{"id":"https://openalex.org/W2124999867","doi":"https://doi.org/10.4049/jimmunol.171.8.3941","title":"Intratumor CpG-Oligodeoxynucleotide Injection Induces Protective Antitumor T Cell Immunity","display_name":"Intratumor CpG-Oligodeoxynucleotide Injection Induces Protective Antitumor T Cell Immunity","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2124999867","doi":"https://doi.org/10.4049/jimmunol.171.8.3941","mag":"2124999867","pmid":"https://pubmed.ncbi.nlm.nih.gov/14530311"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.171.8.3941","doi":"https://doi.org/10.4049/jimmunol.171.8.3941","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.171.8.3941","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/171/8/3941/1173643/3941.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/171/8/3941/1173643/3941.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041804592","display_name":"Anke S. Lonsdorf","orcid":"https://orcid.org/0000-0003-3582-7238","observed_orcids":["https://orcid.org/0000-0003-3582-7238"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Anke S Lonsdorf","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","Section of Endocrinology, University Hospitals of Ulm , Ulm ,","*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","\u2020Section of Endocrinology, University Hospitals of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Section of Endocrinology, University Hospitals of Ulm , Ulm ,","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"\u2020Section of Endocrinology, University Hospitals of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086377316","display_name":"Haydar Kuekrek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haydar Kuekrek","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Britta V Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britta V Stern","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001086144","display_name":"Bernhard Otto Boehm","orcid":"https://orcid.org/0000-0002-2706-7710","observed_orcids":["https://orcid.org/0000-0002-2706-7710"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard O Boehm","raw_affiliation_strings":["Section of Endocrinology, University Hospitals of Ulm , Ulm ,","\u2020Section of Endocrinology, University Hospitals of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Endocrinology, University Hospitals of Ulm , Ulm ,","institution_ids":["https://openalex.org/I4210155144"]},{"raw_affiliation_string":"\u2020Section of Endocrinology, University Hospitals of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103858135","display_name":"Paul Lehmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul V Lehmann","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064125084","display_name":"Magdalena Tary\u2010Lehmann","orcid":"https://orcid.org/0000-0002-0709-1609","observed_orcids":["https://orcid.org/0000-0002-0709-1609"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magdalena Tary-Lehmann","raw_affiliation_strings":["Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"*Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106; and","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086377316"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.3045,"has_fulltext":true,"cited_by_count":113,"citation_normalized_percentile":{"value":0.92914599,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"171","issue":"8","first_page":"3941","last_page":"3946"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.9710000157356262},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.8740000128746033},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.781000018119812},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rag1-knockout-mice","display_name":"Rag1 knockout mice","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C22801619","wikidata":"https://www.wikidata.org/wiki/Q477471","display_name":"CpG Oligodeoxynucleotide","level":5,"score":0.6753191351890564},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5519940257072449},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5090836882591248},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44952550530433655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41642555594444275},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3424321413040161},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33698809146881104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3132094740867615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.303941011428833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1461387574672699},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09319940209388733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05243566632270813},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.03714582324028015},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016399","descriptor_name":"Lymphoma, T-Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.171.8.3941","doi":"https://doi.org/10.4049/jimmunol.171.8.3941","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.171.8.3941","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/171/8/3941/1173643/3941.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:14530311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14530311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.171.8.3941","doi":"https://doi.org/10.4049/jimmunol.171.8.3941","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.171.8.3941","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/171/8/3941/1173643/3941.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2087017593","display_name":null,"funder_award_id":"AI 47756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G766838549","display_name":"SINGLE CELL ANALYSIS OF T CELL IMMUNITY IN HIV","funder_award_id":"5r01ai047756-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124999867.pdf","grobid_xml":"https://content.openalex.org/works/W2124999867.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1515712626","https://openalex.org/W1518943038","https://openalex.org/W1577612079","https://openalex.org/W1596882411","https://openalex.org/W1599912281","https://openalex.org/W1600937541","https://openalex.org/W1623460711","https://openalex.org/W1787529017","https://openalex.org/W1826114831","https://openalex.org/W1855377691","https://openalex.org/W1903411571","https://openalex.org/W1909773374","https://openalex.org/W1909810986","https://openalex.org/W1930598094","https://openalex.org/W1967067404","https://openalex.org/W1967246876","https://openalex.org/W1968733363","https://openalex.org/W1972365190","https://openalex.org/W1978416272","https://openalex.org/W2000411347","https://openalex.org/W2016862474","https://openalex.org/W2020421317","https://openalex.org/W2023820705","https://openalex.org/W2033441782","https://openalex.org/W2071636826","https://openalex.org/W2081266951","https://openalex.org/W2081767375","https://openalex.org/W2084341407","https://openalex.org/W2092128665","https://openalex.org/W2092312916","https://openalex.org/W2106414148","https://openalex.org/W2106986504","https://openalex.org/W2112295570","https://openalex.org/W2117761826","https://openalex.org/W2118376550","https://openalex.org/W2119817247","https://openalex.org/W2135389367","https://openalex.org/W2150049703","https://openalex.org/W2158500407","https://openalex.org/W2165645608","https://openalex.org/W2171986697","https://openalex.org/W2408571534"],"related_works":["https://openalex.org/W7098124825","https://openalex.org/W2004207481","https://openalex.org/W1626137214","https://openalex.org/W7008830564","https://openalex.org/W2124904079","https://openalex.org/W2167978183","https://openalex.org/W1504879144","https://openalex.org/W2084341407","https://openalex.org/W2169035834","https://openalex.org/W2587141145"],"abstract_inverted_index":{"Tumor":[0],"cells":[1,146],"are":[2,45],"typically":[3],"poorly":[4],"immunogenic.":[5,170],"The":[6,155],"same":[7],"mechanisms":[8],"that":[9,50,158],"evolved":[10],"to":[11,27,55,62,128,151],"avoid":[12],"the":[13,47,51,83,94,139,149],"induction":[14],"of":[15,33,103,124,138,161],"immune":[16,31,52,110],"responses":[17],"against":[18],"self":[19,67],"tissues,":[20],"and,":[21],"hence,":[22],"autoimmune":[23],"disease,":[24],"also":[25],"have":[26],"be":[28,63,71],"overcome":[29],"for":[30,167],"therapy":[32],"cancer.":[34],"Toll-like":[35],"receptor-activating":[36],"microbial":[37],"products":[38],"such":[39],"as":[40],"CpG":[41],"motif":[42],"containing":[43],"DNA":[44],"among":[46],"primary":[48],"stimuli":[49],"system":[53],"uses":[54],"distinguish":[56],"between":[57],"infectious":[58,84],"nonself":[59,85],"(that":[60,68],"is":[61,163],"attacked)":[64],"and":[65,133,144],"noninfectious":[66],"must":[69],"not":[70,114],"attacked).":[72],"We":[73],"tested":[74],"in":[75,87,109,115],"a":[76,88,97,130,164],"murine":[77],"RMA":[78],"lymphoma/C57BL/6":[79],"model":[80],"whether":[81],"providing":[82],"context":[86],"tumor-by":[89],"injecting":[90],"CpG-oligodeoxynucleotides":[91,125,162],"directly":[92],"into":[93],"tumor-would":[95],"elicit":[96],"protective":[98],"antitumor":[99],"response.":[100],"Complete":[101],"remission":[102],"established":[104],"solid":[105],"tumors":[106,169],"was":[107,126],"achieved":[108],"competent":[111],"mice,":[112],"but":[113],"T":[116,135,145],"cell/B":[117],"cell-deficient":[118],"RAG-1":[119,152],"knockout":[120,153],"mice.":[121,154],"Intratumor":[122],"injection":[123,160],"shown":[127],"induce":[129],"tumor-specific":[131],"CD4(+)":[132],"CD8(+)":[134],"cell":[136],"response":[137],"type":[140],"1":[141],"effector":[142],"class,":[143],"adoptively":[147],"transferred":[148],"protection":[150],"data":[156],"show":[157],"intratumor":[159],"promising":[165],"strategy":[166],"rendering":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
