{"id":"https://openalex.org/W2125173993","doi":"https://doi.org/10.1093/jac/dkp186","title":"Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City","display_name":"Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W2125173993","doi":"https://doi.org/10.1093/jac/dkp186","mag":"2125173993","pmid":"https://pubmed.ncbi.nlm.nih.gov/19457933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2707265"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkp186","doi":"https://doi.org/10.1093/jac/dkp186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkp186","pdf_url":"https://academic.oup.com/jac/article-pdf/64/2/278/2113766/dkp186.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jac/article-pdf/64/2/278/2113766/dkp186.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058977225","display_name":"Simona Bratu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Bratu","raw_affiliation_strings":["Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039985590","display_name":"David Landman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Landman","raw_affiliation_strings":["Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. George","raw_affiliation_strings":["Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086626134","display_name":"Jerome Salvani","orcid":"https://orcid.org/0000-0003-1087-3350","observed_orcids":["https://orcid.org/0000-0003-1087-3350"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Salvani","raw_affiliation_strings":["Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024228283","display_name":"John M. Quale","orcid":"https://orcid.org/0000-0001-6043-4298","observed_orcids":["https://orcid.org/0000-0001-6043-4298"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Quale","raw_affiliation_strings":["Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA","institution_ids":["https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024228283"],"corresponding_institution_ids":["https://openalex.org/I181697535"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":2.0803,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.84644307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"64","issue":"2","first_page":"278","last_page":"283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/acrb","display_name":"AcrB","score":0.6710000038146973},{"id":"https://openalex.org/keywords/acrab-efflux-pump","display_name":"AcrAB efflux pump","score":0.9670000076293945},{"id":"https://openalex.org/keywords/kahramanmaras","display_name":"Kahramanmara\u015f","score":0.7680000066757202},{"id":"https://openalex.org/keywords/sox","display_name":"SOX","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rama","display_name":"Rama","score":0.9990000128746033},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tigecycline-resistance","display_name":"tigecycline resistance","score":0.9470000267028809},{"id":"https://openalex.org/keywords/fluoroquinolone-resistance","display_name":"fluoroquinolone resistance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.9789999723434448},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae-carbapenemase","display_name":"KPC","score":0.7149999737739563},{"id":"https://openalex.org/keywords/gyra-mutations","display_name":"gyrA mutations","score":0.5540000200271606},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hospital-isolates","display_name":"hospital isolates","score":0.8640000224113464},{"id":"https://openalex.org/keywords/new-york-city","display_name":"New York City","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8831662535667419},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7026406526565552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5865269899368286},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5810343027114868},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.527262806892395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4632177948951721},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.23970666527748108},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20748993754386902},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.18409600853919983}],"mesh":[{"descriptor_ui":"D000078304","descriptor_name":"Tigecycline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009519","descriptor_name":"New York City","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019353","descriptor_name":"Endemic Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/jac/dkp186","doi":"https://doi.org/10.1093/jac/dkp186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkp186","pdf_url":"https://academic.oup.com/jac/article-pdf/64/2/278/2113766/dkp186.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2707265","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2707265","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Antimicrob Chemother","raw_type":"Text"},{"id":"pmid:19457933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19457933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkp186v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkp186v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkp186v2","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkp186v2","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/jac/dkp186","doi":"https://doi.org/10.1093/jac/dkp186","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jac/dkp186","pdf_url":"https://academic.oup.com/jac/article-pdf/64/2/278/2113766/dkp186.pdf","source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G837009327","display_name":"Study of Mechanisms Leading to Multidrug-Resistant K. pneumoniae and A. baumannii","funder_award_id":"5r01ai070246-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8788023517","display_name":null,"funder_award_id":"R01 AI070246","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125173993.pdf","grobid_xml":"https://content.openalex.org/works/W2125173993.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1573080626","https://openalex.org/W1976898407","https://openalex.org/W2008054915","https://openalex.org/W2009646503","https://openalex.org/W2009945529","https://openalex.org/W2039089224","https://openalex.org/W2043864667","https://openalex.org/W2074663598","https://openalex.org/W2080914311","https://openalex.org/W2096905968","https://openalex.org/W2104620113","https://openalex.org/W2122432936","https://openalex.org/W2124509911","https://openalex.org/W2126661550","https://openalex.org/W2129122982","https://openalex.org/W2131518660","https://openalex.org/W2148704828","https://openalex.org/W2150013876","https://openalex.org/W2151288894","https://openalex.org/W2152094323","https://openalex.org/W2160029267","https://openalex.org/W2162198167","https://openalex.org/W2164544517","https://openalex.org/W2170664206"],"related_works":["https://openalex.org/W7096545016","https://openalex.org/W1983401161","https://openalex.org/W3081038195","https://openalex.org/W2168476660","https://openalex.org/W7127881431","https://openalex.org/W1975868175","https://openalex.org/W2401373256","https://openalex.org/W3109317010","https://openalex.org/W4399386292","https://openalex.org/W1968573238"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Nosocomial":[1],"isolates":[2,60,78,102,112,198,223],"of":[3,18,36,76,84,100,109,122,126,130,137,147,166,201,238],"Klebsiella":[4],"pneumoniae":[5],"resistant":[6],"to":[7,28,62,71,89,105,152,154,182],"all":[8,75],"commonly":[9],"used":[10],"antimicrobial":[11,56],"agents":[12],"have":[13],"emerged":[14],"in":[15,143,157,179,186,192,197,218,221],"many":[16],"regions":[17],"the":[19,29,39,44,63,85,216,239],"world.":[20],"It":[21,231],"is":[22],"unknown":[23],"if":[24],"efflux":[25,40],"systems":[26],"contribute":[27,153],"multidrug":[30],"resistance":[31,88,156,184,209],"phenotype.":[32],"METHODS:":[33],"The":[34],"expression":[35,83,121,125,129,136,146,165,196,200],"genes":[37],"encoding":[38],"pump":[41],"AcrAB":[42],"and":[43,49,53,87,91,149,168,173,175,194,203],"global":[45],"regulators":[46],"MarA,":[47],"SoxS":[48],"RamA":[50],"were":[51,103],"examined":[52],"correlated":[54,134],"with":[55,124,135,188,212,227],"resistance.":[57,244],"RESULTS:":[58],"Twenty":[59],"belonged":[61],"two":[64],"important":[65],"clones":[66],"representing":[67],"KPC-possessing":[68],"strains":[69],"endemic":[70],"our":[72],"region.":[73],"Virtually":[74],"these":[77,101],"had":[79],"negligible":[80],"or":[81],"absent":[82],"genes,":[86],"fluoroquinolones":[90],"aminoglycosides":[92],"could":[93],"be":[94],"explained":[95],"by":[96],"alternative":[97],"mechanisms.":[98],"All":[99],"susceptible":[104],"tigecycline.":[106],"A":[107,160],"group":[108],"14":[110],"heterogeneous":[111],"was":[113,117,132,162,210,224],"also":[114],"examined.":[115],"There":[116],"a":[118,140,189],"correlation":[119,161],"between":[120,164],"marA":[123,150,172,193],"soxS.":[127],"Only":[128],"soxS":[131,167,202],"significantly":[133],"acrB.":[138],"With":[139],"background":[141],"substitution":[142],"GyrA,":[144],"increased":[145,213],"acrB":[148,195,214],"appeared":[151],"fluoroquinolone":[155],"some":[158],"isolates.":[159],"noted":[163],"ramA":[169],"(but":[170],"not":[171],"acrB)":[174],"tigecycline":[176,208,219,243],"MICs.":[177],"Following":[178],"vitro":[180],"exposure":[181],"tigecycline,":[183],"occurred":[185],"association":[187],"marked":[190],"increase":[191],"lacking":[199],"ramA.":[204],"CONCLUSIONS:":[205],"While":[206],"laboratory-derived":[207],"associated":[211,225],"expression,":[215],"variation":[217],"MICs":[220],"clinical":[222],"only":[226],"selected":[228],"regulator":[229],"genes.":[230],"appears":[232],"that":[233],"other":[234],"mechanisms":[235],"beyond":[236],"activation":[237],"acrAB":[240],"system":[241],"mediate":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}