{"id":"https://openalex.org/W2125437156","doi":"https://doi.org/10.3109/00498258409151454","title":"Low-dose chronic inhalation of diesel exhaust and/or coal dust by rats: Effect of age and exposure on lung and liver cytochrome P-450","display_name":"Low-dose chronic inhalation of diesel exhaust and/or coal dust by rats: Effect of age and exposure on lung and liver cytochrome P-450","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W2125437156","doi":"https://doi.org/10.3109/00498258409151454","mag":"2125437156","pmid":"https://pubmed.ncbi.nlm.nih.gov/6334412"},"language":"en","primary_location":{"id":"doi:10.3109/00498258409151454","doi":"https://doi.org/10.3109/00498258409151454","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00498258409151454","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077636545","display_name":"Jean Rabovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Rabovsky","raw_affiliation_strings":["National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058282228","display_name":"Karl J. Marion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. J. Marion","raw_affiliation_strings":["National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089021259","display_name":"Robert D. Groseclose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. D. Groseclose","raw_affiliation_strings":["National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034804807","display_name":"Trent R. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. R. Lewis","raw_affiliation_strings":["National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034386398","display_name":"Martin R. Petersen","orcid":"https://orcid.org/0000-0002-9387-7316","observed_orcids":["https://orcid.org/0000-0002-9387-7316"]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Petersen","raw_affiliation_strings":["National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Occupational Safety and Health, 944 Chestnut Ridge Road, Morgantown, West Virginia, 26505-2888, USA","institution_ids":["https://openalex.org/I198423848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I198423848"],"apc_list":null,"apc_paid":null,"fwci":0.3018,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.40699301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"7","first_page":"595","last_page":"598"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diesel-exhaust","display_name":"diesel exhaust","score":0.9940000176429749},{"id":"https://openalex.org/keywords/coal-dust","display_name":"coal dust","score":1.0},{"id":"https://openalex.org/keywords/chronic-inhalation-exposure","display_name":"chronic inhalation exposure","score":0.8709999918937683},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9430000185966492},{"id":"https://openalex.org/keywords/benzo-a-pyrene-hydroxylase","display_name":"benzo[a]pyrene hydroxylase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lung-microsomes","display_name":"lung microsomes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.8100000023841858},{"id":"https://openalex.org/keywords/low-dose-exposure","display_name":"low-dose exposure","score":0.6520000100135803},{"id":"https://openalex.org/keywords/synergistic-interaction","display_name":"synergistic interaction","score":0.460999995470047},{"id":"https://openalex.org/keywords/respiratory-tract-infections","display_name":"respiratory infections","score":0.5019999742507935},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.7650434970855713},{"id":"https://openalex.org/C3432839","wikidata":"https://www.wikidata.org/wiki/Q336041","display_name":"Diesel exhaust","level":3,"score":0.7012495994567871},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6600944995880127},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6379235982894897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5667513608932495},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.5401292443275452},{"id":"https://openalex.org/C2776674678","wikidata":"https://www.wikidata.org/wiki/Q1778575","display_name":"Coal dust","level":3,"score":0.5261659026145935},{"id":"https://openalex.org/C518851703","wikidata":"https://www.wikidata.org/wiki/Q24489","display_name":"Coal","level":2,"score":0.5004444122314453},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.49282601475715637},{"id":"https://openalex.org/C138171918","wikidata":"https://www.wikidata.org/wiki/Q38423","display_name":"Diesel fuel","level":2,"score":0.4750756621360779},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4446646273136139},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.43700656294822693},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4208196997642517},{"id":"https://openalex.org/C2779229383","wikidata":"https://www.wikidata.org/wiki/Q1501961","display_name":"Benzopyrene","level":4,"score":0.42035141587257385},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.354922890663147},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.3391129970550537},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.324989378452301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2558550238609314},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.208389014005661},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17409026622772217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14813560247421265},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1462947428226471},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1443307101726532},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14274215698242188},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06801578402519226}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000397","descriptor_name":"Air Pollution","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001579","descriptor_name":"Benzopyrene Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003031","descriptor_name":"Coal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004391","descriptor_name":"Dust","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010105","descriptor_name":"Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010578","descriptor_name":"Petroleum","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015660","descriptor_name":"7-Alkoxycoumarin O-Dealkylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00498258409151454","doi":"https://doi.org/10.3109/00498258409151454","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00498258409151454","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},{"id":"pmid:6334412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6334412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica; the fate of foreign compounds in biological systems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1515756335","https://openalex.org/W1775749144","https://openalex.org/W1949792042","https://openalex.org/W1967215004","https://openalex.org/W1993548647","https://openalex.org/W2029223623","https://openalex.org/W2036304894","https://openalex.org/W2051915753","https://openalex.org/W2161739180","https://openalex.org/W2256880598","https://openalex.org/W2329745974"],"related_works":["https://openalex.org/W2125451068","https://openalex.org/W2078725687","https://openalex.org/W1985317227","https://openalex.org/W2329745974","https://openalex.org/W2155866743","https://openalex.org/W2069415595","https://openalex.org/W2034461689","https://openalex.org/W2053533624","https://openalex.org/W2067292081","https://openalex.org/W4240091642"],"abstract_inverted_index":{"Rats":[0],"were":[1,29,44],"exposed":[2,65,75],"by":[3],"inhalation":[4],"to":[5,66,76],"low":[6],"levels":[7],"of":[8,85,95],"diesel":[9,67,88],"exhaust":[10,68,89],"and/or":[11],"coal":[12,70,77,91],"dust,":[13],"seven":[14],"hours/day,":[15],"five":[16],"days/week":[17],"for":[18,52],"24":[19,40],"months.":[20,41],"Cytochrome":[21],"P-450-associated":[22],"benzo[a]pyrene":[23,55],"hydroxylase":[24,56],"and":[25,33,39,50,90,93],"7-ethoxycoumarin":[26],"deethylase":[27],"activities":[28],"assayed":[30],"in":[31,60,73,83],"lung":[32,61],"liver":[34],"microsomes":[35,62],"after":[36],"3,":[37],"6,":[38],"When":[42],"data":[43],"analysed":[45],"across":[46],"all":[47],"time":[48],"intervals":[49],"adjusted":[51],"age,":[53],"lower":[54],"activity":[57],"was":[58],"observed":[59],"from":[63],"rats":[64],"plus":[69],"dust":[71,78,92],"than":[72],"those":[74],"alone.":[79],"Data":[80],"are":[81],"discussed":[82],"terms":[84],"interaction":[86],"between":[87],"effect":[94],"infectious":[96],"agents.":[97]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
