{"id":"https://openalex.org/W2125205754","doi":null,"title":"Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.","display_name":"Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W2125205754","mag":"2125205754","pmid":"https://pubmed.ncbi.nlm.nih.gov/7680954"},"language":"en","primary_location":{"id":"pmid:7680954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.amsterdamumc.nl/en/publications/3180684d-c382-4de6-98e7-7fffaaf6c30c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111739443","display_name":"Rik J. Scheper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Scheper","raw_affiliation_strings":["Department of Pathology, Free University Hospital, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Free University Hospital, Amsterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109188456","display_name":"Henk J. Broxterman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Broxterman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109907966","display_name":"George L. Scheffer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Scheffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076938568","display_name":"Patricia Kaaijk","orcid":"https://orcid.org/0000-0001-9165-1703","observed_orcids":["https://orcid.org/0000-0001-9165-1703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Kaaijk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103061547","display_name":"William S. Dalton","orcid":"https://orcid.org/0000-0001-9417-2599","observed_orcids":["https://orcid.org/0000-0001-9417-2599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W S Dalton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391657","display_name":"Th. H. M. van Heijningen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T H van Heijningen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109226863","display_name":"Coenraad K. van Kalken","orcid":"https://orcid.org/0009-0000-0171-3262","observed_orcids":["https://orcid.org/0009-0000-0171-3262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C K van Kalken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103602458","display_name":"Marilyn L. Slovak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M L Slovak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061495577","display_name":"Elisabeth G.E. de Vries","orcid":"https://orcid.org/0000-0002-8949-7425","observed_orcids":["https://orcid.org/0000-0002-8949-7425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G de Vries","raw_affiliation_strings":["Guided Treatment in Optimal Selected Cancer Patients (GUTS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guided Treatment in Optimal Selected Cancer Patients (GUTS)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103252713","display_name":"Paul van der Valk","orcid":"https://orcid.org/0000-0002-0983-1607","observed_orcids":["https://orcid.org/0000-0002-0983-1607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P van der Valk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.4601,"has_fulltext":false,"cited_by_count":489,"citation_normalized_percentile":{"value":0.99418112,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"53","issue":"7","first_page":"1475","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.4970000088214874},{"id":"https://openalex.org/keywords/vesicular-proteins","display_name":"vesicular proteins","score":0.7099999785423279},{"id":"https://openalex.org/keywords/lysosomal-proteins","display_name":"lysosomal proteins","score":0.6890000104904175},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7070000171661377},{"id":"https://openalex.org/keywords/xenobiotic-exposure","display_name":"xenobiotic exposure","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.8370620012283325},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.6652803421020508},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6440646052360535},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6269958019256592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6133900880813599},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6000176072120667},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.579106867313385},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5580883026123047},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5260277390480042},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4835050404071808},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.44474703073501587},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4197225272655487},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.41656947135925293},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40352073311805725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25614452362060547},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.23475217819213867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17069947719573975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1482449173927307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05471721291542053}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"pmid:7680954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/3180684d-c382-4de6-98e7-7fffaaf6c30c","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/3180684d-c382-4de6-98e7-7fffaaf6c30c","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scheper, R J, Broxterman, H J, Scheffer, G L, Kaaijk, P, Dalton, W S, van Heijningen, T H M, van Kalken, C K, Slovak, M L, de Vries, E G E, van der Valk, P, Meijer, C J L M & Pinedo, H M 1993, 'Overexpression of Mr110,000 vesicular protein in non-P-glycoprotein mediated multidrug-resistance', Cancer research, vol. 53, pp. 1475-1479.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.5428","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.5428","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/53/7/1475.full.pdf","raw_type":"text"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/4122","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/4122","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/7b056c8f-0162-42fe-92c5-fa28dc78375a","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/7b056c8f-0162-42fe-92c5-fa28dc78375a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCHEPER, RJ, BROXTERMAN, HJ, SCHEFFER, GL, KAAIJK, P, DALTON, WS, VANHEIJNINGEN, THM, VANKALKEN, CK, SLOVAK, ML, DEVRIES, EGE, VANDERVALK, P, MEIJER, CJLM & PINEDO, HM 1993, 'OVEREXPRESSION OF A M(R) 110,000 VESICULAR PROTEIN IN NON-P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE', Cancer Research, vol. 53, no. 7, pp. 1475-1479.","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:rug:oai:pure.rug.nl:publications/7b056c8f-0162-42fe-92c5-fa28dc78375a","doi":null,"is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/7b056c8f-0162-42fe-92c5-fa28dc78375a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 53(7), 1475 - 1479. AMER ASSOC CANCER RESEARCH","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu1:oai:dare.ubvu.vu.nl:1871/4122","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1871/4122","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"urn:issn:00085472","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/c5a3b4a4-698c-44a4-bf40-f0aa50165640","doi":null,"is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/c5a3b4a4-698c-44a4-bf40-f0aa50165640","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research, 53, 1475 - 1479. American Association for Cancer Research Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2125205754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7680954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/3180684d-c382-4de6-98e7-7fffaaf6c30c","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/3180684d-c382-4de6-98e7-7fffaaf6c30c","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scheper, R J, Broxterman, H J, Scheffer, G L, Kaaijk, P, Dalton, W S, van Heijningen, T H M, van Kalken, C K, Slovak, M L, de Vries, E G E, van der Valk, P, Meijer, C J L M & Pinedo, H M 1993, 'Overexpression of Mr110,000 vesicular protein in non-P-glycoprotein mediated multidrug-resistance', Cancer research, vol. 53, pp. 1475-1479.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1536659233","https://openalex.org/W1635112096","https://openalex.org/W1706613099","https://openalex.org/W1963644781","https://openalex.org/W2016585612","https://openalex.org/W2101278212","https://openalex.org/W2104733808","https://openalex.org/W2168070336","https://openalex.org/W2615953705"],"related_works":["https://openalex.org/W2001665683","https://openalex.org/W4233023214","https://openalex.org/W2210128335","https://openalex.org/W319135923","https://openalex.org/W2409701566","https://openalex.org/W2058273909","https://openalex.org/W2041056970","https://openalex.org/W111889466","https://openalex.org/W1483848674","https://openalex.org/W2107132176"],"abstract_inverted_index":{"A":[0],"M(r)":[1],"110,000":[2],"protein":[3],"(p110)":[4],"is":[5,82,116],"overexpressed":[6],"in":[7,54,85,105,112],"P-glycoprotein-negative":[8],"multidrug-resistant":[9],"tumor":[10],"cell":[11,18,114],"lines":[12,19,115],"of":[13,29,80,103],"different":[14,33],"histogenetic":[15],"origins.":[16],"These":[17],"show":[20],"an":[21],"ATP-dependent":[22],"drug":[23,30,108],"accumulation":[24],"defect,":[25],"suggesting":[26],"the":[27,48,74,106,113],"presence":[28],"transporter":[31],"molecules":[32],"from":[34],"P-glycoprotein.":[35],"Immunohistochemical":[36],"staining":[37],"with":[38,94,99],"a":[39,51,86,95],"p110-specific":[40],"monoclonal":[41],"antibody":[42],"(LRP-56)":[43],"showed":[44],"that,":[45],"like":[46],"P-glycoprotein,":[47],"molecule":[49,96],"has":[50],"high":[52],"expression":[53],"normal":[55],"epithelial":[56],"cells":[57,72],"and":[58,64,76],"tissues":[59],"chronically":[60],"exposed":[61],"to":[62],"xenobiotics":[63],"potentially":[65],"toxic":[66],"agents,":[67],"such":[68],"as":[69],"bronchial":[70],"cells,":[71],"lining":[73],"intestines,":[75],"kidney":[77],"tubules.":[78],"Staining":[79],"LRP-56":[81],"primarily":[83],"cytoplasmic,":[84],"coarsely":[87],"granular":[88],"fashion,":[89],"indicating":[90],"that":[91],"it":[92],"reacts":[93],"closely":[97],"associated":[98],"vesicular/lysosomal":[100],"structures.":[101],"Involvement":[102],"p110":[104],"energy-dependent":[107],"transport":[109],"process":[110],"present":[111],"unknown.":[117]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}