352734088897705},{"id":"https://openalex.org/C118518473","wikidata":"https://www.wikidata.org/wiki/Q11451","display_name":"Agriculture","level":2,"score":0.42348551750183105},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3719068765640259},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.3205769658088684},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28134334087371826},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2183171510696411},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.10262167453765869},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09750804305076599},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058634","descriptor_name":"Molecular Farming","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2174/1381612811319310002","doi":"https://doi.org/10.2174/1381612811319310002","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612811319310002","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:23394566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23394566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/233298","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/233298","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:publications.rwth-aachen.de:231045","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/231045","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current pharmaceutical design 19(31), 5471-5477 (2013). doi:10.2174/1381612811319310002","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W267809647","https://openalex.org/W348514121","https://openalex.org/W1504978712","https://openalex.org/W1814267858","https://openalex.org/W1935558359","https://openalex.org/W1938146555","https://openalex.org/W1964431647","https://openalex.org/W1966710608","https://openalex.org/W1973026317","https://openalex.org/W1973060237","https://openalex.org/W1976818625","https://openalex.org/W1982261885","https://openalex.org/W1985154901","https://openalex.org/W1988253322","https://openalex.org/W1992194094","https://openalex.org/W1998962839","https://openalex.org/W1999449101","https://openalex.org/W1999615285","https://openalex.org/W1999762007","https://openalex.org/W2007235959","https://openalex.org/W2017076506","https://openalex.org/W2026760618","https://openalex.org/W2029793786","https://openalex.org/W2047694403","https://openalex.org/W2050519822","https://openalex.org/W2052165793","https://openalex.org/W2055366778","https://openalex.org/W2055529119","https://openalex.org/W2065166818","https://openalex.org/W2065804181","https://openalex.org/W2076771656","https://openalex.org/W2084560434","https://openalex.org/W2084600650","https://openalex.org/W2085535868","https://openalex.org/W2087375639","https://openalex.org/W2088465788","https://openalex.org/W2095072719","https://openalex.org/W2099326296","https://openalex.org/W2103456166","https://openalex.org/W2103986567","https://openalex.org/W2104061791","https://openalex.org/W2107410272","https://openalex.org/W2114409495","https://openalex.org/W2128905980","https://openalex.org/W2131304438","https://openalex.org/W2133084831","https://openalex.org/W2137122846","https://openalex.org/W2146221143","https://openalex.org/W2152073450","https://openalex.org/W2154524414","https://openalex.org/W2156801977","https://openalex.org/W2159423922","https://openalex.org/W2160937038","https://openalex.org/W2163779721","https://openalex.org/W2167381455","https://openalex.org/W2168252164"],"related_works":["https://openalex.org/W88216339","https://openalex.org/W2330686171","https://openalex.org/W2042610086","https://openalex.org/W2097641133","https://openalex.org/W4246853176","https://openalex.org/W1814267858","https://openalex.org/W6986761915","https://openalex.org/W2560541791","https://openalex.org/W1557093560","https://openalex.org/W2167381455"],"abstract_inverted_index":{"Many":[0],"different":[1],"plant-based":[2],"systems":[3],"have":[4,17],"been":[5],"used":[6],"to":[7,25,44,53,56,73,159,166],"produce":[8],"recombinant":[9,100],"pharmaceutical":[10,101,126],"proteins":[11],"but":[12,129],"only":[13,118],"a":[14,26,32,111,124],"small":[15],"number":[16],"made":[18],"the":[19,37,48,66,85,90,93,97,121,136,150],"leap":[20],"from":[21],"an":[22],"experimental":[23],"platform":[24,140],"viable":[27,62],"commercial":[28,125,151],"process.":[29],"This":[30],"reflects":[31],"combination":[33],"of":[34,96,123,138,153],"factors,":[35],"principally":[36],"technical":[38],"issues":[39],"that":[40,51,69,75,134],"must":[41,70],"be":[42,54,71],"addressed":[43],"achieve":[45],"competitive":[46,163],"performance,":[47],"economic":[49],"principles":[50],"need":[52],"satisfied":[55],"ensure":[57,74],"manufacturing":[58,127],"processes":[59],"are":[60,80,108],"financially":[61],"and":[63,65,83,164],"sustainable,":[64],"regulatory":[67],"demands":[68,122],"met":[72],"pharmaceuticals":[76],"manufactured":[77],"in":[78,114,142],"plants":[79,116,161],"safe,":[81],"efficacious":[82],"meet":[84,119],"quality":[86],"standards":[87],"demanded":[88],"by":[89],"regulators.":[91],"With":[92],"recent":[94],"approval":[95],"first":[98],"plant-derived":[99],"protein":[102],"designated":[103],"for":[104],"human":[105],"use,":[106],"we":[107,148],"now":[109],"entering":[110],"new":[112],"era":[113],"which":[115],"not":[117],"all":[120],"process":[128],"also":[130],"provide":[131],"unique":[132],"benefits":[133],"allow":[135],"displacement":[137],"established":[139],"technologies":[141],"niche":[143],"markets.":[144],"In":[145],"this":[146],"article,":[147],"consider":[149],"aspects":[152],"molecular":[154],"farming,":[155],"specifically":[156],"those":[157],"required":[158],"make":[160],"more":[162],"attractive":[165],"industry.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}