{"id":"https://openalex.org/W2125062016","doi":"https://doi.org/10.1186/bcr3049","title":"Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness","display_name":"Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness","publication_year":2011,"publication_date":"2011-10-27","ids":{"openalex":"https://openalex.org/W2125062016","doi":"https://doi.org/10.1186/bcr3049","mag":"2125062016","pmid":"https://pubmed.ncbi.nlm.nih.gov/22032731","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262220"},"language":"en","primary_location":{"id":"doi:10.1186/bcr3049","doi":"https://doi.org/10.1186/bcr3049","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3049","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3049","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3049","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076006564","display_name":"Esther H. Lips","orcid":"https://orcid.org/0000-0003-3488-4935","observed_orcids":["https://orcid.org/0000-0003-3488-4935"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Esther H Lips","raw_affiliation_strings":["Department of Experimental Therapy, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Therapy, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011913289","display_name":"Nadja Laddach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129008","display_name":"MRC Holland (Netherlands)","ror":"https://ror.org/02wcat891","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210129008"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nadja Laddach","raw_affiliation_strings":["MRC-Holland, Willem Schoutenstraat 6, 1057 DN, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC-Holland, Willem Schoutenstraat 6, 1057 DN, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210129008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029689310","display_name":"Suvi P. Savola","orcid":"https://orcid.org/0000-0002-6221-8617","observed_orcids":["https://orcid.org/0000-0002-6221-8617"]},"institutions":[{"id":"https://openalex.org/I4210129008","display_name":"MRC Holland (Netherlands)","ror":"https://ror.org/02wcat891","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210129008"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suvi P Savola","raw_affiliation_strings":["MRC-Holland, Willem Schoutenstraat 6, 1057 DN, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC-Holland, Willem Schoutenstraat 6, 1057 DN, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210129008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051110690","display_name":"Marieke A. Vollebergh","orcid":"https://orcid.org/0000-0002-6524-3068","observed_orcids":["https://orcid.org/0000-0002-6524-3068"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marieke A Vollebergh","raw_affiliation_strings":["Department of Molecular Biology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054533242","display_name":"Anne M.M. Oonk","orcid":"https://orcid.org/0000-0001-7403-9707","observed_orcids":["https://orcid.org/0000-0001-7403-9707"]},"institutions":[{"id":"https://openalex.org/I4210156224","display_name":"Deventer Ziekenhuis","ror":"https://ror.org/05w8df681","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210156224"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anne MM Oonk","raw_affiliation_strings":["Department of Medical Oncology, Deventer Hospital, N. Bolkesteinlaan 75, 6416 SE, Deventer, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Deventer Hospital, N. Bolkesteinlaan 75, 6416 SE, Deventer, The Netherlands","institution_ids":["https://openalex.org/I4210156224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026959007","display_name":"Alex L.T. Imholz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156224","display_name":"Deventer Ziekenhuis","ror":"https://ror.org/05w8df681","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210156224"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alex LT Imholz","raw_affiliation_strings":["Department of Medical Oncology, Deventer Hospital, N. Bolkesteinlaan 75, 6416 SE, Deventer, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Deventer Hospital, N. Bolkesteinlaan 75, 6416 SE, Deventer, The Netherlands","institution_ids":["https://openalex.org/I4210156224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020129085","display_name":"Lodewyk F.A. Wessels","orcid":"https://orcid.org/0000-0002-1656-6995","observed_orcids":["https://orcid.org/0000-0002-1656-6995"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lodewyk FA Wessels","raw_affiliation_strings":["Department of Bioinformatics and Statistics, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Statistics, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020517461","display_name":"Jelle Wesseling","orcid":"https://orcid.org/0000-0002-8940-2676","observed_orcids":["https://orcid.org/0000-0002-8940-2676"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jelle Wesseling","raw_affiliation_strings":["Department of Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079501701","display_name":"Petra M. Nederlof","orcid":"https://orcid.org/0000-0002-2358-9765","observed_orcids":["https://orcid.org/0000-0002-2358-9765"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Petra M Nederlof","raw_affiliation_strings":["Department of Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111726498","display_name":"Sjoerd Rodenhuis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Sjoerd Rodenhuis","raw_affiliation_strings":["Department of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111726498"],"corresponding_institution_ids":["https://openalex.org/I2898336195"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.0415,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.86806857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"13","issue":"5","first_page":"R107","last_page":"R107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brcaness","display_name":"BRCAness","score":0.8830000162124634},{"id":"https://openalex.org/keywords/brca1-mutation","display_name":"BRCA1 mutation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/multiplex-ligation-dependent-probe-amplification","display_name":"multiplex ligation-dependent probe amplification","score":0.5270000100135803},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.597000002861023},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.4189999997615814},{"id":"https://openalex.org/keywords/alkylating-chemotherapy","display_name":"alkylating chemotherapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/brca1-promoter-methylation","display_name":"BRCA1 promoter methylation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/survival-benefit","display_name":"survival benefit","score":0.46399998664855957},{"id":"https://openalex.org/keywords/sporadic-breast-cancer","display_name":"sporadic breast cancer","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C120599132","wikidata":"https://www.wikidata.org/wiki/Q602889","display_name":"Multiplex ligation-dependent probe amplification","level":4,"score":0.8588899970054626},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6660012006759644},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.650183379650116},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.5801831483840942},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.434871643781662},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.4336167573928833},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.41086986660957336},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4103233218193054},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3915822505950928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37969911098480225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37821102142333984},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3236073851585388},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29516011476516724},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2238313853740692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2134031355381012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1946687400341034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1897592842578888},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1487596333026886},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11826607584953308},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.09340840578079224}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019313","descriptor_name":"BRCA1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/bcr3049","doi":"https://doi.org/10.1186/bcr3049","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3049","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3049","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3262220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3262220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmid:22032731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22032731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/c8c702c2-bf48-452a-9e64-ac2647f468b6","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/c8c702c2-bf48-452a-9e64-ac2647f468b6","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lips, E H, Laddach, N, Savola, S P, Vollebergh, M A, Oonk, A M M, Imholz, A L T, Wessels, L F A, Wesseling, J, Nederlof, P M & Rodenhuis, S 2011, 'Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness', Breast cancer research, vol. 13, no. 5, pp. R107. https://doi.org/10.1186/bcr3049","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.5501","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.5501","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7c/09/Breast_Cancer_Res_2011_Oct_27_13(5)_R107.tar.gz","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/714c220f-06d2-4be6-a249-16b6bb576cba","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/quantitative-copy-number-analysis-by-multiplex-ligationdependent-probe-amplification-mlpa-of-brca1associated-breast-cancer-regions-identifies-brcaness(714c220f-06d2-4be6-a249-16b6bb576cba).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Breast cancer research, 13(5). BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/bcr3049","doi":"https://doi.org/10.1186/bcr3049","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3049","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3049","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3052533721","display_name":null,"funder_award_id":"030-104","funder_id":"https://openalex.org/F4320323596","funder_display_name":"Center for Translational Molecular Medicine"}],"funders":[{"id":"https://openalex.org/F4320323596","display_name":"Center for Translational Molecular Medicine","ror":"https://ror.org/047wvvg23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125062016.pdf","grobid_xml":"https://content.openalex.org/works/W2125062016.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1523531555","https://openalex.org/W1964932691","https://openalex.org/W1973560717","https://openalex.org/W1975570360","https://openalex.org/W2008233728","https://openalex.org/W2040436551","https://openalex.org/W2074565257","https://openalex.org/W2083508318","https://openalex.org/W2098652713","https://openalex.org/W2100078825","https://openalex.org/W2104867201","https://openalex.org/W2113926943","https://openalex.org/W2114416638","https://openalex.org/W2116035619","https://openalex.org/W2118782378","https://openalex.org/W2128985829","https://openalex.org/W2133258471","https://openalex.org/W2135724221","https://openalex.org/W2136902656","https://openalex.org/W2138550913","https://openalex.org/W2142486051","https://openalex.org/W2143858250","https://openalex.org/W2150133682","https://openalex.org/W2156077962","https://openalex.org/W2157507405","https://openalex.org/W2169790254","https://openalex.org/W2171972386"],"related_works":["https://openalex.org/W2565472205","https://openalex.org/W7097655490","https://openalex.org/W2535064044","https://openalex.org/W3044938093","https://openalex.org/W2134694706","https://openalex.org/W6939386400","https://openalex.org/W2098652713","https://openalex.org/W2326716637","https://openalex.org/W198990198","https://openalex.org/W7066380222"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Our":[1],"group":[2,132],"has":[3],"previously":[4,125,274],"employed":[5],"array":[6],"Comparative":[7],"Genomic":[8],"Hybridization":[9],"(aCGH)":[10],"to":[11,61,69,102,248,313,322],"assess":[12],"the":[13,24,58,89,157,184,195,218,243,258,277,282],"genomic":[14,86],"patterns":[15],"of":[16,34,88,105,113,134,169,198,208,214,226,229,305],"BRCA1-mutated":[17,72,136],"breast":[18,38,73,116,121,172,177,231,250,288],"cancers.":[19],"We":[20,150],"have":[21],"shown":[22,271],"that":[23],"so-called":[25],"BRCA1-like(aCGH)":[26,80,115,131,171],"profile":[27,60],"is":[28,41,51,331],"also":[29],"present":[30],"in":[31,194],"about":[32],"half":[33],"all":[35],"triple-negative":[36,190],"sporadic":[37,76,139],"cancers":[39,74,117,173],"and":[40,75,118,138,160,174,235,239,301,319,333,339],"predictive":[42],"for":[43,262,297],"benefit":[44,261],"from":[45,253,345],"intensified":[46,267],"alkylating":[47,268],"chemotherapy.":[48],"As":[49],"aCGH":[50,91,278],"a":[52,62,79,103,152,254,303],"rather":[53],"complex":[54],"method,":[55],"we":[56,182],"translated":[57],"BRCA1(aCGH)":[59],"Multiplex":[63],"Ligation-dependent":[64],"Probe":[65],"Amplification":[66],"(MLPA)":[67],"assay,":[68],"identify":[70,286],"both":[71,296],"cases":[77,137],"with":[78,141,266,315,342],"profile.":[81],"METHODS:":[82],"The":[83,109,130,328],"most":[84,320],"important":[85],"regions":[87],"original":[90],"based":[92],"classifier":[93,155,216],"(3q22-27,":[94],"5q12-14,":[95],"6p23-22,":[96],"12p13,":[97],"12q21-23,":[98],"13q31-34)":[99],"were":[100,237],"mapped":[101],"set":[104,111,159,168,185,197,221],"34":[106],"MLPA":[107,283,329],"probes.":[108],"training":[110,158,196],"consisted":[112,133],"39":[114],"45":[119],"non-BRCA1-like(aCGH)":[120,176],"cancers,":[122],"which":[123],"had":[124],"been":[126],"analyzed":[127],"by":[128,205],"aCGH.":[129],"germline":[135],"tumours":[140,200,232,264,309],"low":[142],"BRCA1":[143,147],"gene":[144],"expression":[145],"and/or":[146],"promoter":[148],"methylation.":[149],"trained":[151],"shrunken":[153],"centroids":[154],"on":[156,164,187,217],"validation":[161,220],"was":[162,245,270,273],"performed":[163],"an":[165],"independent":[166,219],"test":[167],"40":[170],"32":[175],"cancer":[178,289],"tumours.":[179,191],"In":[180],"addition,":[181],"validated":[183],"prospectively":[186],"69":[188],"new":[189],"RESULTS:":[192],"BRCAness":[193],"84":[199],"could":[201,293],"accurately":[202],"be":[203,294,337],"predicted":[204,223],"prediction":[206],"analysis":[207],"microarrays":[209],"(PAM)":[210],"(accuracy":[211],"94%).":[212],"Application":[213],"this":[215,291],"correctly":[222],"BRCA-like":[224],"status":[225],"62":[227],"out":[228],"72":[230],"(86%).":[233],"Sensitivity":[234],"specificity":[236],"85%":[238],"87%,":[240],"respectively.":[241],"When":[242],"MLPA-test":[244],"subsequently":[246],"applied":[247,295],"46":[249],"tumour":[251],"samples":[252],"randomized":[255],"clinical":[256,298],"trial,":[257],"same":[259],"survival":[260],"BRCA1-like":[263,308],"associated":[265],"chemotherapy":[269,314],"as":[272,302],"reported":[275],"using":[276],"assay.":[279],"CONCLUSIONS:":[280],"Since":[281],"assay":[284,330],"can":[285,335],"BRCA1-deficient":[287],"patients,":[290],"method":[292],"genetic":[299],"testing":[300],"predictor":[304],"treatment":[306],"benefit.":[307],"are":[310],"highly":[311],"sensitive":[312],"DNA":[316,343],"damaging":[317],"agents,":[318],"likely":[321],"poly":[323],"ADP":[324],"ribose":[325],"polymerase":[326],"(PARP)-inhibitors.":[327],"rapid":[332],"robust,":[334],"easily":[336],"multiplexed,":[338],"works":[340],"well":[341],"derived":[344],"paraffin-embedded":[346],"tissues.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}