{"id":"https://openalex.org/W2125372126","doi":"https://doi.org/10.2337/db15-0060","title":"Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model","display_name":"Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W2125372126","doi":"https://doi.org/10.2337/db15-0060","mag":"2125372126","pmid":"https://pubmed.ncbi.nlm.nih.gov/25845663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4876789"},"language":"en","primary_location":{"id":"doi:10.2337/db15-0060","doi":"https://doi.org/10.2337/db15-0060","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db15-0060","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4876789/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053683423","display_name":"Manoj Amrutkar","orcid":"https://orcid.org/0000-0002-1868-0249","observed_orcids":["https://orcid.org/0000-0002-1868-0249"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Manoj Amrutkar","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083514157","display_name":"Emmelie Cansby","orcid":"https://orcid.org/0000-0003-1589-3596","observed_orcids":["https://orcid.org/0000-0003-1589-3596"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Emmelie Cansby","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067455670","display_name":"Urszula Chursa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Urszula Chursa","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068490300","display_name":"Esther Nu\u00f1ez\u2010Dur\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Esther Nu\u00f1ez-Dur\u00e1n","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064944204","display_name":"Bel\u00e9n Chancl\u00f3n","orcid":"https://orcid.org/0000-0001-7170-9699","observed_orcids":["https://orcid.org/0000-0001-7170-9699"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bel\u00e9n Chancl\u00f3n","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110056994","display_name":"Marcus St\u00e5hlman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marcus St\u00e5hlman","raw_affiliation_strings":["Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041295224","display_name":"Vincent Frid\u00e9n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Vincent Frid\u00e9n","raw_affiliation_strings":["Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","3Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"3Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085648546","display_name":"Louise Manner\u00e5s-Holm","orcid":"https://orcid.org/0000-0001-8783-6107","observed_orcids":["https://orcid.org/0000-0001-8783-6107"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Louise Manner\u00e5s-Holm","raw_affiliation_strings":["Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109981466","display_name":"Anna Wickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Wickman","raw_affiliation_strings":["Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","3Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"3Center for Physiology and Bio-Imaging, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028599620","display_name":"Ulf Smith","orcid":"https://orcid.org/0000-0002-1439-4608","observed_orcids":["https://orcid.org/0000-0002-1439-4608"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulf Smith","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047963662","display_name":"Fredrik B\u00e4ckhed","orcid":"https://orcid.org/0000-0002-4871-8818","observed_orcids":["https://orcid.org/0000-0002-4871-8818"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Fredrik B\u00e4ckhed","raw_affiliation_strings":["The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark","Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","4The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]},{"raw_affiliation_string":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"4The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046743882","display_name":"Jan Bor\u00e9n","orcid":"https://orcid.org/0000-0003-0786-8091","observed_orcids":["https://orcid.org/0000-0003-0786-8091"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Bor\u00e9n","raw_affiliation_strings":["Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"2Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033347099","display_name":"Brian W. Howell","orcid":"https://orcid.org/0000-0002-0204-0773","observed_orcids":["https://orcid.org/0000-0002-0204-0773"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian W. Howell","raw_affiliation_strings":["Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY","5Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"5Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001825767","display_name":"Margit Mahlapuu","orcid":"https://orcid.org/0000-0001-8740-8874","observed_orcids":["https://orcid.org/0000-0001-8740-8874"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Margit Mahlapuu","raw_affiliation_strings":["Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001825767"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":1.7999,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.85015596,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"8","first_page":"2791","last_page":"2804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stk25","display_name":"STK25","score":0.9980000257492065},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.7829999923706055},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.8809999823570251},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hepatic-gluconeogenesis","display_name":"hepatic gluconeogenesis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/skeletal-muscle-lipid-accumulation","display_name":"skeletal muscle lipid accumulation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.984000027179718},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.809600830078125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7867525815963745},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.6289820075035095},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5530645251274109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5394246578216553},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5188940167427063},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.4656069576740265},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.45322829484939575},{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.4146898090839386},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4140820801258087},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.3824808597564697},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.305574893951416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19479092955589294}],"mesh":[{"descriptor_ui":"D000099317","descriptor_name":"Hippo Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000103","descriptor_name":"Acetyl-CoA Carboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.2337/db15-0060","doi":"https://doi.org/10.2337/db15-0060","is_oa":false,"landing_page_url":"https://doi.org/10.2337/db15-0060","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4876789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4876789/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4876789/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:25845663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25845663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ef80ce1f-6403-417f-98dd-e1c580432ee8","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ef80ce1f-6403-417f-98dd-e1c580432ee8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Amrutkar, M, Cansby, E, Chursa, U, Nu\u00f1ez-Dur\u00e1n, E, Chancl\u00f3n, B, St\u00e5hlman, M, Frid\u00e9n, V, Manner\u00e5s-Holm, L, Wickman, A, Smith, U, B\u00e4ckhed, G F, Bor\u00e9n, J, Howell, B W & Mahlapuu, M 2015, 'Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model', Diabetes, vol. 64, no. 8, pp. 2791-804. https://doi.org/10.2337/db15-0060","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4876789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4876789/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4876789/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1073272279","display_name":"Regulation of Neuronal Lamination and Dendritogenesis by Reelin-Dab1 Signaling","funder_award_id":"R01NS073662","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2328104004","display_name":null,"funder_award_id":"NNF14OC0009667","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3151342425","display_name":null,"funder_award_id":"NNF14OC0010799","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G79811430","display_name":null,"funder_award_id":"NNF15OC0016484","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320309792","display_name":"\u00c5ke Wiberg Stiftelse","ror":"https://ror.org/03htnqd27"},{"id":"https://openalex.org/F4320320870","display_name":"European Foundation for the Study of Diabetes","ror":"https://ror.org/05tgz4m05"},{"id":"https://openalex.org/F4320321033","display_name":"Svenska Forskningsr\u00e5det Formas","ror":"https://ror.org/03pjs1y45"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125372126.pdf","grobid_xml":"https://content.openalex.org/works/W2125372126.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1581289874","https://openalex.org/W1973939264","https://openalex.org/W1974226533","https://openalex.org/W1984478711","https://openalex.org/W1987116516","https://openalex.org/W1992692192","https://openalex.org/W2007486805","https://openalex.org/W2007527212","https://openalex.org/W2008441088","https://openalex.org/W2013210636","https://openalex.org/W2018239208","https://openalex.org/W2026231752","https://openalex.org/W2027922031","https://openalex.org/W2037918682","https://openalex.org/W2039890062","https://openalex.org/W2041622179","https://openalex.org/W2044318948","https://openalex.org/W2045362322","https://openalex.org/W2048621255","https://openalex.org/W2057218469","https://openalex.org/W2059613020","https://openalex.org/W2065034018","https://openalex.org/W2069760818","https://openalex.org/W2075099191","https://openalex.org/W2075361499","https://openalex.org/W2090365424","https://openalex.org/W2092864050","https://openalex.org/W2092873672","https://openalex.org/W2093824918","https://openalex.org/W2099343588","https://openalex.org/W2103056721","https://openalex.org/W2111942191","https://openalex.org/W2117738749","https://openalex.org/W2120034293","https://openalex.org/W2133082302","https://openalex.org/W2135778913","https://openalex.org/W2140608779","https://openalex.org/W2140916429","https://openalex.org/W2143535526","https://openalex.org/W2145490597","https://openalex.org/W2148562280","https://openalex.org/W2158608859","https://openalex.org/W2163857095","https://openalex.org/W2163915523","https://openalex.org/W2164535496","https://openalex.org/W2168436114","https://openalex.org/W2168526937","https://openalex.org/W2169469988","https://openalex.org/W2171671091","https://openalex.org/W2319790766","https://openalex.org/W6647121870","https://openalex.org/W6678124557"],"related_works":["https://openalex.org/W2069760818","https://openalex.org/W2772393278","https://openalex.org/W2405681874","https://openalex.org/W2117738749","https://openalex.org/W2561857878","https://openalex.org/W2127212889","https://openalex.org/W2609376378","https://openalex.org/W4414383326","https://openalex.org/W7160965986","https://openalex.org/W2756648805"],"abstract_inverted_index":{"Understanding":[0],"the":[1,130,163,171,174,184,195,201],"molecular":[2],"networks":[3],"controlling":[4,129],"ectopic":[5],"lipid":[6,113],"deposition,":[7],"glucose":[8,38,83,140],"tolerance,":[9,84],"and":[10,39,52,63,70,79,88,115,125,139,160,193],"insulin":[11,40,90],"sensitivity":[12],"is":[13],"essential":[14],"to":[15,20,162,190],"identifying":[16],"new":[17],"pharmacological":[18],"approaches":[19],"treat":[21],"type":[22,204],"2":[23,205],"diabetes.":[24,206],"We":[25],"recently":[26],"identified":[27],"serine/threonine":[28],"protein":[29,103],"kinase":[30],"25":[31],"(STK25)":[32],"as":[33],"a":[34,67,108],"negative":[35],"regulator":[36,110],"of":[37,50,77,105,111,127,155,166,173,187,197,203],"homeostasis":[41],"based":[42],"on":[43],"observations":[44],"in":[45,53,119,158],"myoblasts":[46,159],"with":[47,66,151],"acute":[48],"depletion":[49],"STK25":[51,73,156,180,198],"STK25-overexpressing":[54],"transgenic":[55,168],"mice.":[56],"Here,":[57],"we":[58],"challenged":[59],"Stk25":[60,167],"knockout":[61],"mice":[62,93],"wild-type":[64],"littermates":[65],"high-fat":[68],"diet":[69],"showed":[71],"that":[72,179],"deficiency":[74,181],"suppressed":[75],"development":[76],"hyperglycemia":[78],"hyperinsulinemia,":[80],"improved":[81],"systemic":[82],"reduced":[85],"hepatic":[86],"gluconeogenesis,":[87],"increased":[89],"sensitivity.":[91],"Stk25(-/-)":[92,120],"were":[94],"protected":[95],"from":[96],"diet-induced":[97],"liver":[98],"steatosis":[99],"accompanied":[100],"by":[101],"decreased":[102],"levels":[104],"acetyl-CoA":[106],"carboxylase,":[107],"key":[109],"both":[112],"oxidation":[114],"synthesis.":[116],"Lipid":[117],"accumulation":[118],"skeletal":[121],"muscle":[122,131],"was":[123,145],"reduced,":[124],"expression":[126],"enzymes":[128],"oxidative":[132],"capacity":[133],"(Cpt1,":[134],"Acox1,":[135],"Cs,":[136],"Cycs,":[137],"Ucp3)":[138],"metabolism":[141],"(Glut1,":[142],"Glut4,":[143],"Hk2)":[144],"increased.":[146],"These":[147],"data":[148],"are":[149],"consistent":[150],"our":[152],"previous":[153],"study":[154],"knockdown":[157],"reciprocal":[161],"metabolic":[164,185],"phenotype":[165],"mice,":[169],"reinforcing":[170],"validity":[172],"results.":[175],"The":[176],"findings":[177],"suggest":[178],"protects":[182],"against":[183],"consequences":[186],"chronic":[188],"exposure":[189],"dietary":[191],"lipids":[192],"highlight":[194],"potential":[196],"antagonists":[199],"for":[200],"treatment":[202]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
