{"id":"https://openalex.org/W2125202200","doi":"https://doi.org/10.1158/1535-7163.mct-07-0370","title":"Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression","display_name":"Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2125202200","doi":"https://doi.org/10.1158/1535-7163.mct-07-0370","mag":"2125202200","pmid":"https://pubmed.ncbi.nlm.nih.gov/18202008"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-07-0370","doi":"https://doi.org/10.1158/1535-7163.mct-07-0370","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-07-0370","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050786653","display_name":"Katherine M. Aird","orcid":"https://orcid.org/0000-0002-5828-2325","observed_orcids":["https://orcid.org/0000-0002-5828-2325"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine M. Aird","raw_affiliation_strings":["1Department of Surgery,","3Department of Pathology, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"3Department of Pathology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiuyun Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiuyun Ding","raw_affiliation_strings":["1Department of Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032100711","display_name":"Aris Baras","orcid":"https://orcid.org/0000-0002-6830-3396","observed_orcids":["https://orcid.org/0000-0002-6830-3396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aris Baras","raw_affiliation_strings":["1Department of Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008662619","display_name":"Jun-Ping Wei","orcid":"https://orcid.org/0000-0001-6311-6033","observed_orcids":["https://orcid.org/0000-0001-6311-6033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junping Wei","raw_affiliation_strings":["1Department of Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074731037","display_name":"Michael Andrew Morse","orcid":"https://orcid.org/0000-0002-5725-4533","observed_orcids":["https://orcid.org/0000-0002-5725-4533"]},"institutions":[{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Morse","raw_affiliation_strings":["2Duke Comprehensive Cancer Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Duke Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028156079","display_name":"Timothy Dudley Clay","orcid":"https://orcid.org/0000-0002-1953-2694","observed_orcids":["https://orcid.org/0000-0002-1953-2694"]},"institutions":[{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Clay","raw_affiliation_strings":["1Department of Surgery,","2Duke Comprehensive Cancer Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"2Duke Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012804507","display_name":"Herbert Kim Lyerly","orcid":"https://orcid.org/0000-0002-0063-4770","observed_orcids":["https://orcid.org/0000-0002-0063-4770"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herbert K. Lyerly","raw_affiliation_strings":["1Department of Surgery,","2Duke Comprehensive Cancer Center, and","3Department of Pathology, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"2Duke Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039326"]},{"raw_affiliation_string":"3Department of Pathology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089632095","display_name":"Gayathri R. Devi","orcid":"https://orcid.org/0000-0001-9158-7289","observed_orcids":["https://orcid.org/0000-0001-9158-7289"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gayathri R. Devi","raw_affiliation_strings":["1Department of Surgery,","2Duke Comprehensive Cancer Center, and","3Department of Pathology, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Surgery,","institution_ids":[]},{"raw_affiliation_string":"2Duke Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039326"]},{"raw_affiliation_string":"3Department of Pathology, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5105,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.93158149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"38","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-breast-cancer","display_name":"inflammatory breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.8849999904632568},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.8019999861717224},{"id":"https://openalex.org/keywords/inhibitor-of-apoptosis-proteins","display_name":"inhibitor of apoptosis proteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.8730000257492065},{"id":"https://openalex.org/keywords/embelin","display_name":"embelin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/anti-apoptotic-pathways","display_name":"anti-apoptotic pathways","score":0.753000020980835},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6980000138282776},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.9725832939147949},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.7901704907417297},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.676746129989624},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6366670727729797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6180667877197266},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.5390092730522156},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.5277120471000671},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5234041810035706},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5207955241203308},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4661126732826233},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44260311126708984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4079330563545227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3648029863834381},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32856354117393494},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.31395646929740906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24036777019500732},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2362404465675354},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.23608165979385376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22706303000450134},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21078696846961975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20231977105140686},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16564160585403442},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15514370799064636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06776204705238342},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051616","descriptor_name":"Neuronal Apoptosis-Inhibitory Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.mct-07-0370","doi":"https://doi.org/10.1158/1535-7163.mct-07-0370","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-07-0370","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:18202008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18202008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6628359320","display_name":"SPORE IN BREAST CANCER","funder_award_id":"P50CA068438","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W177020039","https://openalex.org/W1512072225","https://openalex.org/W1515269881","https://openalex.org/W1582007138","https://openalex.org/W1606090394","https://openalex.org/W1915574909","https://openalex.org/W1920968130","https://openalex.org/W1974024530","https://openalex.org/W1979563875","https://openalex.org/W1990287461","https://openalex.org/W1992053143","https://openalex.org/W1996341616","https://openalex.org/W2002645985","https://openalex.org/W2004490932","https://openalex.org/W2009218955","https://openalex.org/W2018669222","https://openalex.org/W2019777932","https://openalex.org/W2034269086","https://openalex.org/W2044078154","https://openalex.org/W2058346921","https://openalex.org/W2058627189","https://openalex.org/W2071849431","https://openalex.org/W2080024320","https://openalex.org/W2086224272","https://openalex.org/W2087962373","https://openalex.org/W2089637126","https://openalex.org/W2095022409","https://openalex.org/W2098544382","https://openalex.org/W2107426197","https://openalex.org/W2109781138","https://openalex.org/W2112720107","https://openalex.org/W2115759102","https://openalex.org/W2119337332","https://openalex.org/W2124812632","https://openalex.org/W2125735022","https://openalex.org/W2129916963","https://openalex.org/W2141393790","https://openalex.org/W2142752401","https://openalex.org/W2145477245","https://openalex.org/W2148252918","https://openalex.org/W2151559423","https://openalex.org/W2152852483","https://openalex.org/W2156894263","https://openalex.org/W2159459001","https://openalex.org/W2164032619","https://openalex.org/W2168760093","https://openalex.org/W2168822330","https://openalex.org/W2324278934"],"related_works":["https://openalex.org/W2107123646","https://openalex.org/W324200287","https://openalex.org/W188172289","https://openalex.org/W2124287743","https://openalex.org/W1988789277","https://openalex.org/W2072621272","https://openalex.org/W2102660250","https://openalex.org/W2280177837","https://openalex.org/W2124812632","https://openalex.org/W2168057516"],"abstract_inverted_index":{"Inflammatory":[0],"breast":[1],"cancer":[2],"(IBC)":[3],"patients":[4],"show":[5],"poor":[6],"survival":[7],"and":[8,32,91,114,138,215],"a":[9,64,70,163,208],"significant":[10,174],"incidence":[11],"of":[12,25,28,36,39,116,140,169,222],"epidermal":[13,104],"growth":[14,105],"factor":[15,106],"receptor-2":[16],"(ErbB2)":[17],"overexpression.":[18],"A":[19],"distinct":[20],"mechanism":[21],"involving":[22],"increased":[23],"expression":[24,75],"X-linked":[26],"inhibitor":[27,38,165],"apoptosis":[29,40],"protein":[30,41],"(XIAP)":[31],"survivin,":[33],"key":[34],"members":[35],"the":[37,73,79,152,223],"(IAP)":[42],"family,":[43],"was":[44,76],"observed":[45,77],"post-trastuzumab":[46],"(an":[47],"ErbB2":[48,213],"monoclonal":[49],"antibody)":[50],"treatment":[51,87],"in":[52,72,78,84,95,129,135,148,151,176,181,229,236],"an":[53,233],"ErbB2-overexpressing,":[54],"estrogen":[55],"receptor":[56],"negative,":[57],"IBC":[58,66,237],"cellular":[59],"model,":[60],"SUM190PT,":[61],"isolated":[62],"from":[63],"primary":[65],"tumor.":[67],"In":[68],"contrast,":[69],"decrease":[71,134,147,175],"IAP":[74,224],"non-IBC,":[80],"ErbB2-overexpressing":[81],"SKBR3":[82],"cells":[83],"which":[85,155,198],"trastuzumab":[86,132,184,202],"also":[88],"decreased":[89],"p-AKT":[90,141,159],"cell":[92,149],"viability.":[93,178],"Further,":[94,161],"SUM190PT":[96,153,177,188],"cells,":[97,154],"therapeutic":[98],"sensitivity":[99],"to":[100,145,171,186],"GW583340":[101],"(a":[102],"dual":[103],"receptor/ErbB2":[107],"kinase":[108],"inhibitor)":[109],"corresponded":[110],"with":[111,131,143,183],"XIAP":[112,117,127,170],"down-regulation":[113],"abrogation":[115],"inhibition":[118,128,139],"on":[119,196],"active":[120],"caspase-9":[121],"release.":[122],"Specific":[123],"small":[124],"interfering":[125],"RNA-mediated":[126],"combination":[130,182,230],"caused":[133,173],"inactive":[136],"procaspase-9":[137],"corresponding":[142],"45%":[144],"50%":[146],"viability":[150,189],"have":[156,206],"high":[157],"steady-state":[158],"levels.":[160],"embelin,":[162],"small-molecule":[164],"that":[166],"abrogates":[167],"binding":[168],"procaspase-9,":[172],"However,":[179],"embelin":[180],"failed":[185],"affect":[187],"because":[190],"it":[191],"has":[192],"no":[193],"direct":[194],"effect":[195],"XIAP,":[197],"is":[199],"induced":[200],"by":[201,219],"treatment.":[203],"These":[204],"data":[205],"identified":[207],"novel":[209],"functional":[210],"link":[211],"between":[212],"signaling":[214],"antiapoptotic":[216,225],"pathway":[217,226],"mediated":[218],"XIAP.":[220],"Blockade":[221],"alone":[227],"or":[228],"would":[231],"be":[232],"attractive":[234],"strategy":[235],"therapy.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
