{"id":"https://openalex.org/W2124998586","doi":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","title":"Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity","display_name":"Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2124998586","doi":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","mag":"2124998586","pmid":"https://pubmed.ncbi.nlm.nih.gov/11971976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/133784"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.22.10.3450-3459.2002","doi":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC133784/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Department of Medicine and Brander Cancer Research Institute, New York Medical College","Department of Medicine and Brander Cancer Research Institute, New York Medical College, Hwathorne, 10532, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College, Hwathorne, 10532, USA","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014815165","display_name":"Suqing Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suqing Xie","raw_affiliation_strings":["Department of Medicine and Brander Cancer Research Institute, New York Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332958","display_name":"Jie Chen","orcid":"https://orcid.org/0000-0002-7773-3160","observed_orcids":["https://orcid.org/0000-0002-7773-3160"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]},{"id":"https://openalex.org/I4405264495","display_name":"American Health Foundation","ror":"https://ror.org/023ynsm82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405264495"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["American Health Foundation","American Health Foundation, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Health Foundation","institution_ids":["https://openalex.org/I4210167017","https://openalex.org/I4405264495"]},{"raw_affiliation_string":"American Health Foundation, Valhalla, New York 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110884574","display_name":"Kenji Fukasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenji Fukasawa","raw_affiliation_strings":["Department of Cell Biology, University of Cincinnati College of Medicine","Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45269"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Cincinnati College of Medicine","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45269","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048642675","display_name":"Ulhas Pandurang Naik","orcid":"https://orcid.org/0000-0001-7556-444X","observed_orcids":["https://orcid.org/0000-0001-7556-444X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulhas Naik","raw_affiliation_strings":["Department of Biological Sciences, University of Delaware","Department of Biological Sciences, University of Delaware, Newark, Delaware 19716"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Delaware, Newark, Delaware 19716","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013493640","display_name":"Frank Traganos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank Traganos","raw_affiliation_strings":["Department of Medicine and Brander Cancer Research Institute, New York Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086304089","display_name":"Zbigniew Dar\u017cynkiewicz","orcid":"https://orcid.org/0000-0002-2040-7081","observed_orcids":["https://orcid.org/0000-0002-2040-7081"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Darzynkiewicz","raw_affiliation_strings":["Department of Medicine and Brander Cancer Research Institute, New York Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000968218","display_name":"Meena Jhanwar\u2010Uniyal","orcid":"https://orcid.org/0000-0002-0581-0972","observed_orcids":["https://orcid.org/0000-0002-0581-0972"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]},{"id":"https://openalex.org/I4405264495","display_name":"American Health Foundation","ror":"https://ror.org/023ynsm82","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405264495"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meena Jhanwar-Uniyal","raw_affiliation_strings":["American Health Foundation","American Health Foundation, Valhalla, New York 10595"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Health Foundation","institution_ids":["https://openalex.org/I4210167017","https://openalex.org/I4405264495"]},{"raw_affiliation_string":"American Health Foundation, Valhalla, New York 10595","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048237280","display_name":"Wei Hao Dai","orcid":"https://orcid.org/0000-0003-0169-8327","observed_orcids":["https://orcid.org/0000-0003-0169-8327"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Dai","raw_affiliation_strings":["Department of Medicine and Brander Cancer Research Institute, New York Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Brander Cancer Research Institute, New York Medical College","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5048237280"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":2.0527,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.85661614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"10","first_page":"3450","last_page":"3459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk3","display_name":"PLK3","score":0.984000027179718},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8019999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.9570000171661377},{"id":"https://openalex.org/keywords/centrosome","display_name":"centrosome","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gamma-tubulin","display_name":"gamma-tubulin","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.7369999885559082},{"id":"https://openalex.org/keywords/midbody","display_name":"midbody","score":0.9580000042915344},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kinase-activity","display_name":"kinase activity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/nuclear-membrane-localization","display_name":"nuclear membrane localization","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.8261998295783997},{"id":"https://openalex.org/C84815855","wikidata":"https://www.wikidata.org/wiki/Q7225885","display_name":"Polo-like kinase","level":4,"score":0.7731111645698547},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.772680401802063},{"id":"https://openalex.org/C141561535","wikidata":"https://www.wikidata.org/wiki/Q12565265","display_name":"Telophase","level":5,"score":0.766599178314209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7640324831008911},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6989219784736633},{"id":"https://openalex.org/C164265269","wikidata":"https://www.wikidata.org/wiki/Q6841126","display_name":"Midbody","level":5,"score":0.6719126105308533},{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.6191234588623047},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5394995212554932},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4594477415084839},{"id":"https://openalex.org/C3453395","wikidata":"https://www.wikidata.org/wiki/Q6935034","display_name":"Multipolar spindles","level":5,"score":0.44981083273887634},{"id":"https://openalex.org/C29452124","wikidata":"https://www.wikidata.org/wiki/Q835950","display_name":"Interphase","level":2,"score":0.4370593726634979},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4167681336402893},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.3740781247615814},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25880497694015503},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.18251943588256836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16810888051986694}],"mesh":[{"descriptor_ui":"D000097868","descriptor_name":"Polo-like Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002458","descriptor_name":"Cell Fractionation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.22.10.3450-3459.2002","doi":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.22.10.3450-3459.2002","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:11971976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11971976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:133784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC133784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:133784","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC133784/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3434068877","display_name":null,"funder_award_id":"R01-74229","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1537737236","https://openalex.org/W1584993109","https://openalex.org/W1820990168","https://openalex.org/W1823624119","https://openalex.org/W1964588861","https://openalex.org/W1968868084","https://openalex.org/W1974559056","https://openalex.org/W1987957628","https://openalex.org/W1989943486","https://openalex.org/W1995011897","https://openalex.org/W2011953594","https://openalex.org/W2015474692","https://openalex.org/W2018745023","https://openalex.org/W2022195980","https://openalex.org/W2025909295","https://openalex.org/W2038951216","https://openalex.org/W2068384749","https://openalex.org/W2074730820","https://openalex.org/W2077075729","https://openalex.org/W2079645368","https://openalex.org/W2080092742","https://openalex.org/W2085512260","https://openalex.org/W2102840434","https://openalex.org/W2110906301","https://openalex.org/W2113517398","https://openalex.org/W2116765394","https://openalex.org/W2132300009","https://openalex.org/W2138817040","https://openalex.org/W2163975232","https://openalex.org/W2172117494","https://openalex.org/W2322441397","https://openalex.org/W2334440180"],"related_works":["https://openalex.org/W2102403319","https://openalex.org/W2079038433","https://openalex.org/W2014449216","https://openalex.org/W2990419678","https://openalex.org/W2128261127","https://openalex.org/W1978289106","https://openalex.org/W3186464055","https://openalex.org/W2059676290","https://openalex.org/W2058727957","https://openalex.org/W2119769227"],"abstract_inverted_index":{"Human":[0],"Polo-like":[1],"kinase":[2],"3":[3],"(Plk3,":[4],"previously":[5],"termed":[6],"Prk":[7],"or":[8],"Fnk)":[9],"is":[10],"involved":[11],"in":[12,46,121,149,222,231,241],"regulation":[13,224],"of":[14,70,92,116,126,142,157,182,191,225,238],"cell":[15,131,151,233,242],"cycle":[16,243],"progression":[17],"through":[18],"the":[19,56,65,90,122,180,204,223,232],"M":[20],"phase":[21],"(B.":[22],"Ouyang,":[23],"H.":[24],"Pan,":[25],"L.":[26],"Lu,":[27],"J.":[28,37],"Li,":[29,33],"P.":[30],"Stambrook,":[31],"B.":[32],"and":[34,63,81,108,163,194,228,234,245],"W.":[35],"Dai,":[36],"Biol.":[38],"Chem.":[39],"272:28646-28651,":[40],"1997).":[41],"Here":[42],"we":[43],"report":[44],"that":[45,74,82,216,235],"most":[47],"interphase":[48],"cells":[49,158,168],"endogenous":[50],"Plk3":[51,62,75,96,117,127,146,172,217,239],"was":[52,76,87,118,184,207],"predominantly":[53],"localized":[54,100],"around":[55],"nuclear":[57],"membrane.":[58],"Double":[59],"labeling":[60],"with":[61,79,159],"gamma-tubulin,":[64],"latter":[66],"a":[67,113,143,170],"major":[68],"component":[69],"pericentriole":[71],"materials,":[72],"revealed":[73],"closely":[77],"associated":[78],"centrosomes":[80,86],"its":[83],"localization":[84],"to":[85,98,101,135,155,187],"dependent":[88],"on":[89,138],"integrity":[91],"microtubules.":[93],"Throughout":[94],"mitosis,":[95],"appeared":[97],"be":[99],"mitotic":[102,109],"apparatus":[103],"such":[104],"as":[105],"spindle":[106],"poles":[107],"spindles.":[110],"During":[111],"telophase,":[112],"significant":[114],"amount":[115],"also":[119],"detected":[120],"midbody.":[123,165],"Ectopic":[124],"expression":[125,237],"mutants":[128],"dramatically":[129],"changed":[130],"morphology":[132],"primarily":[133],"due":[134],"their":[136],"effects":[137],"microtubule":[139,226],"dynamics.":[140],"Expression":[141,190],"constitutively":[144],"active":[145],"(Plk3-A)":[147],"resulted":[148],"rapid":[150],"shrinkage,":[152],"which":[153,183],"led":[154],"formation":[156],"an":[160,219],"elongated,":[161],"unsevered,":[162],"taxol-sensitive":[164],"In":[166],"contrast,":[167],"expressing":[169],"kinase-defective":[171,205],"(Plk3(K52R))":[173],"mutant":[174,206],"exhibited":[175],"extended,":[176],"deformed":[177],"cytoplasmic":[178],"structures,":[179],"phenotype":[181],"somewhat":[185],"refractory":[186],"taxol":[188],"treatment.":[189],"both":[192],"Plk3-A":[193],"Plk3(K52R)":[195],"induced":[196],"apparent":[197],"G(2)/M":[198],"arrest":[199,244],"followed":[200],"by":[201],"apoptosis,":[202],"although":[203],"less":[208],"effective.":[209],"Taken":[210],"together,":[211],"our":[212],"studies":[213],"strongly":[214],"suggest":[215],"plays":[218],"important":[220],"role":[221],"dynamics":[227],"centrosomal":[229],"function":[230],"deregulated":[236],"results":[240],"apoptosis.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
