{"id":"https://openalex.org/W2125274635","doi":"https://doi.org/10.1200/jco.2012.45.1278","title":"Randomized Multicenter Phase II Trial Comparing Two Schedules of Etirinotecan Pegol (NKTR-102) in Women With Recurrent Platinum-Resistant/Refractory Epithelial Ovarian Cancer","display_name":"Randomized Multicenter Phase II Trial Comparing Two Schedules of Etirinotecan Pegol (NKTR-102) in Women With Recurrent Platinum-Resistant/Refractory Epithelial Ovarian Cancer","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2125274635","doi":"https://doi.org/10.1200/jco.2012.45.1278","mag":"2125274635","pmid":"https://pubmed.ncbi.nlm.nih.gov/24081946"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2012.45.1278","doi":"https://doi.org/10.1200/jco.2012.45.1278","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2012.45.1278","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2012.45.1278?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2012.45.1278?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058535647","display_name":"Ignace B. Vergote","orcid":"https://orcid.org/0000-0002-7589-8981","observed_orcids":["https://orcid.org/0000-0002-7589-8981"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Ignace B. Vergote","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071585351","display_name":"Agustin A. Garc\u00eda","orcid":"https://orcid.org/0009-0000-2990-6234","observed_orcids":["https://orcid.org/0009-0000-2990-6234"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Agustin Garcia","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058900589","display_name":"John Paul Micha","orcid":"https://orcid.org/0000-0002-8533-2324","observed_orcids":["https://orcid.org/0000-0002-8533-2324"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"John Micha","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077571168","display_name":"Charles H. Pippitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Charles Pippitt","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028472820","display_name":"Johanna C. Bendell","orcid":"https://orcid.org/0000-0001-9426-5891","observed_orcids":["https://orcid.org/0000-0001-9426-5891"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Johanna Bendell","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086880664","display_name":"Daniel L. Spitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Daniel Spitz","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060578315","display_name":"Nicholas Simon Reed","orcid":"https://orcid.org/0000-0003-4498-5190","observed_orcids":["https://orcid.org/0000-0003-4498-5190"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Nicholas Reed","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089620663","display_name":"Graham G. Dark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Graham Dark","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047292923","display_name":"Paula M. Fracasso","orcid":"https://orcid.org/0000-0003-1211-3304","observed_orcids":["https://orcid.org/0000-0003-1211-3304"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Paula M. Fracasso","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","Johanna Bendell, Sarah Cannon Research Institute, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]},{"raw_affiliation_string":"Johanna Bendell, Sarah Cannon Research Institute, Nashville, TN","institution_ids":["https://openalex.org/I4210100810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110112259","display_name":"Emad N. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Emad N. Ibrahim","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084112410","display_name":"Vincent Anthony Armenio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Vincent A. Armenio","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054372225","display_name":"Linda Duska","orcid":"https://orcid.org/0000-0002-8878-4123","observed_orcids":["https://orcid.org/0000-0002-8878-4123"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Linda Duska","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032037898","display_name":"C. J. Poole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Chris Poole","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071242826","display_name":"Christine Gennigens","orcid":"https://orcid.org/0000-0003-0714-2485","observed_orcids":["https://orcid.org/0000-0003-0714-2485","https://orcid.org/0000-0003-4526-6219"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Christine Gennigens","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022173747","display_name":"Luc Yves Dirix","orcid":"https://orcid.org/0000-0002-7792-9964","observed_orcids":["https://orcid.org/0000-0002-7792-9964"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Luc Y. Dirix","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076065186","display_name":"Abraham C.F. Leung","orcid":"https://orcid.org/0009-0000-8555-1378","observed_orcids":["https://orcid.org/0009-0000-8555-1378"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Abraham C.F. Leung","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","and Vincent A. Armenio, Pharma Resource, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]},{"raw_affiliation_string":"and Vincent A. Armenio, Pharma Resource, Providence, RI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110708136","display_name":"Carol Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Carol Zhao","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081987650","display_name":"Raoudha Soufi\u2010Mahjoubi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Raoudha Soufi-Mahjoubi","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047753094","display_name":"Gordon J.S. Rustin","orcid":"https://orcid.org/0000-0002-2749-5467","observed_orcids":["https://orcid.org/0000-0002-2749-5467"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]},{"id":"https://openalex.org/I4210134544","display_name":"Centre Hospitalier Universitaire de Li\u00e8ge","ror":"https://ror.org/044s61914","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210134544"]},{"id":"https://openalex.org/I4210137948","display_name":"Gynecologic Oncology Associates","ror":"https://ror.org/03vct0j86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137948"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Gordon Rustin","raw_affiliation_strings":["Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ignace B. Vergote, University Hospital Leuven, Leuven; Christine Gennigens, Centre Hospitalier Universitaire de Li\u00e8ge, Li\u00e8ge; Luc Y. Dirix, Gasthuis Zusters Antwerpen, Antwerp, Belgium; Agustin Garcia, University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles; John Micha, Gynecologic Oncology Associates, Newport Beach; Emad N. Ibrahim, Beaver Medical Group, Redlands; Abraham C.F. Leung, Carol Zhao, and Raoudha Soufi-Mahjoubi, Nektar Therapeutics, San Francisco, CA;","institution_ids":["https://openalex.org/I2800231306","https://openalex.org/I4210117038","https://openalex.org/I4210134544","https://openalex.org/I4210137948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0034,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.95701148,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"32","first_page":"4060","last_page":"4066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-epithelial-ovarian-cancer","display_name":"recurrent epithelial ovarian cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.8700000047683716},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9559999704360962},{"id":"https://openalex.org/keywords/irinotecan-metabolite","display_name":"irinotecan metabolite","score":0.9340000152587891},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.921999990940094},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9449999928474426},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dehydration","display_name":"dehydration","score":0.5669999718666077},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9029929637908936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6092996597290039},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6089958548545837},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5771490931510925},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5625172853469849},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.500016450881958},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.48159071803092957},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.46290478110313416},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4543738067150116},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.440059632062912},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.4194575250148773},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.36135199666023254},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34022119641304016},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33701300621032715},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3291172981262207},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2793843746185303},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.15384936332702637},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009375","descriptor_name":"Neoplasms, Glandular and Epithelial","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017671","descriptor_name":"Platinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017671","descriptor_name":"Platinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017671","descriptor_name":"Platinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017671","descriptor_name":"Platinum Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1200/jco.2012.45.1278","doi":"https://doi.org/10.1200/jco.2012.45.1278","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2012.45.1278","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2012.45.1278?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:24081946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24081946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:4878105","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4878105","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/156767","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/156767","pdf_url":null,"source":{"id":"https://openalex.org/S4306401300","display_name":"ORBi (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology (2013)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1200/jco.2012.45.1278","doi":"https://doi.org/10.1200/jco.2012.45.1278","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2012.45.1278","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2012.45.1278?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G9000901327","display_name":"University of Virginia Cancer Center Support Grant","funder_award_id":"P30CA044579","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125274635.pdf","grobid_xml":"https://content.openalex.org/works/W2125274635.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1913802169","https://openalex.org/W2002710053","https://openalex.org/W2003471469","https://openalex.org/W2033201978","https://openalex.org/W2033561964","https://openalex.org/W2044398655","https://openalex.org/W2044421413","https://openalex.org/W2052846363","https://openalex.org/W2088092675","https://openalex.org/W2136313288","https://openalex.org/W2139248078","https://openalex.org/W2154908899","https://openalex.org/W2165948908","https://openalex.org/W2166310305","https://openalex.org/W2202035925","https://openalex.org/W2710005605","https://openalex.org/W4251935449"],"related_works":["https://openalex.org/W4311628015","https://openalex.org/W3191427281","https://openalex.org/W2047348737","https://openalex.org/W1928747779","https://openalex.org/W1976468768","https://openalex.org/W2044557261","https://openalex.org/W2602723266","https://openalex.org/W2412478066","https://openalex.org/W2419341326","https://openalex.org/W2595611375"],"abstract_inverted_index":{"PURPOSE:":[0],"Etirinotecan":[1,171],"pegol":[2,33,55,172,220,259,290],"(NKTR-102)":[3],"is":[4,275],"a":[5],"unique,":[6],"long-acting":[7],"topoisomerase-I":[8],"inhibitor":[9],"with":[10,36,176,199,208,225,230],"prolonged":[11],"systemic":[12],"exposure":[13],"to":[14,52,113,182,286],"SN38":[15],"(7-ethyl-10-hydroxycamptothecin),":[16],"the":[17,177,200,269,294],"active":[18],"metabolite":[19],"of":[20,31,45,94,202,210,218,238,257,293],"irinotecan.":[21],"This":[22],"randomized":[23],"phase":[24,271,279],"II":[25,272],"trial":[26],"investigated":[27],"two":[28],"dosing":[29],"schedules":[30,217],"etirinotecan":[32,54,219,258,289],"in":[34,223,303],"patients":[35,48,224],"platinum-resistant/refractory":[37],"ovarian":[38,228,305],"carcinoma.":[39],"PATIENTS":[40],"AND":[41],"METHODS:":[42],"A":[43],"total":[44],"71":[46],"eligible":[47],"were":[49,196],"randomly":[50],"assigned":[51],"receive":[53],"145":[56,260],"mg/m(2)":[57,261],"every":[58,118,125,136,144,150,153,204,212,240,263],"14":[59,119,137,151,213],"or":[60,65,301],"21":[61,126,145,154,205,241,264],"days":[62,138,155,206,242,265],"until":[63],"progression":[64],"unacceptable":[66],"adverse":[67],"events":[68],"(AEs).":[69],"The":[70,104,236,254],"primary":[71],"end":[72,84],"point":[73],"was":[74,108,131,156,165,173,243,266],"objective":[75],"response":[76,87,129],"rate":[77],"(ORR)":[78],"by":[79,88],"RECIST":[80],"(version":[81],"1.0).":[82],"Secondary":[83],"points":[85],"included":[86],"Gynecologic":[89],"Cancer":[90],"Intergroup":[91],"criteria,":[92],"duration":[93,130],"ORR,":[95],"progression-free":[96],"survival":[97,101],"(PFS),":[98],"and":[99,121,139,152,158,162,167,188,194,233,246,251,274],"overall":[100,105],"(OS).":[102],"RESULTS:":[103],"confirmed":[106],"ORR":[107,232],"20%":[109,115],"(95%":[110],"CI,":[111],"10%":[112],"30%):":[114],"for":[116,123,134,142,149,268,277],"once":[117,124,135,143,203,211,239,262],"days,":[120],"19%":[122],"days.":[127,146,214],"Median":[128,147],"4.1":[132,157],"months":[133,141],"4.0":[140],"PFS":[148,234,250],"5.3":[159],"months,":[160,169],"respectively,":[161],"median":[163],"OS":[164,252],"10.0":[166],"11.7":[168],"respectively.":[170],"well":[174],"tolerated,":[175],"most":[178],"common":[179],"grade":[180],"3":[181],"4":[183],"AEs":[184],"being":[185],"dehydration":[186],"(24%)":[187],"diarrhea":[189],"(23%).":[190],"Diarrhea,":[191],"dehydration,":[192],"nausea,":[193],"neutropenia":[195],"less":[197],"frequent":[198],"schedule":[201,237,256],"than":[207],"that":[209],"CONCLUSION:":[215],"Both":[216],"showed":[221],"activity":[222],"heavily":[226],"pretreated":[227],"cancer,":[229],"encouraging":[231],"rates.":[235,253],"better":[244],"tolerated":[245],"had":[247],"slightly":[248],"longer":[249],"treatment":[255],"selected":[267],"expanded":[270],"study":[273],"preferred":[276],"future":[278],"III":[280],"studies.":[281],"These":[282],"findings":[283],"provide":[284],"support":[285],"directly":[287],"compare":[288],"versus":[291],"one":[292],"approved":[295],"drugs":[296],"(eg,":[297],"pegylated":[298],"liposomal":[299],"doxorubicin":[300],"topotecan)":[302],"platinum-resistant":[304],"cancer.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}