{"id":"https://openalex.org/W2125247349","doi":"https://doi.org/10.1007/s00540-008-0649-8","title":"A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain","display_name":"A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2125247349","doi":"https://doi.org/10.1007/s00540-008-0649-8","mag":"2125247349","pmid":"https://pubmed.ncbi.nlm.nih.gov/19011787"},"language":"en","primary_location":{"id":"doi:10.1007/s00540-008-0649-8","doi":"https://doi.org/10.1007/s00540-008-0649-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00540-008-0649-8","pdf_url":null,"source":{"id":"https://openalex.org/S168195842","display_name":"Journal of Anesthesia","issn_l":"0913-8668","issn":["0913-8668","1438-8359"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Anesthesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Naomi Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Ito","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101419429","display_name":"Shigeru Saito","orcid":"https://orcid.org/0000-0002-5362-2909","observed_orcids":["https://orcid.org/0000-0002-5362-2909"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Saito","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063918859","display_name":"Makiko Yamada","orcid":"https://orcid.org/0000-0002-2897-3045","observed_orcids":["https://orcid.org/0000-0002-2897-3045"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Hardy Yamada","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068337381","display_name":"Shiro Koizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shiro Koizuka","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025636438","display_name":"Hideaki Obata","orcid":"https://orcid.org/0000-0002-4848-0926","observed_orcids":["https://orcid.org/0000-0002-4848-0926"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Obata","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082536500","display_name":"Koichi Nishikawa","orcid":"https://orcid.org/0000-0002-9256-334X","observed_orcids":["https://orcid.org/0000-0002-9256-334X"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Nishikawa","raw_affiliation_strings":["Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","Gunma University Graduate school of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan","institution_ids":["https://openalex.org/I165735259"]},{"raw_affiliation_string":"Gunma University Graduate school of Medicine","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055033211","display_name":"Yasuhiko Tabata","orcid":"https://orcid.org/0000-0001-8974-277X","observed_orcids":["https://orcid.org/0000-0001-8974-277X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiko Tabata","raw_affiliation_strings":["Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","Kyoto univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Kyoto univ","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":null,"fwci":1.4604,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83046788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"22","issue":"4","first_page":"449","last_page":"452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.8438000082969666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.06289999932050705,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/gelatin-hydrogel","display_name":"gelatin hydrogel","score":0.7490000128746033},{"id":"https://openalex.org/keywords/angiogenic-therapy","display_name":"angiogenic therapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lumbar-sympathectomy","display_name":"lumbar sympathectomy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/nerve-block","display_name":"nerve block","score":0.7210000157356262},{"id":"https://openalex.org/keywords/arteriosclerosis-obliterans","display_name":"arteriosclerosis obliterans","score":0.9190000295639038},{"id":"https://openalex.org/keywords/thromboangiitis-obliterans","display_name":"thromboangiitis obliterans","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foot-ulcer-healing","display_name":"foot ulcer healing","score":0.7919999957084656},{"id":"https://openalex.org/keywords/intramuscular-injection","display_name":"intramuscular injection","score":0.7289999723434448},{"id":"https://openalex.org/keywords/multimodal-pain-therapy","display_name":"multimodal pain management","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9529878497123718},{"id":"https://openalex.org/C2991975920","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain medicine","level":3,"score":0.6577881574630737},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6206761598587036},{"id":"https://openalex.org/C2779526319","wikidata":"https://www.wikidata.org/wiki/Q615057","display_name":"Anesthesiology","level":2,"score":0.5894694328308105},{"id":"https://openalex.org/C3018458959","wikidata":"https://www.wikidata.org/wiki/Q3155223","display_name":"Limb ischemia","level":3,"score":0.5526507496833801},{"id":"https://openalex.org/C2908961088","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain therapy","level":2,"score":0.4650852084159851},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.4504967927932739},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3359875977039337},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.30616024136543274},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2828625440597534},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2370082437992096}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001162","descriptor_name":"Arteriosclerosis Obliterans","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001162","descriptor_name":"Arteriosclerosis Obliterans","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005121","descriptor_name":"Extremities","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010148","descriptor_name":"Intractable Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013562","descriptor_name":"Sympathectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016523","descriptor_name":"Foot Ulcer","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00540-008-0649-8","doi":"https://doi.org/10.1007/s00540-008-0649-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00540-008-0649-8","pdf_url":null,"source":{"id":"https://openalex.org/S168195842","display_name":"Journal of Anesthesia","issn_l":"0913-8668","issn":["0913-8668","1438-8359"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Anesthesia","raw_type":"journal-article"},{"id":"pmid:19011787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19011787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of anesthesia","raw_type":"Case Reports"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0000046868","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2433/79258","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JOURNAL OF ANESTHESIA","raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/79258","doi":null,"is_oa":false,"landing_page_url":"http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=KyotoUniv&SrcApp=KyotoUniv&DestLinkType=FullRecord&KeyUT=ISI:000260955700018&DestApp=WOS","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W207556809","https://openalex.org/W1498242025","https://openalex.org/W1537192388","https://openalex.org/W1586474677","https://openalex.org/W1971432549","https://openalex.org/W1973768806","https://openalex.org/W2006658893","https://openalex.org/W2007262189","https://openalex.org/W2018087757","https://openalex.org/W2043517681","https://openalex.org/W2057410741","https://openalex.org/W2068667623","https://openalex.org/W2075323420","https://openalex.org/W2075790920","https://openalex.org/W2076202270","https://openalex.org/W2092246905","https://openalex.org/W2100134652","https://openalex.org/W2112267683","https://openalex.org/W2114587721","https://openalex.org/W2406526090","https://openalex.org/W2408899745","https://openalex.org/W2411407950","https://openalex.org/W2437701028","https://openalex.org/W3148375785"],"related_works":["https://openalex.org/W2075790920","https://openalex.org/W2168956697","https://openalex.org/W2063446635","https://openalex.org/W1978768368","https://openalex.org/W1997643216","https://openalex.org/W6983757437","https://openalex.org/W2026616377","https://openalex.org/W2094698249","https://openalex.org/W2962229641","https://openalex.org/W2100292649"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
