{"id":"https://openalex.org/W2125319783","doi":"https://doi.org/10.1186/1476-4598-8-116","title":"Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3","display_name":"Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3","publication_year":2009,"publication_date":"2009-12-01","ids":{"openalex":"https://openalex.org/W2125319783","doi":"https://doi.org/10.1186/1476-4598-8-116","mag":"2125319783","pmid":"https://pubmed.ncbi.nlm.nih.gov/19968878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2795753"},"language":"en","primary_location":{"id":"doi:10.1186/1476-4598-8-116","doi":"https://doi.org/10.1186/1476-4598-8-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-8-116","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-8-116","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-8-116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052973808","display_name":"Bianca R. Dias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bianca R Dias","raw_affiliation_strings":["Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. coquiek@yahoo.com","Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil. coquiek@yahoo.com","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076205281","display_name":"Elaine Guadelupe Rodrigues","orcid":"https://orcid.org/0000-0002-3248-3081","observed_orcids":["https://orcid.org/0000-0002-3248-3081"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elaine G Rodrigues","raw_affiliation_strings":["Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Universidade Federal de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032600704","display_name":"Leonardo Nimrichter","orcid":"https://orcid.org/0000-0001-9281-6856","observed_orcids":["https://orcid.org/0000-0001-9281-6856"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo Nimrichter","raw_affiliation_strings":["Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","Universidade Federal do Rio de Janeiro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]},{"raw_affiliation_string":"Universidade Federal do Rio de Janeiro","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037253743","display_name":"Ernesto Satoshi Nakayasu","orcid":"https://orcid.org/0000-0002-4056-2695","observed_orcids":["https://orcid.org/0000-0002-4056-2695"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ernesto S Nakayasu","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, Texas, USA","University of Texas at, El Paso"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, Texas, USA","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"University of Texas at, El Paso","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054601444","display_name":"Igor Correia de Almeida","orcid":"https://orcid.org/0000-0002-2443-8213","observed_orcids":["https://orcid.org/0000-0002-2443-8213"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor C Almeida","raw_affiliation_strings":["The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, Texas, USA","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074953319","display_name":"Luiz Rodolpho Travassos","orcid":"https://orcid.org/0000-0002-7692-2795","observed_orcids":["https://orcid.org/0000-0002-7692-2795"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Luiz R Travassos","raw_affiliation_strings":["Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Universidade Federal de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Oncology Unit (UNONEX), Department of Microbiology, Immunology and Parasitology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074953319"],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":0.8141,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.72986474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"116","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm3-ganglioside","display_name":"GM3 ganglioside","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inkt-cells","display_name":"invariant natural killer T cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cd1d-restricted-nkt-cells","display_name":"CD1d-restricted NKT cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/dendritic-cell-priming","display_name":"dendritic cell priming","score":0.8209999799728394},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.5849999785423279},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7120000123977661},{"id":"https://openalex.org/keywords/lipid-antigen-presentation","display_name":"lipid antigen presentation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/alpha-galactosylceramide","display_name":"alpha-galactosylceramide","score":0.8610000014305115},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6608039140701294},{"id":"https://openalex.org/C2778607024","wikidata":"https://www.wikidata.org/wiki/Q4216825","display_name":"CD1D","level":5,"score":0.4968755543231964},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.42721864581108093},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4207281172275543},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41365569829940796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3507001996040344},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3357042372226715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2998737096786499},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29746735095977783},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27506089210510254},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.25603970885276794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17789843678474426}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1476-4598-8-116","doi":"https://doi.org/10.1186/1476-4598-8-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-8-116","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-8-116","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2795753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2795753","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmid:19968878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19968878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3199943","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/32017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unifesp.br:11600/9699","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/9699","pdf_url":"http://repositorio.unifesp.br/handle/11600/9699","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.337.2621","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.337.2621","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biomedcentral.com/content/pdf/1476-4598-8-116.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:b4a92ce5c8f743ef8b584ae0ab83cc07","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b4a92ce5c8f743ef8b584ae0ab83cc07","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 8, Iss 1, p 116 (2009)","raw_type":"article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/32017","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/32017","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1476-4598-8-116","doi":"https://doi.org/10.1186/1476-4598-8-116","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-8-116","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-8-116","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1340722568","display_name":"Border Biomedical Research Center","funder_award_id":"G12RR008124","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2940309123","display_name":null,"funder_award_id":"5G12RR008124","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G3529779747","display_name":null,"funder_award_id":"5G12RR008124","funder_id":"https://openalex.org/F4320333121","funder_display_name":"University of Texas at El Paso"},{"id":"https://openalex.org/G8510171074","display_name":null,"funder_award_id":"5G12RR008124","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333121","display_name":"University of Texas at El Paso","ror":"https://ror.org/04d5vba33"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125319783.pdf","grobid_xml":"https://content.openalex.org/works/W2125319783.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1481454862","https://openalex.org/W1537132972","https://openalex.org/W1538328956","https://openalex.org/W1544910869","https://openalex.org/W1586984865","https://openalex.org/W1976710853","https://openalex.org/W1987340797","https://openalex.org/W1987967274","https://openalex.org/W1992523113","https://openalex.org/W1995529916","https://openalex.org/W1999083645","https://openalex.org/W2008657122","https://openalex.org/W2013660817","https://openalex.org/W2017339636","https://openalex.org/W2027908113","https://openalex.org/W2050530546","https://openalex.org/W2056682628","https://openalex.org/W2057007315","https://openalex.org/W2066741901","https://openalex.org/W2069556438","https://openalex.org/W2073232640","https://openalex.org/W2090777237","https://openalex.org/W2092768308","https://openalex.org/W2093041058","https://openalex.org/W2097309924","https://openalex.org/W2105962478","https://openalex.org/W2111780570","https://openalex.org/W2121477549","https://openalex.org/W2124871789","https://openalex.org/W2139710737","https://openalex.org/W2151164793","https://openalex.org/W2156580324","https://openalex.org/W2159312193","https://openalex.org/W2167660905","https://openalex.org/W2168526937","https://openalex.org/W2172243708","https://openalex.org/W2172260092","https://openalex.org/W2320059132","https://openalex.org/W4313335791","https://openalex.org/W4313335817"],"related_works":["https://openalex.org/W7099322899","https://openalex.org/W2902957108","https://openalex.org/W2980351681","https://openalex.org/W4405621033","https://openalex.org/W1987340797","https://openalex.org/W1996682503","https://openalex.org/W2002076033","https://openalex.org/W2918518466","https://openalex.org/W2161713965","https://openalex.org/W2040393349"],"abstract_inverted_index":{"BACKGROUND:":[0],"CD1d-restricted":[1],"iNKT":[2,56,131,175,278,298],"cells":[3,50,73,88,112,127,135,228,273],"are":[4,33,42],"protective":[5],"against":[6],"murine":[7,132,260],"melanoma":[8,72,102,261,306],"B16F10-Nex2":[9,200,227],"growing":[10,101],"subcutaneously":[11],"in":[12,23,25,44,71,99,193,218,222,241,259,290,302],"syngeneic":[13],"C57Bl/6":[14],"mice":[15,223,303],"as":[16],"inferred":[17],"from":[18,98,110],"the":[19,36,45,59,66,80,116,185,242,253],"fast":[20],"tumor":[21,87,210,239,272],"development":[22],"CD1d-KO":[24],"comparison":[26],"with":[27,86,89,157,163,167,197,226,231,246,305],"wild":[28],"type":[29],"animals.":[30],"CD1d":[31],"glycoproteins":[32],"related":[34],"to":[35,55,64,122,129,136],"class":[37],"I":[38],"MHC":[39],"molecules,":[40],"and":[41,78,95,113,149,152,165,229,257,267],"involved":[43],"presentation,":[46],"particularly":[47],"by":[48,144,188,284],"dentritic":[49],"(DC),":[51],"of":[52,82,115,208,255,265],"lipid":[53,68],"antigens":[54],"cells.":[57,201,292,307],"In":[58],"present":[60],"work":[61],"we":[62],"attempted":[63],"identify":[65],"endogenous":[67],"mediator":[69],"expressed":[70],"inducing":[74],"such":[75],"immunesurveillance":[76],"response":[77],"study":[79],"possibility":[81],"protecting":[83],"animals":[84],"challenged":[85,224,304],"lipid-primed":[90],"DC.":[91],"RESULTS:":[92],"Crude":[93],"cytosolic":[94],"membrane":[96],"fractions":[97,117],"vivo":[100,219],"contained":[103],"iNKT-stimulating":[104],"substances.":[105],"Lipids":[106],"were":[107,154],"then":[108],"extracted":[109],"these":[111,291],"one":[114],"(i.e.":[118],"F3A)":[119],"was":[120,142,161,171,195,213,220,244],"shown":[121],"prime":[123,275],"bone":[124],"marrow-derived":[125],"dendritic":[126],"(BMDC)":[128],"stimulate":[130],"hybridoma":[133],"(DN32D3)":[134],"produce":[137],"IL-2.":[138],"The":[139,215,263],"active":[140],"fraction":[141],"analyzed":[143],"electrospray":[145],"ionization-mass":[146],"spectrometry":[147],"(ESI-LIT-MS)":[148],"both":[150],"iGb3":[151,160,266],"iGb4":[153],"identified":[155],"along":[156],"GM3.":[158],"When":[159],"incubated":[162],"BMDC":[164,294],"tested":[166,221],"DN32D3":[168],"cells,":[169],"IL-2":[170],"equally":[172],"produced":[173,289],"indicating":[174],"cell":[176,206,211],"activation.":[177],"GM3":[178,285],"consistently":[179],"inhibited":[180],"this":[181],"response.":[182],"To":[183],"assess":[184],"antitumor":[186,216,280],"response-induced":[187],"iGb3,":[189],"a":[190,296],"cytotoxicity":[191],"assay":[192],"vitro":[194],"used":[196],"[3H]-thymidine":[198],"labeled":[199],"At":[202],"target/effector":[203],"(iGb3-activated":[204],"iNKT)":[205],"ratio":[207],"100(-1)-100(-4)":[209],"lysis":[212],"shown.":[214],"activity":[217,301],"i.v.":[225],"treated":[230],"iGb3-":[232],"or":[233],"alpha-galactosylceramide-primed":[234],"DCs.":[235],"A":[236],"4-fold":[237],"lower":[238],"load":[240],"lungs":[243],"observed":[245],"either":[247],"treatment.":[248],"CONCLUSION:":[249],"Our":[250],"results":[251],"show":[252],"expression":[254,264],"globo":[256],"isoglobohexosylceramides":[258],"B16F10-Nex2.":[262],"its":[268],"precursor,":[269],"iGb4,":[270],"on":[271],"may":[274],"an":[276],"effective":[277],"cell-dependent":[279],"response,":[281],"modulated":[282],"negatively":[283],"which":[286],"is":[287],"also":[288],"iGb3-primed":[293],"exerted":[295],"significant":[297],"cell-mediated":[299],"anti-tumor":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}