{"id":"https://openalex.org/W2125068366","doi":"https://doi.org/10.1186/1471-2474-9-120","title":"Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants","display_name":"Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants","publication_year":2008,"publication_date":"2008-09-11","ids":{"openalex":"https://openalex.org/W2125068366","doi":"https://doi.org/10.1186/1471-2474-9-120","mag":"2125068366","pmid":"https://pubmed.ncbi.nlm.nih.gov/18786270","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553787"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2474-9-120","doi":"https://doi.org/10.1186/1471-2474-9-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2474-9-120","pdf_url":"https://bmcmusculoskeletdisord.biomedcentral.com/counter/pdf/10.1186/1471-2474-9-120","source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmusculoskeletdisord.biomedcentral.com/counter/pdf/10.1186/1471-2474-9-120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113621637","display_name":"Elian J. Uitterlinden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"EJ Uitterlinden","raw_affiliation_strings":["Dept, of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, the Netherlands. e.uitterlinden@erasmusmc.nl","Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept, of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, the Netherlands. e.uitterlinden@erasmusmc.nl","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015379450","display_name":"J.L.M. Koevoet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"JLM Koevoet","raw_affiliation_strings":["Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","Dept. of Otorhinolaryngology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Dept. of Otorhinolaryngology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137498958","display_name":"CF Verkoelen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"CF Verkoelen","raw_affiliation_strings":["Dept. of Urology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Urology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112160740","display_name":"SMA Bierma-Zeinstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"SMA Bierma-Zeinstra","raw_affiliation_strings":["Dept. of General Practice, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of General Practice, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012290052","display_name":"Holger Jahr","orcid":"https://orcid.org/0000-0001-7308-5584","observed_orcids":["https://orcid.org/0000-0001-7308-5584"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H Jahr","raw_affiliation_strings":["Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077676327","display_name":"Harrie Weinans","orcid":"https://orcid.org/0000-0002-2275-6170","observed_orcids":["https://orcid.org/0000-0002-2275-6170"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H Weinans","raw_affiliation_strings":["Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035697100","display_name":"Jan A.N. Verhaar","orcid":"https://orcid.org/0000-0003-3016-9600","observed_orcids":["https://orcid.org/0000-0003-3016-9600"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"JAN Verhaar","raw_affiliation_strings":["Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010022270","display_name":"GJVM van Osch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"GJVM van Osch","raw_affiliation_strings":["Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","Dept. of Otorhinolaryngology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"Dept. of Otorhinolaryngology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113621637"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.2068,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78493624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7422000169754028,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13335","display_name":"Pharmacological Effects of Medicinal Plants","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucosamine","display_name":"glucosamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyaluronic-acid-production","display_name":"hyaluronic acid production","score":0.8759999871253967},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9570000171661377},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.8379999995231628},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.925000011920929},{"id":"https://openalex.org/keywords/hyaluronan-synthase","display_name":"hyaluronan synthase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/has1","display_name":"HAS1","score":0.45500001311302185},{"id":"https://openalex.org/keywords/hyaluronan-synthase-2","display_name":"HAS2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/has3","display_name":"HAS3","score":0.996999979019165},{"id":"https://openalex.org/keywords/intra-articular-hyaluronic-acid","display_name":"viscosupplementation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.9371429085731506},{"id":"https://openalex.org/C2778125326","wikidata":"https://www.wikidata.org/wiki/Q327506","display_name":"Glucosamine","level":2,"score":0.8425725698471069},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8079593181610107},{"id":"https://openalex.org/C2909830753","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Viscosupplementation","level":5,"score":0.7186363935470581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4660395681858063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4576948285102844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4427407383918762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3626100718975067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34485703706741333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17028284072875977},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.10647252202033997},{"id":"https://openalex.org/C3019843197","wikidata":"https://www.wikidata.org/wiki/Q9644","display_name":"Intra articular","level":4,"score":0.06738921999931335},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076002","descriptor_name":"Hyaluronan Synthases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000117","descriptor_name":"Acetylglucosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005944","descriptor_name":"Glucosamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2474-9-120","doi":"https://doi.org/10.1186/1471-2474-9-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2474-9-120","pdf_url":"https://bmcmusculoskeletdisord.biomedcentral.com/counter/pdf/10.1186/1471-2474-9-120","source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"},{"id":"pmid:18786270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18786270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC musculoskeletal disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2553787","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2553787/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskelet Disord","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:openaire/013936da-455c-4988-a097-f4bc3c353f59","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/013936da-455c-4988-a097-f4bc3c353f59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uitterlinden, EJ, Koevoet, W, Verkoelen, CF, Bierma - Zeinstra, S, Jahr, H, Weinans, HH, Verhaar, J & van Osch, G 2008, 'Glucosamine increases hyaluronic acid production in human osteoarthritic synovium', BMC Musculoskeletal Disorders, vol. 11, no. 9, pp. 120-120. https://doi.org/10.1186/1471-2474-9-120","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/013936da-455c-4988-a097-f4bc3c353f59","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/013936da-455c-4988-a097-f4bc3c353f59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Musculoskeletal Disorders, 11(9), 120 - 120. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:14701","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/14701","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Musculoskeletal Disorders, 9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:70db949dcb6a4877ba244b1ddd05e832","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/70db949dcb6a4877ba244b1ddd05e832","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Musculoskeletal Disorders, Vol 9, Iss 1, p 120 (2008)","raw_type":"article"},{"id":"pmh:oai:repub.eur.nl:14701","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/14701","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Musculoskeletal Disorders vol. 9","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2474-9-120","doi":"https://doi.org/10.1186/1471-2474-9-120","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2474-9-120","pdf_url":"https://bmcmusculoskeletdisord.biomedcentral.com/counter/pdf/10.1186/1471-2474-9-120","source":{"id":"https://openalex.org/S35439863","display_name":"BMC Musculoskeletal Disorders","issn_l":"1471-2474","issn":["1471-2474"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Musculoskeletal Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125068366.pdf","grobid_xml":"https://content.openalex.org/works/W2125068366.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1570732","https://openalex.org/W348026187","https://openalex.org/W1721064672","https://openalex.org/W1895543855","https://openalex.org/W1967927251","https://openalex.org/W1976782359","https://openalex.org/W1980911592","https://openalex.org/W1988737738","https://openalex.org/W1990896810","https://openalex.org/W1995763698","https://openalex.org/W1997035556","https://openalex.org/W2001161438","https://openalex.org/W2003513603","https://openalex.org/W2009275174","https://openalex.org/W2021245612","https://openalex.org/W2027020554","https://openalex.org/W2035696265","https://openalex.org/W2035819854","https://openalex.org/W2040177459","https://openalex.org/W2058505385","https://openalex.org/W2064662371","https://openalex.org/W2064985599","https://openalex.org/W2068700013","https://openalex.org/W2080719283","https://openalex.org/W2087181702","https://openalex.org/W2090044039","https://openalex.org/W2094622773","https://openalex.org/W2103907900","https://openalex.org/W2106059946","https://openalex.org/W2107277218","https://openalex.org/W2117566184","https://openalex.org/W2118238661","https://openalex.org/W2130513475","https://openalex.org/W2131913743","https://openalex.org/W2145642830","https://openalex.org/W2153862724","https://openalex.org/W4243231451"],"related_works":["https://openalex.org/W1976782359","https://openalex.org/W1967927251","https://openalex.org/W2777181382","https://openalex.org/W2145015909","https://openalex.org/W2400695568","https://openalex.org/W2217853438","https://openalex.org/W1967139262","https://openalex.org/W7145503399","https://openalex.org/W2759625015","https://openalex.org/W2025344536"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glucosamine":[1],"(GlcN)":[2],"used":[3],"by":[4,58,199,217],"patients":[5],"with":[6,22,89],"osteoarthritis":[7],"was":[8,111,126,196],"demonstrated":[9],"to":[10,29,155],"reduce":[11,30],"pain,":[12],"but":[13,178],"the":[14,87,141,187,200],"working":[15],"mechanism":[16],"is":[17,26,221],"still":[18],"not":[19,197],"clear.":[20],"Viscosupplementation":[21],"hyaluronic":[23,129],"acid":[24,130],"(HA)":[25],"also":[27,172],"described":[28],"pain":[31],"in":[32,113],"osteoarthritis.":[33],"The":[34,77],"synthesis":[35],"of":[36,42,52,81,86,91,168,186,202,241],"HA":[37,56,109,152,174,188,215,243],"requires":[38],"GlcN":[39,53,203,212,233],"as":[40],"one":[41],"its":[43,235],"main":[44],"building":[45],"blocks.":[46],"We":[47],"therefore":[48],"hypothesized":[49],"that":[50,210,232],"addition":[51,90,201],"might":[54,230],"increase":[55,214],"production":[57,110,153,175,216],"synovium":[59,64,218],"tissue.":[60],"METHODS:":[61],"Human":[62],"osteoarthritic":[63],"explants":[65],"were":[66],"obtained":[67],"at":[68,224],"total":[69],"knee":[70],"surgery":[71],"and":[72,99,105,135,146,194,220],"pre-cultured":[73],"for":[74,128],"1":[75],"day.":[76],"experimental":[78],"conditions":[79],"consisted":[80],"a":[82],"2":[83,134,158,193],"days":[84],"continuation":[85],"culture":[88,114],"N-Acetyl-glucosamine":[92],"(GlcN-Ac;":[93],"5":[94,100,106,147,169],"mM),":[95,101],"glucosamine-hydrochloride":[96],"(GlcN-HCl;":[97],"0.5":[98,104,144,179],"glucose":[102],"(Gluc;":[103],"mM).":[107],"Hereafter":[108],"measured":[112],"medium":[115],"supernatant":[116],"using":[117],"an":[118],"enzyme-linked":[119],"binding":[120],"protein":[121],"assay.":[122],"Real":[123],"time":[124],"RT-PCR":[125],"performed":[127],"synthase":[131],"(HAS)":[132],"1,":[133,192],"3":[136,195],"on":[137],"RNA":[138],"isolated":[139],"from":[140],"explants.":[142],"RESULTS:":[143],"mM":[145,148,170,180],"GlcN-HCl":[149],"significantly":[150],"increased":[151,173],"compared":[154],"control":[156],"(approximately":[157,176],"-":[159],"4-fold),":[160],"whereas":[161],"GlcN-Ac":[162],"had":[163],"no":[164],"significant":[165],"effect.":[166],"Addition":[167],"Gluc":[171,181],"2-fold),":[177],"did":[182],"not.":[183],"Gene":[184],"expression":[185],"forming":[189],"enzymes":[190],"HAS":[191],"altered":[198],"or":[204],"Gluc.":[205,228],"CONCLUSION:":[206],"Our":[207],"data":[208],"suggest":[209],"exogenous":[211],"can":[213],"tissue":[219],"more":[222],"effective":[223],"lower":[225],"concentrations":[226],"than":[227],"This":[229],"indicate":[231],"exerts":[234],"potential":[236],"analgesic":[237],"properties":[238],"through":[239],"stimulation":[240],"synovial":[242],"production.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
