{"id":"https://openalex.org/W2125076239","doi":"https://doi.org/10.1002/jcb.20604","title":"Translating the histone code into leukemia","display_name":"Translating the histone code into leukemia","publication_year":2005,"publication_date":"2005-09-15","ids":{"openalex":"https://openalex.org/W2125076239","doi":"https://doi.org/10.1002/jcb.20604","mag":"2125076239","pmid":"https://pubmed.ncbi.nlm.nih.gov/16167339"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.20604","doi":"https://doi.org/10.1002/jcb.20604","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20604","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20604","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20604","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014695559","display_name":"Bryan E. Linggi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan E. Linggi","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA","Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103504978","display_name":"Stephen J. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Brandt","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee","Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee","Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee","Tennessee Valley VA Healthcare System, Nashville, Tennessee","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Tennessee Valley VA Healthcare System, Nashville, Tennessee","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080143491","display_name":"Zu\u2010Wen Sun","orcid":"https://orcid.org/0000-0001-8389-0843","observed_orcids":["https://orcid.org/0000-0001-8389-0843"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zu\u2010Wen Sun","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068430189","display_name":"Scott W. Hiebert","orcid":"https://orcid.org/0000-0001-5621-1454","observed_orcids":["https://orcid.org/0000-0001-5621-1454"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott W. Hiebert","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee","Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068430189"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I901861585"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.488,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.42981396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"5","first_page":"938","last_page":"950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-code","display_name":"histone code","score":0.9980000257492065},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9120000004768372},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.6970000267028809},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9190000295639038},{"id":"https://openalex.org/keywords/histone-modifying-enzymes","display_name":"histone-modifying enzymes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.7070000171661377},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/oncogenic-transcription-factor","display_name":"oncogenic transcription factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.847000002861023},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.6954636573791504},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.6557955145835876},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.6454911828041077},{"id":"https://openalex.org/C56428682","wikidata":"https://www.wikidata.org/wiki/Q24785535","display_name":"Histone H2A","level":4,"score":0.6170895099639893},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.5585290193557739},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5212762355804443},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.5139641165733337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5116439461708069},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.45420995354652405},{"id":"https://openalex.org/C173681060","wikidata":"https://www.wikidata.org/wiki/Q5773169","display_name":"Histone octamer","level":5,"score":0.42018434405326843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4046478271484375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38387495279312134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20343321561813354},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2012244462966919},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.1919255554676056},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.18330249190330505}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051548","descriptor_name":"Histone Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051560","descriptor_name":"Proto-Oncogene Proteins c-bcl-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.20604","doi":"https://doi.org/10.1002/jcb.20604","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20604","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20604","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:16167339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16167339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jcb.20604","doi":"https://doi.org/10.1002/jcb.20604","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcb.20604","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcb.20604","source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2316747042","display_name":"Regulation and Function of the TAL1/SCL Gene","funder_award_id":"R01HL049118","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G275963511","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G3084507769","display_name":"Function of Myeloid Translocation Gene Related-1","funder_award_id":"R01CA112005","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G505683346","display_name":"Role of TEL and the t(12;21) in B cell ALL","funder_award_id":"R01CA077274","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G6849296902","display_name":"Role of AML1-ETO in Acute Leukemia","funder_award_id":"R01CA064140","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8081739646","display_name":"Mechanism of inv(16) mediated leukemogenesis","funder_award_id":"R01CA087549","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309601","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125076239.pdf","grobid_xml":"https://content.openalex.org/works/W2125076239.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W266334352","https://openalex.org/W1501663750","https://openalex.org/W1504303645","https://openalex.org/W1515793897","https://openalex.org/W1910848366","https://openalex.org/W1940451643","https://openalex.org/W1965812853","https://openalex.org/W1966322170","https://openalex.org/W1968048144","https://openalex.org/W1969945914","https://openalex.org/W1970632714","https://openalex.org/W1973023394","https://openalex.org/W1975003600","https://openalex.org/W1976287566","https://openalex.org/W1982166080","https://openalex.org/W1988754209","https://openalex.org/W1993906178","https://openalex.org/W1996400683","https://openalex.org/W1998749998","https://openalex.org/W1999144014","https://openalex.org/W2002698073","https://openalex.org/W2004499293","https://openalex.org/W2006299889","https://openalex.org/W2006881752","https://openalex.org/W2012220765","https://openalex.org/W2013313605","https://openalex.org/W2016400574","https://openalex.org/W2017196344","https://openalex.org/W2025545218","https://openalex.org/W2035175374","https://openalex.org/W2035380835","https://openalex.org/W2035915355","https://openalex.org/W2036256995","https://openalex.org/W2036565444","https://openalex.org/W2037471080","https://openalex.org/W2045077330","https://openalex.org/W2048613921","https://openalex.org/W2049868369","https://openalex.org/W2053734578","https://openalex.org/W2056369410","https://openalex.org/W2058607217","https://openalex.org/W2070312499","https://openalex.org/W2075079030","https://openalex.org/W2075907707","https://openalex.org/W2082432425","https://openalex.org/W2082570129","https://openalex.org/W2091655002","https://openalex.org/W2092194090","https://openalex.org/W2092912586","https://openalex.org/W2101518963","https://openalex.org/W2101951432","https://openalex.org/W2103419911","https://openalex.org/W2110953702","https://openalex.org/W2116229314","https://openalex.org/W2124515729","https://openalex.org/W2124732783","https://openalex.org/W2125410827","https://openalex.org/W2128741634","https://openalex.org/W2134453935","https://openalex.org/W2135154556","https://openalex.org/W2140204965","https://openalex.org/W2141753711","https://openalex.org/W2141882676","https://openalex.org/W2143591283","https://openalex.org/W2143658931","https://openalex.org/W2147106865","https://openalex.org/W2147561347","https://openalex.org/W2148654292","https://openalex.org/W2150056778","https://openalex.org/W2150118183","https://openalex.org/W2156719499","https://openalex.org/W2158773950","https://openalex.org/W2163668223","https://openalex.org/W2165223374","https://openalex.org/W2166647372","https://openalex.org/W2166907165","https://openalex.org/W2171074974","https://openalex.org/W2324225179","https://openalex.org/W2331070544","https://openalex.org/W2334098414","https://openalex.org/W3148685323","https://openalex.org/W4211075966","https://openalex.org/W4212766227"],"related_works":["https://openalex.org/W2374560515","https://openalex.org/W7127894653","https://openalex.org/W2171249113","https://openalex.org/W2143658931","https://openalex.org/W4233572646","https://openalex.org/W3000957318","https://openalex.org/W1523220187","https://openalex.org/W2138027836","https://openalex.org/W2051933106","https://openalex.org/W2004937788"],"abstract_inverted_index":{"The":[0,18],"\"histone":[1],"code\"":[2],"is":[3],"comprised":[4],"of":[5,9,29,63,104,112,115],"the":[6,26,64,78,89,102,124,134],"covalent":[7],"modifications":[8,20,40],"histone":[10,59,79,90,105,125],"tails":[11],"that":[12,21,66],"function":[13],"to":[14,42,49,132],"regulate":[15],"gene":[16,129],"transcription.":[17],"post-translational":[19],"occur":[22],"in":[23,81,123],"histones":[24],"within":[25],"regulatory":[27],"regions":[28],"genes":[30],"include":[31],"acetylation,":[32],"methylation,":[33],"phosphorylation,":[34],"ubiquitination,":[35],"sumoylation,":[36],"and":[37,46,48],"ADP-ribosylation.":[38],"These":[39,121],"serve":[41],"alter":[43,77,128],"chromatin":[44],"structure":[45],"accessibility,":[47],"act":[50],"as":[51],"docking":[52],"sites":[53],"for":[54,136],"transcription":[55,119],"factors":[56,65],"or":[57,108],"other":[58],"modifying":[60,106],"enzymes.":[61],"Several":[62],"are":[67],"disrupted":[68,94],"by":[69,95,100,110,117],"chromosomal":[70,96],"translocations":[71],"associated":[72],"with":[73],"hematological":[74],"malignancies":[75],"can":[76],"code":[80,91,126],"a":[82],"gene-specific":[83],"manner.":[84],"Here,":[85],"we":[86],"discuss":[87],"how":[88],"may":[92,127],"be":[93],"translocations,":[97],"either":[98],"directly":[99],"altering":[101],"activity":[103],"enzymes,":[107],"indirectly":[109],"recruitment":[111],"this":[113],"type":[114],"enzyme":[116],"oncogenic":[118],"factors.":[120],"alterations":[122],"expression":[130],"pattern":[131],"set":[133],"stage":[135],"leukemogenesis.":[137]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}
