{"id":"https://openalex.org/W2125514916","doi":"https://doi.org/10.1136/thx.2009.127860","title":"Stable breathing through deeper sleeping","display_name":"Stable breathing through deeper sleeping","publication_year":2010,"publication_date":"2010-02-01","ids":{"openalex":"https://openalex.org/W2125514916","doi":"https://doi.org/10.1136/thx.2009.127860","mag":"2125514916","pmid":"https://pubmed.ncbi.nlm.nih.gov/20147587"},"language":"en","primary_location":{"id":"doi:10.1136/thx.2009.127860","doi":"https://doi.org/10.1136/thx.2009.127860","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2009.127860","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/65/2/95.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/65/2/95.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058046289","display_name":"Julian P. Saboisky","orcid":"https://orcid.org/0000-0002-9450-6023","observed_orcids":["https://orcid.org/0000-0002-9450-6023"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Saboisky","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049574784","display_name":"Danny Joel Eckert","orcid":"https://orcid.org/0000-0003-3503-2363","observed_orcids":["https://orcid.org/0000-0003-3503-2363"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Eckert","raw_affiliation_strings":["Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047479450","display_name":"Atul Malhotra","orcid":"https://orcid.org/0000-0002-9509-1827","observed_orcids":["https://orcid.org/0000-0002-9509-1827"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Malhotra","raw_affiliation_strings":["Sleep Disorders Research Program @ BIDMC, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sleep Disorders Research Program @ BIDMC, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047479450"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"2","first_page":"95","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arousal-threshold","display_name":"arousal threshold","score":0.8230000138282776},{"id":"https://openalex.org/keywords/loop-gain","display_name":"loop gain","score":0.6880000233650208},{"id":"https://openalex.org/keywords/genioglossus-muscle-activity","display_name":"genioglossus muscle activity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.6359999775886536},{"id":"https://openalex.org/keywords/palatal-surgery","display_name":"palatal surgery","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxygen-therapy","display_name":"oxygen therapy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/negative-intrathoracic-pressure","display_name":"negative intrathoracic pressure","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8784223794937134},{"id":"https://openalex.org/C39300077","wikidata":"https://www.wikidata.org/wiki/Q9530","display_name":"Breathing","level":2,"score":0.499147891998291},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.18641537427902222}],"mesh":[{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012132","descriptor_name":"Respiratory Muscles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012684","descriptor_name":"Sensory Thresholds","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015656","descriptor_name":"Respiratory Mechanics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/thx.2009.127860","doi":"https://doi.org/10.1136/thx.2009.127860","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2009.127860","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/65/2/95.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmid:20147587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20147587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Comment"},{"id":"pmh:oai:open-archive.highwire.org:thoraxjnl:65/2/95","doi":null,"is_oa":false,"landing_page_url":"http://thorax.bmj.com/cgi/content/short/65/2/95","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/thx.2009.127860","doi":"https://doi.org/10.1136/thx.2009.127860","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2009.127860","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/65/2/95.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125514916.pdf","grobid_xml":"https://content.openalex.org/works/W2125514916.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W75661469","https://openalex.org/W86149107","https://openalex.org/W176521327","https://openalex.org/W1550070515","https://openalex.org/W1907753500","https://openalex.org/W1968771781","https://openalex.org/W1994514417","https://openalex.org/W1998771643","https://openalex.org/W2001717327","https://openalex.org/W2025076604","https://openalex.org/W2031452919","https://openalex.org/W2031929064","https://openalex.org/W2037230674","https://openalex.org/W2040308656","https://openalex.org/W2047789059","https://openalex.org/W2062290383","https://openalex.org/W2066544084","https://openalex.org/W2066549636","https://openalex.org/W2069549923","https://openalex.org/W2071398317","https://openalex.org/W2073056023","https://openalex.org/W2073188226","https://openalex.org/W2106219309","https://openalex.org/W2107651449","https://openalex.org/W2129643487","https://openalex.org/W2132327194","https://openalex.org/W2135299483","https://openalex.org/W2143959552","https://openalex.org/W2165867819","https://openalex.org/W2170936790","https://openalex.org/W2185139471","https://openalex.org/W2258738341","https://openalex.org/W2315303495","https://openalex.org/W2337812196","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2185926067","https://openalex.org/W86149107","https://openalex.org/W2553491817","https://openalex.org/W3211704752","https://openalex.org/W2152450535","https://openalex.org/W2113363140","https://openalex.org/W2781784885","https://openalex.org/W2135299483","https://openalex.org/W2969527734","https://openalex.org/W4367607958"],"abstract_inverted_index":{"Although":[0],"there":[1],"is":[2,44,103,153,176],"evidence":[3],"that":[4,31,96,156,215,233],"patients":[5,42,81,116,217],"with":[6,15,62,82,117,218,240],"obstructive":[7],"sleep":[8,172],"apnoea":[9],"(OSA)":[10],"have":[11,127,142,221],"anatomical":[12,49,65],"susceptibility":[13],"coupled":[14],"abnormalities":[16],"in":[17,24,52,76,108,130,146,162,196,244],"upper":[18],"airway":[19],"motor":[20,60],"control":[21,61,70,148],"and/or":[22],"instability":[23],"ventilatory":[25,69,147],"control,":[26],"the":[27,32,46,87,99,109,131,163,190,193,197,208,213,245],"data":[28],"now":[29,93],"suggest":[30],"mechanisms":[33],"underlying":[34,101],"OSA":[35,43,118,164,200,219],"vary":[36],"considerably":[37],"between":[38],"patients.1":[39],"In":[40,114],"some":[41,222],"primarily":[45,126],"result":[47],"of":[48,80,89,98,189,192,199,210,224],"problems,":[50],"while":[51],"others":[53],"it":[54],"may":[55,73,141],"be":[56,74,106,179],"due":[57],"to":[58,105,122,139,178,205],"dysfunctional":[59],"only":[63,77],"minimal":[64],"abnormality.":[66],"Similarly,":[67],"abnormal":[68],"(loop":[71],"gain)":[72],"important":[75],"a":[78,85],"subgroup":[79],"OSA.2":[83],"As":[84],"result,":[86],"concept":[88,155],"individualised":[90],"therapy":[91],"has":[92,157,201],"emerged,":[94],"such":[95],"treatment":[97],"major":[100],"abnormality":[102,129,145],"likely":[104],"beneficial":[107],"appropriately":[110],"targeted":[111],"patient":[112],"subgroups.3":[113],"theory,":[115],"who":[119,136],"respond":[120,137],"well":[121,138],"palatal":[123],"surgery":[124],"probably":[125],"an":[128,144],"velopharyngeal":[132],"anatomy,4":[133],"whereas":[134],"those":[135],"oxygen":[140],"mainly":[143],"instability.5":[149],"6\n\nThe":[150],"arousal":[151,170,194],"threshold":[152,195],"one":[154],"received":[158],"some\u2014but":[159],"not":[160],"sufficient\u2014attention":[161],"arena.7":[165],"8":[166],"The":[167,187],"trigger":[168],"for":[169],"from":[171],"during":[173],"respiratory":[174],"events":[175],"believed":[177],"increasing":[180],"negative":[181],"intrathoracic":[182],"pressure9":[183],"(see":[184],"figure":[185],"1).":[186],"realisation":[188],"importance":[191],"pathogenesis":[198],"recently":[202,231],"been":[203],"brought":[204],"light":[206],"by":[207],"work":[209],"Younes,":[211],"particularly":[212],"emphasis":[214],"most":[216],"spontaneously":[220],"periods":[223,237],"stable":[225,235],"breathing.10":[226],"11":[227],"Jordan":[228],"et":[229],"al":[230],"observed":[232],"these":[234],"breathing":[236],"were":[238],"associated":[239],"markedly":[241],"increased":[242],"activity":[243],"genioglossus,":[246],"\u2026":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}